blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

Italy joins the Federated Register

Click here for more information on the Federated Register.

2025-06-12

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register User Manual
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2734214

EP2734214 - TARGETED OSMOTIC LYSIS OF CANCER CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.04.2020
Database last updated on 28.03.2026
FormerThe patent has been granted
Status updated on  26.04.2019
FormerGrant of patent is intended
Status updated on  29.01.2019
FormerExamination is in progress
Status updated on  21.12.2018
FormerGrant of patent is intended
Status updated on  19.08.2018
FormerExamination is in progress
Status updated on  18.11.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
115 System Building, 3810 W. Lakeshore Drive
Baton Rouge, LA 70808 / US
[2019/22]
Former [2014/22]For all designated states
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
115 System Building, 3810 W. Lakeshore Drive
Baton Rouge, LA 70808 / US
Inventor(s)01 / PAUL, Dennis, J.
836 Louisiana Avenue
New Orleans, LA 70115 / US
02 / GOULD, Harry, J.
1750 St. Charles Avenue
Unit 308
New Orleans, LA 70130 / US
 [2014/22]
Representative(s)Forrest, Stuart, et al
WP Thompson
138 Fetter Lane
London EC4A 1BT / GB
[N/P]
Former [2019/22]Rees, Kerry
WP Thompson
138 Fetter Lane
London EC4A 1BT / GB
Former [2014/22]WP Thompson
Coopers Building
Church Street
Liverpool L1 3AB / GB
Application number, filing date12814986.119.07.2012
[2019/22]
WO2012US47312
Priority number, dateUS201161510258P21.07.2011         Original published format: US 201161510258 P
[2014/22]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013012997
Date:24.01.2013
Language:EN
[2013/04]
Type: A1 Application with search report 
No.:EP2734214
Date:28.05.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 24.01.2013 takes the place of the publication of the European patent application.
[2014/22]
Type: B1 Patent specification 
No.:EP2734214
Date:29.05.2019
Language:EN
[2019/22]
Search report(s)International search report - published on:RU24.01.2013
(Supplementary) European search report - dispatched on:EP06.03.2015
ClassificationIPC:A61K35/00, A61K31/70, G01N33/50, A61N1/00, A61P35/00
[2018/34]
CPC:
A61K31/7048 (EP,US); A61K31/4375 (EP,US); A61K31/704 (EP,US);
A61K45/06 (US); A61N1/36002 (EP,US); A61N2/002 (US);
A61N7/00 (US); A61P35/00 (EP); A61P35/02 (EP);
A61P43/00 (EP); A61N1/0452 (EP,US); A61N1/0456 (EP,US) (-)
Former IPC [2014/22]A61K35/00, A61K31/704, G01N33/50, A61N1/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/22]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:GEZIELTE OSMOTISCHE LYSE VON KREBSZELLEN[2014/22]
English:TARGETED OSMOTIC LYSIS OF CANCER CELLS[2014/22]
French:LYSE OSMOTIQUE CIBLÉE DE CELLULES CANCÉREUSES[2014/22]
Entry into regional phase19.02.2014National basic fee paid 
19.02.2014Search fee paid 
19.02.2014Designation fee(s) paid 
19.02.2014Examination fee paid 
Examination procedure19.02.2014Examination requested  [2014/22]
25.09.2015Amendment by applicant (claims and/or description)
07.07.2016Despatch of a communication from the examining division (Time limit: M06)
20.12.2016Reply to a communication from the examining division
04.07.2017Despatch of a communication from the examining division (Time limit: M06)
15.01.2018Reply to a communication from the examining division
20.08.2018Communication of intention to grant the patent
19.12.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
30.01.2019Communication of intention to grant the patent
16.04.2019Fee for grant paid
16.04.2019Fee for publishing/printing paid
16.04.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  07.07.2016
Opposition(s)03.03.2020No opposition filed within time limit [2020/19]
Fees paidRenewal fee
28.07.2014Renewal fee patent year 03
27.07.2015Renewal fee patent year 04
27.07.2016Renewal fee patent year 05
27.07.2017Renewal fee patent year 06
27.07.2018Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU19.07.2012
AL29.05.2019
AT29.05.2019
CY29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
HR29.05.2019
IT29.05.2019
LT29.05.2019
LV29.05.2019
MK29.05.2019
MT29.05.2019
PL29.05.2019
RO29.05.2019
RS29.05.2019
SI29.05.2019
SK29.05.2019
SM29.05.2019
TR29.05.2019
BE31.07.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
IS29.09.2019
PT30.09.2019
[2022/31]
Former [2021/34]HU19.07.2012
AL29.05.2019
AT29.05.2019
CY29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
HR29.05.2019
IT29.05.2019
LT29.05.2019
LV29.05.2019
MT29.05.2019
PL29.05.2019
RO29.05.2019
RS29.05.2019
SI29.05.2019
SK29.05.2019
SM29.05.2019
TR29.05.2019
BE31.07.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
IS29.09.2019
PT30.09.2019
Former [2021/32]HU19.07.2012
AL29.05.2019
AT29.05.2019
CY29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
HR29.05.2019
IT29.05.2019
LT29.05.2019
LV29.05.2019
PL29.05.2019
RO29.05.2019
RS29.05.2019
SI29.05.2019
SK29.05.2019
SM29.05.2019
TR29.05.2019
BE31.07.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
IS29.09.2019
PT30.09.2019
Former [2021/31]AL29.05.2019
AT29.05.2019
CY29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
HR29.05.2019
IT29.05.2019
LT29.05.2019
LV29.05.2019
PL29.05.2019
RO29.05.2019
RS29.05.2019
SI29.05.2019
SK29.05.2019
SM29.05.2019
TR29.05.2019
BE31.07.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
IS29.09.2019
PT30.09.2019
Former [2021/26]AL29.05.2019
AT29.05.2019
CY29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
HR29.05.2019
IT29.05.2019
LT29.05.2019
LV29.05.2019
PL29.05.2019
RO29.05.2019
RS29.05.2019
SI29.05.2019
SK29.05.2019
SM29.05.2019
TR29.05.2019
BE31.07.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
PT30.09.2019
Former [2020/25]AL29.05.2019
AT29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
HR29.05.2019
IT29.05.2019
LT29.05.2019
LV29.05.2019
PL29.05.2019
RO29.05.2019
RS29.05.2019
SI29.05.2019
SK29.05.2019
SM29.05.2019
TR29.05.2019
BE31.07.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
PT30.09.2019
Former [2020/17]AL29.05.2019
AT29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
HR29.05.2019
IT29.05.2019
LT29.05.2019
LV29.05.2019
RO29.05.2019
RS29.05.2019
SK29.05.2019
SM29.05.2019
TR29.05.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
PT30.09.2019
Former [2020/14]AL29.05.2019
AT29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
HR29.05.2019
IT29.05.2019
LT29.05.2019
LV29.05.2019
RO29.05.2019
RS29.05.2019
SK29.05.2019
SM29.05.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
PT30.09.2019
Former [2020/12]AL29.05.2019
AT29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
HR29.05.2019
IT29.05.2019
LT29.05.2019
LV29.05.2019
RO29.05.2019
RS29.05.2019
SK29.05.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
PT30.09.2019
Former [2020/11]AL29.05.2019
AT29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
HR29.05.2019
LT29.05.2019
LV29.05.2019
RO29.05.2019
RS29.05.2019
SK29.05.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
PT30.09.2019
Former [2020/10]AL29.05.2019
AT29.05.2019
CZ29.05.2019
DK29.05.2019
ES29.05.2019
HR29.05.2019
LT29.05.2019
LV29.05.2019
RO29.05.2019
RS29.05.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
PT30.09.2019
Former [2020/09]AL29.05.2019
CZ29.05.2019
DK29.05.2019
ES29.05.2019
HR29.05.2019
LT29.05.2019
LV29.05.2019
RS29.05.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
PT30.09.2019
Former [2019/51]AL29.05.2019
ES29.05.2019
HR29.05.2019
LT29.05.2019
LV29.05.2019
RS29.05.2019
BG29.08.2019
NO29.08.2019
GR30.08.2019
PT30.09.2019
Former [2019/50]AL29.05.2019
ES29.05.2019
HR29.05.2019
LT29.05.2019
LV29.05.2019
RS29.05.2019
NO29.08.2019
GR30.08.2019
PT30.09.2019
Former [2019/48]ES29.05.2019
LT29.05.2019
NO29.08.2019
PT30.09.2019
Former [2019/47]ES29.05.2019
LT29.05.2019
NO29.08.2019
Documents cited:Search[Y] WO0047215  (CELLPATH INC et al.) [Y] 1-14 * claims 1,4,5 *
 [Y] WO2007130124  (UNIV LOUISVILLE RES FOUND et al.) [Y] 1-14 * claims 1,4,5 *
 [YD] WO2006028969  (BIONAUT PHARMACEUTICALS INC et al.) [YD] 1-14 * claims *
 [Y]   WINNICKA KATARZYNA ET AL: "Antiproliferative activity of derivatives of ouabain, digoxin and proscillaridin a in human MCF-7 and MDA-MB-231 breast cancer cells", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 31, no. 6, June 2008 (2008-06-01), pages 1131 - 1140, XP002736348, ISSN: 0918-6158 [Y] 1-14 * page 1131, abstract *

DOI:   http://dx.doi.org/10.1248/bpb.31.1131
 [Y]   KORECKIJ THEODORE D ET AL: "Low Dose, Alternating Electric Current Inhibits Growth of Prostate Cancer", PROSTATE, vol. 70, no. 5, April 2010 (2010-04-01), pages 529 - 539, XP002736349, ISSN: 0270-4137 [Y] 1-14 * page 529, abstract *

DOI:   http://dx.doi.org/10.1002/pros.21087
 [Y]   ZHOU YU-FENG: "High intensity focused ultrasound in clinical tumor ablation.", WORLD JOURNAL OF CLINICAL ONCOLOGY 10 JAN 2011, vol. 2, no. 1, 10 January 2011 (2011-01-10), pages 8 - 27, XP002736350, ISSN: 2218-4333 [Y] 1-14 * page 8, abstract *

DOI:   http://dx.doi.org/10.5306/wjco.v2.i1.8
 [Y]   RAYLMAN R R ET AL: "Exposure to strong static magnetic field slows the growth of human cancer cells in vitro", BIOELECTROMAGNETICS WILEY-LISS FOR BIOELECTROMAGN. SOC. USA, vol. 17, no. 5, 1996, pages 358 - 363, XP002736351, ISSN: 0197-8462 [Y] 1-14 * page 358, abstract *

DOI:   http://dx.doi.org/10.1002/(SICI)1521-186X(1996)17:5<358::AID-BEM2>3.0.CO;2-2
International search[Y]   SEBASTIEN ROGER ET AL.: "Voltage-gated sodium channels: new targets in cancer I therapy?", CURR PHARM DES, vol. 12, no. 28, 2006, pages 3681 - 3695, XP002487314 [Y]

DOI:   http://dx.doi.org/10.2174/138161206778522047
 [Y]   DATABASE PUBMED JELLETT J.F. ET AL.: "Paralytic shellfish poison (saxitoxin family) bioassays: automated endpoint determination and standartisation of the in vitro tissue culture bioassay, and comparison with the standard mouse bioassay.", Database accession no. 1440621 [Y]
 [Y]   "PARALYTIC SHELLFISH POISON (SAXITOXIN FAMILY) BIOASSAYS: AUTOMATED ENDPOINT DETERMINATION AND STANDARDIZATION OF THE IN VITRO TISSUE CULTURE BIOASSAY, AND COMPARISON WITH THE STANDARD MOUSE BIOASSAY PUB - TOXICON,", TOXICON, vol. 30, no. 10, October 1992 (1992-10-01), pages 1143 - 1156, XP025805523

DOI:   http://dx.doi.org/10.1016/0041-0101(92)90430-D
 [Y]   GUBIN YU. I. ET AL.: "Tsitoksicheskie kardiosteroidy (obzor literatury)", FITOTERAPIYA. CHASOPIS, 2010, pages 51 - 56 [Y]
 [Y]   DATABASE PUBMED [online] HAN F. ET AL.: "Fast electrical lysis of cells for capillary electrophoresis", XP001175983, Database accession no. 14572031 [Y]

DOI:   http://dx.doi.org/10.1021/ac0341970
 [Y]   ANAL CHEM., vol. 75, no. 15, 1 August 2003 (2003-08-01), pages 3688 - 3696
 [Y]   DATABASE PUBMED [online] TYLER W.J. ET AL.: "Remote exitation of neuronal circuits using low-intensity, low- frequency ultrasound", XP055143724, Database accession no. 18958151 [Y]

DOI:   http://dx.doi.org/10.1371/journal.pone.0003511
 [Y]   PLOS ONE, vol. 3, no. 10, 2008, pages E351 1
 [Y]   DATABASE PUBMED [online] WANKERL K. ET AL.: "L-type voltage-gated Ca2+ channels: a single molecular switch for long-term potentiation /long-term depression-like plasticity and activity- dependent metaplasticity in humans", XP055143726, Database accession no. 20445045 [Y]

DOI:   http://dx.doi.org/10.1523/JNEUROSCI.4673-09.2010
 [Y]   J NEUROSCI, vol. 30, no. 18, 5 May 2010 (2010-05-05), pages 6197 - 204
by applicantUS7393657
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.