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EP2748192
European procedure
Extract from the Register of European Patents
EP Citations: EP2748192
| Cited in | Search | Type: | Patent literature | Publication No.: | WO2007087245
[X] (MERCK & CO INC et al.) | Type: | Patent literature | Publication No.: | KR20040075272
[X] (IAC IN NAT UNIV CHUNGNAM et al.) | Type: | Patent literature | Publication No.: | EP2599878
[E] (ASTELLAS PHARMA INC et al.) * - translation ofD16 * | Type: | Non-patent literature | Publication information: | [X] SUSANNA V. ULAHANNAN ET AL: "Antiangiogenic Agents in Combination with Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer", CANCER INVESTIGATION, vol. 29, no. 4, 6 April 2011 (2011-04-06), pages 325 - 337, XP055192118, ISSN: 0735-7907, DOI: 10.3109/07357907.2011.554476 | DOI: | http://dx.doi.org/10.3109/07357907.2011.554476 | Type: | Non-patent literature | Publication information: | [X] P. BEAUDRY ET AL: "Potent antitumor effects of ZD6474 on neuroblastoma via dual targeting of tumor cells and tumor endothelium", MOLECULAR CANCER THERAPEUTICS, vol. 7, no. 2, 1 February 2008 (2008-02-01), pages 418 - 424, XP055193451, ISSN: 1535-7163, DOI: 10.1158/1535-7163.MCT-07-0568 | DOI: | http://dx.doi.org/10.1158/1535-7163.MCT-07-0568 | Type: | Non-patent literature | Publication information: | [XI] CARLOMAGNO F ET AL: "ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinase", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 62, no. 24, 15 December 2002 (2002-12-15), pages 7284 - 7290, XP003011914, ISSN: 0008-5472 | Type: | Non-patent literature | Publication information: | [XI] ARIGHI E ET AL: "RET tyrosine kinase signaling in development and cancer", CYTOKINE AND GROWTH FACTOR REVIEWS, ELSEVIER LTD, GB, vol. 16, no. 4-5, 1 August 2005 (2005-08-01), pages 441 - 467, XP027682307, ISSN: 1359-6101, [retrieved on 20050801] | Type: | Non-patent literature | Publication information: | [T] MINSOO SONG: "Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 9, 27 January 2015 (2015-01-27), pages 3672 - 3681, XP055193521, ISSN: 0022-2623, DOI: 10.1021/jm501464c | DOI: | http://dx.doi.org/10.1021/jm501464c | Type: | Non-patent literature | Publication information: | [T] OKAMOTO KIYOSHI ET AL: "Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models", CANCER LETTERS, vol. 340, no. 1, 12 July 2013 (2013-07-12), pages 97 - 103, XP028731370, ISSN: 0304-3835, DOI: 10.1016/J.CANLET.2013.07.007 | DOI: | http://dx.doi.org/10.1016/j.canlet.2013.07.007 | Cited in | International search | Type: | Patent literature | Publication No.: | US2011118298
[A] (FRITZ CHRISTIAN et al.) [A] | Type: | Patent literature | Publication No.: | US2010130527
[A] (LEHRER RAPHAEL et al.) [A] | Type: | Patent literature | Publication No.: | US2011003298
[A] (LIEW CHOONG-CHIN et al.) [A] | Type: | Patent literature | Publication No.: | US2012208706
[T] (DOWNING SEAN R et al.) [T] | Type: | Non-patent literature | Publication information: | [A] WONG ET AL.: "A Novel KIF5B-ALK Variant in Nonsmall Cell Lung Cancer.", CANCER, vol. 117, 15 June 2011 (2011-06-15), pages 2709 - 2718, XP055145917 [A] | DOI: | http://dx.doi.org/10.1002/cncr.25843 | Type: | Non-patent literature | Publication information: | [T] LIPSON ET AL.: "Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies.", NATURE MEDICINE, vol. 18, March 2012 (2012-03-01), pages 382 - 384, XP055145920 [T] | DOI: | http://dx.doi.org/10.1038/nm.2673 | Type: | Non-patent literature | Publication information: | [T] KOHNO ET AL.: "KIF5B-RET fusions in lung adenocarcinoma.", NATURE MEDICINE, vol. 18, no. 3, March 2012 (2012-03-01), pages 375 - 377, XP055145929 [T] | DOI: | http://dx.doi.org/10.1038/nm.2644 | Type: | Non-patent literature | Publication information: | [T] JU ET AL.: "A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing.", GENOME RESEARCH, vol. 22, 22 December 2011 (2011-12-22), pages 436 - 445, XP055145939 [T] | DOI: | http://dx.doi.org/10.1101/gr.133645.111 | Type: | Non-patent literature | Publication information: | [T] SUEHARA, Y. ET AL.: "Identification of KIF5B-RET and GOPC-ROS1 fusions in lung adenocarcinomas through a comprehensive mRNA-based screen for tyrosine kinase fusions.", CLIN. CANCER RES., 10 October 2012 (2012-10-10), XP055081500 [T] | DOI: | http://dx.doi.org/10.1158/1078-0432.CCR-12-0838 | Cited in | Examination | Type: | Non-patent literature | Publication information: | ANONYMOUS: "Protein kinase inhibitor - Wikipedia", WIKIPEDIA, 5 August 2011 (2011-08-05), XP055355535, Retrieved from the Internet | Cited in | Opposition | Type: | Patent literature | Publication No.: | WO2007087245
| Type: | Patent literature | Publication No.: | KR20040075272
| Type: | Patent literature | Publication No.: | EP2599878
| Type: | Patent literature | Publication No.: | WO2012014795
| Type: | Patent literature | Publication No.: | WO2005051308
| Type: | Patent literature | Publication No.: | WO2013018882
| Type: | Patent literature | Publication No.: | EP2740742
| Type: | Patent literature | Publication No.: | WO2010128659
| Type: | Patent literature | Publication No.: | EP2428508
| Type: | Patent literature | Publication No.: | US201615045716
| Type: | Patent literature | Publication No.: | WO2007087245
| Type: | Patent literature | Publication No.: | KR20040075272
| Type: | Patent literature | Publication No.: | EP2599878
| Type: | Patent literature | Publication No.: | EP2740742
| Type: | Patent literature | Publication No.: | WO2007087245
| Type: | Patent literature | Publication No.: | KR20040075272
| Type: | Patent literature | Publication No.: | WO2012014795
| Type: | Patent literature | Publication No.: | EP2599878
| Type: | Patent literature | Publication No.: | WO2005051308
| Type: | Patent literature | Publication No.: | WO2013018882
| Type: | Patent literature | Publication No.: | EP2740742
| Type: | Patent literature | Publication No.: | WO2010128659
| Type: | Patent literature | Publication No.: | EP2428508
| Type: | Patent literature | Publication No.: | WO2010006432
| Type: | Non-patent literature | Publication information: | ULAHANNAN ET AL.: "Antiangiogenic Agents in Combination with Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer", CANCER INVESTIGATION, vol. 29, no. 4, 2011, pages 325 - 337, XP055192118 | DOI: | http://dx.doi.org/10.3109/07357907.2011.554476 | Type: | Non-patent literature | Publication information: | BEAUDRY ET AL., MOLECULAR CANCER THERAPEUTICS, vol. 7, no. 2, 2008, pages 418 - 424, XP055193451 | DOI: | http://dx.doi.org/10.1158/1535-7163.MCT-07-0568 | Type: | Non-patent literature | Publication information: | CARLOMAGNO ET AL., CANCER RESEARCH, vol. 62, no. 24, 2002, pages 7284 - 7290, XP003011914 | Type: | Non-patent literature | Publication information: | ARIGHI ET AL., CYTOKINE AND GROWTH FACTOR REVIEWS, vol. 16, no. 4-5, 2005, pages 441 - 467, XP027682307 | Type: | Non-patent literature | Publication information: | SONG: "Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 9, 2015, pages 3672 - 3681, XP055193521 | DOI: | http://dx.doi.org/10.1021/jm501464c | Type: | Non-patent literature | Publication information: | OKAMOTO ET AL.: "Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models", CANCER LETTERS, vol. 340, no. 1, 2013, pages 97 - 103, XP028731370 | DOI: | http://dx.doi.org/10.1016/j.canlet.2013.07.007 | Type: | Non-patent literature | Publication information: | DRUGBANK EXCERPTS FOR AXITINIB (A), BOSUTINIB (B), CEDIRANIB (C), DASATINIB (D), AND ERLOTINIB (E | Type: | Non-patent literature | Publication information: | LEE ET AL.: "vandetanib in pretreated patients with advanced non-small cell lung cancer-harboring ret rearrangement a phase ii clinical trial", ANNALS OF ONCOLOGY, vol. 28, 2016, pages 292 - 297, XP055632028 | DOI: | http://dx.doi.org/10.1093/annonc/mdw559 | Type: | Non-patent literature | Publication information: | HORIIKE ET AL.: "Sorafenib treatment for patients withRETfusion-positive non-small cell lung cancer", LUNG CANCER, vol. 93, 2016, pages 43 - 46, XP029423005 | DOI: | http://dx.doi.org/10.1016/j.lungcan.2015.12.011 | Type: | Non-patent literature | Publication information: | CHEN ET AL.: "small molecule inhibitor regoraenib inhibits ret signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo", ONCOTARGET, vol. 8, no. 61, 2017, pages 104090 - 104103, XP055632038 | DOI: | http://dx.doi.org/10.18632/oncotarget.22011 | Type: | Non-patent literature | Publication information: | ZABALLOS ET AL.: "Key signaling pathways in thyroid cancer", JOURNAL OF ENDOCRINOLOGY, vol. 235, 2017, pages R43 - R61, XP055632083 | DOI: | http://dx.doi.org/10.1530/JOE-17-0266 | Type: | Non-patent literature | Publication information: | TAKEUCHI ET AL.: "KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer", CLINICAL CANCER RESEARCH, vol. 15, no. 9, 2009, pages 3143 - 3149, XP055069999 | DOI: | http://dx.doi.org/10.1158/1078-0432.CCR-08-3248 | Type: | Non-patent literature | Publication information: | KOHNO ET AL.: "KIF5B-RET fusions in lung adenocarcinoma", NATURE MEDICINE, vol. 18, no. 3, 2012, pages 375 - 377, XP055145929 | DOI: | http://dx.doi.org/10.1038/nm.2644 | Type: | Non-patent literature | Publication information: | TAKEUCHI ET AL.: "RET, ROS1 and ALK fusions in lung cancer", NATURE MEDICINE, vol. 18, no. 3, 2012, pages 378 - 381, XP055077341 | DOI: | http://dx.doi.org/10.1038/nm.2658 | Type: | Non-patent literature | Publication information: | JU ET AL.: "A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing", GENOME RESEARCH VOL., vol. 22, 2011, pages 436 - 445, XP003031534 | DOI: | http://dx.doi.org/10.1101/GR.133645.111 | Type: | Non-patent literature | Publication information: | LIPSON ET AL.: "Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies", NATURE MEDICINE, vol. 18, no. 3, 2012, pages 382 - 384, XP055145920 | DOI: | http://dx.doi.org/10.1038/nm.2673 | Type: | Non-patent literature | Publication information: | SOMAIAH ET AL.: "molecular targeted agents and biologic therapies for non-small cell lung cancer", JOURNAL OF THORACIC ONCOLOGY, vol. 5, no. 12, 2010, XP055632092 | DOI: | http://dx.doi.org/10.1097/01.JTO.0000391362.10517.1f | Type: | Non-patent literature | Publication information: | YOKOTA: "KIF5B/RET fusion gene in surgically treated adenocarcinoma of lung", ONCOLOGY REPORTS, vol. 28, 2012, pages 1 187 - 1192, XP055632098 | DOI: | http://dx.doi.org/10.3892/or.2012.1908 | Type: | Non-patent literature | Publication information: | SHUM ET AL.: "noncoding oligonucleotides the belle of the ball in gene therapy", ADVANCES IN GENETICS, vol. 89, 2015, XP055632109 | DOI: | http://dx.doi.org/10.1016/bs.adgen.2014.10.004 | Type: | Non-patent literature | Publication information: | GAUTSCHI ET AL.: "targeting RET in patients with RET Rearranged lung cancers results from the global multicenter RET registry", CLIN ONCOL, vol. 35, 2017, pages l403 - 1410, XP055632115 | DOI: | http://dx.doi.org/10.1200/JCO.2016.70.9352 | Type: | Non-patent literature | Publication information: | KIF5B-RET COSF1233 COSMIC ENTRY | Type: | Non-patent literature | Publication information: | KIF5B-ALK COSF1059 COSMIC ENTRY | Type: | Non-patent literature | Publication information: | "Protein kinase inhibitor", WIKIPEDIA, 5 August 2015 (2015-08-05), XP055355535 | Type: | Non-patent literature | Publication information: | FERRARA ET AL.: "clinical and translational implications of ret rearrangements in non-small cell lung cancer", J THORACIC ONCOL, vol. 13, 2018, pages 27 - 45, XP055632126 | DOI: | http://dx.doi.org/10.1016/j.jtho.2017.10.021 | Type: | Non-patent literature | Publication information: | BRONTE ET AL.: "targeting RET rearranged non-small cell lung cancer future prospects", LCTT, vol. 10, 2019, pages 27 - 36, XP055632130 | DOI: | http://dx.doi.org/10.2147/LCTT.S192830 | Type: | Non-patent literature | Publication information: | EMEA: "Scientific Discussion", TASIGNATM, 2007, XP055632132 | Type: | Non-patent literature | Publication information: | AZANZA ET AL.: "comparative pharmacology of tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia", INT J CLIN PHARMACOL PHARMACOTHER, vol. 3, 2018, pages 134, XP055632165 | DOI: | http://dx.doi.org/10.15344/2456-3501/2018/134 | Type: | Non-patent literature | Publication information: | SCHOEBERL ET AL.: "An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation", CANCER RES, vol. 70, 2010, pages 2485 - 94, XP002581703 | DOI: | http://dx.doi.org/10.1158/0008-5472.CAN-09-3145 | Type: | Non-patent literature | Publication information: | "What is Bronchogenic Carcinoma?", INOGEN, 20 August 2018 (2018-08-20), XP055556171, Retrieved from the Internet | Type: | Non-patent literature | Publication information: | MEYERSON: "broken genes in solid tumours", NATURE, vol. 448, 2007, pages 545 - 6, XP055632177 | Type: | Non-patent literature | Publication information: | MAHER ET AL.: "Chimeric transcript discovery by paired-end transcriptome sequencing", PNAS USA, vol. 106, 2009, pages 12353 - 8, XP002606464 | DOI: | http://dx.doi.org/10.1073/PNAS.0904720106 | Type: | Non-patent literature | Publication information: | TAKEUCHI: "discovery stories of RET fusions in lung cancer a mini review", FRONT PHYSIOL, vol. 10, 2019, pages 216, XP055632185 | DOI: | http://dx.doi.org/10.3389/fphys.2019.00216 | Type: | Non-patent literature | Publication information: | JU ET AL.: "A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing", GENOME RES, vol. 22, 2012, pages 436 - 45, XP055145939 | DOI: | http://dx.doi.org/10.1101/gr.133645.111 | Type: | Non-patent literature | Publication information: | LIPSON ET AL.: "Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies",", NAT MED, vol. 18, no. 3, 2012, pages 382 - 4, XP055145920 | DOI: | http://dx.doi.org/10.1038/nm.2673 | Type: | Non-patent literature | Publication information: | ULAHANNAN ET AL.: "Antiangiogenic Agents in Combination with Chemotherapy in Patients with Advanced Non-Small Cell Lung Cancer", CANCER INVESTIGATION, vol. 29, no. 4, 2011, pages 325 - 337 | Type: | Non-patent literature | Publication information: | BEAUDRY ET AL., MOLECULAR CANCER THERAPEUTICS, vol. 7, no. 2, 2008, pages 418 - 424 | Type: | Non-patent literature | Publication information: | CARLOMAGNO ET AL., CANCER RESEARCH, vol. 62, no. 24, 2002, pages 7284 - 7290 | Type: | Non-patent literature | Publication information: | ARIGHI ET AL., CYTOKINE AND GROWTH FACTOR REVIEWS, vol. 16, no. 4-5, 2005, pages 441 - 467 | Type: | Non-patent literature | Publication information: | SONG: "Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 9, 2015, pages 3672 - 3681 | Type: | Non-patent literature | Publication information: | OKAMOTO ET AL.: "Antitumor activities of the targeted multi-tyrosine kinase inhibitor lenvatinib (E7080) against RET gene fusion-driven tumor models", CANCER LETTERS, vol. 340, no. 1, 2013, pages 97 - 103 | Type: | Non-patent literature | Publication information: | DRUGBANK EXCERPTS FOR AXITINIB (A), BOSUTINIB (B), CEDIRANIB (C), DASATINIB (D), AND ERLOTINIB (E | Type: | Non-patent literature | Publication information: | LEE ET AL.: "vandetanib in pretreated patients with advanced non-small cell lung cancer-harboring ret rearrangement a phase ii clinical trial", ANNALS OF ONCOLOGY, vol. 28, 2016, pages 292 - 297 | Type: | Non-patent literature | Publication information: | HORIIKE ET AL.: "Sorafenib treatment for patients withRETfusion-positive non-small cell lung cancer", LUNG CANCER, vol. 93, 2016, pages 43 - 46 | Type: | Non-patent literature | Publication information: | CHEN ET AL.: "small molecule inhibitor regoraenib inhibits ret signaling in neuroblastoma cells and effectively suppresses tumor growth in vivo", ONCOTARGET, vol. 8, no. 61, 2017, pages 104090 - 104103 | Type: | Non-patent literature | Publication information: | ZABALLOS ET AL.: "Key signaling pathways in thyroid cancer", JOURNAL OF ENDOCRINOLOGY, vol. 235, 2017, pages R43 - R61 | Type: | Non-patent literature | Publication information: | TAKEUCHI ET AL.: "KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer", CLINICAL CANCER RESEARCH, vol. 15, no. 9, 2009, pages 3143 - 3149 | Type: | Non-patent literature | Publication information: | KOHNO ET AL.: "KIF5B-RET fusions in lung adenocarcinoma", NATURE MEDICINE, vol. 18, no. 3, 2012, pages 375 - 377 | Type: | Non-patent literature | Publication information: | TAKEUCHI ET AL.: "RET, ROS1 and ALK fusions in lung cancer", NATURE MEDICINE, vol. 18, no. 3, 2012, pages 378 - 381 | Type: | Non-patent literature | Publication information: | JU ET AL.: "A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing", GENOME RESEARCH VOL., vol. 22, 2011, pages 436 - 445 | Type: | Non-patent literature | Publication information: | LIPSON ET AL.: "Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies", NATURE MEDICINE, vol. 18, no. 3, 2012, pages 382 - 384 | Type: | Non-patent literature | Publication information: | SOMAIAH ET AL.: "molecular targeted agents and biologic therapies for non-small cell lung cancer", JOURNAL OF THORACIC ONCOLOGY, vol. 5, no. 12, 2010 | Type: | Non-patent literature | Publication information: | Assignment for US 15/045716 | Type: | Non-patent literature | Publication information: | YOKOTA: "KIF5B/RET fusion gene in surgically treated adenocarcinoma of lung", ONCOLOGY REPORTS, vol. 28, 2012, pages 1 187 - 1192 | Type: | Non-patent literature | Publication information: | SHUM ET AL.: "noncoding oligonucleotides the belle of the ball in gene therapy", ADVANCES IN GENETICS, vol. 89, 2015 | Type: | Non-patent literature | Publication information: | GAUTSCHI ET AL.: "targeting RET in patients with RET Rearranged lung cancers results from the global multicenter RET registry", CLIN ONCOL, vol. 35, 2017, pages l403 - 1410 | Type: | Non-patent literature | Publication information: | KIF5B-RET COSF1233 COSMIC ENTRY | Type: | Non-patent literature | Publication information: | KIF5B-ALK COSF1059 COSMIC ENTRY | Type: | Non-patent literature | Publication information: | "Protein kinase inhibitor", WIKIPEDIA, 5 August 2015 (2015-08-05) | Type: | Non-patent literature | Publication information: | FERRARA ET AL.: "clinical and translational implications of ret rearrangements in non-small cell lung cancer", J THORACIC ONCOL, vol. 13, 2018, pages 27 - 45 | Type: | Non-patent literature | Publication information: | BRONTE ET AL.: "targeting RET rearranged non-small cell lung cancer future prospects", LCTT, vol. 10, 2019, pages 27 - 36 | Type: | Non-patent literature | Publication information: | EMEA: "Scientific Discussion", TASIGNATM, 2007 | Type: | Non-patent literature | Publication information: | AZANZA ET AL.: "comparative pharmacology of tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia", INT J CLIN PHARMACOL PHARMACOTHER, vol. 3, 2018, pages 134 | Type: | Non-patent literature | Publication information: | SCHOEBERL ET AL.: "An ErbB3 antibody, MM-121, is active in cancers with ligand-dependent activation", CANCER RES, vol. 70, 2010, pages 2485 - 94 | Type: | Non-patent literature | Publication information: | certified translation of EP 2740742's priority application | Type: | Non-patent literature | Publication information: | "What is Bronchogenic Carcinoma?", INOGEN, 20 August 2018 (2018-08-20), Retrieved from the Internet | Type: | Non-patent literature | Publication information: | MEYERSON: "broken genes in solid tumours", NATURE, vol. 448, 2007, pages 545 - 6 | Type: | Non-patent literature | Publication information: | MAHER ET AL.: "Chimeric transcript discovery by paired-end transcriptome sequencing", PNAS USA, vol. 106, 2009, pages 12353 - 8 | Type: | Non-patent literature | Publication information: | TAKEUCHI: "discovery stories of RET fusions in lung cancer a mini review", FRONT PHYSIOL, vol. 10, 2019, pages 216 | Type: | Non-patent literature | Publication information: | JU ET AL.: "A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing", GENOME RES, vol. 22, 2012, pages 436 - 45 | Type: | Non-patent literature | Publication information: | Assignment of US 61/526613 | Type: | Non-patent literature | Publication information: | Assignment of US 61/537024 | Type: | Non-patent literature | Publication information: | Assignment of US 61/542112 * . * * . * | Type: | Non-patent literature | Publication information: | Assignment of US 61/594739 | Type: | Non-patent literature | Publication information: | YOH ET AL, LANCET RESPIR. 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