EP2757152 - METHOD FOR INHIBITING CELL GROWTH, NUCLEIC ACID MOLECULE HAVING RNA INTERFERENCE EFFECT ON NEK10 VARIANT GENE, AND ANTICANCER AGENT [Right-click to bookmark this link] | Status | The application has been withdrawn Status updated on 29.04.2016 Database last updated on 03.09.2024 | Most recent event Tooltip | 29.04.2016 | Withdrawal of application | published on 01.06.2016 [2016/22] | Applicant(s) | For all designated states Nippon Kayaku Kabushiki Kaisha 11-2, Fujimi 1-chome Chiyoda-ku Tokyo 102-8172 / JP | [2014/30] | Inventor(s) | 01 /
SATO, Takamichi c/o Nippon Kayaku Kabushiki Kaisha Pharmaceuticals Research Laboratories 31-12 Shimo 3-chome Kita-ku Tokyo 115-8588 / JP | [2014/30] | Representative(s) | Andrae Westendorp Patentanwälte Partnerschaft Uhlandstrasse 2 80336 München / DE | [N/P] |
Former [2014/30] | Andrae Westendorp Patentanwälte Partnerschaft Uhlandstrasse 2 80336 München / DE | Application number, filing date | 12831615.5 | 29.08.2012 | WO2012JP71868 | Priority number, date | JP20110200756 | 14.09.2011 Original published format: JP 2011200756 | [2014/30] | Filing language | JA | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2013038907 | Date: | 21.03.2013 | Language: | JA | [2013/12] | Type: | A1 Application with search report | No.: | EP2757152 | Date: | 23.07.2014 | Language: | EN | [2014/30] | Search report(s) | International search report - published on: | JP | 21.03.2013 | (Supplementary) European search report - dispatched on: | EP | 03.08.2015 | Classification | IPC: | C12N15/00, A61K31/713, A61K48/00, A61P35/00, C12N15/09, C12N15/113, C12Q1/02, C12Q1/68, G01N33/15, G01N33/50 | [2014/30] | CPC: |
A61K31/713 (EP,US);
A61P35/00 (EP);
C12N15/1137 (EP,US);
C12Q1/6886 (EP,US);
C12Y207/11001 (EP,US);
G01N33/5011 (US);
G01N33/574 (EP,US);
C12N2310/14 (EP,US);
C12N2320/34 (US);
C12Q2600/106 (US);
C12Q2600/158 (EP,US);
G01N2500/04 (US);
G01N2500/10 (US)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/30] | Title | German: | VERFAHREN ZUR ZELLWACHSTUMSHINDERUNG, NUKLEINSÄUREMOLEKÜL MIT RNA-INTERFERENZEFFEKT AUF DAS NEK10-VARIANTEN-GEN UND ANTIKREBSMITTEL | [2014/30] | English: | METHOD FOR INHIBITING CELL GROWTH, NUCLEIC ACID MOLECULE HAVING RNA INTERFERENCE EFFECT ON NEK10 VARIANT GENE, AND ANTICANCER AGENT | [2014/30] | French: | PROCÉDÉ D'INHIBITION DE LA CROISSANCE CELLULAIRE, MOLÉCULE D'ACIDE NUCLÉIQUE AYANT L'EFFET D'UN ARN D'INTERFÉRENCE SUR UN VARIANT DU GÈNE NEK10, ET AGENT ANTICANCÉREUX | [2014/30] | Entry into regional phase | 24.02.2014 | Translation filed | 24.02.2014 | National basic fee paid | 24.02.2014 | Search fee paid | 24.02.2014 | Designation fee(s) paid | 24.02.2014 | Examination fee paid | Examination procedure | 24.02.2014 | Examination requested [2014/30] | 10.02.2016 | Amendment by applicant (claims and/or description) | 22.04.2016 | Application withdrawn by applicant [2016/22] | Fees paid | Renewal fee | 10.07.2014 | Renewal fee patent year 03 | 10.08.2015 | Renewal fee patent year 04 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [XA]WO2004094636 (GALAPAGOS GENOMICS NV [BE], et al) [X] 8-13 * pages 100, 211 * * page 335 * [A] 1-7; | [Y]JP2005192567 (DAIICHI SEIYAKU CO, et al) [Y] 1-7 * the whole document *; | [X]US2008113351 (NAITO YUKI [JP], et al) [X] 8-13 * claims 1,7,18,24; sequences 83479, 545324 *; | [X]WO2009099991 (BRIGHAM & WOMENS HOSPITAL [US], et al) [X] 8-13 * paragraphs [0081] , [0089] , [0090] * * page 127; claim 1 *; | [X]WO2004045543 (DHARMACON INC [US]) [X] 8-13 * ID number 5015583 *;; claim 1; sequence 1486438 * | [XI] - Larissa Moniz, "Characterization of NimA-related Kinase 10 (NEK10): A Role in Checkpoint Control", University of Toronto, Toronto, CA, (20100831), URL: http://hdl.handle.net/1807/24833, (20150316), XP055176698 [X] 8-13 * the whole document * [I] 1-7 | [XA] - DEBRA A. O'LEARY ET AL, "Identification of Small Molecule and Genetic Modulators of AON-Induced Dystrophin Exon Skipping by High-Throughput Screening", PLOS ONE, (20091217), vol. 4, no. 12, doi:10.1371/journal.pone.0008348, ISSN 1932-6203, page e8348, XP055083574 [X] 8-13 * page 6, column r - page 8, column l * [A] 1-7 DOI: http://dx.doi.org/10.1371/journal.pone.0008348 | [Y] - MAVADDAT N ET AL, "Genetic susceptibility to breast cancer", MOLECULAR ONCOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 4, no. 3, ISSN 1574-7891, (20100521), pages 174 - 191, (20100521), XP027106316 [Y] 1-7 * page 177; figure 1; table 1 * | [Y] - R. NASSIRPOUR ET AL, "Nek6 Mediates Human Cancer Cell Transformation and Is a Potential Cancer Therapeutic Target", MOLECULAR CANCER RESEARCH, (20100420), vol. 8, no. 5, doi:10.1158/1541-7786.MCR-09-0291, ISSN 1541-7786, pages 717 - 728, XP055176730 [Y] 1-7 * figures 1,3,4,5; table 1 * DOI: http://dx.doi.org/10.1158/1541-7786.MCR-09-0291 | [A] - O'REGAN LAURA ET AL, "Mitotic regulation by NIMA-related kinases", CELL DIVISION, BIOMED CENTRAL LTD, LO, (20070829), vol. 2, no. 1, doi:10.1186/1747-1028-2-25, ISSN 1747-1028, page 25, XP021030656 [A] 1-7 * the whole document * DOI: http://dx.doi.org/10.1186/1747-1028-2-25 | [A] - L. O'REGAN ET AL, "The Nek6 and Nek7 Protein Kinases Are Required for Robust Mitotic Spindle Formation and Cytokinesis", MOLECULAR AND CELLULAR BIOLOGY, (20090504), vol. 29, no. 14, doi:10.1128/MCB.01867-08, ISSN 0270-7306, pages 3975 - 3990, XP055176735 [A] 1-7 * figures 5,10 * DOI: http://dx.doi.org/10.1128/MCB.01867-08 | [A] - NOBUYUKI TSUNODA ET AL, "Nek2 as a novel molecular target for the treatment of breast carcinoma", CANCER SCIENCE, (20081127), vol. 100, no. 1, doi:10.1111/j.1349-7006.2008.01007.x, ISSN 1347-9032, pages 111 - 116, XP055176738 [A] 1-7 * figures 1,2,4,5 * DOI: http://dx.doi.org/10.1111/j.1349-7006.2008.01007.x | [IP] - LARISSA MONIZ ET AL, "Nek family of kinases in cell cycle, checkpoint control and cancer", CELL DIVISION, BIOMED CENTRAL LTD, LO, (20111031), vol. 6, no. 1, doi:10.1186/1747-1028-6-18, ISSN 1747-1028, page 18, XP021114160 [IP] 1-7 * the whole document * DOI: http://dx.doi.org/10.1186/1747-1028-6-18 | [A] - LOH S H Y ET AL, "Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen", CELL DEATH AND DIFFERENTIATION, NATURE PUBLISHING GROUP, GB, vol. 15, no. 2, doi:10.1038/SJ.CDD.4402258, ISSN 1350-9047, (20071116), pages 283 - 298, (20071116), XP002560487 [A] 8-13 * table 2 * DOI: http://dx.doi.org/10.1038/sj.cdd.4402258 | International search | [Y]WO2010094734 (BIOFOCUS DPI B V [NL], et al); | [A]WO2007117038 (JAPAN FOUND CANCER [JP], et al); | [A]JP2007282628 (DAIICHI SEIYAKU CO); | [A]WO2005061704 (TAKEDA PHARMACEUTICAL [JP], et al); | [A]JP2004203745 (EISAI CO LTD); | [Y] - MONIZ, L. S. ET AL., "NeklO mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation", MOLECULAR AND CELLULAR BIOLOGY, (201101), vol. 31, no. 1, pages 30 - 42, XP055143033 DOI: http://dx.doi.org/10.1128/MCB.00648-10 | [Y] - "HOMO SAPIENS CDNA FLJ25966 FIS, CLONE TST05207", GENBANK, (20060914), URL: N N N N, XP055148110 | [Y] - LI, J. J. ET AL., "Mitotic kinases: the key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis", PHARMACOLOGY & THERAPEUTICS, (2006), vol. 111, pages 74 - 984, XP027900643 | [Y] - BOWERS, A. J. ET AL., "Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors", GENE, (2004), vol. 328, pages 135 - 142, XP004496552 DOI: http://dx.doi.org/10.1016/j.gene.2003.12.002 | [Y] - BELHAM, C. ET AL., "A mitotic cascade of NIMA family kinases", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2003), vol. 278, no. 37, pages 34897 - 34909, XP055143034 DOI: http://dx.doi.org/10.1074/jbc.M303663200 | [Y] - FRY, A. M. ET AL., "A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators", THE EMBO JOURNAL, (1998), vol. 17, no. 2, pages 470 - 481, XP002991357 DOI: http://dx.doi.org/10.1093/emboj/17.2.470 | [Y] - DAVIES, H. ET AL., "Somatic mutations of the protein kinase gene family in human lung cancer", CANCER RES., (2005), vol. 65, no. 17, pages 7591 - 7595, XP002484151 | [Y] - ANTONIOU, A. C. ET AL., "Common breast cancer susceptibility alleles and the risk of breast cancer for BRCA1 and BRCA2 mutation carriers: implications for risk prediction", CANCER RES., (2010), vol. 70, no. 23, pages 9742 - 9754, XP055143035 DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-1907 | [Y] - AHMED, S. ET AL., "Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2", NATURE GENETICS, (2009), vol. 41, no. 5, pages 585 - 590, XP055143037 DOI: http://dx.doi.org/10.1038/ng.354 | [Y] - MAVADDAT, N. ET AL., "Familial relative risks for breast cancer by pathological subtype: a population-based cohort study", BREAST CANCER RESEARCH, (2010), vol. 12, no. R10, pages 1 - 12, XP021070774 | [Y] - GORODNOVA, T. V. ET AL., "Distribution of FGFR2, TNRC9, MAP3K1, LSP1, and 8q24 alleles in genetically enriched breast cancer patients versus elderly tumor-free women", CANCER GENETICS AND CYTOGENETICS, (2010), vol. 199, pages 69 - 72, XP027020234 | [A] - ZENG, M. ET AL., "Identifying mRNAs bound by human RBMY protein in the testis", JOURNAL OF REPRODUCTION AND DEVELOPMENT, (201103), vol. 57, no. 1, pages 107 - 112, XP055143044 DOI: http://dx.doi.org/10.1262/jrd.10-092N | by applicant | - M.J. O'CONNELL ET AL., TRENDS IN CELL BIOLOGY, (2003), vol. 13, pages 221 - 228 | - L. O'REGAN ET AL., CELL DIVISION, (2007), vol. 2, pages 25 - 36 | - L.S. MONIZ ET AL., MOLECULAR AND CELLULAR BIOLOGY, (2011), vol. 31, pages 30 - 42 | - S. AHMED ET AL., NATURE GENETICS, (2009), vol. 41, pages 585 - 590 | - A.C. ANTONIOU ET AL., CANCER RESEARCH, (2010), vol. 70, pages 9742 - 9754 | - P. ANTON ET AL., NATURE, (2002), vol. 418, pages 38 - 39 | - L. DAVID ET AL., NAT. GENET., (2002), vol. 32, pages 107 - 108 | - T. R. BRUMMELKAMP ET AL., SCIENCE, (2002), vol. 296, pages 550 - 553 | - N.S. LEE ET AL., NAT. BIOTECH., (2001), vol. 19, pages 500 - 505 | - M. MIYAGISHI; K. TAIRA, NAT. BIOTECH., (2002), vol. 19, pages 497 - 500 | - P.J. PADDISON ET AL., PROC. NATL. ACAD. SCI. USA, (2002), vol. 99, pages 1443 - 1448 | - C.P. PAUL ET AL., NAT. BIOTECH., (2002), vol. 19, pages 505 - 508 | - G. SUI ET AL., PROC. NATL. ACAD. SCI. USA, (2002), vol. 99, pages 5515 - 5520 | - G.M. BARTON; R. MEDZHITOV, PROC. NATL. ACAD. SCI. USA, (2002), vol. 99, pages 14943 - 14945 | - P.J. PADDISON ET AL., GENES DEV., (2002), vol. 16, pages 948 - 958 |