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Extract from the Register of European Patents

EP About this file: EP2771367

EP2771367 - GIGAXONIN FUSION PROTEIN AND METHODS FOR TREATING GIANT AXONAL NEUROPATHY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  12.10.2018
Database last updated on 30.12.2024
FormerThe patent has been granted
Status updated on  03.11.2017
FormerGrant of patent is intended
Status updated on  05.07.2017
FormerExamination is in progress
Status updated on  23.12.2016
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Indiana University Research and Technology Corporation
518 Indiana Avenue
Indianapolis, IN 46202 / US
[2017/25]
Former [2014/36]For all designated states
Indiana University Research and Technology Corporation
351 West 10th Street
Indianapolis, IN 46202 / US
Inventor(s)01 / PAYNE, R. Mark
9925 Hunt Club Road
Zionsville Indiana 46077 / US
02 / BABBEY, Clifford M.
4311 Park Ave.
Indianapolis Indiana 46205 / US
03 / MARTIN, Kyle B.
6429 Ferrari Place
Apt. D
Indianapolis Indiana 46224 / US
04 / BEARD, Samuel M.
5459 East 79th Street
Indianapolis Indiana 46250 / US
 [2014/36]
Representative(s)Dehns
10 Old Bailey
London EC4M 7NG / GB
[N/P]
Former [2014/36]Gardner, Rebecca Katherine
Dehns
St Bride's House
10 Salisbury Square
London EC4Y 8JD / GB
Application number, filing date12843112.925.10.2012
[2017/49]
WO2012US61979
Priority number, dateUS201161550940P25.10.2011         Original published format: US 201161550940 P
[2014/36]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013063309
Date:02.05.2013
Language:EN
[2013/18]
Type: A1 Application with search report 
No.:EP2771367
Date:03.09.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 02.05.2013 takes the place of the publication of the European patent application.
[2014/36]
Type: B1 Patent specification 
No.:EP2771367
Date:06.12.2017
Language:EN
[2017/49]
Search report(s)International search report - published on:KR02.05.2013
(Supplementary) European search report - dispatched on:EP12.02.2015
ClassificationIPC:C07K19/00, A61K38/17, A61P25/00
[2014/36]
CPC:
C07K14/47 (EP,US); A61P25/00 (EP); A61K38/00 (EP,US);
C07K2319/10 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/36]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:GIGAXONINFUSIONSPROTEIN UND VERFAHREN ZUR BEHANDLUNG VON AXONALER NEUROPATHIE[2014/36]
English:GIGAXONIN FUSION PROTEIN AND METHODS FOR TREATING GIANT AXONAL NEUROPATHY[2014/36]
French:PROTÉINE DE FUSION À BASE DE GIGAXONINE ET MÉTHODES DE TRAITEMENT D'UNE NEUROPATHIE À AXONES GÉANTS[2014/36]
Entry into regional phase28.04.2014National basic fee paid 
28.04.2014Search fee paid 
28.04.2014Designation fee(s) paid 
28.04.2014Examination fee paid 
Examination procedure28.04.2014Examination requested  [2014/36]
14.09.2015Amendment by applicant (claims and/or description)
02.01.2017Despatch of a communication from the examining division (Time limit: M04)
11.05.2017Reply to a communication from the examining division
06.07.2017Communication of intention to grant the patent
25.10.2017Fee for grant paid
25.10.2017Fee for publishing/printing paid
25.10.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  02.01.2017
Opposition(s)07.09.2018No opposition filed within time limit [2018/46]
Fees paidRenewal fee
27.10.2014Renewal fee patent year 03
27.10.2015Renewal fee patent year 04
27.10.2016Renewal fee patent year 05
27.10.2017Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.10.2012
AL06.12.2017
AT06.12.2017
CY06.12.2017
CZ06.12.2017
DK06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
MC06.12.2017
MK06.12.2017
NL06.12.2017
PL06.12.2017
PT06.12.2017
RO06.12.2017
RS06.12.2017
SE06.12.2017
SI06.12.2017
SK06.12.2017
SM06.12.2017
TR06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
IS06.04.2018
[2020/33]
Former [2020/32]HU25.10.2012
AT06.12.2017
CY06.12.2017
CZ06.12.2017
DK06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
MC06.12.2017
MK06.12.2017
NL06.12.2017
PL06.12.2017
PT06.12.2017
RO06.12.2017
RS06.12.2017
SE06.12.2017
SI06.12.2017
SK06.12.2017
SM06.12.2017
TR06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
IS06.04.2018
Former [2020/31]HU25.10.2012
AT06.12.2017
CY06.12.2017
CZ06.12.2017
DK06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
MC06.12.2017
MK06.12.2017
NL06.12.2017
PL06.12.2017
PT06.12.2017
RO06.12.2017
RS06.12.2017
SE06.12.2017
SI06.12.2017
SK06.12.2017
SM06.12.2017
TR06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2020/30]HU25.10.2012
AT06.12.2017
CZ06.12.2017
DK06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
MC06.12.2017
NL06.12.2017
PL06.12.2017
PT06.12.2017
RO06.12.2017
RS06.12.2017
SE06.12.2017
SI06.12.2017
SK06.12.2017
SM06.12.2017
TR06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2020/28]AT06.12.2017
CZ06.12.2017
DK06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
MC06.12.2017
NL06.12.2017
PL06.12.2017
PT06.12.2017
RO06.12.2017
RS06.12.2017
SE06.12.2017
SI06.12.2017
SK06.12.2017
SM06.12.2017
TR06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2020/16]AT06.12.2017
CZ06.12.2017
DK06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
MC06.12.2017
NL06.12.2017
PL06.12.2017
RO06.12.2017
RS06.12.2017
SE06.12.2017
SI06.12.2017
SK06.12.2017
SM06.12.2017
TR06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2019/28]AT06.12.2017
CZ06.12.2017
DK06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
MC06.12.2017
NL06.12.2017
PL06.12.2017
RO06.12.2017
RS06.12.2017
SE06.12.2017
SI06.12.2017
SK06.12.2017
SM06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2018/52]AT06.12.2017
CZ06.12.2017
DK06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
NL06.12.2017
PL06.12.2017
RO06.12.2017
RS06.12.2017
SE06.12.2017
SI06.12.2017
SK06.12.2017
SM06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2018/51]AT06.12.2017
CZ06.12.2017
DK06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
NL06.12.2017
PL06.12.2017
RO06.12.2017
RS06.12.2017
SE06.12.2017
SK06.12.2017
SM06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2018/40]AT06.12.2017
CZ06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
NL06.12.2017
PL06.12.2017
RO06.12.2017
RS06.12.2017
SE06.12.2017
SK06.12.2017
SM06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2018/39]AT06.12.2017
CZ06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
IT06.12.2017
LT06.12.2017
LV06.12.2017
NL06.12.2017
PL06.12.2017
RS06.12.2017
SE06.12.2017
SK06.12.2017
SM06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2018/38]AT06.12.2017
CZ06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
LT06.12.2017
LV06.12.2017
NL06.12.2017
PL06.12.2017
RS06.12.2017
SE06.12.2017
SK06.12.2017
SM06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2018/37]CZ06.12.2017
EE06.12.2017
ES06.12.2017
FI06.12.2017
HR06.12.2017
LT06.12.2017
LV06.12.2017
NL06.12.2017
PL06.12.2017
RS06.12.2017
SE06.12.2017
SK06.12.2017
SM06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2018/34]ES06.12.2017
FI06.12.2017
HR06.12.2017
LT06.12.2017
LV06.12.2017
NL06.12.2017
RS06.12.2017
SE06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2018/24]ES06.12.2017
FI06.12.2017
HR06.12.2017
LT06.12.2017
LV06.12.2017
RS06.12.2017
SE06.12.2017
BG06.03.2018
NO06.03.2018
GR07.03.2018
Former [2018/22]ES06.12.2017
FI06.12.2017
LT06.12.2017
NO06.03.2018
Documents cited:Search[Y]  - MARK PAYNE R ET AL, "Cardiomyopathy of Friedreich's Ataxia: Use of Mouse Models to Understand Human Disease and Guide Therapeutic Development", PEDIATRIC CARDIOLOGY, SPRINGER-VERLAG, US, (20110301), vol. 32, no. 3, doi:10.1007/S00246-011-9943-6, ISSN 1432-1971, pages 366 - 378, XP019888591 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1007/s00246-011-9943-6
 [YP]  - SILKE MUSSCHE ET AL, "Proteomic analysis in giant axonal neuropathy: New insights into disease mechanisms", MUSCLE & NERVE, (20120716), vol. 46, no. 2, doi:10.1002/mus.23306, ISSN 0148-639X, pages 246 - 256, XP055167084 [YP] 6-9,12-15 * the whole document *

DOI:   http://dx.doi.org/10.1002/mus.23306
 [Y]  - J. DING, "Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin", THE JOURNAL OF CELL BIOLOGY, (20020729), vol. 158, no. 3, doi:10.1083/jcb.200202055, ISSN 0021-9525, pages 427 - 433, XP055166508 [Y] 1-4 * the whole document *

DOI:   http://dx.doi.org/10.1083/jcb.200202055
 [Y]  - MARCELLA FLINTERMAN ET AL, "Delivery of Therapeutic Proteins as Secretable TAT Fusion Products", MOLECULAR THERAPY, (20081202), vol. 17, no. 2, doi:10.1038/mt.2008.256, ISSN 1525-0016, pages 334 - 342, XP055166511 [Y] 1-4 * the whole document *

DOI:   http://dx.doi.org/10.1038/mt.2008.256
 [Y]  - BOMONT P ET AL, "THE GENE ENCODING GIGAXONIN, A NEW MEMBER OF THE CYTOSKELETAL BTB/KELCH REPEAT FAMILY, IS MUTATED IN GIANT AXONAL NEUROPATHY", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, (20001101), vol. 26, no. 3, doi:10.1038/81701, ISSN 1061-4036, pages 370 - 373, XP001156497 [Y] 5,10,11 * the whole document *

DOI:   http://dx.doi.org/10.1038/81701
 [A]  - P. BOMONT, "Intermediate filament aggregation in fibroblasts of giant axonal neuropathy patients is aggravated in non dividing cells and by microtubule destabilization", HUMAN MOLECULAR GENETICS, (20030415), vol. 12, no. 8, doi:10.1093/hmg/ddg092, pages 813 - 822, XP055166900 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1093/hmg/ddg092
International search[A]US5569648  (LEWIS MICHAEL E [US], et al);
 [A]US2006063152  (OHARA OSAMU [JP], et al);
 [A]  - BOMONT, P. ET AL., "The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy", NATURE GENETICS, (200011), vol. 26, no. 3, pages 370 - 374, XP001156497

DOI:   http://dx.doi.org/10.1038/81701
 [A]  - YANG, Y. ET AL., "Giant axonal neuropathy", CELLULAR AND MOLECULAR LIFE SCIENCES, (200703), vol. 64, no. 5, pages 601 - 609, XP019488172

DOI:   http://dx.doi.org/10.1007/s00018-007-6396-4
 [A]  - CULLEN, V. C. ET AL., "Gigaxonin is associated with the Golgi and dimerises via its BTB domain", NEUROREPORT, (20040409), vol. 15, no. 5, pages 873 - 876, XP008173843

DOI:   http://dx.doi.org/10.1097/00001756-200404090-00028
by applicant   - J. DING ET AL., "identified microtubule-associated protein IB as a neuronal binding partner for Gigaxonin, involved in maintaining the integrity of cytoskeletal structures and promoting neuronal stability", THE JOURNAL OF CELL BIOLOGY, (2002), vol. 158, no. 3, pages 427 - 433
    - MUSSCHE ET AL., "speculate that disturbed cytoskeletal regulation is responsible for formation of aggregates of intermediate filaments", MUSCLE AND NERVE, (2012), vol. 46, pages 246 - 256
    - BOMONT ET AL., "reported that gigaxonin is mutated in GAN", NATURE GENETICS, (2000), vol. 26, pages 370 - 374
    - FLINTERMAN ET AL., REPORTED DELIVERY OF THERAPEUTIC PROTEINS AS SECRETABLE TAT FUSION PROTEINS, vol. 17, no. 2, (2009), pages 334 - 342, URL: www.moleculartherapy.org
    - PAYNE ET AL., "use of TAT fusion proteins in treating Friedreich's Ataxia", PEDIATR CARDIOL, (2011), vol. 32, pages 366 - 378
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.