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Extract from the Register of European Patents

EP About this file: EP2791135

EP2791135 - ANABASINE DERIVATIVES TARGETING THE NICOTINIC ACETYLCHOLINE RECEPTORS [Right-click to bookmark this link]
Former [2014/43]NICOTINIC RECEPTOR TARGETED COMPOUNDS AND COMPOSITIONS
[2018/01]
StatusNo opposition filed within time limit
Status updated on  12.04.2019
Database last updated on 13.11.2024
FormerThe patent has been granted
Status updated on  15.05.2018
FormerGrant of patent is intended
Status updated on  11.01.2018
FormerExamination is in progress
Status updated on  02.11.2016
Most recent event   Tooltip26.06.2020Lapse of the patent in a contracting state
New state(s): MK		published on 29.07.2020  [2020/31]
Applicant(s)For all designated states
KemPharm Consulting Inc.
1809 NW 47 Street
Gainesville FL 32605 / US
[2018/27]
Former [2014/43]For all designated states
University of Florida Research Foundation
P.O. Box 115575
Gainesville, FL 32611-5575 / US
Inventor(s)01 / KEM, William, Reade
1809 NW 47th Street
Gainesville, FL 32605-3454 / US
02 / SOTI, Ferenc
708 SW 16th Ave. Apt. 207
Gainesville, FL 32601-8521 / US
03 / XING, Hong
2104 NW 47th Place
Gainesville, FL 32605 / US
 [2014/43]
Representative(s)Helbig, Christian
Wagner + Helbig Patentanwälte Pfarrstrasse 14
80538 München / DE
[2014/43]
Application number, filing date12857224.511.12.2012
[2018/23]
WO2012US68943
Priority number, dateUS201161569539P12.12.2011         Original published format: US 201161569539 P
[2014/43]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013090260
Date:20.06.2013
Language:EN
[2013/25]
Type: A1 Application with search report 
No.:EP2791135
Date:22.10.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 20.06.2013 takes the place of the publication of the European patent application.
[2014/43]
Type: B1 Patent specification 
No.:EP2791135
Date:06.06.2018
Language:EN
[2018/23]
Type: B8 Corrected title page of specification 
No.:EP2791135
Date:18.07.2018
[2018/29]
Search report(s)International search report - published on:KR20.06.2013
(Supplementary) European search report - dispatched on:EP16.09.2015
ClassificationIPC:C07D451/02, A61K31/46, A61P25/00
[2014/43]
CPC:
C07D409/14 (EP,US); A61P25/00 (EP); A61P25/16 (EP);
A61P25/18 (EP); A61P25/28 (EP); A61P25/30 (EP);
A61P29/00 (EP); A61P35/00 (EP); A61P39/02 (EP);
A61P43/00 (EP); C07D401/04 (EP,US); C07D401/14 (EP,US);
C07D405/14 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/43]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:AUF NIKOTINISCHE ACETYLCHOLINREZEPTOREN GERICHTETE ANABASINDERIVATE[2018/06]
English:ANABASINE DERIVATIVES TARGETING THE NICOTINIC ACETYLCHOLINE RECEPTORS[2018/06]
French:DÉRIVÉS D'ANABASINE CIBLANT LES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE[2018/06]
Former [2014/43]AUF NIKOTINISCHEN REZEPTOR GERICHTETE VERBINDUNGEN UND ZUSAMMENSETZUNGEN
Former [2014/43]NICOTINIC RECEPTOR TARGETED COMPOUNDS AND COMPOSITIONS
Former [2014/43]COMPOSÉS ET COMPOSITIONS CIBLANT UN RÉCEPTEUR NICOTINIQUE
Entry into regional phase09.07.2014National basic fee paid 
09.07.2014Search fee paid 
09.07.2014Designation fee(s) paid 
09.07.2014Examination fee paid 
Examination procedure09.07.2014Examination requested  [2014/43]
24.02.2015Loss of particular rights, legal effect: Claims
01.04.2015Despatch of communication of loss of particular rights: Claims {1}
06.04.2016Amendment by applicant (claims and/or description)
29.06.2016Despatch of a communication from the examining division (Time limit: M06)
06.01.2017Reply to a communication from the examining division
26.04.2017Despatch of a communication from the examining division (Time limit: M04)
28.08.2017Reply to a communication from the examining division
21.09.2017Despatch of a communication from the examining division (Time limit: M02)
22.11.2017Reply to a communication from the examining division
12.01.2018Communication of intention to grant the patent
25.04.2018Fee for grant paid
25.04.2018Fee for publishing/printing paid
30.04.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  29.06.2016
Opposition(s)07.03.2019No opposition filed within time limit [2019/20]
Fees paidRenewal fee
29.12.2014Renewal fee patent year 03
28.12.2015Renewal fee patent year 04
27.12.2016Renewal fee patent year 05
05.10.2017Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU11.12.2012
AL06.06.2018
AT06.06.2018
CY06.06.2018
CZ06.06.2018
DK06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
MC06.06.2018
MK06.06.2018
NL06.06.2018
PL06.06.2018
PT06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SI06.06.2018
SK06.06.2018
SM06.06.2018
TR06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
IE11.12.2018
LU11.12.2018
MT11.12.2018
BE31.12.2018
[2020/31]
Former [2020/30]HU11.12.2012
AL06.06.2018
AT06.06.2018
CY06.06.2018
CZ06.06.2018
DK06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
MC06.06.2018
NL06.06.2018
PL06.06.2018
PT06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SI06.06.2018
SK06.06.2018
SM06.06.2018
TR06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
IE11.12.2018
LU11.12.2018
MT11.12.2018
BE31.12.2018
Former [2020/28]AL06.06.2018
AT06.06.2018
CY06.06.2018
CZ06.06.2018
DK06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
MC06.06.2018
NL06.06.2018
PL06.06.2018
PT06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SI06.06.2018
SK06.06.2018
SM06.06.2018
TR06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
IE11.12.2018
LU11.12.2018
MT11.12.2018
BE31.12.2018
Former [2020/16]AL06.06.2018
AT06.06.2018
CY06.06.2018
CZ06.06.2018
DK06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
MC06.06.2018
NL06.06.2018
PL06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SI06.06.2018
SK06.06.2018
SM06.06.2018
TR06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
IE11.12.2018
LU11.12.2018
MT11.12.2018
BE31.12.2018
Former [2020/08]AL06.06.2018
AT06.06.2018
CY06.06.2018
CZ06.06.2018
DK06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
MC06.06.2018
NL06.06.2018
PL06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SI06.06.2018
SK06.06.2018
SM06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
IE11.12.2018
LU11.12.2018
MT11.12.2018
BE31.12.2018
Former [2019/51]AL06.06.2018
AT06.06.2018
CY06.06.2018
CZ06.06.2018
DK06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
MC06.06.2018
NL06.06.2018
PL06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SI06.06.2018
SK06.06.2018
SM06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
IE11.12.2018
LU11.12.2018
BE31.12.2018
Former [2019/48]AT06.06.2018
CY06.06.2018
CZ06.06.2018
DK06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
MC06.06.2018
NL06.06.2018
PL06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SI06.06.2018
SK06.06.2018
SM06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
IE11.12.2018
LU11.12.2018
Former [2019/40]AT06.06.2018
CY06.06.2018
CZ06.06.2018
DK06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
MC06.06.2018
NL06.06.2018
PL06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SI06.06.2018
SK06.06.2018
SM06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
LU11.12.2018
Former [2019/39]AT06.06.2018
CY06.06.2018
CZ06.06.2018
DK06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
NL06.06.2018
PL06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SI06.06.2018
SK06.06.2018
SM06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
LU11.12.2018
Former [2019/26]AT06.06.2018
CY06.06.2018
CZ06.06.2018
DK06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
NL06.06.2018
PL06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SI06.06.2018
SK06.06.2018
SM06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
Former [2019/11]AT06.06.2018
CY06.06.2018
CZ06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
IT06.06.2018
LT06.06.2018
LV06.06.2018
NL06.06.2018
PL06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SK06.06.2018
SM06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
Former [2019/10]AT06.06.2018
CY06.06.2018
CZ06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
LT06.06.2018
LV06.06.2018
NL06.06.2018
PL06.06.2018
RO06.06.2018
RS06.06.2018
SE06.06.2018
SK06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
Former [2019/09]CY06.06.2018
EE06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
LT06.06.2018
LV06.06.2018
NL06.06.2018
RS06.06.2018
SE06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
Former [2019/08]CY06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
LT06.06.2018
LV06.06.2018
NL06.06.2018
RS06.06.2018
SE06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
IS06.10.2018
Former [2019/03]CY06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
LT06.06.2018
LV06.06.2018
NL06.06.2018
RS06.06.2018
SE06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
Former [2018/52]CY06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
LT06.06.2018
LV06.06.2018
RS06.06.2018
SE06.06.2018
BG06.09.2018
NO06.09.2018
GR07.09.2018
Former [2018/51]CY06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
LT06.06.2018
LV06.06.2018
RS06.06.2018
SE06.06.2018
BG06.09.2018
NO06.09.2018
Former [2018/50]CY06.06.2018
ES06.06.2018
FI06.06.2018
HR06.06.2018
LT06.06.2018
SE06.06.2018
BG06.09.2018
NO06.09.2018
Former [2018/49]CY06.06.2018
ES06.06.2018
FI06.06.2018
LT06.06.2018
SE06.06.2018
BG06.09.2018
NO06.09.2018
Former [2018/47]ES06.06.2018
FI06.06.2018
LT06.06.2018
NO06.09.2018
Documents cited:Search[I]WO2006133303  (UNIV FLORIDA [US], et al) [I] 1-15 * compounds H, (S,R)-4-Methyl-DMXBA, (S,R)-5-Methyl-DMXBA, (S,R)-6-Methyl-DMXBA;; example 14; claims 1, 29, 40, 47, 54, 63, 71, 83; table 1 *;
 [A]  - SLAVOV S H ET AL, "A computational study of the binding of 3-(arylidene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 45, no. 6, ISSN 0223-5234, (20100601), pages 2433 - 2446, (20100213), XP027013913 [A] 1-15 * tables 1, 7; compounds 1.1-1.45, 2.1, 2.2 *
 [A]  - HASHIMOTO K ET AL, "ALPHA.7 NICOTINIC RECEPTOR AGONISTS AS POTENTIAL THERAPEUTIC DRUGS FOR SCHIZOPHRENIA", CENTRAL NERVOUS SYSTEM AGENTS IN MEDICINAL CHEMISTRY, BENTHAM SCIENCE PUBLISHERS LTD., BUSSUM, NL, (20050101), vol. 5, no. 3, ISSN 1871-5249, pages 171 - 184, XP009074846 [A] 1-15 * page 174; figure 4 *
 [A]  - ANTOINE TALY ET AL, "Discrimination of agonists versus antagonists of nicotinic ligands based on docking onto AChBP structures", JOURNAL OF MOLECULAR GRAPHICS AND MODELLING, ELSEVIER SCIENCE, NEW YORK, NY, US, vol. 30, doi:10.1016/J.JMGM.2011.06.008, ISSN 1093-3263, (20110622), pages 100 - 109, (20110629), XP028272492 [A] 1-15 * compound 2WN9 (4-OH-DMXBA);; figure 3 *

DOI:   http://dx.doi.org/10.1016/j.jmgm.2011.06.008
International search[A]WO9201688  (PFIZER [US]);
 [A]WO0123385  (UNIV GEORGETOWN [US], et al);
 [A]WO2008095944  (EISAI LONDON RES LAB LTD [GB], et al);
 [X]  - SVETOSLAV H. SLAVOV ET AL., "A computational study of the binding of 3-(aryl idene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein.", EUROPEAN JOURNAL OF MEDICINAL CHEMIST .Y., (201006), vol. 45, no. 6, pages 2433 - 2446, XP027013913
 [X]  - KENJI HASHIMOTO ET AL., "alpha7 Nicotinic Agonists as Potential Therapeutic Drugs for Schizophrenia.", CURRENT MEDICINAL CHEMISTRY-CENTRAL NERVOUS SYSTEM AGENTS., (200509), vol. 5, no. 3, pages 171 - 184, XP009074846
 [X]  - NATALE BELLUARDO ET AL., "Central nicotinic receptors, neurotrophic factors and neuroprotection.", BEHAVIOURAL BRAIN RESEARCH., (200008), vol. 113, no. 1-2, pages 2 1 - 34, XP055156520

DOI:   http://dx.doi.org/10.1016/S0166-4328(00)00197-2
 [A]  - ALEXANDER HOEPPING ET AL., "Novel Conformationally Constrained Tropane Analo gues by 6-endo-trig Radical Cyclization and Stille Coupling, Switch of Activity toward the serotonin and/or Norepinephrine Transporter.", JOURNAL OF M EDICINAL CHEMISTRY., (20000518), vol. 43, no. 10, pages 2064 - 2071, XP002169501

DOI:   http://dx.doi.org/10.1021/jm0001121
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.