EP2796462 - ANTI-TUMOR PEPTIDE AND USE THEREFOR [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 25.05.2018 Database last updated on 22.08.2024 | |
Former | The patent has been granted Status updated on 16.06.2017 | ||
Former | Grant of patent is intended Status updated on 09.06.2017 | ||
Former | Examination is in progress Status updated on 16.05.2017 | ||
Former | Grant of patent is intended Status updated on 02.01.2017 | Most recent event Tooltip | 17.07.2020 | Lapse of the patent in a contracting state New state(s): AL | published on 19.08.2020 [2020/34] | Applicant(s) | For all designated states Toagosei Co., Ltd. 1-14-1, Nishi Shimbashi Minato-ku Tokyo 105-8419 / JP | [2017/20] |
Former [2014/44] | For all designated states Toagosei Co., Ltd 1-14-1, Nishi shimbashi Minato-ku, Tokyo 105-8419 / JP | Inventor(s) | 01 /
KOBAYASHI, Nahoko C/O TOAGOSEI CO., LTD. 2, Ookubo Tsukuba-shi Ibaraki 300-2611 / JP | 02 /
YOSHIDA, Tetsuhiko C/O TOAGOSEI CO., LTD. 2, Ookubo Tsukuba-shi Ibaraki 300-2611 / JP | [2017/20] |
Former [2014/44] | 01 /
KOBAYASHI, Nahoko C/O TOAGOSEI CO. LTD. 2 Ookubo Tsukuba-shi Ibaraki 300-2611 / JP | ||
02 /
YOSHIDA, Tetsuhiko C/O TOAGOSEI CO. LTD. 2 Ookubo Tsukuba-shi Ibaraki 300-2611 / JP | Representative(s) | Elsy, David Withers & Rogers LLP 2 London Bridge London SE1 9RA / GB | [N/P] |
Former [2014/44] | Elsy, David Withers & Rogers LLP 4 More London Riverside London SE1 2AU / GB | Application number, filing date | 12860097.0 | 20.12.2012 | [2017/29] | WO2012JP83109 | Priority number, date | JP20110278973 | 20.12.2011 Original published format: JP 2011278973 | JP20110278974 | 20.12.2011 Original published format: JP 2011278974 | [2014/44] | Filing language | JA | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2013094697 | Date: | 27.06.2013 | Language: | JA | [2013/26] | Type: | A1 Application with search report | No.: | EP2796462 | Date: | 29.10.2014 | Language: | EN | [2014/44] | Type: | B1 Patent specification | No.: | EP2796462 | Date: | 19.07.2017 | Language: | EN | [2017/29] | Search report(s) | International search report - published on: | JP | 27.06.2013 | (Supplementary) European search report - dispatched on: | EP | 29.05.2015 | Classification | IPC: | C07K7/06, A61K38/00, A61P35/00, A61P35/02, C07K19/00 | [2014/44] | CPC: |
C07K7/08 (EP,US);
A61K38/08 (EP,US);
A61P35/00 (EP);
A61P35/02 (EP);
A61P43/00 (EP);
C07K7/06 (EP,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/44] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | ANTITUMORPEPTID UND VERWENDUNG DAFÜR | [2014/44] | English: | ANTI-TUMOR PEPTIDE AND USE THEREFOR | [2014/44] | French: | PEPTIDE ANTITUMORAL ET SON UTILISATION | [2014/44] | Entry into regional phase | 17.06.2014 | Translation filed | 17.06.2014 | National basic fee paid | 17.06.2014 | Search fee paid | 17.06.2014 | Designation fee(s) paid | 17.06.2014 | Examination fee paid | Examination procedure | 17.06.2014 | Examination requested [2014/44] | 18.08.2015 | Amendment by applicant (claims and/or description) | 14.03.2016 | Despatch of a communication from the examining division (Time limit: M02) | 18.05.2016 | Reply to a communication from the examining division | 03.01.2017 | Communication of intention to grant the patent | 11.05.2017 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 11.05.2017 | Fee for grant paid | 11.05.2017 | Fee for publishing/printing paid | 08.06.2017 | Information about intention to grant a patent | 08.06.2017 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 14.03.2016 | Opposition(s) | 20.04.2018 | No opposition filed within time limit [2018/26] | Fees paid | Renewal fee | 11.12.2014 | Renewal fee patent year 03 | 09.12.2015 | Renewal fee patent year 04 | 09.12.2016 | Renewal fee patent year 05 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 20.12.2012 | AL | 19.07.2017 | AT | 19.07.2017 | CY | 19.07.2017 | CZ | 19.07.2017 | DK | 19.07.2017 | EE | 19.07.2017 | ES | 19.07.2017 | FI | 19.07.2017 | HR | 19.07.2017 | IT | 19.07.2017 | LT | 19.07.2017 | LV | 19.07.2017 | MC | 19.07.2017 | MK | 19.07.2017 | NL | 19.07.2017 | PL | 19.07.2017 | PT | 19.07.2017 | RO | 19.07.2017 | RS | 19.07.2017 | SE | 19.07.2017 | SI | 19.07.2017 | SK | 19.07.2017 | SM | 19.07.2017 | TR | 19.07.2017 | BG | 19.10.2017 | NO | 19.10.2017 | GR | 20.10.2017 | IS | 19.11.2017 | IE | 20.12.2017 | LU | 20.12.2017 | MT | 20.12.2017 | BE | 31.12.2017 | CH | 31.12.2017 | LI | 31.12.2017 | [2020/34] |
Former [2020/28] | HU | 20.12.2012 | |
AT | 19.07.2017 | ||
CY | 19.07.2017 | ||
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
MC | 19.07.2017 | ||
MK | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
PT | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
TR | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
IE | 20.12.2017 | ||
LU | 20.12.2017 | ||
MT | 20.12.2017 | ||
BE | 31.12.2017 | ||
CH | 31.12.2017 | ||
LI | 31.12.2017 | ||
Former [2020/15] | HU | 20.12.2012 | |
AT | 19.07.2017 | ||
CY | 19.07.2017 | ||
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
MC | 19.07.2017 | ||
MK | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
TR | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
IE | 20.12.2017 | ||
LU | 20.12.2017 | ||
MT | 20.12.2017 | ||
BE | 31.12.2017 | ||
CH | 31.12.2017 | ||
LI | 31.12.2017 | ||
Former [2019/51] | HU | 20.12.2012 | |
AT | 19.07.2017 | ||
CY | 19.07.2017 | ||
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
MC | 19.07.2017 | ||
MK | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
IE | 20.12.2017 | ||
LU | 20.12.2017 | ||
MT | 20.12.2017 | ||
BE | 31.12.2017 | ||
CH | 31.12.2017 | ||
LI | 31.12.2017 | ||
Former [2019/47] | HU | 20.12.2012 | |
AT | 19.07.2017 | ||
CY | 19.07.2017 | ||
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
MC | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
IE | 20.12.2017 | ||
LU | 20.12.2017 | ||
MT | 20.12.2017 | ||
BE | 31.12.2017 | ||
CH | 31.12.2017 | ||
LI | 31.12.2017 | ||
Former [2019/31] | HU | 20.12.2012 | |
AT | 19.07.2017 | ||
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
MC | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
IE | 20.12.2017 | ||
LU | 20.12.2017 | ||
MT | 20.12.2017 | ||
BE | 31.12.2017 | ||
CH | 31.12.2017 | ||
LI | 31.12.2017 | ||
Former [2019/30] | AT | 19.07.2017 | |
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
MC | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
IE | 20.12.2017 | ||
LU | 20.12.2017 | ||
MT | 20.12.2017 | ||
BE | 31.12.2017 | ||
CH | 31.12.2017 | ||
LI | 31.12.2017 | ||
Former [2018/52] | AT | 19.07.2017 | |
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
IE | 20.12.2017 | ||
LU | 20.12.2017 | ||
MT | 20.12.2017 | ||
BE | 31.12.2017 | ||
CH | 31.12.2017 | ||
LI | 31.12.2017 | ||
Former [2018/50] | AT | 19.07.2017 | |
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
IE | 20.12.2017 | ||
LU | 20.12.2017 | ||
MT | 20.12.2017 | ||
BE | 31.12.2017 | ||
Former [2018/45] | AT | 19.07.2017 | |
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
IE | 20.12.2017 | ||
LU | 20.12.2017 | ||
MT | 20.12.2017 | ||
Former [2018/43] | AT | 19.07.2017 | |
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
LU | 20.12.2017 | ||
MT | 20.12.2017 | ||
Former [2018/39] | AT | 19.07.2017 | |
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SI | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
Former [2018/24] | AT | 19.07.2017 | |
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
EE | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
IT | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RO | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
SK | 19.07.2017 | ||
SM | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
Former [2018/21] | AT | 19.07.2017 | |
CZ | 19.07.2017 | ||
DK | 19.07.2017 | ||
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
Former [2018/12] | AT | 19.07.2017 | |
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
LT | 19.07.2017 | ||
LV | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
Former [2018/11] | AT | 19.07.2017 | |
ES | 19.07.2017 | ||
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
LT | 19.07.2017 | ||
NL | 19.07.2017 | ||
PL | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
BG | 19.10.2017 | ||
NO | 19.10.2017 | ||
GR | 20.10.2017 | ||
IS | 19.11.2017 | ||
Former [2018/10] | AT | 19.07.2017 | |
FI | 19.07.2017 | ||
HR | 19.07.2017 | ||
LT | 19.07.2017 | ||
NL | 19.07.2017 | ||
RS | 19.07.2017 | ||
SE | 19.07.2017 | ||
NO | 19.10.2017 | ||
Former [2018/09] | FI | 19.07.2017 | |
LT | 19.07.2017 | ||
NL | 19.07.2017 | ||
SE | 19.07.2017 | ||
NO | 19.10.2017 | ||
Former [2018/08] | FI | 19.07.2017 | |
LT | 19.07.2017 | ||
NL | 19.07.2017 | ||
NO | 19.10.2017 | ||
Former [2018/07] | LT | 19.07.2017 | |
NO | 19.10.2017 | Documents cited: | Search | [A]WO03024408 (UNIV ROCHESTER [US], et al) [A] 1-5 * abstract *; | [A]WO03037172 (GPC BIOTECH INC [US], et al) [A] 1-5 * figure 4/26; claims 3,7; sequence 248 *; | [A]WO2004005472 (SOUTHERN RES INST [US], et al) [A] 1-5 * abstract * * page 37 *; | [A]WO2007056188 (HARVARD COLLEGE [US], et al) [A] 1-5 * abstract * * paragraph [0072] *; | [AD]WO2009093692 (TOAGOSEI CO LTD [JP], et al) [AD] 2,3 * abstract *; | [A]DE102009021681 (UNIV DRESDEN TECH [DE]) [A] 1-5 * abstract *; | [A] - LAPPCHEN ET AL, "Probing FtsZ and Tubulin with C8-Substituted GTP Analogs Reveals Differences in Their Nucleotide Binding Sites", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, (20080222), vol. 15, no. 2, doi:10.1016/J.CHEMBIOL.2007.12.013, ISSN 1074-5521, pages 189 - 199, XP022489110 [A] 1-5 * abstract * * page 189 - page 190, paragraph 1 * DOI: http://dx.doi.org/10.1016/j.chembiol.2007.12.013 | [T] - IWAO OJIMA ET AL, "Drug discovery targeting cell division proteins, microtubules and FtsZ", BIOORGANIC & MEDICINAL CHEMISTRY, (20140901), vol. 22, no. 18, doi:10.1016/j.bmc.2014.02.036, ISSN 0968-0896, pages 5060 - 5077, XP055190224 [T] 1-5 * abstract * * page 5075 * DOI: http://dx.doi.org/10.1016/j.bmc.2014.02.036 | International search | [A]WO2009093692 (TOAGOSEI CO LTD [JP], et al); | [A]WO2011013698 (TOAGOSEI CO LTD [JP], et al); | [A]WO2011013699 (TOAGOSEI CO LTD [JP], et al); | [A] - PARADIS-BLEAU C. ET AL., "Peptide inhibitors of the essential cell division protein FtsA., Protein Engineering", DESIGN & SELECTION, (2005), vol. 18, no. 2, pages 85 - 91, XP055154920 DOI: http://dx.doi.org/10.1093/protein/gzi008 | [A] - PARADIS-BLEAU C. ET AL., "Identification of Pseudomonas aeruginosa FtsZ peptide inhibitors as a tool for development of novel antimicrobials.", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, (2004), vol. 54, no. 1, pages 278 - 280, XP055154923 DOI: http://dx.doi.org/10.1093/jac/dkh318 | [A] - VOLLMER W. ET AL., "The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, (2006), vol. 73, pages 37 - 47, XP019441737 DOI: http://dx.doi.org/10.1007/s00253-006-0586-0 | [A] - HUANG Q. ET AL., "Targeting FtsZ for anti- tuberculosis drug discovery: non-cytotoxic taxanes as novel anti-tuberculosis agents.", JOURNAL OF MEDICINAL CHEMISTRY, (2006), vol. 49, no. 2, pages 463 - 466, XP055154927 DOI: http://dx.doi.org/10.1021/jm050920y | by applicant | WO2007004869 | WO2008081812 | WO2009093692 | WO2011013698 | WO2011013699 | - PROTEIN ENGINEERING, DESIGN & SELECTION, (2005), vol. 18, no. 2, pages 85 - 91 | - JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, (2004), vol. 54, no. 1, pages 278 - 280 | - SHIMIZU ET AL., NATURE BIOTECHNOLOGY, (2001), vol. 19, pages 751 - 755 | - MADIN ET AL., PROC. NATL. ACAD. SCI. USA, (2000), vol. 97, no. 2, pages 559 - 564 |