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Extract from the Register of European Patents

EP About this file: EP2799540

EP2799540 - HUMAN ARGINASE AND PEGYLATED HUMAN ARGINASE AND APPLICATION THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.08.2018
Database last updated on 02.11.2024
FormerThe patent has been granted
Status updated on  08.09.2017
FormerGrant of patent is intended
Status updated on  07.05.2017
FormerExamination is in progress
Status updated on  23.12.2016
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Bio-Cancer Treatment International Ltd. (Shanghai)
Room 202
Building 9
1011 Halei Road
Zhangjiang High-Tech Park, Pudong New Area
Shanghai 201203 / CN
[2014/45]
Inventor(s)01 / CHENG, Ning Man
Rm. 511-513
5/F Bio-Informatics Centre
2 Science ParkWest Avenue
Hong Kong Science Park, Shatin, N.T.
Hong Kong / CN
02 / CHEN, Li
Rm. 511-513
5/F Bio-Informatics Centre
2 Science Park West Avenue
Hong Kong Science Park, Shatin, N.T.
Hong Kong / CN
 [2014/45]
Representative(s)Cabinet Chaillot
16/20, avenue de l'Agent Sarre
B.P. 74
92703 Colombes Cedex / FR
[2014/45]
Application number, filing date12862469.923.12.2012
[2017/41]
WO2012CN87241
Priority number, dateCN20111044596527.12.2011         Original published format: CN201110445965
CN2012106962616.03.2012         Original published format: CN201210069626
[2014/45]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013097658
Date:04.07.2013
Language:ZH
[2013/27]
Type: A1 Application with search report 
No.:EP2799540
Date:05.11.2014
Language:EN
[2014/45]
Type: B1 Patent specification 
No.:EP2799540
Date:11.10.2017
Language:EN
[2017/41]
Search report(s)International search report - published on:CN04.07.2013
(Supplementary) European search report - dispatched on:EP29.07.2015
ClassificationIPC:C12N9/78, A61K38/50, A61K47/60, A61P43/00, A61P35/00, A61P35/02, A61P7/00
[2017/16]
CPC:
C12N9/78 (EP,KR,US); A61K38/50 (KR,US); A61K47/50 (KR);
A61P35/00 (EP,KR); A61P35/02 (EP); A61P35/04 (EP);
A61P43/00 (EP); A61P7/00 (EP); C12N9/96 (EP,KR,US);
C12Y305/03001 (EP,KR,US); A61K38/00 (EP,US) (-)
Former IPC [2014/45]C12N9/78, A61K38/50, A61K47/48, A61P43/00, A61P35/00, A61P35/02, A61P7/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/45]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:HUMANE ARGINASE UND PEGYLIERTE HUMANE ARGINASE UND VERWENDUNG DAVON[2014/45]
English:HUMAN ARGINASE AND PEGYLATED HUMAN ARGINASE AND APPLICATION THEREOF[2014/45]
French:ARGINASE HUMAINE ET ARGINASE HUMAINE PÉGYLÉE, ET LEUR APPLICATION[2014/45]
Entry into regional phase24.07.2014Translation filed 
24.07.2014National basic fee paid 
24.07.2014Search fee paid 
24.07.2014Designation fee(s) paid 
24.07.2014Examination fee paid 
Examination procedure17.05.2013Request for preliminary examination filed
International Preliminary Examining Authority: CN
24.07.2014Examination requested  [2014/45]
12.02.2016Amendment by applicant (claims and/or description)
23.06.2016Despatch of a communication from the examining division (Time limit: M08)
14.02.2017Reply to a communication from the examining division
08.05.2017Communication of intention to grant the patent
07.08.2017Receipt of the translation of the claim(s)
01.09.2017Fee for grant paid
01.09.2017Fee for publishing/printing paid
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.06.2016
Opposition(s)12.07.2018No opposition filed within time limit [2018/38]
Fees paidRenewal fee
27.11.2014Renewal fee patent year 03
27.11.2015Renewal fee patent year 04
20.12.2016Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU23.12.2012
AL11.10.2017
AT11.10.2017
CY11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
MC11.10.2017
MK11.10.2017
NL11.10.2017
PL11.10.2017
PT11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SI11.10.2017
SK11.10.2017
SM11.10.2017
TR11.10.2017
IE23.12.2017
LU23.12.2017
MT23.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
[2020/34]
Former [2020/28]HU23.12.2012
AT11.10.2017
CY11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
MC11.10.2017
MK11.10.2017
NL11.10.2017
PL11.10.2017
PT11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SI11.10.2017
SK11.10.2017
SM11.10.2017
TR11.10.2017
IE23.12.2017
LU23.12.2017
MT23.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2020/16]HU23.12.2012
AT11.10.2017
CY11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
MC11.10.2017
MK11.10.2017
NL11.10.2017
PL11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SI11.10.2017
SK11.10.2017
SM11.10.2017
TR11.10.2017
IE23.12.2017
LU23.12.2017
MT23.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2019/51]HU23.12.2012
AT11.10.2017
CY11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
MC11.10.2017
MK11.10.2017
NL11.10.2017
PL11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SI11.10.2017
SK11.10.2017
SM11.10.2017
IE23.12.2017
LU23.12.2017
MT23.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2019/47]HU23.12.2012
AT11.10.2017
CY11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
MC11.10.2017
NL11.10.2017
PL11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SI11.10.2017
SK11.10.2017
SM11.10.2017
IE23.12.2017
LU23.12.2017
MT23.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2019/31]HU23.12.2012
AT11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
MC11.10.2017
NL11.10.2017
PL11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SI11.10.2017
SK11.10.2017
SM11.10.2017
IE23.12.2017
LU23.12.2017
MT23.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2019/30]AT11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
MC11.10.2017
NL11.10.2017
PL11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SI11.10.2017
SK11.10.2017
SM11.10.2017
IE23.12.2017
LU23.12.2017
MT23.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2018/52]AT11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
NL11.10.2017
PL11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SI11.10.2017
SK11.10.2017
SM11.10.2017
IE23.12.2017
LU23.12.2017
MT23.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2018/50]AT11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
NL11.10.2017
PL11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SK11.10.2017
SM11.10.2017
IE23.12.2017
LU23.12.2017
MT23.12.2017
BE31.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2018/45]AT11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
NL11.10.2017
PL11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SK11.10.2017
SM11.10.2017
IE23.12.2017
LU23.12.2017
MT23.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2018/43]AT11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
NL11.10.2017
PL11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SK11.10.2017
SM11.10.2017
LU23.12.2017
MT23.12.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2018/40]AT11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
NL11.10.2017
PL11.10.2017
RO11.10.2017
RS11.10.2017
SE11.10.2017
SK11.10.2017
SM11.10.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2018/39]AT11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
IT11.10.2017
LT11.10.2017
LV11.10.2017
NL11.10.2017
PL11.10.2017
RS11.10.2017
SE11.10.2017
SK11.10.2017
SM11.10.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2018/37]AT11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
LT11.10.2017
LV11.10.2017
NL11.10.2017
PL11.10.2017
RS11.10.2017
SE11.10.2017
SK11.10.2017
SM11.10.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2018/35]AT11.10.2017
CZ11.10.2017
DK11.10.2017
EE11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
LT11.10.2017
LV11.10.2017
NL11.10.2017
RS11.10.2017
SE11.10.2017
SK11.10.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2018/24]AT11.10.2017
ES11.10.2017
FI11.10.2017
HR11.10.2017
LT11.10.2017
LV11.10.2017
NL11.10.2017
RS11.10.2017
SE11.10.2017
BG11.01.2018
NO11.01.2018
GR12.01.2018
IS11.02.2018
Former [2018/22]ES11.10.2017
FI11.10.2017
LT11.10.2017
NL11.10.2017
NO11.01.2018
Former [2018/17]NL11.10.2017
Documents cited:Search[XI]US2010247508  (LEUNG YUN CHUNG [CN], et al) [X] 1-5,11-15 * paragraphs 0020, 0044, 0059-0062 * [I] 6-10;
 [A]  - LAVULO LOPETI T ET AL, "Consequences of point mutations on the integrity, oligomeric state, stability, and kinetics of hepatic type 1'arginase resulting in hyperargininemia", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (20010308), Database accession no. PREV200100245087, XP002742151 [A] 1 * abstract *
    [ ] - LAVULO LOPETI T ET AL, "Consequences of point mutations on the integrity, oligomeric state, stability, and kinetics of hepatic type 1'arginase resulting in hyperargininemia", FASEB JOURNAL, & ANNUAL MEETING OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY ON EXPERIMENTAL BIOL; ORLANDO, FLORIDA, USA; MARCH 31-APRIL 04, 2001, (20010308), vol. 15, no. 5, ISSN 0892-6638, page A876
International search[A]CN1345966  (SHANGHAI BIOWINDOW GENE DEV [CN]);
 [A]US2010247508  (LEUNG YUN CHUNG [CN], et al);
 [A]WO2011008495  (UNIV TEXAS [US], et al);
 [A]  - "arginase-1 isoform 2 [Homo sapiens]", GENBANK, (20111106), Database accession no. P_000036.2, XP055174641
 [A]  - "arginase (EC 3.5.3.1), [Homo sapiens]", GENBANK, (19941031), Database accession no. AAA51776.1, XP003031956
 [A]  - WANG; YINGHUA ET AL, "Mutation of Arginines Near the Active Site Cys 124 of Human Dual-specificity Phosphatase and Its Effect on the Enzymatic Activity", ACTA BIOCHIMICA ET BIOPHYSICA SINICA, (20031231), vol. 35, no. 2, pages 149 - 153, XP008174310
 [A]  - ALARCON R. ET AL, "Mutational analysis of substrate recognition by human arginase type I-agmatinase activity of the N130D variant", FEBS JOURNAL, ISSN: 1742-464X, (20061231), vol. 273, pages 5625 - 5631, XP002568501

DOI:   http://dx.doi.org/10.1111/j.1742-4658.2006.05551.x
by applicantUS2010247508
 WO2011008495
 US7951366
    - HARAGUCHI, Y., PROC. NATL. ACAD. SCL., (1987), vol. 84, pages 412 - 415
    - HARAGUCHI. Y. ET AL., PROC. NATL. ACAD. SCI, (1987), vol. 84, pages 412 - 415
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.