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Extract from the Register of European Patents

EP About this file: EP2594565

EP2594565 - 2-acylaminopropanol-type glucosylceramide synthase inhibitors [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  30.08.2019
Database last updated on 06.07.2024
FormerThe patent has been granted
Status updated on  21.09.2018
FormerGrant of patent is intended
Status updated on  14.05.2018
FormerExamination is in progress
Status updated on  25.11.2016
Most recent event   Tooltip23.07.2021Lapse of the patent in a contracting state
New state(s): MT		published on 25.08.2021  [2021/34]
Applicant(s)For all designated states
Genzyme Corporation
50 Binney Street
Cambridge, MA 02142 / US
[2018/29]
Former [2013/21]For all designated states
Genzyme Corporation
500 Kendall Street
Cambridge, MA 02142 / US
Inventor(s)01 / Siegel, Craig
15 Bradford Road
Woburn, Massachusetts 01801 / US
02 / Bastos, Cecilia M
1 Bigelow Way
South Grafton, Massachusetts 01560 / US
03 / Harris, David J
5A Eliot Road
Lexington, Massachusetts 02421 / US
04 / Dios, Angeles
85 America Boulevard
Ashland, MA 01721-1867 / US
05 / Lee, Edward
370 Peakham Road
Sudbury, Massachusetts 01776 / US
06 / Silva, Richard
27 Longacre Road
Needham, Massachusetts 02492 / US
07 / Cuff, Lisa M
241 Exchange Street
Leonminster, Massachusetts 01453 / US
08 / Levine, Mikaela
17 Burpee Road
Swampscott, Massachusetts 01907 / US
09 / Celatka, Cassandra
13 Ocean Avenue
Hull, Massachusetts 02045 / US
10 / Vinick, Frederic
-
Deceased / US
11 / Jozefiak, Thomas
27 Clover Street
Belmont, Massachusetts 02478 / US
12 / Xiang, Yabin
24 Marshall Path
Acton, Massachusetts 01720 / US
13 / Kane, John
10 O-Moore Avenue
Maynard, Massachusetts 01754 / US
14 / Liao, Junkai
33 Noel Road
Andover, Massachusetts 01810 / US
 [2013/30]
Former [2013/29]01 / Siegel, Craig
15 Bradford Road
Woburn, Massachusetts 01801 / US
02 / Bastos, Cecilia M
1 Bigelow Way
South Grafton, Massachusetts 01560 / US
03 / Harris, David J
5A Eliot Road
Lexington, Massachusetts 02421 / US
04 / Dios, Angeles
85 America Boulevard
Ashland, MA 01721-1867 / US
05 / Lee, Edward
370 Peakham Road
Sudbury, Massachusetts 01776 / US
06 / Silva, Richard
27 Longacre Road
Needham, Massachusetts 02492 / US
07 / Cuff, Lisa M
241 Exchange Street
Leonminster, Massachusetts 01453 / US
08 / Levine, Mikaela
17 Burpee Road
Swampscott, Massachusetts 01907 / US
09 / Celatka, Cassandra
13 Ocean Avenue
Hull, Massachusetts 02045 / US
10 / Vinick, Frederic
-
Deceased / US
11 / Jozefiak, Thomas
27 Clover Street
Belmont, Massachusetts 02478 / US
12 / Xiang, Yabin
24 Marshall Path
Acton, Massachusetts 01720 / US
13 / Kane, John
10 O-Moore Avenue
Maynard, Massachusetts 01754 / US
14 / Liao, Junkai
50 Juniper Lane
Tewksbury, Massachusetts 01876 / US
Former [2013/21]01 / Siegel, Craig
15 Bradford Road
Woburn, Massachusetts 01801 / US
02 / Bastos, Cecilia M
1 Bigelow Way
South Grafton, Massachusetts 01560 / US
03 / Harris, David J
5A Eliot Road
Lexington, Massachusetts 02421 / US
04 / Dios, Angeles
148 Overland Road Apartment 1-11
Waltham, Massachusetts 02451 / US
05 / Lee, Edward
370 Peakham Road
Sudbury, Massachusetts 01776 / US
06 / Silva, Richard
27 Longacre Road
Needham, Massachusetts 02492 / US
07 / Cuff, Lisa M
241 Exchange Street
Leonminster, Massachusetts 01453 / US
08 / Levine, Mikaela
17 Burpee Road
Swampscott, Massachusetts 01907 / US
09 / Celatka, Cassandra
13 Ocean Avenue
Hull, Massachusetts 02045 / US
10 / Vinick, Frederic
5 Litchfield Road
Lexington, Massachusetts 02420 / US
11 / Jozefiak, Thomas
27 Clover Street
Belmont, Massachusetts 02478 / US
12 / Xiang, Yabin
24 Marshall Path
Acton, Massachusetts 01720 / US
13 / Kane, John
10 O-Moore Avenue
Maynard, Massachusetts 01754 / US
14 / Liao, Junkai
50 Juniper Lane
Tewksbury, Massachusetts 01876 / US
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2018/43]J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2013/21]Keen, Celia Mary
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date13154970.130.05.2008
[2013/21]
Priority number, dateUS20070932370P31.05.2007         Original published format: US 932370 P
US20070997846P05.10.2007         Original published format: US 997846 P
[2013/21]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2594565
Date:22.05.2013
Language:EN
[2013/21]
Type: A3 Search report 
No.:EP2594565
Date:07.08.2013
Language:EN
[2013/32]
Type: B1 Patent specification 
No.:EP2594565
Date:24.10.2018
Language:EN
[2018/43]
Search report(s)(Supplementary) European search report - dispatched on:EP10.07.2013
ClassificationIPC:C07D319/18, C07D405/06, C07D405/12, C07D407/12, C07D409/12, C07D409/14, C07D411/12, C07D413/12, C07D413/14, C07D295/125, A61K31/357, A61P3/10
[2013/21]
CPC:
C07D417/14 (EP,US); A61P13/12 (EP); A61P3/08 (EP);
A61P3/10 (EP); C07D295/125 (EP,US); C07D319/18 (EP,US);
C07D405/06 (EP,US); C07D405/12 (EP,US); C07D405/14 (EP,US);
C07D407/12 (EP,US); C07D409/12 (EP,US); C07D409/14 (EP,US);
C07D411/12 (EP,US); C07D413/12 (EP,US); C07D413/14 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/43]
Former [2013/21]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Glukosylceramid-Synthase-Hemmer vom 2-Acylaminpropanol-Typ[2013/21]
English:2-acylaminopropanol-type glucosylceramide synthase inhibitors[2013/21]
French:Inhibiteurs de glucosylcéramide synthase de type 2-acylaminopropanol[2013/21]
Examination procedure07.02.2014Examination requested  [2014/12]
26.03.2014Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
05.06.2014Amendment by applicant (claims and/or description)
04.11.2015Despatch of a communication from the examining division (Time limit: M04)
14.03.2016Reply to a communication from the examining division
22.07.2016Despatch of a communication from the examining division (Time limit: M06)
20.01.2017Reply to a communication from the examining division
12.06.2017Despatch of a communication from the examining division (Time limit: M06)
30.11.2017Reply to a communication from the examining division
15.05.2018Communication of intention to grant the patent
12.09.2018Fee for grant paid
12.09.2018Fee for publishing/printing paid
12.09.2018Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP08768008.8  / EP2167485
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20080768008) is  02.02.2011
Opposition(s)25.07.2019No opposition filed within time limit [2019/40]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
05.06.2014Request for further processing filed
05.06.2014Full payment received (date of receipt of payment)
Request granted
25.06.2014Decision despatched
Fees paidRenewal fee
14.03.2013Renewal fee patent year 03
14.03.2013Renewal fee patent year 04
14.03.2013Renewal fee patent year 05
14.03.2013Renewal fee patent year 06
27.03.2014Renewal fee patent year 07
12.05.2015Renewal fee patent year 08
10.05.2016Renewal fee patent year 09
10.05.2017Renewal fee patent year 10
11.05.2018Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.05.2008
AT24.10.2018
CY24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
MT24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
IE30.05.2019
LU30.05.2019
BE31.05.2019
CH31.05.2019
LI31.05.2019
[2021/34]
Former [2021/32]HU30.05.2008
AT24.10.2018
CY24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
IE30.05.2019
LU30.05.2019
BE31.05.2019
CH31.05.2019
LI31.05.2019
Former [2021/26]AT24.10.2018
CY24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
IE30.05.2019
LU30.05.2019
BE31.05.2019
CH31.05.2019
LI31.05.2019
Former [2020/26]AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
IE30.05.2019
LU30.05.2019
BE31.05.2019
CH31.05.2019
LI31.05.2019
Former [2020/21]AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
IE30.05.2019
LU30.05.2019
CH31.05.2019
LI31.05.2019
Former [2020/17]AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
TR24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
LU30.05.2019
CH31.05.2019
LI31.05.2019
Former [2020/11]AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
LU30.05.2019
CH31.05.2019
LI31.05.2019
Former [2020/07]AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
MC24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/50]AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
SI24.10.2018
SK24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/40]AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
SK24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/37]AT24.10.2018
CZ24.10.2018
DK24.10.2018
EE24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
RO24.10.2018
SE24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/35]AT24.10.2018
CZ24.10.2018
DK24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
SE24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/34]AT24.10.2018
DK24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
IT24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
SE24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/26]AT24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
SE24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
PT24.02.2019
Former [2019/24]AT24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
SE24.10.2018
BG24.01.2019
NO24.01.2019
GR25.01.2019
IS24.02.2019
Former [2019/23]AT24.10.2018
ES24.10.2018
FI24.10.2018
HR24.10.2018
LT24.10.2018
LV24.10.2018
NL24.10.2018
PL24.10.2018
BG24.01.2019
NO24.01.2019
IS24.02.2019
Former [2019/22]FI24.10.2018
LT24.10.2018
NL24.10.2018
PL24.10.2018
BG24.01.2019
NO24.01.2019
IS24.02.2019
Former [2019/21]FI24.10.2018
LT24.10.2018
NL24.10.2018
NO24.01.2019
IS24.02.2019
Former [2019/20]LT24.10.2018
NL24.10.2018
NO24.01.2019
Former [2019/17]NL24.10.2018
Documents cited:Search[I]WO2006053043  (GENZYME CORP [US], et al) [I] 1-15 * claim 1 *;
 [A]US6051598  (SHAYMAN JAMES A [US], et al) [A] 1-15 * column 8, formula I *;
 [IP]WO2007134086  (GENZYME CORP [US], et al) [IP] 1-15 * page 12 *;
 [E]WO2009045503  (GENZYME CORP [US], et al) [E] 1-15 * the whole document *
 [X]  - ALBERTI, CARLO GIUSEPPE, "Chloramphenicol. XII and XIII. Chloramphenicol analogs. p-Nitrophenyldiaminopropanols", CA, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, Database accession no. 1957:17088, URL: STN, XP002495477 [X] 1-6,10,11,13 * abstract *
 [A]  - JIMBO ET AL, "Development of a new inhibitor of glucosylceramide synthase", JOURNAL OF BIOCHEMISTRY, (2000), vol. 127, no. 3, ISSN 0021-924X, pages 485 - 491, XP002372070 [A] 1-15 * page 488; table 1 *
Examination   - R. R. VUNNAM ET AL., "Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain", CHEMISTRY AND PHYSICS OF LIPIDS, (1980), vol. 26, pages 265 - 278
by applicantUS6569889
 US6255336
 US5916911
 US5302609
 US6660749
 US6610703
 US5472969
 US5525616
 WO2006053043
 US6916802
 US5849326
 US6855830
    - NOJRI ET AL., PROC. NATL. ACAD. SCL USA, (1986), vol. 83, page 782
    - YAMASHITA ET AL., PROC. NATL. ACAD. SCL USA, (2003), vol. 100, no. 6, page 3445
    - TAGAMI ET AL., J BIOL CHEM., (2002), vol. 277, no. 5, page 3085
    - YAMASHITA ET AL., PROC. NATL. ACAD. SC. USA, (2003), vol. 100, pages 3445 - 3449
    - SVENSSON, M. ET AL., "Epithelial Glucosphingolipid Expression as a Determinant of Bacterial Adherence and Cytokine Production", INFECT. AND IMMUN., (1994), vol. 62, pages 4404 - 4410
    - INOKUCHI, J. ET AL., "Antitumor Activity in Mice of an Inhibitor of Glycosphingolipid Biosynthesis", CANCER LETT., (1987), vol. 38, pages 23 - 30
    - HAKOMORI, S., "New Directions in Cancer Therapy Based on Aberrant Expression of Glycosphingolipids: Anti-adhesion and Ortho-Signaling Therapy", CANCER CELLS, (1991), vol. 3, pages 461 - 470
    - INOKUCHI, J. ET AL., "Inhibition of Experimental Metastasis of Murine Lewis Long Carcinoma by an Inhibitor of Glucosylceramide Synthase and its Possible Mechanism of Action", CANCER RES., (1990), vol. 50, pages 6731 - 6737, XP008103809
    - ZICHE, M. ET AL., "Angiogenesis Can Be Stimulated or Repressed in In Vivo by a Change in GM3 :GD3 Ganglioside Ratio", LAB. INVEST., (1992), vol. 67, pages 711 - 715, XP002918640
    - COMUZZIE, OBES. RES., (2003), vol. 11 I, no. 1, page 75
    - RUBINO ET AL., ANN. SURG., (2004), vol. 240, no. 2, page 389
    - GILL-RANDALL ET AL., DIABET. MED., (2004), vol. 21, no. 7, page 759
    - FREIREICH ET AL., CANCER CHEMOTHER. REPORTS, (1996), vol. 50, no. 4, page 219
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.