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EP About this file: EP2712627

EP2712627 - RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  20.04.2018
Database last updated on 20.09.2024
FormerExamination is in progress
Status updated on  28.07.2017
Most recent event   Tooltip20.04.2018Application deemed to be withdrawnpublished on 23.05.2018  [2018/21]
Applicant(s)For all designated states
YEDA RESEARCH AND DEVELOPMENT CO. LTD.
P.O. Box 95
Rehovot 76100 / IL
[2014/14]
Inventor(s)01 / Avigdor Scherz
4 Tor Ha'aviv Street
76329 Rehovot / IL
 [2014/14]
Representative(s)Grünecker Patent- und Rechtsanwälte PartG mbB
Leopoldstraße 4
80802 München / DE
[N/P]
Former [2014/14]Grünecker, Kinkeldey, Stockmair & Schwanhäusser
Leopoldstrasse 4
80802 München / DE
Application number, filing date13186941.401.03.2009
[2014/14]
Priority number, dateUS20080064298P27.02.2008         Original published format: US 64298 P
[2014/14]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2712627
Date:02.04.2014
Language:EN
[2014/14]
Type: A3 Search report 
No.:EP2712627
Date:16.04.2014
[2014/16]
Search report(s)(Supplementary) European search report - dispatched on:EP13.03.2014
ClassificationIPC:A61K41/00, A61P35/00, A61K49/00, A61K49/08, A61K49/14, A61K51/08, A61K51/04
[2014/16]
CPC:
A61K51/0485 (EP,US); A61K41/0071 (EP,US); A61K49/0036 (EP,US);
A61K49/0056 (EP,US); A61K49/085 (EP,US); A61K49/14 (EP,US);
A61K51/082 (EP,US); A61K51/088 (EP,US); A61P35/00 (EP);
A61P35/04 (EP); A61P43/00 (EP); A61K41/0057 (US);
A61K51/044 (US); A61K51/0446 (US); A61K51/0451 (US);
C07D257/04 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2014/14]
TitleGerman:RGD-(Bacterio)chlorophyllkonjugate für die photodynamische Therapie und Abbildung von nekrotischem Tumoren[2014/14]
English:RGD-(bacterio)chlorophyll conjugates for photodynamic therapy and imaging of necrotic tumors[2014/14]
French:Conjugués de RGD-(bactério)chlorophylle utilisés pour la thérapie photodynamique et imagerie de tumeurs nécrosantes[2014/14]
Examination procedure08.10.2014Amendment by applicant (claims and/or description)
08.10.2014Examination requested  [2014/47]
01.08.2017Despatch of a communication from the examining division (Time limit: M04)
12.12.2017Application deemed to be withdrawn, date of legal effect  [2018/21]
15.01.2018Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2018/21]
Parent application(s)   TooltipEP09714191.5  / EP2257309
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20090714191) is  21.09.2011
Fees paidRenewal fee
01.10.2013Renewal fee patent year 03
01.10.2013Renewal fee patent year 04
01.10.2013Renewal fee patent year 05
21.03.2014Renewal fee patent year 06
24.03.2015Renewal fee patent year 07
25.03.2016Renewal fee patent year 08
24.03.2017Renewal fee patent year 09
23.03.2018Renewal fee patent year 10
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XP]WO2008023378  (YEDA RES & DEV [IL], et al) [XP] 1-9 * claims 13-37,48,76-84,100,103 * * examples 31-39,41-43 * * compound 24 * * figures 36,37 * * page 41, lines 18-28 * * page 42, line 15 - page 43, line 10 * * page 45, lines 21-29 * * pages 69-70 * * page 73, lines 10-24 *;
 [A]  - BOISBRUN ET AL, "Design and photophysical properties of new RGD targeted tetraphenylchlorins and porphyrins", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20080206), vol. 64, no. 16, ISSN 0040-4020, pages 3494 - 3504, XP022509600 [A] 1-9

DOI:   http://dx.doi.org/10.1016/j.tet.2008.01.142
 [A]  - FROCHOT ET AL, "Interest of RGD-containing linear or cyclic peptide targeted tetraphenylchlorin as novel photosensitizers for selective photodynamic activity", BIOORGANIC CHEMISTRY, ACADEMIC PRESS INC., NEW YORK, NY, US, (20070429), vol. 35, no. 3, ISSN 0045-2068, pages 205 - 220, XP022057138 [A] 1-9

DOI:   http://dx.doi.org/10.1016/j.bioorg.2006.11.005
 [A]  - CONWAY C L ET AL, "In vivo and in vitro characterisation of a protoporphyrin IX-cyclic RGD peptide conjugate for use in photodynamic therapy", PHOTOCHEMICAL AND PHOTOBIOLOGICAL SCIENCES 2008 GB, (20071218), vol. 7, no. 3, pages 290 - 298, XP008107014 [A] 1-9 * published online 18.12.2007 *

DOI:   http://dx.doi.org/10.1039/b715141a
 [A]  - CHALEIX V ET AL, "RGD-porphyrin conjugates: Synthesis and potential application in photodynamic therapy", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH VERLAG, WEINHEIM, DE, (20030101), vol. 8, ISSN 1434-193X, pages 1486 - 1493, XP002373372 [A] 1-9

DOI:   http://dx.doi.org/10.1002/ejoc.200390208
by applicantDE4121876
 WO9309795
 US5650292
 US5726169
 EP0927045
 US5955585
 US6147195
 US6333319
 EP1246826
 US6569846
 US6576239
 US6740637
 WO2004045492
 WO2005120573
 US7045117
 WO2008023378
    - ALFSEN, A.; H. YU ET AL., "HIV-1-infected blood mononuclear cells form an integrin- and agrin-dependent viral synapse to induce efficient HIV-1 transcytosis across epithelial cell monolayer", MOL BIOL CELL, (2005), vol. 16, no. 9, doi:doi:10.1091/MBC.E05-03-0192, pages 4267 - 79, XP002633915

DOI:   http://dx.doi.org/10.1091/MBC.E05-03-0192
    - BECKER, A.; B. RIEFKE ET AL., "Macromolecular contrast agents for optical imaging of tumors: comparison of indotricarbocyanine-labeled human serum albumin and transferrin", PHOTOCHEM PHOTOBIOL, (2000), vol. 72, no. 2, doi:doi:10.1562/0031-8655(2000)072<0234:MCAFOI>2.0.CO;2, pages 234 - 41, XP008023884

DOI:   http://dx.doi.org/10.1562/0031-8655(2000)072<0234:MCAFOI>2.0.CO;2
    - BERTON, G.; C. A. LOWELL, "Integrin signalling in neutrophils and macrophages", CELL SIGNAL, (1999), vol. 11, no. 9, pages 621 - 35
    - BOEHM-VISWANATHAN T., "Is angiogenesis inhibition the Holy Grail of cancer therapy?", CURR OPIN ONCOL., (2000), vol. 12, no. 1, pages 89 - 94
    - BRANDIS, A.; O. MAZOR ET AL., "Novel water-soluble bacteriochlorophyll derivatives for vascular-targeted photodynamic therapy: synthesis, solubility, phototoxicity and the effect of serum proteins", PHOTOCHEM PHOTOBIOL, (2005), vol. 81, no. 4, doi:doi:10.1562/2004-12-01-RA-389, pages 983 - 93, XP055038294

DOI:   http://dx.doi.org/10.1562/2004-12-01-RA-389
    - BRITTON MM, "Nuclear magnetic resonance studies of convection in the 1.4-cyclohexanedione-bromate-acid reaction", J PHYS CHEM A, (2006), vol. 110, no. 15, pages 5075 - 80
    - BROWN, J. M.; A. J. GIACCIA, "The unique physiology of solid tumors: opportunities (and problems) for cancer therapy", CANCER RES, (1998), vol. 58, no. 7, pages 1408 - 16
    - BROWN, J. M.; W. R. WILSON, "Exploiting tumour hypoxia in cancer treatment", NAT REV CANCER, (2004), vol. 4, no. 6, doi:doi:10.1038/nrc1367, pages 437 - 47, XP055019077

DOI:   http://dx.doi.org/10.1038/nrc1367
    - BROWN, N. S.; R. BICKNELL, "Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer", BREAST CANCER RES, (2001), vol. 3, no. 5, pages 323 - 7
    - BURSTEIN HJ; POLYAK K; WONG JS; LESTER SC; KAELIN CM, "Ductal carcinoma in situ of the breast", N ENGL J MED, (2004), vol. 350, no. 14, pages 1430 - 41
    - BUSSOLATI, G.; M. BONGIOVANNI ET AL., "Assessment of necrosis and hypoxia in ductal carcinoma in situ of the breast: basis for a new classification", VIRCHOWS ARCH, (2000), vol. 437, no. 4, pages 360 - 4
    - CAO, Y., "Tumor angiogenesis and therapy", BIOMED PHARMACOTHER, (2005), vol. 59, no. 2, pages 340 - 3
    - CELLINI C; HUSTON TL; MARTINS D; CHRISTOS P; CARSON J; KEMPER S; SIMMONS RM, "Multiple re-excisions versus mastectomy in patients with persistent residual disease following breast conservation surgery", AM J SURG., (2005), vol. 189, no. 6, doi:doi:10.1016/j.amjsurg.2005.03.005, pages 662 - 6, XP004898866

DOI:   http://dx.doi.org/10.1016/j.amjsurg.2005.03.005
    - CUTULI, B.; C. COHEN-SOLAL-LE NIR ET AL., "Breast-conserving therapy for ductal carcinoma in situ of the breast: the French Cancer Centers' experience", INT J RADIAT ONCOL BIOL PHYS, (2002), vol. 53, no. 4, pages 868 - 79
    - DEAN, M.; T. FOJO ET AL., "Tumour stem cells and drug resistance", NAT REV CANCER, (2005), vol. 5, no. 4, doi:doi:10.1038/nrc1590, pages 275 - 84, XP002378836

DOI:   http://dx.doi.org/10.1038/nrc1590
    - DEWHIRST, M. W., "Concepts of oxygen transport at the microcirculatory level", SEMIN RADIAT ONCOL, (1998), vol. 8, no. 3, doi:doi:10.1016/S1053-4296(98)80040-4, pages 143 - 50, XP005454781

DOI:   http://dx.doi.org/10.1016/S1053-4296(98)80040-4
    - DOUGHERTY, T. J.; C. J. GOMER ET AL., "Photodynamic therapy", J NATL CANCER INST, (1998), vol. 90, no. 12, pages 889 - 905
    - EDWARDS, J. G.; D. E. SWINSON ET AL., "Tumor necrosis correlates with angiogenesis and is a predictor of poor prognosis in malignant mesothelioma", CHEST, (2003), vol. 124, no. 5, pages 1916 - 23
    - FOLKMAN J., "Endogenous inhibitors of angiogenesis", HARVEY LECT., (1996), vol. 92, pages 65 - 82
    - FOLKMAN J., "Angiogenesis and angiogenesis inhibition: an overview", EXS, (1997), vol. 79, pages 1 - 8
    - FOLKMAN J., "A novel anti-vascular therapy for cancer", CANCER BIOL THER, (2004), vol. 3, no. 3, pages 338 - 9
    - GAZDAR AF; KURVARI V; VIRMANI A; GOLLAHON L; SAKAGUCHI M; WESTERFIELD M; KODAGODA D; STASNY V; CUNNINGHAM HT; WISTUBA II, "Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer", INT J CANCER, (1998), vol. 78, no. 6, pages 766 - 74
    - GROSS S.; BRANDIS A. ET AL., "Protein-A-mediated targeting of bacteriochlorophyll-IgG to Staphylococcus aureus: a model for enhanced site- specific photocytotoxicity", PHOTOCHEM PHOTOBIOL, (1997), vol. 66, no. 6, pages 872 - 8, XP007911288
    - GROSS S.; GILEAD A.; BRANDIS A.; SCHREIBER S.; MACHLUF Y.; NEEMAN M.; SCHERZ A.; SALOMON Y., "Selective vascular and tumor responses of photodynamic therapy (PDT) with Pd bacteriopheophorbide (TOOKAD%: online and offline analyses", PROCEEDINGS OF THE 94TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR), TORONTO, (20030405), vol. 44, page 27
    - GROSS S; GILEAD A; SCHERZ A; NEEMAN M; SALOMON Y, "Monitoring photodynamic therapy of solid tumors online by BOLD-contrast MRI", NAT MED, vol. 9, no. 10, doi:doi:10.1038/nm940, pages 1327 - 31, XP002515155

DOI:   http://dx.doi.org/10.1038/nm940
    - GUIDI AJ; FISCHER L; HARRIS JR; SCHNITT SJ, "Microvessel density and distribution in ductal carcinoma in situ of the breast", J NATL CANCER INST., (1994), vol. 86, no. 8, pages 614 - 9
    - GUIDI AJ; SCHNITT SJ; FISCHER L; TOGNAZZI K; HARRIS JR; DVORAK HF; BROWN LF, "Vascular permeability factor (vascular endothelial growth factor) expression and angiogenesis in patients with ductal carcinoma in situ of the breast", CANCER, (1997), vol. 80, no. 10, pages 1945 - 53
    - GUINEBRETIERE JM; LE MONIQUE G; GAVOILLE A; BAHI J; CONTESSO G, "Angiogenesis and risk of breast cancer in women with fibrocystic disease", J NATL CANCER INST, (1994), vol. 86, no. 8, pages 635 - 6
    - HE, X.; P. E. BRENCHLEY ET AL., "Hypoxia increases heparanase- dependent tumor cell invasion, which can be inhibited by antiheparanase antibodies", CANCER RES, (2004), vol. 64, no. 11, pages 3928 - 33
    - HENDEY, B.; M. LAWSON ET AL., "Intracellular calcium and calcineurin regulate neutrophil motility on vitronectin through a receptor identified by antibodies to integrins alphav and beta3", BLOOD, (1996), vol. 87, no. 5, pages 2038 - 48
    - HOFMANN, B.; A. BOGDANOV, JR. ET AL., "Mechanism of gadophrin-2 accumulation in tumor necrosis", J MAGN RESON IMAGING, (1999), vol. 9, no. 2, pages 336 - 41
    - HOLLAND R; HENDRIKS JH; VEBEEK AL; MRAVUNAC M; SCHUURMANS STEKHOVEN JH, "Extent, distribution, and mammographic/histological correlations of breast ductal carcinoma in situ", LANCET, (1990), vol. 335, no. 8688, pages 519 - 22
    - IYER, A. K.; G. KHALED ET AL., "Exploiting the enhanced permeability and retention effect for tumor targeting", DRUG DISCOV TODAY, (2006), vol. 11, no. 17-18, doi:doi:10.1016/j.drudis.2006.07.005, pages 812 - 8, XP025027163

DOI:   http://dx.doi.org/10.1016/j.drudis.2006.07.005
    - KAMEL, I. R.; D. A. BLUEMKE ET AL., "Role of diffusion-weighted imaging in estimating tumor necrosis after chemoembolization of hepatocellular carcinoma", AJR AM J ROENTGENOL, (2003), vol. 181, no. 3, pages 708 - 10
    - KATO, T.; T. KIMURA ET AL., "Clinicopathologic study of angiogenesis in Japanese patients with breast cancer", WORLD J SURG, (1997), vol. 21, no. 1, pages 49 - 56
    - KENNAN, R. P.; B. E. SCANLEY ET AL., "Physiologic basis for BOLD MR signal changes due to hypoxia/hyperoxia: separation of blood volume and magnetic susceptibility effects", MAGN RESON MED, (1997), vol. 37, no. 6, pages 953 - 6, XP002125855
    - KEPPLE J; VAN ZEE KJ; DOWLATSHAHI K; HENRY-TILLMAN RS; ISRAEL PZ; KLIMBERG VS, "Minimally invasive breast surgery", J AM COLL SURG, (2004), vol. 199, no. 6, doi:doi:10.1016/j.jamcollsurg.2004.07.032, pages 961 - 75, XP004651182

DOI:   http://dx.doi.org/10.1016/j.jamcollsurg.2004.07.032
    - KIERAN MW; FOLKMAN J; HEYMACH J, "Angiogenesis inhibitors and hypoxia", NAT MED., (2003), vol. 9, no. 9, page 1104
    - KOUDINOVA, N. V.; J. H. PINTHUS ET AL., "Photodynamic therapy with Pd-Bacteriopheophorbide (TOOKAD): successful in vivo treatment of human prostatic small cell carcinoma xenografts", INT J CANCER, (2003), vol. 104, no. 6, pages 782 - 9
    - KRIPPL P; LANGSENLEHNER U; RENNER W; YAZDANI-BIUKI B; WOLF G; WASCHER TC; PAULWEBER B; HAAS J; SAMONIGG H, "A common 936 C/T gene polymorphism of vascular endothelial growth factor is associated with decreased breast cancer risk", INT J CANCER., (2003), vol. 106, no. 4, pages 468 - 71
    - LANG, P; M. F. WENDLAND ET AL., "Osteogenic sarcoma: noninvasive in vivo assessment of tumor necrosis with diffusion-weighted MR imaging", RADIOLOGY, (1998), vol. 206, no. 1, pages 227 - 35
    - LEE, A. H.; L. C. HAPPERFIELD ET AL., "Angiogenesis and inflammation in invasive carcinoma of the breast", J CLIN PATHOL, (1997), vol. 50, no. 8, pages 669 - 73
    - LEE, K.; R. A. ROTH ET AL., "Hypoxia, drug therapy and toxicity", PHARMACOL THER, (2007), vol. 113, no. 2, doi:doi:10.1016/j.pharmthera.2006.08.001, pages 229 - 46, XP005738005

DOI:   http://dx.doi.org/10.1016/j.pharmthera.2006.08.001
    - LEE, S. E.; S. K. HONG ET AL., "Prognostic significance of tumor necrosis in primary transitional cell carcinoma of upper urinary tract", JPN J CLIN ONCOL, (2007), vol. 37, no. L, pages 49 - 55
    - LEEK, R. D.; R. J. LANDERS ET AL., "Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast", BR J CANCER, (1999), vol. 79, no. 5-6, pages 991 - 5
    - LEHTIO, K.; O. ESKOLA ET AL., "Imaging perfusion and hypoxia with PET to predict radiotherapy response in head-and-neck cancer", INT J RADIAT ONCOL BIOLPHYS, (2004), vol. 59, no. 4, pages 971 - 82
    - LYONS, S. K., "Advances in imaging mouse tumour models in vivo", J PATHOL, (2005), vol. 205, no. 2, pages 194 - 205
    - MAEDA, H.; J. WU ET AL., "Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review", J CONTROL RELEASE, (2000), vol. 65, no. 1-2, doi:doi:10.1016/S0168-3659(99)00248-5, pages 271 - 84, XP004190328

DOI:   http://dx.doi.org/10.1016/S0168-3659(99)00248-5
    - MAESHIMA, Y.; P. C. COLORADO ET AL., "Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties", J BIOL CHEM, (2000), vol. 275, no. 31, doi:doi:10.1074/jbc.C000186200, pages 23745 - 50, XP002177918

DOI:   http://dx.doi.org/10.1074/jbc.C000186200
    - MARUGAN, J. J.; C. MANTHEY ET AL., "Design, synthesis, and biological evaluation of novel potent and selective alphavbeta3/alphavbeta5 integrin dual inhibitors with improved bioavailability. Selection of the molecular core", J MED CHEM, (2005), vol. 48, no. 4, doi:doi:10.1021/jm049725u, pages 926 - 34, XP055015389

DOI:   http://dx.doi.org/10.1021/jm049725u
    - MAZOR, O.; A. BRANDIS ET AL., "WSTI 1, a novel water-soluble bacteriochlorophyll derivative; cellular uptake, pharmacokinetics, biodistribution and vascular-targeted photodynamic activity using melanoma tumors as a model", PHOTOCHEM PHOTOBIOL, (2005), vol. 81, no. 2, pages 342 - 51
    - METZ, S.; H. E. DALDRUP-UNK ET AL., "Detection and quantification of breast tumor necrosis with MR imaging: value of the necrosis-avid contrast agent Gadophrin-3", ACAD RADIOL, (2003), vol. 10, no. 5, pages 484 - 90
    - MINCHINTON, A. 1.; I. F. TANNOCK, "Drug penetration in solid tumours", NAT REV CANCER, (2006), vol. 6, no. 8, pages 583 - 92
    - NI, Y.; G. BORMANS ET AL., "Necrosis avid contrast agents: functional similarity versus structural diversity", INVEST RADIOL, (2005), vol. 40, no. 8, pages 526 - 35
    - NYBERG, P.; M. YLIPALOSAARI ET AL., "Trypsins and their role in carcinoma growth", EXP CELL RES, (2006), vol. 312, no. 8, doi:doi:10.1016/j.yexcr.2005.12.024, pages 1219 - 28, XP024945016

DOI:   http://dx.doi.org/10.1016/j.yexcr.2005.12.024
    - PATAN S; MUNN LL; JAIN RK, "Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis", MICROVASC RES., (1996), vol. 51, no. 2, pages 260 - 72
    - PATTERSON, A. V.; D. M. FERRY ET AL., "Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104", CLIN CANCER RES, (2007), vol. 13, no. 13, doi:doi:10.1158/1078-0432.CCR-07-0478, pages 3922 - 32, XP002539263

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-07-0478
    - PLAKS V; KALCHENKO V; DEKEL N; NEEMAN M, "MRI analysis of angiogenesis during mouse embryo implantation", MAGN RESON MED., (2006), vol. 55, no. 5, pages 1013 - 22
    - PREISE D.; MAZOR O.; KOUDINOVA N.; LISCOVITCH M.; SCHERZ A.; SALOMON Y., "Bypass Of Tumor Drug Resistance By Antivascular Therapy", NEOPLIASIA, (2003), vol. 5, no. 6, pages 475 - 80
    - RANKIN SC, "MRI of the breast", BR J RADIOL., (2000), vol. 73, no. 872, pages 806 - 18
    - RELF M; LEJEUNE S; SCOTT PA; FOX S; SMITH K; LEEK R; MOGHADDAM A; WHITEHOUSE R; BICKNELL R; HARRIS AL, "Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenes", CANCER RES., (1997), vol. 57, no. 5, pages 963 - 9, XP002186837
    - ROSENBACH-BELKIN V; CHEN L; FIEDOR L; TREGUB I; PAVIOTSKY F; BRUMFELD V; SALOMON Y; SCHERZ A, "Serine conjugates of chlorophyll and bacteriochlorophyll: photocytotoxicity in vitro and tissue distribution in mice bearing melanoma tumors", PHOTOCHEM PHOTOBIOL., (1996), vol. 64, no. 1, pages 174 - 81
    - RUBINSTEIN, E.; A. BRANDIS ET AL., "Vascular-Targeted Photodynamic Therapy (VTP), Imaging (VTI) and localization of primary lesions and metastases by novel Bacteriochlorophyll (BCL)-RGD conjugates", PREPARATION
    - SANDERS ME; SCHUYLER PA; DUPONT WD; PAGE DL, "The natural history of low-grade ductal carcinoma in situ of the breast in women treated by biopsy only revealed over 30 years of long-term follow-up", CANCER, (2005), vol. 103, no. 12, pages 2481 - 4
    - SCHAFFNER, P.; M. M. DARD, "Structure and function of RGD peptides involved in bone biology", CELL MOL LIFE SCI, (2003), vol. 60, no. 1, pages 119 - 32
    - SCHNEIDER BP; MILLER KD, "Angiogenesis of breast cancer", J CLIN ONCOL., (2005), vol. 23, no. 8, pages 1782 - 90
    - SCHREIBER S.; GROSS S.; BRANDIS A.; HARMELIN A.; ROSENBACH-BELKIN V.; SCHERZ A.; SALOMON Y., "Local photodynamic therapy (PDT) of rat C6 glioma xenografts with Pd-bacteriopheophorbide leads to decreased metastases and increase of animal cure compared with surgery", INT. J. CANCER, (2002), vol. 99, doi:doi:10.1002/ijc.10299, pages 279 - 285, XP055038741

DOI:   http://dx.doi.org/10.1002/ijc.10299
    - SENGUPTA, S.; C. M. LOHSE ET AL., "Histologic coagulative tumor necrosis as a prognostic indicator of renal cell carcinoma aggressiveness", CANCER, (2005), vol. 104, no. 3, doi:doi:10.1002/cncr.21206, pages 511 - 20, XP055179395

DOI:   http://dx.doi.org/10.1002/cncr.21206
    - SHIMIZU K; ASAI T; OKU N, "Antineovascular therapy, a novel antiangiogenic approach", EXPERT OPIN THER TARGETS, (2005), vol. 9, no. 1, pages 63 - 76
    - SHIRAKAWA, K; H. TSUDA; 2001 ET AL., "Absence of endothelial cells, central necrosis, and fibrosis are associated with aggressive inflammatory breast cancer", CANCER RES, vol. 61, no. 2, pages 445 - 51
    - STREUBEL B; CHOTT A; HUBER D; EXNER M; JTIGER U; WAGNER 0; SCHWARZINGER I, "Lymphoma-specific genetic aberrations in microvascular endothelial cells in B- cell lymphomas", N ENGL J MED., vol. 351, no. 3, pages 250 - 9
    - TAIT, L. R.; R. J. PAULEY ET AL., "Dynamic stromal-epithelial interactions during progression of MCFIODCIS.com xenografts", INT J CANCER, (2007), vol. 120, no. 10, pages 2127 - 34
    - TAKAGI, J., "Structural basis for ligand recognition by RGD (Arg-Gly- Asp)-dependent integrins", BIOCHEM SOC TRANS, (2004), vol. 32, pages 403 - 6
    - TANAKA, T.; S. SHIRAMOTO ET AL., "Tumor targeting based on the effect of enhanced permeability and retention (EPR) and the mechanism of receptor- mediated endocytosis (RME", INT J PHARM, (2004), vol. 277, no. 1-2, pages 39 - 61
    - TANNOCK, 1., "Cell kinetics and chemotherapy: a critical review", CANCER TREAT REP, (1978), vol. 62, no. 8, pages 1117 - 33
    - TANNOCK, I. F.; D. ROTIN, "Acid pH in tumors and its potential for therapeutic exploitation", CANCER RES, (1989), vol. 49, no. 16, pages 4373 - 84
    - TEMMING, K.; R. M. SCHIFFELERS ET AL., "RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature", DRUG RESIST UPDAT, (2005), vol. 8, no. 6, doi:doi:10.1016/j.drup.2005.10.002, pages 381 - 402, XP005328751

DOI:   http://dx.doi.org/10.1016/j.drup.2005.10.002
    - THORPE PE, "Vascular targeting agents as cancer therapeutics", CLIN CANCER RES., (2004), vol. 10, no. 2, doi:doi:10.1158/1078-0432.CCR-0642-03, pages 415 - 27, XP002543457

DOI:   http://dx.doi.org/10.1158/1078-0432.CCR-0642-03
    - TOMES, L.; E. EMBERLEY ET AL., "Necrosis and hypoxia in invasive breast carcinoma", BREAST CANCER RES TREAT, (2003), vol. 81, no. 1, pages 61 - 9
    - VAUPEL, P.; D. K. KELLEHER ET AL., "Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy", SEMIN ONCOL, (2001), vol. 28, no. 2, pages 29 - 35
    - WAPNIR, I. L.; N. BARNARD ET AL., "The inverse relationship between microvessel counts and tumor volume in breast cancer", BREAST J, (2001), vol. 7, no. 3, pages 184 - 8
    - WEERSINK RA; BOGAARDS A; GERTNER M; DAVIDSON SR; ZHANG K; NETCHEV G; TRACHTENBERG J; WILSON BC, "Techniques for delivery and monitoring of TOOKAD (WST09)-mediated photodynamic therapy of the prostate: clinical experience and practicalities", J PHOTOCHEM PHOTOBIOL B., (2005), vol. 79, no. 3, doi:doi:10.1016/j.jphotobiol.2005.01.008, pages 211 - 22, XP025302106

DOI:   http://dx.doi.org/10.1016/j.jphotobiol.2005.01.008
    - WEINMANN, M.; C. BELKA ET AL., "Tumour hypoxia: impact on biology, prognosis and treatment of solid malignant tumours", ONKOLOGIE, (2004), vol. 27, no. 1, pages 83 - 90
    - YANG, M.; E. BARANOV ET AL., "Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases", PROC NATL ACAD SCI USA, (2000), vol. 97, no. 3, doi:doi:10.1073/pnas.97.3.1206, pages 1206 - 11, XP000904536

DOI:   http://dx.doi.org/10.1073/pnas.97.3.1206
    - ZILBERSTEIN J.; BROMBERG A.; FRANTZ A.; ROSENBACH-BELKIN V.; KRITZMANN A.; PFEFERMANN R.; SALOMON Y.; SCHERZ A., "Light-dependent oxygen consumption in bacteriochlorophyll-serine-treated melanoma tumors: on-line determination using a tissue-inserted oxygen microsensor", PHOTOCHEM PHOTOBIOL., (1997), vol. 65, no. 6, pages 1012 - 1019
    - ZILBERSTEIN J.; SCHREIBER S.; BLOEMERS M. C. W. M.; BENDEL P.; NEEMAN M.; SCHECHTMAN E.; KOHEN F.; SCHERZ A.; SALOMON Y., "Antivascular treatment of solid melanoma tumors with bacteriochlorophyll-serine-based photodynamic therapy", PHOTOCHEM. PHOTOBIOL., (2001), vol. 73, doi:doi:10.1562/0031-8655(2001)073<0257:ATOSMT>2.0.CO;2, pages 257 - 266, XP002515153

DOI:   http://dx.doi.org/10.1562/0031-8655(2001)073<0257:ATOSMT>2.0.CO;2
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