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Extract from the Register of European Patents

EP About this file: EP2725359

EP2725359 - Cell separation method using a release system for cell-antibody-substrate conjugates containing a polyethylene glycol spacer unit [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  01.04.2016
Database last updated on 03.10.2024
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
Miltenyi Biotec GmbH
Friedrich-Ebert-Strasse 68
51429 Bergisch Gladbach / DE
[2014/18]
Inventor(s)01 / Dose, Christian, Dr.
Miltenyi Biotec GmbH
Friedrich-Ebert-Strasse 68
D-51429 Bergisch Gladbach / DE
02 / Brieden, Jennifer
Miltenyi Biotec GmbH
Friedrich-Ebert-Strasse 68
D-51429 Bergisch Gladbach / DE
 [2014/18]
Representative(s)Kisters, Michael Marcus
Miltenyi Biotec B.V. & Co. KG
Friedrich-Ebert Strasse 68
51429 Bergisch Gladbach / DE
[N/P]
Former [2014/18]Kisters, Michael Marcus
Patentanwalt Miltenyi Biotec GmbH Corporate Legal Department Friedrich-Ebert Strasse 68
51429 Bergisch Gladbach / DE
Application number, filing date13188639.215.10.2013
[2014/18]
Priority number, dateEP2012018951623.10.2012         Original published format: EP 12189516
[2014/18]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2725359
Date:30.04.2014
Language:EN
[2014/18]
Type: B1 Patent specification 
No.:EP2725359
Date:27.05.2015
Language:EN
[2015/22]
Search report(s)(Supplementary) European search report - dispatched on:EP20.01.2014
ClassificationIPC:G01N33/532, G01N33/543, A61K47/48
[2014/18]
CPC:
G01N33/54333 (EP,US); G01N33/56972 (US); G01N33/532 (EP,US);
G01N33/54353 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/22]
Former [2014/18]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:Zelltrennungsverfahren mit einem Freisetzungssystem für Zell-Antikörper-Substrat-Konjugate mit einer Polyethylenglycol-Distanzeinheit[2014/18]
English:Cell separation method using a release system for cell-antibody-substrate conjugates containing a polyethylene glycol spacer unit[2014/18]
French:Procédé de séparation de cellule utilisant un système de libération pour conjugués cellule-anticorps-substrat contenant une unité d'espacement de polyéthylène glycol[2014/18]
Examination procedure02.10.2014Amendment by applicant (claims and/or description)
02.10.2014Examination requested  [2014/46]
25.11.2014Despatch of a communication from the examining division (Time limit: M02)
21.01.2015Reply to a communication from the examining division
11.02.2015Communication of intention to grant the patent
20.04.2015Fee for grant paid
20.04.2015Fee for publishing/printing paid
20.04.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  25.11.2014
Opposition(s)01.03.2016No opposition filed within time limit [2016/18]
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU15.10.2013
AL27.05.2015
AT27.05.2015
CY27.05.2015
CZ27.05.2015
DK27.05.2015
EE27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
MC27.05.2015
MK27.05.2015
MT27.05.2015
PL27.05.2015
RO27.05.2015
RS27.05.2015
SE27.05.2015
SI27.05.2015
SK27.05.2015
SM27.05.2015
TR27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
IE15.10.2015
LU15.10.2015
[2018/46]
Former [2018/45]HU15.10.2013
AT27.05.2015
CY27.05.2015
CZ27.05.2015
DK27.05.2015
EE27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
MC27.05.2015
MK27.05.2015
MT27.05.2015
PL27.05.2015
RO27.05.2015
RS27.05.2015
SE27.05.2015
SI27.05.2015
SK27.05.2015
SM27.05.2015
TR27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
IE15.10.2015
LU15.10.2015
Former [2018/29]HU15.10.2013
AT27.05.2015
CY27.05.2015
CZ27.05.2015
DK27.05.2015
EE27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
MC27.05.2015
MK27.05.2015
MT27.05.2015
PL27.05.2015
RO27.05.2015
RS27.05.2015
SE27.05.2015
SI27.05.2015
SK27.05.2015
SM27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
IE15.10.2015
LU15.10.2015
Former [2017/40]HU15.10.2013
AT27.05.2015
CY27.05.2015
CZ27.05.2015
DK27.05.2015
EE27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
MC27.05.2015
MT27.05.2015
PL27.05.2015
RO27.05.2015
RS27.05.2015
SE27.05.2015
SI27.05.2015
SK27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
IE15.10.2015
LU15.10.2015
Former [2016/45]AT27.05.2015
CZ27.05.2015
DK27.05.2015
EE27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
MC27.05.2015
PL27.05.2015
RO27.05.2015
RS27.05.2015
SI27.05.2015
SK27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
IE15.10.2015
LU15.10.2015
Former [2016/28]AT27.05.2015
CZ27.05.2015
DK27.05.2015
EE27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
MC27.05.2015
PL27.05.2015
RO27.05.2015
RS27.05.2015
SI27.05.2015
SK27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
LU15.10.2015
Former [2016/26]AT27.05.2015
CZ27.05.2015
DK27.05.2015
EE27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
PL27.05.2015
RO27.05.2015
RS27.05.2015
SI27.05.2015
SK27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
LU15.10.2015
Former [2016/24]AT27.05.2015
CZ27.05.2015
DK27.05.2015
EE27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
PL27.05.2015
RO27.05.2015
RS27.05.2015
SI27.05.2015
SK27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
Former [2016/10]AT27.05.2015
CZ27.05.2015
DK27.05.2015
EE27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
PL27.05.2015
RO27.05.2015
RS27.05.2015
SK27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
Former [2016/09]AT27.05.2015
DK27.05.2015
EE27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
RS27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
Former [2016/07]AT27.05.2015
DK27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
RS27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
Former [2015/51]AT27.05.2015
FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
RS27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
Former [2015/50]FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
RS27.05.2015
BG27.08.2015
NO27.08.2015
GR28.08.2015
IS27.09.2015
PT28.09.2015
Former [2015/49]FI27.05.2015
HR27.05.2015
LT27.05.2015
LV27.05.2015
RS27.05.2015
NO27.08.2015
GR28.08.2015
PT28.09.2015
Documents cited:Search[XDA]US5332679  (SIMONS DONALD M [US], et al) [XD] 1-7 * the whole document * * example 3 * * column 10; table 1 * [A] 8-13;
 [YD]US5518882  (LUND GARRY [CA], et al) [YD] 1-13 * the whole document * * claim 1 * * figure 2 ** column 7, lines 40-51 *;
 [XY]  - SHAN KE ET AL, "Avidin-Biotin-PEG-CPA Complexes as Potential EPR-Directed Therapeutic Protein Carriers: Preparation and Characterization", BIOCONJUGATE CHEMISTRY, (20070901), vol. 18, no. 5, doi:10.1021/bc700182t, ISSN 1043-1802, pages 1644 - 1650, XP055050030 [X] 1-7 * the whole document * * figures 1, 2 * * page 1645, column 1 - page 1646, column 1 * * page 1648, column 2 * [Y] 1-13

DOI:   http://dx.doi.org/10.1021/bc700182t
 [XA]  - KE S ET AL, "Intermolecular interaction of avidin and PEGylated biotin", BIOCONJUGATE CHEMISTRY, ACS, WASHINGTON, DC, US, vol. 18, no. 6, doi:10.1021/BC700204K, ISSN 1043-1802, (20071121), pages 2109 - 2114, (20071019), XP002573017 [X] 1-7 * the whole document * * abstract * [A] 8-13

DOI:   http://dx.doi.org/10.1021/bc700204k
 [XA]  - RAMPERSAUD A A ET AL, "Novel discrete PEG-based crosslinking reagents for conjugation of antibodies and proteins to biotin, fluorochromes, enzymes and gold that eliminate aggregation, improves solubility, reduces non-specific binding and enhances low level detection limits", MOLECULAR BIOLOGY OF THE CELL, & ANNUAL MEETING OF THE AMERICAN-SOCIETY-FOR-CELL-BIOLOGY (ASCB); DENVER, CO, USA; DECEMBER 03 -07, 2011, (2011), vol. 22, ISSN 1059-1524, page 1931, XP055050022 [X] 1-4 * the whole document * * figures 1,7 * [A] 5-13
by applicantUS4656252
 WO9216841
 US5215927
 US5506121
 US5518882
 US6869606
 US2008255004
    - M. QURESHI ET AL., J. BIOL. CHEM., (2001), vol. 276, pages 46422 - 46428
    - T. SANO ET AL., PROC.NATL. ACAD. SCI. USA, (1995), vol. 92, pages 3180 - 3184
    - ANALYTICAL BIOCHEMISTRY, (2002), vol. 308, pages 343 - 357
    - KE SHAN ET AL., "Avidin-Biotin-PEG-CPA Complexes as Potential EPR-Directed Therapeutic Protein Carriers: Preparation and Characterization", BIOCONJUGATE CHEMISTRY, (20070901), vol. 18, no. 5, pages 1644 - 1650
    - "Intermolecular interaction of avidin and PEGylated biotin", BIOCONJUGATE CHEMISTRY, (20071121), vol. 18, no. 6, pages 2109 - 2114
    - JAMES HIRSCH ET AL., ANALYTICAL BIOCHEMISTRY, (2002), vol. 308, pages 343 - 357
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