-
EP2833920
European procedure
- EP About this file
- EP Legal status
- EP Federated register
- EP Event history
- EP Citations
- EP Patent family
- EP All documents
Extract from the Register of European Patents
EP About this file: EP2833920
| EP2833920 - MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE [Right-click to bookmark this link] | Status | The application has been withdrawn Status updated on 30.11.2018 Database last updated on 02.09.2024 | |
| Former | Examination is in progress Status updated on 18.01.2017 | Most recent event Tooltip | 30.11.2018 | Change - divisional application(s) | published on 02.01.2019 [2019/01] | 30.11.2018 | Withdrawal of application | published on 02.01.2019 [2019/01] | Applicant(s) | For all designated states Moderna Therapeutics, Inc. 320 Bent Street Cambridge, Massachusetts 02141 / US | [2015/26] |
| Former [2015/07] | For all designated states Moderna Therapeutics, Inc. 200 Technology Square Cambridge, MA 02139 / US | Inventor(s) | 01 /
BANCEL, Stephane c/o Moderna Therapeutics, Inc. 320 Bent Street Cambridge, Massachusetts 02141 / US | 02 /
CHAKRABORTY, Tirtha 153 Woburn Street Medford, Massachusetts 02155 / US | 03 /
DE FOUGEROLLES, Antonin Avenue Neptune 15 1410 Waterloo / BE | 04 /
ELBASHIR, Sayda M. 149 Grove Street Cambridge, Massachusetts 02138 / US | 05 /
JOHN, Matthias 338 Harvard Street 5 Cambridge, Massachusetts 02138 / US | 06 /
ROY, Atanu 115 Hill Street 9 Stoneham, Massachusetts 02180 / US | 07 /
WHORISKEY, Susan 47 Louise Road Belmont, Massachusetts 02478 / US | 08 /
WOOD, Kristy M. 501 Huron Avenue Unit 2 Cambridge, Massachusetts 02138 / US | 09 /
HATALA, Paul 26 Monument Street 1 Charlestown, Massachusetts 02124 / US | 10 /
SCHRUM, Jason P. 4601 Flat Rock Road Apt. 417 Philadelphia, Pennsylvania 19127 / US | 11 /
EJEBE, Kenechi 3 East 101 Street, Apt. 6l New York, New York 10029 / US | 12 /
ELLSWORTH, Jeff Lynn 23 Meriam Street Lexington, Massachusetts 02420 / US | 13 /
GUILD, Justin 495 Edgell Road Framingham, Massachusetts 01701 / US | [2015/40] |
| Former [2015/31] | 01 /
BANCEL, Stephane 320 Bent Street Cambridge, Massachusetts 02141 / US | ||
| 02 /
CHAKRABORTY, Tirtha 153 Woburn Street Medford, Massachusetts 02155 / US | |||
| 03 /
DE FOUGEROLLES, Antonin Avenue Neptune 15 1410 Waterloo / BE | |||
| 04 /
ELBASHIR, Sayda M. 149 Grove Street Cambridge, Massachusetts 02138 / US | |||
| 05 /
JOHN, Matthias 338 Harvard Street 5 Cambridge, Massachusetts 02138 / US | |||
| 06 /
ROY, Atanu 115 Hill Street 9 Stoneham, Massachusetts 02180 / US | |||
| 07 /
WHORISKEY, Susan 47 Louise Road Belmont, Massachusetts 02478 / US | |||
| 08 /
WOOD, Kristy M. 501 Huron Avenue Unit 2 Cambridge, Massachusetts 02138 / US | |||
| 09 /
HATALA, Paul 26 Monument Street 1 Charlestown, Massachusetts 02124 / US | |||
| 10 /
SCHRUM, Jason P. 4601 Flat Rock Road Apt. 417 Philadelphia, Pennsylvania 19127 / US | |||
| 11 /
EJEBE, Kenechi 3 East 101 Street, Apt. 6l New York, New York 10029 / US | |||
| 12 /
ELLSWORTH, Jeff Lynn 23 Meriam Street Lexington, Massachusetts 02420 / US | |||
| 13 /
GUILD, Justin 495 Edgell Road Framingham, Massachusetts 01701 / US | |||
| Former [2015/07] | 01 /
BANCEL, Stephane 200 Technology Square Cambridge, Massachusetts 02139 / US | ||
| 02 /
CHAKRABORTY, Tirtha 153 Woburn Street Medford, Massachusetts 02155 / US | |||
| 03 /
DE FOUGEROLLES, Antonin Avenue Neptune 15 1410 Waterloo / BE | |||
| 04 /
ELBASHIR, Sayda M. 149 Grove Street Cambridge, Massachusetts 02138 / US | |||
| 05 /
JOHN, Matthias 338 Harvard Street 5 Cambridge, Massachusetts 02138 / US | |||
| 06 /
ROY, Atanu 115 Hill Street 9 Stoneham, Massachusetts 02180 / US | |||
| 07 /
WHORISKEY, Susan 47 Louise Road Belmont, Massachusetts 02478 / US | |||
| 08 /
WOOD, Kristy M. 501 Huron Avenue Unit 2 Cambridge, Massachusetts 02138 / US | |||
| 09 /
HATALA, Paul 26 Monument Street 1 Charlestown, Massachusetts 02124 / US | |||
| 10 /
SCHRUM, Jason P. 4601 Flat Rock Road Apt. 417 Philadelphia, Pennsylvania 19127 / US | |||
| 11 /
EJEBE, Kenechi 3 East 101 Street, Apt. 6l New York, New York 10029 / US | |||
| 12 /
ELLSWORTH, Jeff Lynn 23 Meriam Street Lexington, Massachusetts 02420 / US | |||
| 13 /
GUILD, Justin 495 Edgell Road Framingham, Massachusetts 01701 / US | Representative(s) | Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | [2015/07] | Application number, filing date | 13712973.0 | 09.03.2013 | WO2013US30062 | Priority number, date | US201261618862P | 02.04.2012 Original published format: US 201261618862 P | US201261618866P | 02.04.2012 Original published format: US 201261618866 P | US201261618868P | 02.04.2012 Original published format: US 201261618868 P | US201261618870P | 02.04.2012 Original published format: US 201261618870 P | US201261618873P | 02.04.2012 Original published format: US 201261618873 P | US201261618878P | 02.04.2012 Original published format: US 201261618878 P | US201261618885P | 02.04.2012 Original published format: US 201261618885 P | US201261618896P | 02.04.2012 Original published format: US 201261618896 P | US201261618911P | 02.04.2012 Original published format: US 201261618911 P | US201261618922P | 02.04.2012 Original published format: US 201261618922 P | US201261618953P | 02.04.2012 Original published format: US 201261618953 P | US201261618961P | 02.04.2012 Original published format: US 201261618961 P | US201261618957P | 02.04.2012 Original published format: US 201261618957 P | US201261618945P | 02.04.2012 Original published format: US 201261618945 P | US201261648286P | 17.05.2012 Original published format: US 201261648286 P | US201261648244P | 17.05.2012 Original published format: US 201261648244 P | US201261668157P | 05.07.2012 Original published format: US 201261668157 P | US201261681648P | 10.08.2012 Original published format: US 201261681648 P | US201261681675P | 10.08.2012 Original published format: US 201261681675 P | US201261681654P | 10.08.2012 Original published format: US 201261681654 P | US201261681687P | 10.08.2012 Original published format: US 201261681687 P | US201261681696P | 10.08.2012 Original published format: US 201261681696 P | US201261681647P | 10.08.2012 Original published format: US 201261681647 P | US201261681704P | 10.08.2012 Original published format: US 201261681704 P | US201261681720P | 10.08.2012 Original published format: US 201261681720 P | US201261681742P | 10.08.2012 Original published format: US 201261681742 P | US201261681658P | 10.08.2012 Original published format: US 201261681658 P | US201261681649P | 10.08.2012 Original published format: US 201261681649 P | US201261681645P | 10.08.2012 Original published format: US 201261681645 P | US201261681661P | 10.08.2012 Original published format: US 201261681661 P | US201261681712P | 10.08.2012 Original published format: US 201261681712 P | US201261681650P | 10.08.2012 Original published format: US 201261681650 P | US201261681667P | 10.08.2012 Original published format: US 201261681667 P | US201261696381P | 04.09.2012 Original published format: US 201261696381 P | US201261709303P | 03.10.2012 Original published format: US 201261709303 P | US201261712490P | 11.10.2012 Original published format: US 201261712490 P | US201261737203P | 14.12.2012 Original published format: US 201261737203 P | US201261737168P | 14.12.2012 Original published format: US 201261737168 P | US201261737213P | 14.12.2012 Original published format: US 201261737213 P | US201261737155P | 14.12.2012 Original published format: US 201261737155 P | US201261737134P | 14.12.2012 Original published format: US 201261737134 P | US201261737139P | 14.12.2012 Original published format: US 201261737139 P | US201261737152P | 14.12.2012 Original published format: US 201261737152 P | US201261737184P | 14.12.2012 Original published format: US 201261737184 P | US201261737160P | 14.12.2012 Original published format: US 201261737160 P | US201261737191P | 14.12.2012 Original published format: US 201261737191 P | US201261737174P | 14.12.2012 Original published format: US 201261737174 P | US201261737135P | 14.12.2012 Original published format: US 201261737135 P | US201261737130P | 14.12.2012 Original published format: US 201261737130 P | US201261737147P | 14.12.2012 Original published format: US 201261737147 P | US201261618935P | 02.04.2012 Original published format: US 201261618935 P | [2015/07] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2013151666 | Date: | 10.10.2013 | Language: | EN | [2013/41] | Type: | A2 Application without search report | No.: | EP2833920 | Date: | 11.02.2015 | Language: | EN | The application published by WIPO in one of the EPO official languages on 10.10.2013 takes the place of the publication of the European patent application. | [2015/07] | Search report(s) | International search report - published on: | EP | 09.01.2014 | Classification | IPC: | A61K48/00, C07K14/47, C12N15/85 | [2015/07] | CPC: |
C12N15/85 (EP,US);
A61K48/0066 (US);
A61K31/7115 (US);
A61K38/17 (EP,US);
A61K38/177 (US);
A61K38/1816 (EP,US);
A61K38/1891 (EP,US);
A61K38/191 (EP,US);
A61K38/193 (EP,US);
A61K38/212 (EP,US);
A61K38/45 (EP,US);
A61K38/4846 (EP,US);
A61K47/543 (US);
A61K48/0033 (US);
A61K48/0041 (EP);
A61K48/005 (EP,US);
A61K48/0075 (US);
A61K9/0019 (EP);
A61K9/1271 (US);
A61K9/145 (US);
A61K9/5123 (EP,US);
A61K9/5146 (US);
A61K9/5153 (US);
A61P1/00 (EP);
A61P1/04 (EP);
A61P11/00 (EP);
A61P13/00 (EP);
A61P13/12 (EP);
A61P15/00 (EP);
A61P17/00 (EP);
A61P17/02 (EP);
A61P17/04 (EP);
A61P17/06 (EP);
A61P17/08 (EP);
A61P17/14 (EP);
A61P19/00 (EP);
A61P19/02 (EP);
A61P19/10 (EP);
A61P21/00 (EP);
A61P21/04 (EP);
A61P25/00 (EP);
A61P25/02 (EP);
A61P25/14 (EP);
A61P25/18 (EP);
A61P25/24 (EP);
A61P25/28 (EP);
A61P25/30 (EP);
A61P27/02 (EP);
A61P29/00 (EP);
A61P3/00 (EP);
A61P3/06 (EP);
A61P3/10 (EP);
A61P31/00 (EP);
A61P31/04 (EP);
A61P31/10 (EP);
A61P31/12 (EP);
A61P31/14 (EP);
A61P31/18 (EP);
A61P35/00 (EP);
A61P35/02 (EP);
A61P35/04 (EP);
A61P37/00 (EP);
A61P37/02 (EP);
A61P37/06 (EP);
A61P37/08 (EP);
A61P43/00 (EP);
A61P5/00 (EP);
A61P7/00 (EP);
A61P7/02 (EP);
A61P7/04 (EP);
A61P7/06 (EP);
A61P9/00 (EP);
A61P9/10 (EP);
C07H21/02 (EP,US);
C07K14/005 (US);
C07K14/435 (US);
C07K14/43595 (US);
C07K14/47 (US);
C07K14/4705 (US);
C07K14/4713 (US);
C07K14/4723 (US);
C07K14/4746 (US);
C07K14/475 (US);
C07K14/485 (US);
C07K14/495 (US);
C07K14/505 (US);
C07K14/515 (US);
C07K14/525 (US);
C07K14/535 (US);
C07K14/5418 (US);
C07K14/56 (US);
C07K14/61 (US);
C07K14/62 (US);
C07K14/705 (US);
C07K14/745 (US);
C07K16/00 (US);
C07K16/2863 (US);
C07K16/2887 (US);
C07K16/40 (US);
C12N15/11 (US);
C12N15/52 (US);
C12N15/87 (EP,US);
C12N15/88 (EP);
C12N9/0069 (EP,US);
C12N9/0091 (EP,US);
C12N9/1051 (US);
C12N9/1241 (EP,US);
C12N9/16 (US);
C12N9/2402 (US);
C12N9/2445 (US);
C12N9/6435 (EP,US);
C12N9/6437 (EP,US);
C12N9/644 (EP,US);
C12N9/6443 (EP,US);
C12N9/6451 (US);
C12N9/88 (US);
C12N9/93 (EP,US);
C12P13/04 (US);
C12P21/00 (US);
C12P21/005 (US);
C12Y603/02019 (EP,US);
A61K38/00 (US);
C12Y113/12007 (EP,US);
C12Y116/03001 (EP,US);
C12Y207/07012 (EP,US);
C12Y304/21007 (EP,US);
C12Y304/21022 (EP,US);
C12Y304/21027 (EP,US);
C12Y403/02001 (EP,US);
Y02A50/30 (EP,US)
(-)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/07] | Title | German: | MODIFIZIERTE POLYNUKLEOTIDE ZUR HERSTELLUNG VON BIOLOGISCHEN STOFFEN UND PROTEINEN IN ZUSAMMENHANG MIT ERKRANKUNGEN BEIM MENSCHEN | [2015/07] | English: | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF BIOLOGICS AND PROTEINS ASSOCIATED WITH HUMAN DISEASE | [2015/07] | French: | POLYNUCLÉOTIDES MODIFIÉS DESTINÉS À LA PRODUCTION DE PRODUITS BIOLOGIQUES ET DE PROTÉINES ASSOCIÉES À UNE MALADIE HUMAINE | [2015/07] | Entry into regional phase | 30.10.2014 | National basic fee paid | 30.10.2014 | Designation fee(s) paid | 30.10.2014 | Examination fee paid | Examination procedure | 30.10.2014 | Examination requested [2015/07] | 07.08.2015 | Amendment by applicant (claims and/or description) | 06.09.2016 | Despatch of a communication from the examining division (Time limit: M06) | 12.04.2017 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 20.06.2017 | Reply to a communication from the examining division | 26.11.2018 | Application withdrawn by applicant [2019/01] | 27.11.2018 | Date of oral proceedings | Divisional application(s) | EP18208097.8 | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 06.09.2016 | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 20.06.2017 | Request for further processing filed | 20.06.2017 | Full payment received (date of receipt of payment) Request granted | 30.06.2017 | Decision despatched | Fees paid | Renewal fee | 27.03.2015 | Renewal fee patent year 03 | 31.03.2016 | Renewal fee patent year 04 | 27.03.2017 | Renewal fee patent year 05 | 27.03.2018 | Renewal fee patent year 06 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [XYI]US2007143878 (BHAT BARKUR G [US], et al) [X] 1,42 * paragraph [0107] * [Y] 38-77 [I] 1-77; | [Y]WO2012019168 (MODERNA THERAPEUTICS INC [US], et al) [Y] 38-77 * abstract *; | [E]WO2013039857 (MODERNA THERAPEUTICS [US], et al) [E] 1-77* the whole document *; | [XYI] - RUETSCHI U ET AL, "Human 4-Hydroxyphenylpyruvate Dioxygenase Gene (HPD)", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, (19970915), vol. 44, no. 3, doi:10.1006/GENO.1997.4887, ISSN 0888-7543, pages 292 - 299, XP004459167 [X] 1,42 * page 293, column 1, line 12 - line 18 * * page 293, column 1, line 27 - line 32 * * page 295, column 2, line 1 - line 10 * [Y] 38-77 [I] 1-77 DOI: http://dx.doi.org/10.1006/geno.1997.4887 | [XYI] - NEVE SOREN ET AL, "Tissue distribution, intracellular localization and proteolytic processing of rat 4-hydroxyphenylpyruvate dioxygenase.", CELL BIOLOGY INTERNATIONAL, (2003), vol. 27, no. 8, ISSN 1065-6995, pages 611 - 624, XP002699194 [X] 1,42 * page 619, column 1, line 13 - page 620, column 1, line 36 * [Y] 38-77 [I] 1-77 DOI: http://dx.doi.org/10.1016/S1065-6995(03)00117-3 | [XYI] - ENDO F ET AL, "A nonsense mutation in the 4-hydroxyphenylpyruvic acid dioxygenase gene (Hpd) causes skipping of the constitutive exon and hypertyrosinemia in mouse strain III", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, (199501), vol. 25, no. 1, doi:10.1016/0888-7543(95)80122-3, ISSN 0888-7543, pages 164 - 169, XP004796536 [X] 1,42 * page 165, column 2, line 24 - line 34 * [Y] 38-77 [I] 1-77 DOI: http://dx.doi.org/10.1016/0888-7543(95)80122-3 | [XYI] - REN WEIWEI ET AL, "Molecular cloning and characterization of 4-hydroxyphenylpyruvate dioxygenase gene from Lactuca sativa.", JOURNAL OF PLANT PHYSIOLOGY 1 JUL 2011, (201107), vol. 168, no. 10, ISSN 1618-1328, pages 1076 - 1083, XP002699195 [X] 1,42 * "Plant materials..Etc" on page 1078 * [Y] 38-77 [I] 1-77 DOI: http://dx.doi.org/10.1016/j.jplph.2010.12.017 | [T] - Anonymous, "Messenger RNA", (20130619), Internet: Wikipedia, URL: http://en.wikipedia.org/wiki/Messenger_RNA, (20130619), XP002699196 | by applicant | US4587044 | US4605735 | US4667025 | US4762779 | US4789737 | US4824941 | US4828979 | US4835263 | US4876335 | US4904582 | US4948882 | US4958013 | US4966891 | US4981957 | US5034506 | US5082830 | US5109124 | US5112963 | US5118802 | US5118800 | US5138045 | US5214136 | US5218105 | US5221732 | US5245022 | US5254469 | US5258506 | US5262536 | US5272250 | US5292873 | US5317098 | US5319080 | US5359044 | US5371241 | US5391723 | US5393878 | US5414077 | US5416203 | US5446137 | US5447914 | US5451463 | US5466786 | US5486603 | US5489677 | US5510475 | US5512439 | US5512667 | US5514785 | US5519115 | US5519134 | US5525465 | US5539082 | US5541313 | US5545730 | US5552538 | US5565552 | US5567810 | US5567811 | US5574142 | US5576427 | US5578717 | US5578718 | US5580731 | US5585481 | US5585108 | US5587371 | US5591584 | US5591722 | US5595726 | US5597696 | US5597909 | US5599923 | US5599928 | US5602240 | US5607914 | US5608046 | US5610300 | US5627053 | US5639873 | US5646265 | US5658873 | US5670633 | US5688941 | US5700920 | US5714577 | US5714331 | US5719262 | US5734015 | US5798336 | US5821224 | US5849490 | US5856127 | WO9914346 | US5905187 | US5994308 | US5998374 | US6004573 | US6107460 | US6177274 | US6191254 | US6211148 | US6217912 | US6265389 | US6267987 | US6268490 | US6294664 | US6300489 | US6320017 | US6329504 | US6399370 | US6476189 | US6478825 | US6492328 | WO02098443 | US6514701 | US6517869 | US2003073619 | US6555525 | US6573361 | US6576755 | US6576752 | WO03051401 | US6586524 | US6605698 | US6624140 | US6638531 | US6642203 | US6653280 | US6652886 | US6670461 | WO2004010106 | US6696238 | US6696038 | EP1392341 | US6727066 | US6730659 | WO2004041203 | US6743598 | US6743769 | US6747007 | US2004142474 | WO2004065561 | WO2004067728 | US6783931 | US6790833 | US6794490 | US6794499 | EP1458410 | US6818407 | US6835536 | US6835713 | US6835393 | US6838435 | WO2005005622 | US2005032730 | US2005059624 | US2005059005 | US6872705 | US6875907 | US6884776 | US6887847 | US6900297 | US6906035 | US6911524 | US6936432 | US2005222064 | US2005261218 | WO2005118857 | US6998484 | US7001924 | WO2006022712 | EP1646714 | WO2006044456 | WO2006044682 | WO2006044503 | WO2006044505 | US7037646 | US7053207 | WO2006058088 | WO2006065480 | WO2006065479 | US7071293 | WO2006071903 | US7078380 | US7084125 | US7091185 | US7094759 | US2006247195 | WO2006122828 | US7166769 | WO2007024708 | WO2007024323 | WO2007036366 | US2007117112 | WO2007064952 | US2007141030 | US7244710 | US7314858 | WO2008052770 | US7374930 | US7374778 | US7385034 | WO2008078180 | US2008166414 | US7399845 | WO2008083949 | US7404969 | US7413875 | WO2008103276 | WO2008121949 | US2008267873 | WO2008140615 | US2009042829 | US2009042825 | WO2009077134 | US7582301 | US2009226470 | US2009227660 | EP2104739 | WO2009127230 | US2009286852 | US2010003337 | WO2010001381 | US2010004315 | US2010004313 | WO2010005740 | WO2010005721 | WO2010005723 | WO2010005726 | WO2010005725 | US2010009424 | US2010028943 | US2010036115 | US2010047261 | WO2010021865 | WO2010030763 | US2010068285 | US2010068286 | US2010069426 | US2010087337 | US2010104645 | US2010104655 | US2010120024 | US7737108 | WO2010075072 | WO2010080724 | US2010189729 | US2010196983 | US2010215580 | US2010216804 | WO2010098861 | US2010239608 | US2010255574 | US2010260817 | EP2240572 | WO2010123569 | WO2010129709 | US7833992 | US2010293625 | WO2010138193 | WO2010138192 | US2010303850 | US2010324120 | US2011020388 | WO2011013062 | WO2011012316 | US2011027217 | WO2011015312 | US7893302 | WO2011022460 | US2011065103 | US2011077287 | WO2011043913 | WO2011062965 | US2011143436 | US2011143397 | WO2011071931 | WO2011071936 | WO2011072218 | US7964578 | WO2011076807 | WO2011084518 | WO2011084521 | WO2011084513 | WO2011085231 | US2011171248 | WO2011090965 | US2011200582 | US8003129 | US2011217377 | US2011223201 | WO2011115862 | WO2011120053 | US2011244026 | WO2011127255 | US8039214 | US2011262491 | US2011269950 | US2011274759 | US8057821 | WO2011149733 | US2011294717 | WO2011150264 | US2011293723 | WO2011150249 | US2011293701 | WO2011150258 | WO2011150240 | US2011293700 | WO2011153120 | US2011311472 | US2012004293 | WO2012002629 | US2012009649 | WO2012006378 | WO2012006380 | US2012009145 | WO2012006376 | US8101385 | WO2012013326 | WO2012013501 | WO2012014939 | US2012024422 | US2012027806 | US2012028342 | WO2012016269 | US2012046346 | WO2012024621 | WO2012024632 | WO2012022512 | US8124379 | US2012053333 | WO2012031046 | WO2012031043 | WO2012030901 | US2012058153 | US2012058154 | US2012064110 | WO2012040184 | US2012076836 | WO2012044638 | WO2012054365 | WO2012054923 | WO2012061259 | US2012121718 | WO2012068187 | US2012140790 | WO2012082165 | WO2012082574 | US8206747 | US8211473 | US2012171229 | US8217147 | US2012177724 | US2012178702 | WO2012094304 | WO2012095255 | WO2012099755 | US2012189700 | WO2012099805 | US8236330 | US8236280 | US2012202871 | US2012201859 | US8241670 | US8241610 | US2012207845 | WO2012109121 | US8246968 | US8246995 | WO2012110636 | US8257745 | US8263665 | US2012228565 | US2012237565 | WO2012125987 | US8273363 | US2012244222 | WO2012129648 | WO2012131104 | WO2012131106 | US8283333 | US2012258176 | US8287910 | US8287849 | US2012265001 | US8293276 | US2012269761 | US2012270927 | WO2012149252 | WO2012149255 | WO2012149259 | WO2012149265 | WO2012149268 | WO2012149282 | WO2012149301 | WO2012149405 | WO2012149411 | WO2012149454 | WO2012148684 | US2012282343 | WO2012150467 | US2012283427 | US2012283503 | WO2012151438 | US2012288541 | US8313777 | US8318208 | US8318211 | US2012302940 | WO2012166923 | WO2012170930 | WO2012170889 | US2012321719 | WO2013006825 | WO2013009736 | WO2013012476 | WO2013019669 | - SCIENCE, (1992), vol. 255, pages 996 - 998 | - T. E. CREIGHTON, Proteins: Structure and Molecular Properties, W.H. FREEMAN & CO., (1983), pages 79 - 86 | - J. MOL BIOL, (1997), vol. 266, no. 4, pages 814 - 830 | - CARILLO ET AL., SIAM J. APPLIED MATH., (1988), vol. 48, page 1073 | - STEPHEN F. ALTSCHUL; THOMAS L. MADDEN; ALEJANDRO A. SCHDFFER; JINGHUI ZHANG; ZHENG ZHANG; WEBB MILLER; DAVID J. LIPMAN, "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", NUCLEIC ACIDS RES., (1997), vol. 25, doi:doi:10.1093/nar/25.17.3389, pages 3389 - 3402, XP002905950 DOI: http://dx.doi.org/10.1093/nar/25.17.3389 | - WANG ET AL., NUCLEIC ACIDS RES., (2009), vol. 37, pages D933 - 7 | - ZAIOU, J MOL MED, (2007), vol. 85, page 317 | - FADL ET AL., PHARMAZIE, (1995), vol. 50, pages 382 - 7 | - NOMURA ET AL., BIOORG MED. CHEM., (2003), vol. 11, pages 2453 - 61 | - GRIMSON A; FARH KK; JOHNSTON WK; GARRETT-ENGELE P; LIM LP; BARTEL DP, MOL CELL, (20070706), vol. 27, no. L, pages 91 - 105 | - BONAUER ET AL., CURR DRUG TARGETS, (2010), vol. 11, pages 943 - 949 | - ANAND; CHERESH, CURR OPIN HEMATOL, (2011), vol. 18, pages 171 - 176 | - CONTRERAS; RAO, LEUKEMIA, (20111220), vol. 26, pages 404 - 413 | - BARTEL, CELL, (2009), vol. 136, pages 215 - 233 | - LANDGRAF ET AL., CELL, (2007), vol. 129, pages 1401 - 1414 | - GETNER; NALDINI, TISSUE ANTIGENS, (2012), vol. 80, pages 393 - 403 | - SCHMITT ET AL., GASTROENTEROLOGY, (2010), vol. 139, pages 999 - 1007 | - GONZALEZ-ASEQUINOLAZA ET AL., GASTROENTEROLOGY, (2010), vol. 139, pages 726 - 729 | - HERDEWIJN, P., Oligonucleotide synthesis: methods and applications, Methods in Molecular Biology, HUMANA PRESS, (2005), vol. 288 | - ESVELT ET AL., NATURE, (2011), vol. 472, no. 7344, pages 499 - 503 | - BRIEBA ET AL., BIOCHEMISTRY, (2002), vol. 41, pages 5144 - 5149 | - OGATA ET AL., J. ORG. CHEM., (2009), vol. 74, pages 2585 - 2588 | - PURMAL ET AL., NUCL. ACIDS RES., (1994), vol. 22, no. 1, pages 72 - 78 | - FUKUHARA ET AL., BIOCHEMISTRY, (1962), vol. 1, no. 4, pages 563 - 568 | - XU ET AL., TETRAHEDRON, (1992), vol. 48, no. 9, pages 1729 - 1740 | - MAHON ET AL., BIOCONJUG CHEM., (2010), vol. 21, pages 1448 - 1454 | - SCHROEDER ET AL., J INTERN MED., (2010), vol. 267, pages 9 - 21 | - AKINC ET AL., NAT BIOTECHNOL., (2008), vol. 26, pages 561 - 569 | - LOVE ET AL., PROC NATL ACAD SCI U S A., (2010), vol. 107, pages 1864 - 1869 | - SIEGWART ET AL., PROC NATL ACAD SCI U S A., (2011), vol. 108, pages 12996 - 3001 | - FRANK-KAMENETSKY ET AL., PROC NATL ACAD SCI U S A., (2008), vol. 105, pages 11915 - 11920 | - AKINC ET AL., MOL THER., (2009), vol. 17, pages 872 - 879 | - LOVE ET AL., PROC NATI ACAD SCI U S A., (2010), vol. 107, pages 1864 - 1869 | - LEUSCHNER ET AL., NAT BIOTECHNOL., (2011), vol. 29, pages 1005 - 1010 | - MURUGAIAH ET AL., ANALYTICAL BIOCHEMISTRY, (2010), vol. 401, page 61 | - LIU; HUANG, MOLECULAR THERAPY., (2010), pages 669 - 670 | - CHO ET AL., "Adv. Funct. Mater. z", 8TH INTERNATIONAL JUDAH FOLKMAN CONFERENCE, (20101008), vol. 19, pages 3112 - 3118 | - LEUSCHNER ET AL., NAT BIOTECHNOL, (2011), vol. 29, pages 1005 - 1010 | - WHITEHEAD ET AL., MOL. THER., (2011), vol. 19, pages 1688 - 1694 | - WHEELER ET AL., GENE THERAPY., (1999), vol. 6, pages 271 - 281 | - ZHANG ET AL., GENE THERAPY., (1999), vol. 6, pages 1438 - 1447 | - JEFFS ET AL., PHARM RES., (2005), vol. 22, pages 362 - 372 | - MORRISSEY ET AL., NAT BIOTECHNOT, (2005), vol. 2, pages 1002 - 1007 | - ZIMMERMANN ET AL., NATURE, (2006), vol. 441, pages 111 - 114 | - HEYES ET AL., J CONTR REL., (2005), vol. 107, pages 276 - 287 | - SEMPLE ET AL., NATURE BIOTECH., (2010), vol. 28, pages 172 - 176 | - JUDGE ET AL., J CLIN INVEST., (2009), vol. 119, pages 661 - 673 | - DEFOUGEROLLES, HUM GENE THER., (2008), vol. 19, pages 125 - 132 | - BASHA ET AL., MOL THER., (2011), vol. 19, pages 2186 - 2200 | - LANDEN ET AL., CANCER BIOLOGY & THERAPY, (2006), vol. 5, no. 12, pages 1708 - 1713 | - LAI ET AL., PNAS, (2007), vol. 104, no. 5, pages 1482 - 487 | - LAI ET AL., ADV DRUG DELIV REV., (2009), vol. 61, no. 2, pages 158 - 171 | - YANG ET AL., ANGEW. CHEM. INT. ED., (2011), vol. 50, pages 2597 - 2600 | - ALEKU ET AL., CANCER RES., (2008), vol. 68, pages 9788 - 9798 | - STRUMBERG ET AL., INT J CLIN PHARMACOL THER, (2012), vol. 50, pages 76 - 78 | - SANTEL ET AL., GENE THER, (2006), vol. 13, pages 1222 - 1234 | - SANTEL ET AL., GENE THER, (2006), vol. 13, pages 1360 - 1370 | - GUTBIER ET AL., PULM PHARMACOL. THER., (2010), vol. 23, pages 334 - 344 | - KAUFMANN ET AL., MICROVASC RES, (2010), vol. 80, pages 286 - 293 | - WEIDE ET AL., J IMMUNOTHER., (2009), vol. 32, pages 498 - 507 | - WEIDE ET AL., J IMMUNOTHER., (2008), vol. 31, pages 180 - 188 | - PASCOLO, EXPERT OPIN. BIOL. THER., vol. 4, pages 1285 - 1294 | - FOTIN-MLECZEK ET AL., J. IMMUNOTHER., (2011), vol. 34, pages 1 - 15 | - SONG ET AL., NATURE BIOTECHNOL., (2005), vol. 23, pages 709 - 717 | - PEER ET AL., PROC NATL ACAD SCI U S A., (2007), vol. 6, no. 104, pages 4095 - 4100 | - AKINC ET AL., MOL THER., (2010), vol. 18, pages 1357 - 1364 | - SONG ET AL., NAT BIOTECHNOL., (2005), vol. 23, pages 709 - 717 | - BASHA ET AL., MOL. THER., (2011), vol. 19, pages 2186 - 2200 | - FENSKE; CULLIS, EXPERT OPIN DRUG DELIV., (2008), vol. 5, pages 25 - 44 | - PEER ET AL., SCIENCE, (2008), vol. 319, pages 627 - 630 | - PEER; LIEBERMAN, GENE THER., (2011), vol. 18, pages 1127 - 1133 | - KOLHATKAR ET AL., CURR DRUG DISCOV TECHNOL., (2011), vol. 8, pages 197 - 206 | - MUSACCHIO; TORCHILIN, FRONT BIOSCI., (2011), vol. 16, pages 1388 - 1412 | - YU ET AL., MOL MEMBR BIOL., (2010), vol. 27, pages 286 - 298 | - PATIL ET AL., CRIT REV THER DRUG CARRIER SYST., (2008), vol. 25, pages 1 - 61 | - BENOIT ET AL., BIOMACROMOLECULES, (2011), vol. 12, pages 2708 - 2714 | - ZHAO ET AL., EXPERT OPIN DRUG DELIV., (2008), vol. 5, pages 309 - 319 | - SRINIVASAN ET AL., METHODS MOL BIOL., (2012), vol. 820, pages 105 - 116 | - BEN-ARIE ET AL., METHODS MOL BIOL., (2012), vol. 757, pages 497 - 507 | - PEER, J CONTROL RELEASE, (2010), vol. 20, pages 63 - 68 | - PEER ET AL., PROC NATL ACAD SCI U S A., (2007), vol. 104, pages 4095 - 4100 | - KIM ET AL., METHODS MOL BIOL., (2011), vol. 721, pages 339 - 353 | - SUBRAMANYA ET AL., MOL THER., (2010), vol. 18, pages 2028 - 2037 | - ZHANG ET AL., ACS NANO, (2008), vol. 2, no. 8, pages 1696 - 1702 | - HEYES ET AL., MOL THER., (2007), vol. 15, pages 713 - 720 | - KIRPOTIN ET AL., CANCER RES., (2006), vol. 66, pages 6732 - 6740 | - HUM GENE THER., (2008), vol. 19, pages 125 - 132 | - ROZEMA ET AL., PROC NATL ACAD SCI U S A., (2007), vol. 104, pages 12982 - 12887 | - HU-LIESKOVAN ET AL., CANCER RES., (2005), vol. 65, pages 8984 - 8982 | - HEIDEL ET AL., PROC NATL ACAD SCI USA, (2007), vol. 104, pages 5715 - 21 | - SULLIVAN ET AL., EXPERT OPIN DRUG DELIV., (2010), vol. 7, pages 1433 - 1446 | - MANGANIELLO ET AL., BIOMATERIALS, (2012), vol. 33, pages 2301 - 2309 | - SINGHA ET AL., NUCLEIC ACID THER., (2011), vol. 2, pages 133 - 147 | - SCHAFFERT; WAGNER, GENE THER., (2008), vol. 16, pages 1131 - 1138 | - CHATURVEDI ET AL., EXPERT OPIN DRUG DELIV., (2011), vol. 8, pages 1455 - 1468 | - DAVIS, MOL PHARM., (2009), vol. 6, pages 659 - 668 | - DAVIS, NATURE, (2010), vol. 464, pages 1067 - 1070 | - GILJOHANN ET AL., JOURN. AMER. CHEM. SOC., (2009), vol. 131, no. 6, pages 2072 - 2073 | - WANG ET AL., NAT MATER., (2006), vol. 5, pages 791 - 796 | - FULLER ET AL., BIOMATERIALS, (2008), vol. 29, pages 1526 - 1532 | - DEKOKER ET AL., ADV DRUG DELIV REV., (2011), vol. 63, pages 748 - 761 | - ENDRES ET AL., BIOMATERIALS, (2011), vol. 32, pages 7721 - 7731 | - SU ET AL., MOL PHARM., (20110606), vol. 8, no. 3, pages 774 - 87 | - LI ET AL., J CONTR REL., (2010), vol. 142, pages 416 - 421 | - LI ET AL., J CONTR REL., (2012), vol. 158, pages 108 - 114 | - YANG ET AL., MOL THER., (2012), vol. 20, pages 609 - 615 | - KAZIKAWA ET AL., J CONTR REL., (2004), vol. 97, pages 345 - 356 | - KAZIKAWA ET AL., J CONTR REL., (2006), vol. 111, pages 368 - 370 | - PITELLA ET AL., BIOMATERIALS, (2011), vol. 32, pages 3106 - 3114 | - SIEGWART ET AL., PROC NATL ACAD SCI U S A., (2011), vol. 108, pages 12996 - 13001 | - SHI ET AL., ANGEW CHEM INT ED., (2011), vol. 50, pages 7027 - 7031 | - CARON ET AL., MOL. THER., (2001), vol. 3, no. 3, pages 310 - 8 | - EL-ANDALOUSSI ET AL., CURR. PHARM. DES., (2003), vol. 11, no. 28, pages 3597 - 611 | - DESHAYES ET AL., CELL. MOL. LIFE SCI., (2005), vol. 62, no. 16, pages 1839 - 49 | - CRONICAN ET AL., ACS CHEM. BIOL., (2010), vol. 5, pages 747 - 752 | - MCNAUGHTON ET AL., PROC. NATL. ACAD. SCI. USA, (2009), vol. 106, pages 6111 - 6116 | - SAWYER, CHEM BIOL DRUG DES., (2009), vol. 73, pages 3 - 6 | - VERDINE; HILINSKI, METHODS ENZYMOL., (2012), vol. 503, pages 3 - 33 | - GODFRIN ET AL., EXPERT OPIN BIOL THER., (2012), vol. 12, pages 127 - 133 | - FANG ET AL., EXPERT OPIN BIOL THER., (2012), vol. 12, pages 385 - 389 | - HU ET AL., PROC NATL ACAD SCI U S A., (2011), vol. 108, pages 10980 - 10985 | - LUND ET AL., PHARM RES., (2010), vol. 27, pages 400 - 420 | - HUCKRIEDE ET AL., J LIPOSOME RES., (2007), vol. 17, pages 39 - 47 | - CUSI, HUM VACCIN., (2006), vol. 2, pages 1 - 7 | - DE JONGE ET AL., GENE THER., (2006), vol. 13, pages 400 - 411 | - YOON; PARK, EXPERT OPIN DRUG DELIV., (2010), vol. 7, pages 321 - 330 | - POSTEMA; GILJA, CURR PHARM BIOTECHNOL., (2007), vol. 8, pages 355 - 361 | - NEWMAN; BETTINGER, GENE THER., (2007), vol. 14, pages 465 - 475 | - ANDRE ET AL., CURR GENE THER., (2010), vol. 10, pages 267 - 280 | - CHIARELLA ET AL., CURR GENE THER., (2010), vol. 10, pages 281 - 286 | - HOJMAN, CURR GENE THER., (2010), vol. 10, pages 128 - 138 | - FROST, EXPERT OPIN. DRUG DELIV., (2007), vol. 4, pages 427 - 440 | - NIELSEN ET AL., SCIENCE, (1991), vol. 254, pages 1497 - 1500 | - MARTIN ET AL., HELV. CHIM. ACTA, (1995), vol. 78, pages 486 - 504 | - LEE ET AL., NATURE NANOTECHNOLOGY, (2012), vol. 7, pages 389 - 393 | - GRABOW; JAEGAR, NATURE MATERIALS, (2012), vol. 11, pages 269 - 269 | - BATTIG ET AL., J. AM. CHEM. SOCIETY, (2012), vol. 134, pages 12410 - 12413 | - SMITH ET AL., CANCER CHEMOTHERAPTY AND PHARMACOLOGY, (1999), vol. 44, no. 4, pages 267 - 274 | - SPICER; MIKOS, JOURNAL OF CONTROLLED RELEASE, (2010), vol. 148, pages 49 - 55 | - KIDD ET AL., JOURNAL OF CONTROLLED RELEASE, (2012), vol. 157, pages 80 - 85 | - CATELAS ET AL., TISSUE ENGINEERING, (2008), vol. 14, pages 119 - 128 | WO2011US46861 | WO2011US54636 | WO2011US54617 |