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Extract from the Register of European Patents

EP About this file: EP2874664

EP2874664 - COMPOSITION FOR THERAPEUTIC USE, INCLUDING AN ORGANIC LIPID PHASE AND A RARE-EARTH RADIOISOTOPE COMPLEX [Right-click to bookmark this link]
Former [2015/22]COMPOSITION FOR THERAPEUTIC USE, INCLUDING AN ORGANIC LIPID PHASE AND A RARE- EARTH RADIOISOTOPE COMPLEX
[2019/11]
StatusNo opposition filed within time limit
Status updated on  03.07.2020
Database last updated on 25.09.2024
FormerThe patent has been granted
Status updated on  17.05.2019
FormerGrant of patent is intended
Status updated on  26.02.2019
FormerExamination is in progress
Status updated on  22.06.2018
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Centre Eugene Marquis
Rue de Flandre
35000 Rennes / FR
For all designated states
Ecole Nationale Supérieure de Chimie
Beaulieu
263 avenue Général Leclerc
35700 Rennes / FR
For all designated states
Université de Rennes I
2 Rue du Thabor
35000 Rennes Cedex / FR
[N/P]
Former [2015/22]For all designated states
Centre Eugene Marquis
Rue de Flandre
35000 Rennes / FR
For all designated states
Ecole Nationale Superieure de Chimie
Beaulieu
263 avenue Général Leclerc
35700 Rennes / FR
For all designated states
Université de Rennes I
2 Rue du Thabor
35000 Rennes Cedex / FR
Inventor(s)01 / LEPAREUR, Nicolas
25 rue de la Touche
35770 Vern-sur-Seiche / FR
02 / GARIN, Etienne
Le Fumeson
35520 La Meziere / FR
03 / NOIRET, Nicolas
23 rue Raoul de la Futaye
35250 Saint-Sulpice-la-Foret / FR
04 / ARDISSON, Valérie
1 allée Louis Jobbe Duval
35000 Rennes / FR
 [2019/25]
Former [2015/22]01 / LEPAREUR, Nicolas
25 rue de la Touche
F-35770 Vern-sur-Seiche / FR
02 / GARIN, Etienne
Le Fumeson
F-35520 La Meziere / FR
03 / NOIRET, Nicolas
23 rue Raoul de la Futaye
F-35250 Saint-Sulpice-la-Foret / FR
04 / ARDISSON, Valérie
1 allée Louis Jobbe Duval
F-35000 Rennes / FR
Representative(s)Vidon Brevets & Stratégie
16B, rue de Jouanet
BP 90333
35703 Rennes Cedex 7 / FR
[2019/25]
Former [2015/22]Vidon Brevets & Stratégie
16B, rue de Jouanet
BP 90333
35703 Rennes Cedex 7 / FR
Application number, filing date13739670.117.07.2013
[2019/25]
WO2013EP65131
Priority number, dateFR2012005695118.07.2012         Original published format: FR 1256951
[2015/22]
Filing languageFR
Procedural languageFR
PublicationType: A1 Application with search report
No.:WO2014012997
Date:23.01.2014
Language:FR
[2014/04]
Type: A1 Application with search report 
No.:EP2874664
Date:27.05.2015
Language:FR
The application published by WIPO in one of the EPO official languages on 23.01.2014 takes the place of the publication of the European patent application.
[2015/22]
Type: B1 Patent specification 
No.:EP2874664
Date:19.06.2019
Language:FR
[2019/25]
Search report(s)International search report - published on:EP23.01.2014
ClassificationIPC:A61K51/04, A61K51/12, A61P35/00, A61K103/30, A61K103/32
[2015/22]
CPC:
A61K51/0404 (EP,US); A61K51/0497 (US); A61K51/0478 (EP,US);
A61K51/1217 (EP,US); A61P35/00 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/22]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:ZUSAMMENSETZUNG ZUR THERAPEUTISCHEN VERWENDUNG, MIT EINER ORGANISCHEN LIPIDPHASE UND EINEM KOMPLEX VON EINEM RADIOISOTOP DER SELTENEN ERDEN[2019/11]
English:COMPOSITION FOR THERAPEUTIC USE, INCLUDING AN ORGANIC LIPID PHASE AND A RARE-EARTH RADIOISOTOPE COMPLEX[2019/11]
French:COMPOSITION À USAGE THÉRAPEUTIQUE COMPRENANT UNE PHASE ORGANIQUE LIPIDIQUE ET UN COMPLEXE DE TERRE RARE RADIOISOTOPIQUE[2015/22]
Former [2015/22]ZUSAMMENSETZUNG ZUR THERAPEUTISCHEN VERWENDUNG, MIT EINER ORGANISCHEN LIPIDPHASE UND EINEM SELTENERDRADIOISOTOPKOMPLEX
Former [2015/22]COMPOSITION FOR THERAPEUTIC USE, INCLUDING AN ORGANIC LIPID PHASE AND A RARE- EARTH RADIOISOTOPE COMPLEX
Entry into regional phase07.01.2015National basic fee paid 
07.01.2015Designation fee(s) paid 
07.01.2015Examination fee paid 
Examination procedure07.01.2015Examination requested  [2015/22]
22.05.2015Amendment by applicant (claims and/or description)
25.06.2018Despatch of a communication from the examining division (Time limit: M06)
08.11.2018Reply to a communication from the examining division
27.02.2019Communication of intention to grant the patent
09.05.2019Fee for grant paid
09.05.2019Fee for publishing/printing paid
09.05.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  25.06.2018
Opposition(s)03.06.2020No opposition filed within time limit [2020/32]
Fees paidRenewal fee
22.07.2015Renewal fee patent year 03
27.07.2016Renewal fee patent year 04
27.07.2017Renewal fee patent year 05
27.07.2018Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU17.07.2013
AL19.06.2019
AT19.06.2019
CY19.06.2019
CZ19.06.2019
DK19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
MC19.06.2019
MK19.06.2019
MT19.06.2019
PL19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SI19.06.2019
SK19.06.2019
SM19.06.2019
TR19.06.2019
LU17.07.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
IS19.10.2019
PT21.10.2019
[2022/31]
Former [2021/34]HU17.07.2013
AL19.06.2019
AT19.06.2019
CY19.06.2019
CZ19.06.2019
DK19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
MC19.06.2019
MT19.06.2019
PL19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SI19.06.2019
SK19.06.2019
SM19.06.2019
TR19.06.2019
LU17.07.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
IS19.10.2019
PT21.10.2019
Former [2021/33]HU17.07.2013
AL19.06.2019
AT19.06.2019
CY19.06.2019
CZ19.06.2019
DK19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
MC19.06.2019
PL19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SI19.06.2019
SK19.06.2019
SM19.06.2019
TR19.06.2019
LU17.07.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
IS19.10.2019
PT21.10.2019
Former [2021/26]AL19.06.2019
AT19.06.2019
CY19.06.2019
CZ19.06.2019
DK19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
MC19.06.2019
PL19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SI19.06.2019
SK19.06.2019
SM19.06.2019
TR19.06.2019
LU17.07.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
IS19.10.2019
PT21.10.2019
Former [2020/37]AL19.06.2019
AT19.06.2019
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DK19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
MC19.06.2019
PL19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SI19.06.2019
SK19.06.2019
SM19.06.2019
TR19.06.2019
LU17.07.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
IS19.10.2019
PT21.10.2019
Former [2020/36]AL19.06.2019
AT19.06.2019
CZ19.06.2019
DK19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
MC19.06.2019
PL19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SK19.06.2019
SM19.06.2019
TR19.06.2019
LU17.07.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
IS19.10.2019
PT21.10.2019
Former [2020/25]AL19.06.2019
AT19.06.2019
CZ19.06.2019
DK19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
MC19.06.2019
PL19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SK19.06.2019
SM19.06.2019
TR19.06.2019
LU17.07.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
PT21.10.2019
IS24.02.2020
Former [2020/24]AL19.06.2019
AT19.06.2019
CZ19.06.2019
DK19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
MC19.06.2019
PL19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SK19.06.2019
SM19.06.2019
TR19.06.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
PT21.10.2019
IS24.02.2020
Former [2020/22]AL19.06.2019
AT19.06.2019
CZ19.06.2019
DK19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
MC19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SK19.06.2019
SM19.06.2019
TR19.06.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
IS19.10.2019
PT21.10.2019
Former [2020/17]AL19.06.2019
AT19.06.2019
CZ19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
MC19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SK19.06.2019
SM19.06.2019
TR19.06.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
IS19.10.2019
PT21.10.2019
Former [2020/14]AL19.06.2019
AT19.06.2019
CZ19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SK19.06.2019
SM19.06.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
IS19.10.2019
PT21.10.2019
Former [2020/12]AL19.06.2019
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EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
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RO19.06.2019
RS19.06.2019
SE19.06.2019
SK19.06.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
IS19.10.2019
PT21.10.2019
Former [2020/11]AL19.06.2019
AT19.06.2019
CZ19.06.2019
EE19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
SK19.06.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
PT21.10.2019
Former [2020/10]AL19.06.2019
AT19.06.2019
CZ19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
RO19.06.2019
RS19.06.2019
SE19.06.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
PT21.10.2019
Former [2020/09]AL19.06.2019
CZ19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
RS19.06.2019
SE19.06.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
Former [2019/51]AL19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
RS19.06.2019
SE19.06.2019
BG19.09.2019
NO19.09.2019
GR20.09.2019
Former [2019/50]AL19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
LV19.06.2019
RS19.06.2019
SE19.06.2019
NO19.09.2019
GR20.09.2019
Former [2019/49]AL19.06.2019
FI19.06.2019
HR19.06.2019
LT19.06.2019
SE19.06.2019
NO19.09.2019
Former [2019/48]FI19.06.2019
LT19.06.2019
SE19.06.2019
NO19.09.2019
Former [2019/47]FI19.06.2019
LT19.06.2019
NO19.09.2019
Cited inInternational search[A]WO2011101436  (ENSCR [FR], et al) [A] 6,7 * examples 5-7 ** figure 1 *;
 [X]  - URIZZI P ET AL, "Attachment of radiometals to LDL with lipid analogues of EDTA or DTPA type complexing agents. Comparison of two labeling procedures", JOURNAL DE CHIMIE PHYSIQUE, SOCIETE DE CHIMIE PHYSIQUE, PARIS, FR, (19970101), vol. 94, no. 2, ISSN 0021-7689, pages 371 - 375, XP008089471 [X] 1 * page 373, sections "precipitation reactions" et "results and discussion" *
 [YD]  - YU J ET AL, "Y-oxine-ethiodol, a potential radiopharmaceutical for the treatment of liver cancer", APPLIED RADIATION AND ISOTOPES, ELSEVIER, OXFORD, GB, vol. 58, no. 5, ISSN 0969-8043, (20030501), pages 567 - 573, (20030501), XP027388557 [YD] 1-9 * abstract * * page 570, column left, paragraph last * * page 571, column left, paragraph 2 * * page 571, column right, paragraph lqst - page 572, column right, paragraph 2 *
 [YD]  - SUBRAMANIAN SURESH ET AL, "Preparation of Lu-177-Labeled Oxine in Lipiodol as a Possible Agent for Therapy of Hepatocellular Carcinoma: A Preliminary Animal Study", CANCER BIOTHERAPY & RADIOPHARMACEUTICALS, (201010), vol. 25, no. 5, ISSN 1084-9785, pages 539 - 543, XP002693466 [YD] 1-9 * page 542, column right, paragraph 2 - page 543, column left, paragraph 2 *

DOI:   http://dx.doi.org/10.1089/CBR.2010.0792
 [YD]  - DAS TAPAS ET AL, "Preparation of 166Ho-oxine-lipiodol and its preliminary bioevaluation for the potential application in therapy of liver cancer.", NUCLEAR MEDICINE COMMUNICATIONS MAY 2009, (200905), vol. 30, no. 5, ISSN 0143-3636, pages 362 - 367, XP008160641 [YD] 1-9 * page 366 - page 367, column left, paragraph 2 *

DOI:   http://dx.doi.org/10.1097/MNM.0b013e328329981a
 [Y]  - JIANLIN Y ET AL, "Raman spectroscopic studies on tropolone complexes with La, Nd, Sm, Yb", SPECTROCHIMICA ACTA. PART A: MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, ELSEVIER, AMSTERDAM, NL, vol. 64, no. 4, doi:10.1016/J.SAA.2005.09.017, ISSN 1386-1425, (20060701), pages 1072 - 1076, (20060701), XP028036481 [Y] 1-9 * page 1072, column left, lines 1-6 * * page 1074, column left, paragraph 2 *

DOI:   http://dx.doi.org/10.1016/j.saa.2005.09.017
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    - S.J. WANG ET AL., J. NUCL. MED., (1996), vol. 37, pages 332 - 335
    - J. YU ET AL., APPL. RADIAT. ISOT., (2003), vol. 58, pages 567 - 573
    - P.Y. MU ET AL., J. RADIOANAL. NUCL. CHEM., (2007), vol. 272, pages 669 - 671
    - S. SUBRAMANIAN ET AL., CANCER BIOTH. RADIOPHARM., (2010), vol. 25, pages 539 - 543
    - T. DAS ET AL., NUCL. MED. COMMUN., (2009), vol. 30, pages 362 - 367
    - S.J. OH ET AL., APPL. RADIAT. ISOT., (2001), vol. 54, pages 419 - 427
    - S.J. OH ET AL., APPL. RADIAT. ISOT., (2003), vol. 59, pages 225 - 230
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.