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Extract from the Register of European Patents

EP About this file: EP2812443

EP2812443 - CD47 ANTIBODIES AND METHODS OF USE THEREOF [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  26.04.2019
Database last updated on 03.10.2024
FormerGrant of patent is intended
Status updated on  06.12.2018
FormerExamination is in progress
Status updated on  15.11.2016
Most recent event   Tooltip06.08.2024New entry: Decision (+date) in appeal procedure 
Applicant(s)For all designated states
Inhibrx, Inc.
11025 N. Torrey Pines Road, Suite 200
La Jolla, CA 92037 / US
[2018/42]
Former [2016/01]For all designated states
Inhibrx LP
11099 North Torrey Pines Road, Suite 280
La Jolla, CA 92037 / US
Former [2014/51]For all designated states
Inhibrx LLC
11099 North Torrey Pines Road, Suite 280
La Jolla CA 92037 / US
Inventor(s)01 / ECKELMAN, Brendan
11025 N. Torrey Pines Road
Suite 200
La Jolla, CA 92037 / US
02 / TIMMER, John
11025 N. Torrey Pines Road
Suite 200
La Jolla, CA 92037 / US
03 / RAZAI, Amir
11025 N. Torrey Pines Road
Suite 200
La Jolla, CA 92037 / US
04 / DEVERAUX, Quinn
11025 N. Torrey Pines Road
Suite 200
La Jolla, CA 92037 / US
05 / JONES, Kyle
11025 N. Torrey Pines Road
Suite 200
La Jolla, CA 92037 / US
06 / NGUY, Peter, L.
11025 N. Torrey Pines Road
Suite 200
La Jolla, CA 92037 / US
 [2019/22]
Former [2014/51]01 / ECKELMAN, Brendan
11099 N. Torrey Pines Road
Suite 130
La Jolla, CA 92037 / US
02 / TIMMER, John
11099 N. Torrey Pines Road
Suite 130
La Jolla, CA 92037 / US
03 / RAZAI, Amir
11099 N. Torrey Pines Road
Suite 130
La Jolla, CA 92037 / US
04 / DEVERAUX, Quinn
11099 N. Torrey Pines Road
Suite 130
La Jolla, CA 92037 / US
05 / JONES, Kyle
11099 N. Torrey Pines Road
Suite 130
La Jolla, CA 92037 / US
06 / NGUY, Peter, L.
11099 N. Torrey Pines Road
Suite 130
La Jolla, CA 92037 / US
Representative(s)Jones Day
Rechtsanwälte, Attorneys-at-Law, Patentanwälte
Prinzregentenstrasse 11
80538 München / DE
[2014/51]
Application number, filing date13746964.906.02.2013
[2019/22]
WO2013US24995
Priority number, dateUS201261595216P06.02.2012         Original published format: US 201261595216 P
US201261659752P14.06.2012         Original published format: US 201261659752 P
[2014/51]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013119714
Date:15.08.2013
Language:EN
[2013/33]
Type: A1 Application with search report 
No.:EP2812443
Date:17.12.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 15.08.2013 takes the place of the publication of the European patent application.
[2014/51]
Type: B1 Patent specification 
No.:EP2812443
Date:29.05.2019
Language:EN
[2019/22]
Search report(s)International search report - published on:US15.08.2013
(Supplementary) European search report - dispatched on:EP06.10.2015
ClassificationIPC:C12P21/08, A61K39/395, C07K16/28
[2015/45]
CPC:
C07K16/2803 (EP,EA,KR,US); A61K39/3955 (EA,US); A61K39/39558 (EA,US);
A61K45/06 (EP,EA,KR,US); A61P35/00 (EP,KR); C07K14/70503 (EP,EA,KR,US);
C07K16/30 (EA,US); A61K2039/505 (EP,EA,KR,US); C07K2317/21 (EA,US);
C07K2317/24 (EP,EA,US); C07K2317/34 (EP,EA,KR,US); C07K2317/565 (EP,EA,KR,US);
C07K2317/70 (EP,EA,KR,US); C07K2317/76 (EP,EA,KR,US); C07K2319/21 (EP,EA,KR,US) (-)
Former IPC [2014/51]C12P21/08, A61K39/395
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/51]
Extension statesBA04.09.2014
ME04.09.2014
TitleGerman:CD47-ANTIKÖRPER UND VERFAHREN ZUR VERWENDUNG DAVON[2014/51]
English:CD47 ANTIBODIES AND METHODS OF USE THEREOF[2014/51]
French:ANTICORPS ANTI-CD47 ET LEURS MÉTHODES D'UTILISATION[2014/51]
Entry into regional phase04.09.2014National basic fee paid 
04.09.2014Search fee paid 
04.09.2014Designation fee(s) paid 
04.09.2014Examination fee paid 
Examination procedure04.09.2014Examination requested  [2014/51]
29.04.2016Amendment by applicant (claims and/or description)
29.07.2016Despatch of a communication from the examining division (Time limit: M06)
24.01.2017Reply to a communication from the examining division
05.10.2017Despatch of a communication from the examining division (Time limit: M04)
13.02.2018Reply to a communication from the examining division
06.11.2018Cancellation of oral proceeding that was planned for 12.11.2018
08.11.2018Observations by third parties
12.11.2018Date of oral proceedings (cancelled)
07.12.2018Communication of intention to grant the patent
17.04.2019Fee for grant paid
17.04.2019Fee for publishing/printing paid
17.04.2019Receipt of the translation of the claim(s)
Divisional application(s)EP19173042.3  / EP3578569
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  29.07.2016
Opposition(s)Opponent(s)01  28.02.2020  03.03.2020  ADMISSIBLE
Forty Seven, Inc.
333 Lakeside Drive
Foster City, CA 94404 / US
Opponent's representative
Carpmaels & Ransford LLP, et al, et al
One Southampton Row
London WC1B 5HA / GB
 [2022/10]
Former [2021/37]
Opponent(s)01  28.02.2020  03.03.2020  ADMISSIBLE
Forty Seven, Inc.
1490 O'Brien Drive, Suite A
Menlo Park CA 94025 / US
Opponent's representative
Carpmaels & Ransford LLP, et al, et al
One Southampton Row
London WC1B 5HA / GB
Former [2020/15]
Opponent(s)01  28.02.2020  03.03.2020  ADMISSIBLE
Forty Seven, Inc.
1490 O'Brien Drive, Suite A
Menlo Park CA 94025 / US
Opponent's representative
Chapman, Desmond Mark, et al, et al
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
18.03.2020Invitation to proprietor to file observations on the notice of opposition
28.07.2020Reply of patent proprietor to notice(s) of opposition
27.10.2021Date of oral proceedings
21.12.2021Despatch of interlocutory decision in opposition
21.12.2021Despatch of minutes of oral proceedings
Appeal following opposition07.02.2022Appeal received No.  T0326/22
07.02.2022Payment of appeal fee
29.04.2022Statement of grounds filed
01.08.2024Result of appeal procedure: appeal of the opponent was rejected
01.08.2024Date of oral proceedings
Fees paidRenewal fee
26.02.2015Renewal fee patent year 03
26.02.2016Renewal fee patent year 04
27.02.2017Renewal fee patent year 05
27.02.2018Renewal fee patent year 06
27.02.2019Renewal fee patent year 07
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Documents cited:Search[X]  - I. BABIC ET AL, "SHPS-1 Induces Aggregation of Ba/F3 Pro-B Cells Via an Interaction with CD47", THE JOURNAL OF IMMUNOLOGY, (20000401), vol. 164, no. 7, doi:10.4049/jimmunol.164.7.3652, ISSN 0022-1767, pages 3652 - 3658, XP055216058 [X] 1,2,4-6,12 * page 3654, column l, paragraph l - page 3655, column r, line 2 *

DOI:   http://dx.doi.org/10.4049/jimmunol.164.7.3652
 [X]  - RAVINDRA MAJETI1 ET AL, "CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells", DEVELOPMENTAL CELL, CELL PRESS, CAMBRIDGE, MA, US, vol. 138, no. 2, doi:10.1016/J.CELL.2009.05.045, ISSN 1097-4172, (20090723), pages 286 - 299, (20090723), XP002632714 [X] 1,2,4-6,12 * page 288, column r, paragraph 3 - page 290, column r, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/J.CELL.2009.05.045
 [I]  - M. P. CHAO ET AL, "Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia", CANCER RESEARCH, (20110215), vol. 71, no. 4, doi:10.1158/0008-5472.CAN-10-2238, ISSN 0008-5472, pages 1374 - 1384, XP055029988 [I] 7-9,13-15 * page 1376, column r, paragraph l - page 1380, column l, line 9; figure 7 *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-10-2238
 [A]  - X. W. ZHAO ET AL, "CD47-signal regulatory protein- (SIRP ) interactions form a barrier for antibody-mediated tumor cell destruction", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20111108), vol. 108, no. 45, doi:10.1073/pnas.1106550108, ISSN 0027-8424, pages 18342 - 18347, XP055055636 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1073/pnas.1106550108
International search[Y]US2004147731  (PARKOS CHARLES A [US]);
 [A]US2005288491  (WILSON DAVID S [US], et al);
 [Y]US2007148163  (TAKAHASHI NOBUAKI [JP], et al);
 [Y]US2008131431  (SMITH CRAIG A [US], et al);
 [A]US2009035322  (MARTIN JOEL H [US], et al);
 [X]US2011014119  (JAISWAL SIDDHARTHA [US], et al);
 [A]US2011223107  (TREMBLAY GILLES BERNARD [CA], et al);
 [Y]  - OLIVEIRA ET AL., "Integrin-associated protein (CD47) is a putative mediator for soluble fibrinogen interaction with human red blood cells membrane.", BIOCHIM BIOPHYS ACTA, (20111104), vol. 1818, no. 3, pages 481 - 90, XP028397658

DOI:   http://dx.doi.org/10.1016/j.bbamem.2011.10.028
 [A]  - "Inorganic pyrophosphatase.", UNIPROT, (20111214), Database accession no. G4EMT6_MYCIO, XP003033834
    [ ] - "IG HEAVY CHAIN V REGION (7D4) - MOUSE (FRAGMENT) [MUS MUSCULUS]", UNIPROTKB, (19990723), Database accession no. C37263, XP003034203
 [A]  - STAVNEZER ET AL., "Evolution of isotype switching", SEMIN IMMUNOL., (2004), vol. 16, no. 4, pages 257 - 75, XP004620322

DOI:   http://dx.doi.org/10.1016/j.smim.2004.08.005
 [A]  - BRINKHOUS ET AL., "Fixation platelets and platelet agglutination/aggregation tests.", METHODS ENZYMOL., (1989), vol. 169, pages 149 - 63, XP008174638

DOI:   http://dx.doi.org/10.1016/0076-6879(89)69056-8
other   - KIKUCHI et al., "A bivalent single-chain Fv fragment against CD47 induces apoptosis for leukemic cells", Biochem Biophys Res Commun, (20040000), vol. 315, no. 4, pages 912 - 918, XP004491573

DOI:   http://dx.doi.org/10.1016/j.bbrc.2004.01.128
OppositionEP1931710
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