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Extract from the Register of European Patents

EP About this file: EP2872620

EP2872620 - DERIVATION AND SELF-RENEWAL OF ISI1+ CELLS AND USES THEREOF [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 20.11.2020 Database last updated on 02.09.2024
Former	The patent has been granted Status updated on 13.12.2019
Former	Grant of patent is intended Status updated on 11.08.2019
Former	Examination is in progress Status updated on 21.11.2016
Most recent event Tooltip	08.07.2022	Lapse of the patent in a contracting state New state(s): MK	published on 10.08.2022 [2022/32]
Applicant(s)	For all designated states IsletOne AB Backvindeln 9 129 42 Hägersten / SE
	[2015/39]
Former [2015/21]	For all designated states IsletOne AB Backvindeln 9 129 42 Hägersten / SE
	For all designated states Grinnemo, Karl-Henrik Backvindeln 9 129 42 Hägersten / SE
	For all designated states Simonson, Oscar Gyllenstiernsgatan 20 115 26 Stockholm / SE
	For all designated states Corbascio, Matthias Hällmarksvägen 49 186 53 Vallentuna / SE
	For all designated states Sylvén, Christer Rånövägen 22 168 39 Bromma / SE
	For all designated states Wärdell, Eva Viktoriavägen 5 125 34 Älvsjö / SE
Inventor(s)	01 / GRINNEMO, Karl-Henrik Backvindeln 9 SE-129 42 Hägersten / SE
	02 / SIMONSON, Oscar Gyllenstiernsgatan 20 SE-115 26 Stockholm / SE
	03 / CORBASCIO, Matthias Hällmarksvägen 49 SE-186 53 Vallentuna / SE
	04 / SYLVÉN, Christer Rånövägen 22 SE-168 39 Bromma / SE
	05 / WÄRDELL, Eva Viktoriavägen 5 SE-125 34 Älvsjö / SE
	[2015/21]
Representative(s)	Novitas Patent AB P.O. Box 55557 102 04 Stockholm / SE
	[2015/21]
Application number, filing date	13753363.4	11.07.2013
	[2020/03]
	WO2013SE00112
Priority number, date	US201261670640P	12.07.2012 Original published format: US 201261670640 P
	[2015/21]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2014011095
	Date:	16.01.2014
	Language:	EN
	[2014/03]
	Type:	A1 Application with search report
	No.:	EP2872620
	Date:	20.05.2015
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 16.01.2014 takes the place of the publication of the European patent application.
	[2015/21]
	Type:	B1 Patent specification
	No.:	EP2872620
	Date:	15.01.2020
	Language:	EN
	[2020/03]
Search report(s)	International search report - published on:	EP	16.01.2014
Classification	IPC:	C12N5/077, A61K35/34, C12N5/0775	[2019/19]
	CPC:	C12N5/0657 (EP,US); A61K35/34 (US); C12N5/0668 (EP,US); C12N2501/40 (US); C12N2501/415 (EP,US); C12N2533/52 (EP,US)
	Former IPC [2015/21]	C12N5/0735, C12N5/071
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/21]
Extension states	BA	Not yet paid
	ME	Not yet paid
Title	German:	ERHALT UND SELBSTERNEUERUNG VON LSL1+ ZELLEN UND DEREN VERWENDUNG	[2019/19]
	English:	DERIVATION AND SELF-RENEWAL OF ISI1+ CELLS AND USES THEREOF	[2015/21]
	French:	DÉRIVATION ET AUTO-RENOUVELLEMENT DES CELLULES LSL1+ ET LEUR UTILISATION	[2019/19]
	Former [2015/21]	ABLEITUNG UND SELBSTERNEUERUNG VON ISI1+-ZELLEN UND VERWENDUNG DAVON
	Former [2015/21]	DÉRIVATION ET AUTO-RENOUVELLEMENT DE CELLULES ISI1+ ET LEURS UTILISATIONS
Entry into regional phase	10.02.2015	National basic fee paid
	10.02.2015	Designation fee(s) paid
	10.02.2015	Examination fee paid
Examination procedure	10.02.2015	Examination requested [2015/21]
	22.10.2015	Amendment by applicant (claims and/or description)
	13.05.2016	Despatch of a communication from the examining division (Time limit: M06)
	17.11.2016	Reply to a communication from the examining division
	11.07.2017	Despatch of a communication from the examining division (Time limit: M06)
	17.01.2018	Reply to a communication from the examining division
	27.06.2018	Despatch of a communication from the examining division (Time limit: M01)
	24.07.2018	Reply to a communication from the examining division
	02.04.2019	Despatch of a communication from the examining division (Time limit: M01)
	03.04.2019	Reply to a communication from the examining division
	12.08.2019	Communication of intention to grant the patent
	04.12.2019	Fee for grant paid
	04.12.2019	Fee for publishing/printing paid
	04.12.2019	Receipt of the translation of the claim(s)
	29.01.2020	Request for correction of the decision to grant filed
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 13.05.2016
Opposition(s)	16.10.2020	No opposition filed within time limit [2020/52]
Fees paid	Renewal fee
	09.07.2015	Renewal fee patent year 03
	11.07.2016	Renewal fee patent year 04
	29.06.2017	Renewal fee patent year 05
	30.07.2018	Renewal fee patent year 06
	25.06.2019	Renewal fee patent year 07
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	11.07.2013
	AL	15.01.2020
	AT	15.01.2020
	CY	15.01.2020
	CZ	15.01.2020
	EE	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	MC	15.01.2020
	MK	15.01.2020
	MT	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SI	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	TR	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
	IE	11.07.2020
	LU	11.07.2020
	BE	31.07.2020
	[2022/31]
Former [2022/30]	HU	11.07.2013
	AL	15.01.2020
	AT	15.01.2020
	CY	15.01.2020
	CZ	15.01.2020
	EE	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	MC	15.01.2020
	MT	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SI	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	TR	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
	IE	11.07.2020
	LU	11.07.2020
	BE	31.07.2020
Former [2022/27]	HU	11.07.2013
	AT	15.01.2020
	CY	15.01.2020
	CZ	15.01.2020
	EE	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	MC	15.01.2020
	MT	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SI	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	TR	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
	IE	11.07.2020
	LU	11.07.2020
	BE	31.07.2020
Former [2022/26]	AT	15.01.2020
	CZ	15.01.2020
	EE	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	MC	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SI	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	TR	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
	IE	11.07.2020
	LU	11.07.2020
	BE	31.07.2020
Former [2021/37]	AT	15.01.2020
	CZ	15.01.2020
	EE	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	MC	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SI	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
	IE	11.07.2020
	LU	11.07.2020
	BE	31.07.2020
Former [2021/24]	AT	15.01.2020
	CZ	15.01.2020
	EE	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	MC	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SI	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
	LU	11.07.2020
	BE	31.07.2020
Former [2021/20]	AT	15.01.2020
	CZ	15.01.2020
	EE	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	MC	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SI	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
	LU	11.07.2020
Former [2021/13]	AT	15.01.2020
	CZ	15.01.2020
	EE	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	MC	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SI	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
Former [2021/11]	AT	15.01.2020
	CZ	15.01.2020
	EE	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SI	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
Former [2020/50]	CZ	15.01.2020
	EE	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
Former [2020/49]	CZ	15.01.2020
	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SK	15.01.2020
	SM	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
Former [2020/48]	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	RO	15.01.2020
	RS	15.01.2020
	SM	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
Former [2020/47]	FI	15.01.2020
	HR	15.01.2020
	LT	15.01.2020
	LV	15.01.2020
	RS	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
Former [2020/40]	FI	15.01.2020
	HR	15.01.2020
	LV	15.01.2020
	RS	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
	IS	15.05.2020
Former [2020/39]	FI	15.01.2020
	HR	15.01.2020
	LV	15.01.2020
	RS	15.01.2020
	BG	15.04.2020
	NO	15.04.2020
	GR	16.04.2020
Former [2020/38]	FI	15.01.2020
	HR	15.01.2020
	LV	15.01.2020
	RS	15.01.2020
	NO	15.04.2020
	GR	16.04.2020
Former [2020/37]	FI	15.01.2020
	HR	15.01.2020
	LV	15.01.2020
	RS	15.01.2020
	NO	15.04.2020
Former [2020/35]	FI	15.01.2020
	NO	15.04.2020
Cited in	International search	[Y]WO2007016366 (UNIV YALE [US], et al) [Y] 1-21* claims 12,12,45,47 *;
		[Y]WO2008094597 (UNIV GEORGIA RES FOUND [US], et al) [Y] 1-21 * page 39; figure 13 *;
		[X]WO2010011352 (UNIV GEORGIA RES FOUND [US], et al) [X] 1-21 * abstract *;
		[X]US2011305672 (DALTON STEPHEN [US], et al) [X] 1-21 * paragraphs [0003] , [0203] , [0335] *;
		[Y] - GENEAD R ET AL, "Early first trimester human embryonic cardiac Islet-1 progenitor cells and cardiomyocytes: Immunohistochemical and electrophysiological characterization", STEM CELL RESEARCH, ELSEVIER, NL, vol. 4, no. 1, ISSN 1873-5061, (20100101), pages 69 - 76, (20091106), XP026829842 [Y] 1-21 * page 70, column 1, paragraph 2 *
		[Y] - LAUGWITZ KARL-LUDWIG ET AL, "Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages", NATURE: INTERNATIONAL WEEKLY JOURNAL OF SCIENCE (AND SUPPLEMENTARY INFORMATION), NATURE PUBLISHING GROUP, UNITED KINGDOM, (20050210), vol. 433, no. 7026, doi:10.1038/NATURE03215, ISSN 0028-0836, pages 647 - 653, XP002477756 [Y] 1-21 * page 652; figure 2 * DOI: http://dx.doi.org/10.1038/nature03215
		[Y] - GENEAD RAMI ET AL, "Islet-1 cells are cardiac progenitors present during the entire lifespan: from the embryonic stage to adulthood.", STEM CELLS AND DEVELOPMENT OCT 2010, (201010), vol. 19, no. 10, ISSN 1557-8534, pages 1601 - 1615, XP009174175 [Y] 1-21 * page 1611, column 2, paragraph 1 * DOI: http://dx.doi.org/10.1089/scd.2009.0483
		[Y] - KLAUS ALEXANDRA ET AL, "Wnt/beta-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, (20120501), vol. 109, no. 27, ISSN 0027-8424, pages 10921 - 10926, XP009174150 [Y] 1-21 * figures 2-4 * DOI: http://dx.doi.org/10.1073/pnas.1121236109
		[Y] - MITTAL ASHOK ET AL, "Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest", MECHANISMS OF DEVELOPMENT, (201009), vol. 127, no. 9-12, ISSN 0925-4773, pages 472 - 484, XP009174149 [Y] 1-21 * the whole document * DOI: http://dx.doi.org/10.1016/j.mod.2010.08.005
	Examination	WO2005046596
		- DOMOGATSKAYA ANNA ET AL, "Laminin-511 but not -332, -111, or -411 enables mouse embryonic stem cell self-renewal in vitro", STEM CELLS, ALPHAMED PRESS, INC, UNITED STATES, (20081101), vol. 26, no. 11, doi:10.1634/STEMCELLS.2007-0389, ISSN 1549-4918, pages 2800 - 2809, XP009109423 DOI: http://dx.doi.org/10.1634/stemcells.2007-0389
	by applicant	- GENEAD ET AL., PLOSONE, (2012), vol. 7, page E36804
		- LAM ET AL., PEDIATR. CARDIOL., (2009), vol. 30, page 690
		- LAUGWITZ ET AL., NATURE, (2005), vol. 433, page 647
		- WESTGREN ET AL., ACTA SCAND OBSTET GYNECOL, (1994), vol. 73, pages 601 - 604

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