| EP2825649 - SELECTIVE CELL TARGETING USING ADENOVIRUS AND CHEMICAL DIMERS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 10.07.2020 Database last updated on 09.04.2026 | |
| Former | The patent has been granted Status updated on 28.06.2019 | ||
| Former | Grant of patent is intended Status updated on 07.03.2019 | ||
| Former | Examination is in progress Status updated on 28.04.2017 | Most recent event Tooltip | 08.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 10.08.2022 [2022/32] | Applicant(s) | For all designated states The Salk Institute for Biological Studies Office of Technology Management 10010 N. Torrey Pines Road La Jolla, CA 92037 / US | [2015/04] | Inventor(s) | 01 /
O'SHEA, Clodagh 5052 Long Branch Ave. San Diego, California 92107 / US | 02 /
MIYAKE-STONER, Shigeki 3951 H Miramar St. La Jolla, California 92037 / US | 03 /
POWERS, Colin 11595 Caminito La Bar 12 San Diego, California 92126 / US | [2015/04] | Representative(s) | Docherty, Robert Charles, et al Symbiosis IP Limited York Biotech Campus Office 14FA05 Sand Hutton York, YO41 1LZ / GB | [N/P] |
| Former [2019/31] | Docherty, Robert Charles, et al Symbiosis IP Limited NAFIC Office 14FA05 Sand Hutton York, North Yorkshire YO41 1LZ / GB | ||
| Former [2015/04] | Docherty, Robert Charles, et al Symbiosis IP Limited 106 Heworth Green York YO31 7TQ / GB | Application number, filing date | 13760608.3 | 13.03.2013 | [2019/31] | WO2013US31002 | Priority number, date | US201261610416P | 13.03.2012 Original published format: US 201261610416 P | [2015/04] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2013138505 | Date: | 19.09.2013 | Language: | EN | [2013/38] | Type: | A1 Application with search report | No.: | EP2825649 | Date: | 21.01.2015 | Language: | EN | The application published by WIPO in one of the EPO official languages on 19.09.2013 takes the place of the publication of the European patent application. | [2015/04] | Type: | B1 Patent specification | No.: | EP2825649 | Date: | 31.07.2019 | Language: | EN | [2019/31] | Search report(s) | International search report - published on: | KR | 19.09.2013 | (Supplementary) European search report - dispatched on: | EP | 11.01.2016 | Classification | IPC: | C12N15/861, A61K35/761 | [2016/06] | CPC: |
A61K35/761 (EP,US);
A61K48/00 (US);
A61P35/00 (EP);
A61P43/00 (EP);
C12N15/113 (US);
C12N15/86 (EP,US);
C12N7/00 (US);
C07K2319/20 (EP,US);
C12N2710/10034 (US);
|
| Former IPC [2015/04] | C12N15/62, C12N15/34, A61P35/00 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/04] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | SELEKTIVES TARGETING VON ZELLEN MITTELS ADENOVIRALER UND CHEMISCHER DIMERE | [2015/04] | English: | SELECTIVE CELL TARGETING USING ADENOVIRUS AND CHEMICAL DIMERS | [2015/04] | French: | CIBLAGE CELLULAIRE SÉLECTIF À L'AIDE D'ADÉNOVIRUS ET DE DIMÈRES CHIMIQUES | [2015/04] | Entry into regional phase | 25.09.2014 | National basic fee paid | 25.09.2014 | Search fee paid | 25.09.2014 | Designation fee(s) paid | 25.09.2014 | Examination fee paid | Examination procedure | 25.09.2014 | Examination requested [2015/04] | 25.07.2016 | Amendment by applicant (claims and/or description) | 02.05.2017 | Despatch of a communication from the examining division (Time limit: M04) | 30.08.2017 | Reply to a communication from the examining division | 30.07.2018 | Despatch of a communication from the examining division (Time limit: M04) | 14.11.2018 | Reply to a communication from the examining division | 06.12.2018 | Despatch of a communication from the examining division (Time limit: M01) | 19.12.2018 | Reply to a communication from the examining division | 08.03.2019 | Communication of intention to grant the patent | 18.06.2019 | Fee for grant paid | 18.06.2019 | Fee for publishing/printing paid | 18.06.2019 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 02.05.2017 | Opposition(s) | 03.06.2020 | No opposition filed within time limit [2020/33] | Fees paid | Renewal fee | 25.03.2015 | Renewal fee patent year 03 | 10.03.2016 | Renewal fee patent year 04 | 10.03.2017 | Renewal fee patent year 05 | 13.03.2018 | Renewal fee patent year 06 | 13.03.2019 | Renewal fee patent year 07 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 13.03.2013 | AL | 31.07.2019 | CY | 31.07.2019 | CZ | 31.07.2019 | DK | 31.07.2019 | EE | 31.07.2019 | ES | 31.07.2019 | FI | 31.07.2019 | HR | 31.07.2019 | IT | 31.07.2019 | LT | 31.07.2019 | LV | 31.07.2019 | MC | 31.07.2019 | MK | 31.07.2019 | MT | 31.07.2019 | NL | 31.07.2019 | PL | 31.07.2019 | RO | 31.07.2019 | RS | 31.07.2019 | SE | 31.07.2019 | SI | 31.07.2019 | SK | 31.07.2019 | SM | 31.07.2019 | TR | 31.07.2019 | IS | 30.10.2019 | BG | 31.10.2019 | NO | 31.10.2019 | GR | 01.11.2019 | PT | 02.12.2019 | LU | 13.03.2020 | BE | 31.03.2020 | CH | 31.03.2020 | LI | 31.03.2020 | [2022/32] |
| Former [2022/27] | HU | 13.03.2013 | |
| AL | 31.07.2019 | ||
| CY | 31.07.2019 | ||
| CZ | 31.07.2019 | ||
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| MC | 31.07.2019 | ||
| MT | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| SI | 31.07.2019 | ||
| SK | 31.07.2019 | ||
| SM | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| IS | 30.10.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| LU | 13.03.2020 | ||
| BE | 31.03.2020 | ||
| CH | 31.03.2020 | ||
| LI | 31.03.2020 | ||
| Former [2021/12] | AL | 31.07.2019 | |
| CZ | 31.07.2019 | ||
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| MC | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| SI | 31.07.2019 | ||
| SK | 31.07.2019 | ||
| SM | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| IS | 30.10.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| LU | 13.03.2020 | ||
| BE | 31.03.2020 | ||
| CH | 31.03.2020 | ||
| LI | 31.03.2020 | ||
| Former [2021/07] | AL | 31.07.2019 | |
| CZ | 31.07.2019 | ||
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| MC | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| SI | 31.07.2019 | ||
| SK | 31.07.2019 | ||
| SM | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| IS | 30.10.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| LU | 13.03.2020 | ||
| CH | 31.03.2020 | ||
| LI | 31.03.2020 | ||
| Former [2021/04] | AL | 31.07.2019 | |
| CZ | 31.07.2019 | ||
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| MC | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| SI | 31.07.2019 | ||
| SK | 31.07.2019 | ||
| SM | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| IS | 30.10.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| LU | 13.03.2020 | ||
| Former [2020/49] | AL | 31.07.2019 | |
| CZ | 31.07.2019 | ||
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| MC | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| SI | 31.07.2019 | ||
| SK | 31.07.2019 | ||
| SM | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| IS | 30.10.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| Former [2020/37] | AL | 31.07.2019 | |
| CZ | 31.07.2019 | ||
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| SI | 31.07.2019 | ||
| SK | 31.07.2019 | ||
| SM | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| IS | 30.10.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| Former [2020/36] | AL | 31.07.2019 | |
| CZ | 31.07.2019 | ||
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| SK | 31.07.2019 | ||
| SM | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| IS | 30.10.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| Former [2020/27] | AL | 31.07.2019 | |
| CZ | 31.07.2019 | ||
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| SK | 31.07.2019 | ||
| SM | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| IS | 24.02.2020 | ||
| Former [2020/25] | AL | 31.07.2019 | |
| CZ | 31.07.2019 | ||
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| SK | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| IS | 24.02.2020 | ||
| Former [2020/24] | AL | 31.07.2019 | |
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| IS | 24.02.2020 | ||
| Former [2020/23] | AL | 31.07.2019 | |
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| IT | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| PL | 31.07.2019 | ||
| RO | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| IS | 30.11.2019 | ||
| PT | 02.12.2019 | ||
| Former [2020/22] | AL | 31.07.2019 | |
| DK | 31.07.2019 | ||
| EE | 31.07.2019 | ||
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| IS | 30.11.2019 | ||
| PT | 02.12.2019 | ||
| Former [2020/17] | AL | 31.07.2019 | |
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| TR | 31.07.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| IS | 30.11.2019 | ||
| PT | 02.12.2019 | ||
| Former [2020/15] | AL | 31.07.2019 | |
| ES | 31.07.2019 | ||
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| IS | 30.11.2019 | ||
| PT | 02.12.2019 | ||
| Former [2020/12] | ES | 31.07.2019 | |
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| IS | 30.11.2019 | ||
| PT | 02.12.2019 | ||
| Former [2020/11] | ES | 31.07.2019 | |
| FI | 31.07.2019 | ||
| HR | 31.07.2019 | ||
| LT | 31.07.2019 | ||
| LV | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| RS | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| GR | 01.11.2019 | ||
| PT | 02.12.2019 | ||
| Former [2020/10] | FI | 31.07.2019 | |
| LT | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| SE | 31.07.2019 | ||
| BG | 31.10.2019 | ||
| NO | 31.10.2019 | ||
| PT | 02.12.2019 | ||
| Former [2020/09] | FI | 31.07.2019 | |
| LT | 31.07.2019 | ||
| NL | 31.07.2019 | ||
| NO | 31.10.2019 | ||
| Former [2020/08] | LT | 31.07.2019 | |
| NO | 31.10.2019 | Documents cited: | Search | [XYI] WO2012024350 (SALK INST FOR BIOLOGICAL STUDI et al.) [X] 1-5,7-14 * page 30, line 12 - line 28 *[Y] 6 [I] 15,16 | [Y] JOEL N. GLASGOW ET AL: "A Strategy for Adenovirus Vector Targeting with a Secreted Single Chain Antibody", PLOS ONE, vol. 4, no. 12, 21 December 2009 (2009-12-21), pages e8355, XP055163048, DOI: 10.1371/journal.pone.0008355 [Y] 6 * abstract * * figure 1 * DOI: http://dx.doi.org/10.1371/journal.pone.0008355 | [AD] WAEHLER REINHARD ET AL: "Engineering targeted viral vectors for gene therapy", NATURE REVIEWS GENETICS, vol. 8, no. 8, 1 August 2007 (2007-08-01), pages 573 - 587, XP002663591, ISSN: 1471-0056, [retrieved on 20070703], DOI: 10.1038/NRG2141 [AD] 1-16 * the whole document * DOI: http://dx.doi.org/10.1038/NRG2141 | [A] CHONG HEUNG ET AL: "A system for small-molecule control of conditionally replication-competent adenoviral vectors", MOLECULAR THERAPY, NATURE PUBLISHING GROUP, GB, vol. 5, no. 2, 1 February 2002 (2002-02-01), pages 195 - 203, XP002344532, ISSN: 1525-0016, DOI: 10.1006/MTHE.2002.0531 [A] 1-16 * the whole document * DOI: http://dx.doi.org/10.1006/mthe.2002.0531 | International search | [X] WO2012024350 (SALK INST FOR BIOLOGICAL STUDI et al.) [X] | [A] US6506379 (CLACKSON TIMOTHY P et al.) [A] | [A] US6984635 (SCHREIBER STUART L et al.) [A] | [Y] GLASGOW, JOEL N. ET AL.: "A strategy for adenovirus vector targeting with a secreted single chain antibody", PLOS ONE, vol. 4, no. 12, 21 December 2009 (2009-12-21), pages E8355, XP055163048 [Y] DOI: http://dx.doi.org/10.1371/journal.pone.0008355 | [A] VERHEIJE, M. H. ET AL.: "Retargeting of viruses to generate oncolytic agent s", ADVANCES IN VIROLOGY, vol. 2012, 14 November 2011 (2011-11-14), pages 1 - 15, XP055163052 [A] DOI: http://dx.doi.org/10.1155/2012/798526 | by applicant | WO2012024350 | US2011048006 | PESONEN, S. ET AL., MOLECULAR PHARMACEUTICS, vol. 8, no. 1, 2010, pages 12 - 28 | ZHANG H; BEREZOV A; WANG Q; ZHANG G; DREBIN J; MURALI R ET AL.: "ErbB receptors: from oncogenes to targeted cancer therapies", J CLIN INVEST, vol. 117, no. 8, 2007, pages 2051 - 2058 [A] | LI HJ; EVERTS M; PEREBOEVA L; KOMAROVA S; IDAN A; CURIEL DT ET AL.: "Adenovirus tumor targeting and hepatic untargeting by a coxsackie/adenovirus receptor ectodomain anti-carcinoembryonic antigen bispecific adapter", CANCER RES., vol. 67, no. 11, 2007, pages 5354 - 5361 | HAISMA HJ; PINEDO HM; RIJSWIJK A; DER MEULEN-MUILEMAN I; SOSNOWSKI BA; YING W ET AL.: "Tumor-specific gene transfer via an adenoviral vector targeted to the pan-carcinoma antigen EpCAM", GENE THER, vol. 6, no. 8, 1999, pages 1469 - 1474, XP001157238, DOI: doi:10.1038/sj.gt.3300969 DOI: http://dx.doi.org/10.1038/sj.gt.3300969 | DE VRIJ J; UIL TG; VAN DEN HENGEL SK; CRAMER SJ; KOPPERS-LALIC D; VERWEIJ MC ET AL.: "Adenovirus targeting to HLA-A1/MAGE-A1-positive tumor cells by fusing a single-chain T-cell receptor with minor capsid protein IX", GENE THER, vol. 15, no. 13, 2008, pages 978 - 989, XP055044025, DOI: doi:10.1038/gt.2008.26 DOI: http://dx.doi.org/10.1038/gt.2008.26 | NOUREDDINI SC; CURIEL DT: "Genetic targeting strategies for adenovirus", MOL PHARM, vol. 2, no. 5, 2005, pages 341 - 347, XP002397944, DOI: doi:10.1021/mp050045c DOI: http://dx.doi.org/10.1021/mp050045c | NICKLIN SA; WU E; NEMEROW GR; BAKER AH: "The influence of adenovirus fiber structure and function on vector development for gene therapy", MOL THER, vol. 12, no. 3, 2005, pages 384 - 393, XP005472372, DOI: doi:10.1016/j.ymthe.2005.05.008 DOI: http://dx.doi.org/10.1016/j.ymthe.2005.05.008 | BATZER ET AL., NUCLEIC ACID RES., vol. 19, 1991, pages 5081 | OHTSUKA ET AL., J. BIOL. CHEM., vol. 260, 1985, pages 2605 - 2608 | ROSSOLINI ET AL., MOL. CELL. PROBES, vol. 8, 1994, pages 91 - 98 | LEICHER ET AL., J. BIOL. CHEM., vol. 273, no. 52, 1998, pages 35095 - 35101 | MANIATIS ET AL.: "Molecular Cloning: A Laboratory Manual", 1982, COLD SPRING HARBOR LABORATORY | SMITH; WATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482 | NEEDLEMAN; WUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 | PEARSON; LIPMAN, PROC. NAT'L. ACAD. SCI. USA, vol. 85, 1988, pages 2444 | "Current Protocols in Molecular Biology", 1995 | ALTSCHUL ET AL., NUC. ACIDS RES., vol. 25, 1977, pages 3389 - 3402 | ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410 | HENIKOFF; HENIKOFF, PROC. NATL. ACAD. SCI. USA, vol. 89, 1989, pages 10915 | INNIS ET AL.: "PCR Protocols, A Guide to Methods and Applications", 1990, ACADEMIC PRESS, INC. | FORD ET AL., GENE THERAPY, vol. 8, 2001, pages 1 - 4 | PROCHIANTZ, NAT. METHODS, vol. 4, 2007, pages 119 - 120 | LIEBERMAN, PHARMACEUTICAL DOSAGE FORMS, vol. 1-3, 1992 | LLOYD, THE ART, SCIENCE AND TECHNOLOGY OF PHARMACEUTICAL COMPOUNDING, 1999 | "Remington: The Science and Practice of Pharmacy", 2003 | PICKAR, DOSAGE CALCULATIONS, 1999 | BERGE ET AL., JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19 | POZNIC, M., JBIOSCI, vol. 34, no. 2, 2009, pages 305 - 312 | TOMKO, R.P. ET AL., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 94, no. 7, 2009, pages 3352 - 3356 | BERGELSON, J.M. ET AL., SCIENCE, vol. 275, no. 5304, 1997, pages 1320 - 1323 | ANDERS, M. ET AL., BR J CANCER, vol. 100, no. 2, 2009, pages 352 - 359 | DIETEL, M. ET AL., JOURNAL OF MOLECULAR MEDICINE, vol. 89, no. 6, 2011, pages 621 - 630 | MATSUMOTO, K. ET AL., UROLOGY, vol. 66, no. 2, 2005, pages 441 - 446 | REIN, D.T.; M. BREIDENBACH; D.T. CURIEL, FUTURE ONCOLOGY, vol. 2, no. 1, 2006, pages 137 - 143 | DMITRIEV, I. ET AL., J. VIROL., vol. 72, no. 12, 1998, pages 9706 - 9713 | BAUERSCHMITZ, G.J.; S.D. BARKER; A. HEMMINKI, INT J ONCOL, vol. 21, no. 6, 2002, pages 1161 - 1174 | BREIDENBACH, M. ET AL., HUM GENE THER., vol. 15, no. 5, 2004, pages 509 - 518 | CRIPE, T.P. ET AL., CANCER RES, vol. 61, no. 7, 2001, pages 2953 - 2960 | FECHNER, H. ET AL., GENE THER, vol. 7, no. 22, 2000, pages 1954 - 1968 | HEMMI, S. ET AL., HUM GENE THER, vol. 9, no. 16, 1998, pages 2363 - 2373 | HEMMINKI, A.; R.D. ALVAREZ, BIODRUGS, vol. 16, no. 2, 2002, pages 77 - 87 | KANERVA, A. ET AL., CLIN CANCER RES, vol. 8, no. 1, 2002, pages 275 - 280 | LI, Y. ET AL., CANCER RES, vol. 59, no. 2, 1999, pages 325 - 330 | MILLER, C.R. ET AL., CANCER RES, vol. 58, no. 24, 1998, pages 5738 - 5748 | REIN, D.T. ET AL., INT J CANCER, vol. 111, no. 5, 2004, pages 698 - 704 | LIU, Y.; P. VALADON; J. SCHNITZER, VIROLOGY JOURNAL, vol. 7, no. 1, 2010, pages 316 | BELOUSOVA, N. ET AL., J. VIROL., vol. 76, no. 17, 2002, pages 8621 - 8631 | BELOUSOVA, N. ET AL., J VIROL, vol. 76, no. 17, 2002, pages 8621 - 8631 | KONTERMANN, R.E., CURR OPIN MOL THER, vol. 12, no. 2, 2010, pages 176 - 183 | WAEHLER, R.; S.J. RUSSELL; D.T. CURIEL, NAT REV GENET, vol. 8, no. 8, 2007, pages 573 - 587 | CHEN, J. ET AL., PROC NATL ACAD SCI USA, vol. 92, no. 11, 1995, pages 4947 - 4951 | DE WILDT, R.M. ET AL., PROC NATL ACAD SCI USA, vol. 99, no. 13, 2002, pages 8530 - 8535 | CLACKSON, T., CHEM BIOL DRUG DES, vol. 67, no. 6, 2006, pages 440 - 442 | O'SHEA, C. ET AL., EMBO J, vol. 24, no. 6, 2005, pages 1211 - 1221 | FANG, J. ET AL., MOL THER, vol. 15, no. 6, 2007, pages 1153 - 1159 | VANEYCKEN, I. ET AL., JOURNAL OF NUCLEAR MEDICINE, vol. 51, no. 7, 2010, pages 1099 - 1106 | BEHAR, G. ET AL., FEBS JOURNAL, vol. 276, no. 14, 2009, pages 3881 - 3893 | DUFFY, M.J., CLIN CHEM, vol. 47, no. 4, 2001, pages 624 - 630 | GAINKAM, L.O. ET AL., JOURNAL OF NUCLEAR MEDICINE : OFFICIAL PUBLICATION, SOCIETY OF NUCLEAR MEDICINE, vol. 49, no. 5, 2008, pages 788 - 795 | ROOVERS, R. ET AL., CANCER IMMUNOLOGY, IMMUNOTHERAPY, vol. 56, no. 3, 2007, pages 303 - 317 | HUBBARD, K.E. ET AL., GENES & DEVELOPMENT, vol. 24, no. 16, 2010, pages 1695 - 1708 | JACINTO E; HALL MN: "Tor signalling in bugs, brain and brawn", NAT REV MOL CELL BIOL, vol. 4, no. 2, 2003, pages 117 - 126 | BAYLE JH; GRIMLEY JS; STANKUNAS K; GESTWICKI JE; WANDLESS TJ; CRABTREE GR: "Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity", CHEM BIOL., vol. 13, no. 1, 2006, pages 99 - 107, XP025131705, DOI: doi:10.1016/j.chembiol.2005.10.017 DOI: http://dx.doi.org/10.1016/j.chembiol.2005.10.017 | SONE, T. ET AL., JBIOTECHNOL., vol. 136, no. 3-4, 10 September 2008 (2008-09-10), pages 113 - 121 | SONE, T ET AL., JBIOTECHNOL, vol. 136, no. 3-4, 10 September 2008 (2008-09-10), pages 113 - 121 | KAST, P, GENE, vol. 138, 1994, pages 109 - 114 | ZHAO, L.J. ET AL., J BIOL CHEM., vol. 281, no. 48, 1 December 2006 (2006-12-01), pages 36613 - 36623 | ENGELMAN, J.A. ET AL., J CLIN INV., vol. 116, no. 10, 2 October 2006 (2006-10-02), pages 2695 - 2706 |