EP2832367 - AGENT FOR PREVENTING OR TREATING GIANT CELL TUMOR OR CHONDROSARCOMA ARISING IN BONE/SOFT TISSUE [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 21.05.2021 Database last updated on 15.07.2024 | |
Former | The patent has been granted Status updated on 12.06.2020 | ||
Former | Grant of patent is intended Status updated on 17.02.2020 | ||
Former | Examination is in progress Status updated on 15.09.2017 | Most recent event Tooltip | 27.04.2024 | Lapse of the patent in a contracting state New state(s): MK | published on 29.05.2024 [2024/22] | Applicant(s) | For all designated states Nippon Chemiphar Co., Ltd. 2-3, Iwamoto-cho 2-chome Chiyoda-ku Tokyo 101-0032 / JP | [2015/06] | Inventor(s) | 01 /
TAKEUCHI, Akihiko c/o National University Corporation Kanazawa University Nu 7 Kakuma-machi Kanazawa-shi Ishikawa 920-1164 / JP | 02 /
TSUCHIYA, Hiroyuki c/o National University Corporation Kanazawa University Nu 7 Kakuma-machi Kanazawa-shi Ishikawa 920-1164 / JP | [2015/06] | Representative(s) | Godemeyer Blum Lenze Patentanwälte Partnerschaft mbB - werkpatent An den Gärten 7 51491 Overath / DE | [2020/29] |
Former [2015/06] | Godemeyer Blum Lenze Patentanwälte Partnerschaft mbB werkpatent An den Gärten 7 51491 Overath / DE | Application number, filing date | 13769796.7 | 18.03.2013 | [2020/29] | WO2013JP57706 | Priority number, date | JP20120070351 | 26.03.2012 Original published format: JP 2012070351 | JP20120235784 | 25.10.2012 Original published format: JP 2012235784 | [2015/06] | Filing language | JA | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2013146435 | Date: | 03.10.2013 | Language: | JA | [2013/40] | Type: | A1 Application with search report | No.: | EP2832367 | Date: | 04.02.2015 | Language: | EN | [2015/06] | Type: | B1 Patent specification | No.: | EP2832367 | Date: | 15.07.2020 | Language: | EN | [2020/29] | Search report(s) | International search report - published on: | JP | 03.10.2013 | (Supplementary) European search report - dispatched on: | EP | 13.11.2015 | Classification | IPC: | A61K45/00, A61K31/38, A61P35/00, G01N33/15, G01N33/50, G01N33/52, A61K31/167, A61K31/196, A61K31/405, A61K31/421, A61K31/427, A61K31/4439, A61K31/517 | [2015/50] | CPC: |
A61K31/4439 (EP,US);
A61K45/00 (CN);
A61K31/167 (EP,CN,US);
A61K31/192 (EP,CN,US);
A61K31/196 (EP,CN,US);
A61K31/38 (EP,CN,US);
A61K31/405 (EP,CN,US);
A61K31/421 (EP,CN,US);
A61K31/427 (EP,US);
A61K31/517 (EP,US);
A61K45/06 (US);
A61P19/00 (EP);
A61P19/02 (EP);
A61P19/08 (EP);
A61P29/00 (EP);
A61P35/00 (EP);
A61P43/00 (EP);
C12Q1/6876 (US);
|
Former IPC [2015/06] | A61K45/00, A61K31/38, A61P35/00, G01N33/15, G01N33/50, G01N33/52 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/06] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | MITTEL ZUR PRÄVENTION ODER BEHANDLUNG VON RIESENZELLENTUMOREN ODER CHONDROSARKOMEN IN KNOCHEN UND WEICHEM GEWEBE | [2015/06] | English: | AGENT FOR PREVENTING OR TREATING GIANT CELL TUMOR OR CHONDROSARCOMA ARISING IN BONE/SOFT TISSUE | [2015/06] | French: | AGENT POUR PRÉVENIR OU TRAITER UNE TUMEUR DE CELLULE GÉANTE OU UN CHONDROSARCOME SURVENANT DANS UN OS/TISSU MOU | [2015/06] | Entry into regional phase | 20.10.2014 | Translation filed | 20.10.2014 | National basic fee paid | 20.10.2014 | Search fee paid | 20.10.2014 | Designation fee(s) paid | 20.10.2014 | Examination fee paid | Examination procedure | 20.10.2014 | Examination requested [2015/06] | 03.06.2016 | Amendment by applicant (claims and/or description) | 15.09.2017 | Despatch of a communication from the examining division (Time limit: M04) | 24.01.2018 | Reply to a communication from the examining division | 17.12.2018 | Despatch of a communication from the examining division (Time limit: M04) | 23.04.2019 | Reply to a communication from the examining division | 18.02.2020 | Communication of intention to grant the patent | 08.06.2020 | Fee for grant paid | 08.06.2020 | Fee for publishing/printing paid | 08.06.2020 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 15.09.2017 | Opposition(s) | 16.04.2021 | No opposition filed within time limit [2021/25] | Fees paid | Renewal fee | 10.03.2015 | Renewal fee patent year 03 | 10.03.2016 | Renewal fee patent year 04 | 10.03.2017 | Renewal fee patent year 05 | 13.03.2018 | Renewal fee patent year 06 | 13.03.2019 | Renewal fee patent year 07 | 12.03.2020 | Renewal fee patent year 08 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 18.03.2013 | AL | 15.07.2020 | AT | 15.07.2020 | CY | 15.07.2020 | CZ | 15.07.2020 | DK | 15.07.2020 | EE | 15.07.2020 | ES | 15.07.2020 | FI | 15.07.2020 | HR | 15.07.2020 | IT | 15.07.2020 | LT | 15.07.2020 | LV | 15.07.2020 | MC | 15.07.2020 | MK | 15.07.2020 | NL | 15.07.2020 | PL | 15.07.2020 | RO | 15.07.2020 | RS | 15.07.2020 | SE | 15.07.2020 | SI | 15.07.2020 | SK | 15.07.2020 | SM | 15.07.2020 | BG | 15.10.2020 | NO | 15.10.2020 | GR | 16.10.2020 | IS | 15.11.2020 | PT | 16.11.2020 | IE | 18.03.2021 | LU | 18.03.2021 | BE | 31.03.2021 | CH | 31.03.2021 | LI | 31.03.2021 | [2024/22] |
Former [2023/30] | HU | 18.03.2013 | |
AL | 15.07.2020 | ||
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CY | 15.07.2020 | ||
CZ | 15.07.2020 | ||
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EE | 15.07.2020 | ||
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BG | 15.10.2020 | ||
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GR | 16.10.2020 | ||
IS | 15.11.2020 | ||
PT | 16.11.2020 | ||
IE | 18.03.2021 | ||
LU | 18.03.2021 | ||
BE | 31.03.2021 | ||
CH | 31.03.2021 | ||
LI | 31.03.2021 | ||
Former [2023/27] | HU | 18.03.2013 | |
AL | 15.07.2020 | ||
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CZ | 15.07.2020 | ||
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EE | 15.07.2020 | ||
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BG | 15.10.2020 | ||
NO | 15.10.2020 | ||
GR | 16.10.2020 | ||
IS | 15.11.2020 | ||
PT | 16.11.2020 | ||
IE | 18.03.2021 | ||
LU | 18.03.2021 | ||
BE | 31.03.2021 | ||
CH | 31.03.2021 | ||
LI | 31.03.2021 | ||
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SM | 15.07.2020 | ||
BG | 15.10.2020 | ||
NO | 15.10.2020 | ||
GR | 16.10.2020 | ||
IS | 15.11.2020 | ||
PT | 16.11.2020 | ||
IE | 18.03.2021 | ||
LU | 18.03.2021 | ||
BE | 31.03.2021 | ||
CH | 31.03.2021 | ||
LI | 31.03.2021 | ||
Former [2022/11] | AL | 15.07.2020 | |
AT | 15.07.2020 | ||
CZ | 15.07.2020 | ||
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MC | 15.07.2020 | ||
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RO | 15.07.2020 | ||
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SK | 15.07.2020 | ||
SM | 15.07.2020 | ||
BG | 15.10.2020 | ||
NO | 15.10.2020 | ||
GR | 16.10.2020 | ||
IS | 15.11.2020 | ||
PT | 16.11.2020 | ||
IE | 18.03.2021 | ||
LU | 18.03.2021 | ||
CH | 31.03.2021 | ||
LI | 31.03.2021 | ||
Former [2022/09] | AL | 15.07.2020 | |
AT | 15.07.2020 | ||
CZ | 15.07.2020 | ||
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BG | 15.10.2020 | ||
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GR | 16.10.2020 | ||
IS | 15.11.2020 | ||
PT | 16.11.2020 | ||
IE | 18.03.2021 | ||
LU | 18.03.2021 | ||
Former [2022/07] | AL | 15.07.2020 | |
AT | 15.07.2020 | ||
CZ | 15.07.2020 | ||
DK | 15.07.2020 | ||
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GR | 16.10.2020 | ||
IS | 15.11.2020 | ||
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IE | 18.03.2021 | ||
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SM | 15.07.2020 | ||
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GR | 16.10.2020 | ||
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SM | 15.07.2020 | ||
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GR | 16.10.2020 | ||
IS | 15.11.2020 | ||
PT | 16.11.2020 | ||
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RO | 15.07.2020 | ||
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NO | 15.10.2020 | ||
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IS | 15.11.2020 | ||
PT | 16.11.2020 | ||
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NO | 15.10.2020 | ||
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IS | 15.11.2020 | ||
PT | 16.11.2020 | ||
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CZ | 15.07.2020 | ||
DK | 15.07.2020 | ||
EE | 15.07.2020 | ||
ES | 15.07.2020 | ||
FI | 15.07.2020 | ||
HR | 15.07.2020 | ||
IT | 15.07.2020 | ||
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NL | 15.07.2020 | ||
PL | 15.07.2020 | ||
RO | 15.07.2020 | ||
RS | 15.07.2020 | ||
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GR | 16.10.2020 | ||
IS | 15.11.2020 | ||
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FI | 15.07.2020 | ||
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NO | 15.10.2020 | ||
GR | 16.10.2020 | ||
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NO | 15.10.2020 | ||
GR | 16.10.2020 | ||
IS | 15.11.2020 | ||
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NO | 15.10.2020 | ||
GR | 16.10.2020 | ||
IS | 15.11.2020 | ||
PT | 16.11.2020 | ||
Former [2021/09] | AT | 15.07.2020 | |
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FI | 15.07.2020 | ||
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BG | 15.10.2020 | ||
NO | 15.10.2020 | ||
GR | 16.10.2020 | ||
PT | 16.11.2020 | ||
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NO | 15.10.2020 | Documents cited: | Search | [A]WO2008026729 (UNIV CHIBA NAT UNIV CORP [JP], et al) [A] 1-14 * the whole document *; | [XI] - K. NISHIDA ET AL, "Chondrosarcoma and Peroxisome Proliferator-Activated Receptor", PPAR RESEARCH, US, (20080101), vol. 274, no. 24, doi:10.1200/JCO.2005.02.766, ISSN 1687-4757, pages 17088 - 7, XP055223868 [X] 1,3-5,7,9,11,13 * page 2, column r, paragraph 2 * * page 4, column r, paragraph 1 * * abstract * [I] 1-14 DOI: http://dx.doi.org/10.1155/2008/250568 | [X] - DE CHIARA ANNAROSARIA ET AL, "Multicentric giant cell tumor with viral-like inclusions associated with Paget's disease of bone: A case treated by steroid therapy", ONCOLOGY REPORTS, (199803), vol. 5, no. 2, ISSN 1021-335X, pages 317 - 320, XP009186928 [X] 1,2,4,7,8,11,12 * page 319, column l, paragraph 1 * DOI: http://dx.doi.org/10.3892/or.5.2.317 | [T] - R. YAMAZAKI ET AL, "Nonsteroidal Anti-Inflammatory Drugs Induce Apoptosis in Association with Activation of Peroxisome Proliferator-Activated Receptor gamma in Rheumatoid Synovial Cells", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, US, (20020701), vol. 302, no. 1, doi:10.1124/jpet.302.1.18, ISSN 0022-3565, pages 18 - 25, XP055224151 DOI: http://dx.doi.org/10.1124/jpet.302.1.18 | International search | [X]JP2005200419 (NAT HEALTH RESEARCH INSTITUTES); | [X]JP2005343802 (SAKAYAMA NORIFUMI); | [X]JP2006501136 (PHARMACIA CORP.); | [X]JP2009533467 (SMITHKLINE BEECHAM CORP.); | [X] - AKIHIKO TAKEUCHI ET AL., "Kotsukyo Saiboshu ni Taisuru PPARy (peroxisome proliferator- activated receptor y) Kasseika ni yoru Ko-Shuyo Koka", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, (20120825), vol. 86, no. 8, page S1319, XP008174894 | [X] - NISHIDA, K. ET AL., "Inhibition of human chondrosarcoma cell growth via apoptosis by peroxisome proliferator-activated receptor- gamma", BR J CANCER, (2002), vol. 86, no. 8, pages 1303 - 9, XP055168739 DOI: http://dx.doi.org/10.1038/sj/bjc/6600241 | [X] - VAISH, V. ET AL., "The role of NF-KB and PPARy in experimentally induced colorectal cancer and chemoprevention by cyclooxygenase-2 inhibitors", TUMOR BIOL, (2010), vol. 31, no. 5, pages 427 - 36, XP055168743 DOI: http://dx.doi.org/10.1007/s13277-010-0051-7 | [X] - LIU, Y. ET AL., "Growth inhibition and differentiation induced by peroxisome proliferator activated receptor gamma ligand rosiglitazone in human melanoma cell line A375", MED ONCOL, (2006), vol. 23, no. 3, pages 393 - 402, XP055168750 DOI: http://dx.doi.org/10.1385/MO:23:3:393 | [X] - XIE, K. H. ET AL., "Rosiglitazone and ATRA on gastric cancer SGC7901 cell line proliferation in vitro", ZHONGGUO YISHI ZAZHI, (2010), vol. 12, no. 6, pages 743 - 7, XP008174893 | by applicant | WO2008026729 | - JPN. J. CANCER RES., (1999), vol. 90, pages 75 - 80 | - FEBS LETT., (1999), vol. 455, pages 135 - 139 | - BIOCHEM. PHARMACOL., (2011), vol. 82, pages 464 - 475 | - CANCER LETT., (2010), vol. 297, pages 65 - 74 | - MOL. PHARMACOL., (2007), vol. 72, pages 674 - 685 | - J. PHARMACOL. EXP. THER., (2002), vol. 302, pages 18 - 25 | - Molecular Cloning | - EXP. OPIN. THER. PATENTS, (1996), vol. 6, no. 5, pages 441 - 456 | - Methods in ENZYMOLOGY, vol. 70 | - METHODS IN ENZYMOLOGY, vol. 73 | - METHODS IN ENZYMOLOGY, vol. 74 | - Immunochemical Techniques (Part D: Selected Immunoassays, vol. 84 | - Immunochemical Techniques (Part E: Monoclonal Antibodies and General Immunoassay Methods, vol. 92 | - METHODS IN ENZYMOLOGY, ACADEMIC PRESS, vol. 121 | - HENCH ET AL., BIOMED. MASTER. SYMP., (1972), vol. 2, page 117 | - AOKI ET AL., CERAMICS, (1975), vol. 10, page 469 | - BULL. INST. CHEM. RES. KYOTOUNI., (1982), vol. 60, page 260 |