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Extract from the Register of European Patents

EP About this file: EP2844347

EP2844347 - COMPOSITIONS AND METHODS FOR TREATING B-LYMPHOID MALIGNANCIES [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  25.09.2020
Database last updated on 25.09.2024
FormerExamination is in progress
Status updated on  15.03.2019
Most recent event   Tooltip25.09.2020Application deemed to be withdrawnpublished on 28.10.2020  [2020/44]
Applicant(s)For all designated states
The Children's Hospital of Philadelphia
34th Street & Civic Center Boulevard
Philadelphia, PA 19104 / US
For all designated states
Trustees of the University of Pennsylvania
3160 Chestnut Street, Suite 200
Philadelphia, PA 19104 / US
[N/P]
Former [2015/11]For all designated states
The Children's Hospital of Philadelphia
34th Street & Civic Center Boulevard
Philadelphia, PA 19104 / US
For all designated states
Trustees Of The University Of Pennsylvania
3160 Chestnut Street, Suite 200
Philadelphia, PA 19104 / US
Inventor(s)01 / THOMAS-TIKHONENKO, Andrei
2007 Pine Street
Philadelphia, PA 19103 / US
02 / CHUNG, Elaine
206 S. 13th Street
1503
Philadelphia, PA 19107 / US
03 / PSATHAS, James
130 Wilson Avenue
Glenside, PA 19038 / US
 [2015/11]
Representative(s)Schneiter, Sorin, et al
Omnis IP SA
Avenue de Riond-Bosson 3
1110 Morges / CH
[N/P]
Former [2015/11]Schneiter, Sorin
Schneiter & Vuille
Chemin de Champ-Colomb 7B
1024 Ecublens / CH
Application number, filing date13784350.401.05.2013
WO2013US39067
Priority number, dateUS201261640987P01.05.2012         Original published format: US 201261640987 P
[2015/11]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013166150
Date:07.11.2013
Language:EN
[2013/45]
Type: A1 Application with search report 
No.:EP2844347
Date:11.03.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 07.11.2013 takes the place of the publication of the European patent application.
[2015/11]
Search report(s)International search report - published on:US07.11.2013
(Supplementary) European search report - dispatched on:EP26.02.2016
ClassificationIPC:A61P35/02, C12Q1/48, G01N33/50
[2016/13]
CPC:
G01N33/5011 (EP,US); G01N33/573 (EP,KR,US); A61K39/39533 (KR);
A61P35/00 (EP); A61P35/02 (EP); C12Q1/485 (EP,US);
C12Y207/01137 (KR); G01N33/5052 (EP,US); A61K38/00 (EP,US);
G01N2333/70596 (EP,KR,US); G01N2333/91215 (EP,KR,US); G01N2500/02 (US);
G01N2500/10 (EP,KR,US) (-)
Former IPC [2015/11]A61P35/02
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/11]
TitleGerman:ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON B-LYMPHOIDEN MALIGNOMEN[2015/11]
English:COMPOSITIONS AND METHODS FOR TREATING B-LYMPHOID MALIGNANCIES[2015/11]
French:COMPOSITIONS ET PROCÉDÉS POUR TRAITER DES TUMEURS MALIGNES B-LYMPHOÏDES[2015/11]
Entry into regional phase24.11.2014National basic fee paid 
24.11.2014Search fee paid 
24.11.2014Designation fee(s) paid 
24.11.2014Examination fee paid 
Examination procedure24.11.2014Examination requested  [2015/11]
26.09.2016Amendment by applicant (claims and/or description)
19.03.2019Despatch of a communication from the examining division (Time limit: M06)
27.09.2019Reply to a communication from the examining division
16.10.2019Despatch of a communication from the examining division (Time limit: M06)
03.06.2020Application deemed to be withdrawn, date of legal effect  [2020/44]
24.06.2020Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2020/44]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  19.03.2019
Fees paidRenewal fee
29.05.2015Renewal fee patent year 03
10.05.2016Renewal fee patent year 04
10.05.2017Renewal fee patent year 05
11.05.2018Renewal fee patent year 06
15.05.2019Renewal fee patent year 07
31.03.2020Renewal fee patent year 08
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[XYI]US2012082664  (BERNETT MATTHEW J [US], et al) [X] 1-4 * cited in the ISR * * abstract * * paragraph [0128] * * paragraphs [0254] - [0256] * [Y] 5 [I] 6;
 [XYI]  - AWAN FARRUKH T ET AL, CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody, BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, PAGE(S) 1204 - 1213, (20100201), ISSN 0006-4971, XP009143421 [X] 1-4 * abstract * [Y] 5 [I] 6

DOI:   http://dx.doi.org/10.1182/blood-2009-06-229039
 [Y]  - NOBUKO ISHIURA ET AL, "Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation", EUROPEAN JOURNAL OF IMMUNOLOGY, DE, (20100425), vol. 40, no. 4, doi:10.1002/eji.200939848, ISSN 0014-2980, pages 1192 - 1204, XP055241634 [Y] 5 * the whole document *

DOI:   http://dx.doi.org/10.1002/eji.200939848
 [Y]  - SO L ET AL, "PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances", BIOCHEMICAL JOURNAL, GB, (20120315), vol. 442, no. 3, doi:10.1042/BJ20112092, ISSN 0264-6021, pages 465 - 481, XP055095314 [Y] 7-11 * cited in the ISR * * abstract * * page 469, column 2 - page 470, column 1 * * figures 1-2 *

DOI:   http://dx.doi.org/10.1042/BJ20112092
 [Y]  - LANNUTTI BRIAN J ET AL, "CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, UNITED STATES, vol. 117, no. 2, doi:10.1182/BLOOD-2010-03-275305, ISSN 1528-0020, (20110113), pages 591 - 594, URL: http://www.bloodjournal.org/, XP008152256 [Y] 7-11 * cited in the ISR * * abstract *

DOI:   http://dx.doi.org/10.1182/blood-2010-03-275305
 [Y]  - M Beckwith ET AL, "The protein product of the proto-oncogene c-cbl forms a complex with phosphatidylinositol 3-kinase p85 and CD19 in anti-IgM-stimulated human B-lymphoma cells", Blood, UNITED STATES, (19961101), page 3502, URL: http://www.bloodjournal.org/content/88/9/3502.full.pdf, (20160215), XP055250165 [Y] 7-11 * the whole document *
 [IP]  - ELAINE Y. CHUNG ET AL, "CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis", JOURNAL OF CLINICAL INVESTIGATION, US, (20120501), vol. 122, no. 6, doi:10.1172/JCI45851, ISSN 0021-9738, pages 2257 - 2266, XP055250174 [IP] 1-11 * the whole document * * page 2263, column 2, paragraph 1 - page 2264, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1172/JCI45851
International search[Y]US2012082664  (BERNETT MATTHEW J [US], et al);
 [X]  - SO L. ET AL., "PI3K Signaling in B and T Lymphocytes: New Developments and Therapeutic Advances", BIOCHEMISTRY JOURNAL, (20120315), vol. 442, no. 3, pages 465 - 481 (1-37), XP055095314

DOI:   http://dx.doi.org/10.1042/BJ20112092
 [Y]  - OTERO ET AL., "Cd19-dependent activation of Akt kinase in B-lymphocytes", J BIOL CHEM., (20010112), vol. 276, no. 2, pages 1474 - 1478, XP055171335

DOI:   http://dx.doi.org/10.1074/jbc.M003918200
 [Y]  - LANNUTTI ET AL., "CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability", BLOOD, (20110113), vol. 117, no. 2, pages 591 - 594, XP008152256

DOI:   http://dx.doi.org/10.1182/blood-2010-03-275305
 [Y]  - ENGEL ET AL., "Abnormal B Lymphocyte Deleveopment, Activation, and Differentiation in Mice that Lack or Overexpress the CD19 Signal Transduction Molecule", IMMUNITY, (199507), vol. 3, pages 39 - 50, XP055171337
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.