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Extract from the Register of European Patents

EP About this file: EP2854826

EP2854826 - LACTOBACILLUS REUTERI ATCC PTA 6475 FOR USE IN PREVENTION OR TREATMENT OF BONE LOSS IN MAMMALS [Right-click to bookmark this link]
Former [2015/15]SELECTION AND USE OF LACTIC ACID BACTERIA PREVENTING BONE LOSS IN MAMMALS
[2018/26]
StatusNo opposition filed within time limit
Status updated on  20.09.2019
Database last updated on 18.11.2024
FormerThe patent has been granted
Status updated on  12.10.2018
FormerGrant of patent is intended
Status updated on  17.06.2018
FormerExamination is in progress
Status updated on  09.02.2018
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
BIOGAIA AB
Box 3242
103 64 Stockholm / SE
For all designated states
Michigan State University
325 E. Grand River
Suite 350
East Lansing, Michigan 48823 / US
[2015/15]
Inventor(s)01 / CONNOLLY, Eamonn
Motionsvägen 3
S-181 29 Lidingö / SE
02 / BRITTON, Robert Allen
2807 Ridge Falls Drive
Manvel, TX 77578 / US
03 / MCCABE, Laura Rae
1330 Orlando Drive
Haslett, Michigan 48840 / US
 [2015/32]
Former [2015/15]01 / CONNOLLY, Eamonn
Motionsvägen 3
S-181 29 Lidingö / SE
02 / BRITTON, Robert Allen
1209 Blanchette Drive
East Lansing, Michigan 48823 / US
03 / MCCABE, Laura Rae
1330 Orlando Drive
Haslett, Michigan 48840 / US
Representative(s)Brann AB
P.O. Box 3690
Sveavägen 63
103 59 Stockholm / SE
[N/P]
Former [2018/46]Brann AB
P.O. Box 3690
Drottninggatan 27
103 59 Stockholm / SE
Former [2015/15]Brann AB
P.O. Box 12246
102 26 Stockholm / SE
Application number, filing date13800449.404.06.2013
[2018/46]
WO2013SE50646
Priority number, dateUS201261689338P04.06.2012         Original published format: US 201261689338 P
[2015/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013184064
Date:12.12.2013
Language:EN
[2013/50]
Type: A1 Application with search report 
No.:EP2854826
Date:08.04.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 12.12.2013 takes the place of the publication of the European patent application.
[2015/15]
Type: B1 Patent specification 
No.:EP2854826
Date:14.11.2018
Language:EN
[2018/46]
Type: B9 Corrected patent specification 
No.:EP2854826
Date:08.05.2019
[2019/19]
Search report(s)International search report - published on:SE12.12.2013
(Supplementary) European search report - dispatched on:EP07.06.2016
ClassificationIPC:A61K35/747, A61P19/08, A23L33/135
[2018/26]
CPC:
A61K35/747 (EP,KR,US); A23L33/135 (EP,KR,US); A61K31/59 (EP,US);
A61P19/00 (EP); A61P19/08 (EP); A61P19/10 (EP);
C12N1/20 (US); C12Q1/689 (US); A23V2002/00 (EP,US);
A61K2035/11 (US); C12Q2600/156 (US); C12Q2600/16 (US);
C12R2001/225 (KR) (-)
C-Set:
A23V2002/00, A23V2200/306, A23V2400/11, A23V2400/173 (EP,US)
Former IPC [2016/27]A61K35/74, A61P19/08, C12Q1/68, A23L33/135
Former IPC [2015/15]A61K35/74, A23L1/30, A61P19/08
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/15]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:LACTOBACILLUS REUTERI ATCC PTA 6475 ZUR VERWENDUNG BEI VORBEUGUNG ODER BEHANDLUNG VON KNOCHENABBAU BEI SÄUGETIEREN[2018/26]
English:LACTOBACILLUS REUTERI ATCC PTA 6475 FOR USE IN PREVENTION OR TREATMENT OF BONE LOSS IN MAMMALS[2018/26]
French:LACTOBACILLUS REUTERI ATCC PTA 6475 ET SON UTILISATION DANS LA PREVENTION OU LE TRAITEMENT DE LA PERTE OSSEUSE CHEZ DES MAMMIFÈRES[2018/26]
Former [2015/15]AUSWAHL UND VERWENDUNG VON MILCHSÄUREBAKTERIEN ZUR VORBEUGUNG VON KNOCHENABBAU BEI SÄUGETIEREN
Former [2015/15]SELECTION AND USE OF LACTIC ACID BACTERIA PREVENTING BONE LOSS IN MAMMALS
Former [2015/15]SÉLECTION ET UTILISATION DE BACTÉRIES LACTIQUES PRÉVENANT LA PERTE OSSEUSE CHEZ DES MAMMIFÈRES
Biological materialThis application mentions deposited biological material, check the file for details
Entry into regional phase19.12.2014National basic fee paid 
19.12.2014Search fee paid 
19.12.2014Designation fee(s) paid 
19.12.2014Examination fee paid 
Examination procedure19.12.2014Examination requested  [2015/15]
22.12.2016Amendment by applicant (claims and/or description)
08.02.2018Despatch of a communication from the examining division (Time limit: M04)
20.03.2018Reply to a communication from the examining division
18.06.2018Communication of intention to grant the patent
02.10.2018Fee for grant paid
02.10.2018Fee for publishing/printing paid
02.10.2018Receipt of the translation of the claim(s)
Divisional application(s)EP18202594.0  / EP3456334
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  08.02.2018
Opposition(s)15.08.2019No opposition filed within time limit [2019/43]
Fees paidRenewal fee
12.06.2015Renewal fee patent year 03
20.06.2016Renewal fee patent year 04
29.06.2017Renewal fee patent year 05
20.06.2018Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL14.11.2018
AT14.11.2018
CY14.11.2018
EE14.11.2018
MC14.11.2018
MK14.11.2018
MT14.11.2018
RO14.11.2018
RS14.11.2018
SM14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
LU04.06.2019
[2022/31]
Former [2021/34]AL14.11.2018
AT14.11.2018
CY14.11.2018
EE14.11.2018
MC14.11.2018
MT14.11.2018
RO14.11.2018
RS14.11.2018
SM14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
LU04.06.2019
Former [2021/26]AL14.11.2018
AT14.11.2018
CY14.11.2018
EE14.11.2018
MC14.11.2018
RO14.11.2018
RS14.11.2018
SM14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
LU04.06.2019
Former [2020/27]AL14.11.2018
AT14.11.2018
EE14.11.2018
MC14.11.2018
RO14.11.2018
RS14.11.2018
SM14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
LU04.06.2019
Former [2020/08]AL14.11.2018
AT14.11.2018
EE14.11.2018
MC14.11.2018
RO14.11.2018
RS14.11.2018
SM14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/37]AL14.11.2018
AT14.11.2018
EE14.11.2018
RO14.11.2018
RS14.11.2018
SM14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/26]AL14.11.2018
AT14.11.2018
RS14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
PT14.03.2019
Former [2019/25]AT14.11.2018
RS14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
Former [2019/24]AT14.11.2018
BG14.02.2019
GR15.02.2019
IS14.03.2019
Former [2019/23]AT14.11.2018
BG14.02.2019
IS14.03.2019
Former [2019/22]BG14.02.2019
IS14.03.2019
Former [2019/21]IS14.03.2019
Documents cited:Search[Y]US2008254011  (ROTHSCHILD PETER [SE], et al) [Y] 1-14 * the whole document *;
 [Y]  - BRENDAN E BOYCE ET AL, "TNF.ALPHA. and pathologic bone resorption", KEIO JOURNAL OF MEDICINE., JP, (20050101), vol. 54, no. 3, doi:10.2302/kjm.54.127, ISSN 0022-9717, pages 127 - 131, XP055270832 [Y] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.2302/kjm.54.127
 [Y]  - SCHOLZ-AHRENS K E ET AL, "Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure", THE JOURNAL OF NUTRITION, AMERICAN SOCIETY FOR NUTRITION, US, (20070301), vol. 137, no. 3, Suppl. S, ISSN 0022-3166, pages 838S - 846S, XP002737535 [Y] 1-14 * the whole document *
 [Y]  - CHING-YI LAI ET AL, "Preventing Bone Loss and Weight Gain with Combinations of Vitamin D and Phytochemicals", JOURNAL OF MEDICINAL FOOD, (20111101), vol. 14, no. 11, doi:10.1089/jmf.2010.0232, ISSN 1096-620X, pages 1352 - 1362, XP055190442 [Y] 13 * the whole document *

DOI:   http://dx.doi.org/10.1089/jmf.2010.0232
 [A]  - IYER CHANDRA ET AL, "Probiotic Lactobacillus reuteri promotes TNF-induced apoptosis in human myeloid leukemia-derived cells by modulation of NF-kappaB and MAPK signalling.", CELLULAR MICROBIOLOGY JUL 2008, (200807), vol. 10, no. 7, ISSN 1462-5822, pages 1442 - 1452, XP002757502 [A] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1111/j.1462-5822.2008.01137.x
 [T]  - BRITTON ROBERT A ET AL, "Probiotic L. reuteri Treatment Prevents Bone Loss in a Menopausal Ovariectomized Mouse Model", JOURNAL OF CELLULAR PHYSIOLOGY, (201411), vol. 229, no. 11, pages 1822 - 1830, XP002757503

DOI:   http://dx.doi.org/10.1002/jcp.24636
International search[X]WO03105893  (ALIMENTARY HEALTH LTD [IE], et al);
 [X]WO2006110088  (BIOGAIA AB [SE]);
 [A]WO2008028300  (UNIV MCGILL [CA], et al);
 [X]EP1918373  (SCHOOL CORP AZABU VETERINARY M [JP]);
 [X]  - WALTER J. ET AL., "Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm", PNAS, (2011), vol. 108, pages 4645 - 4652, XP055179162

DOI:   http://dx.doi.org/10.1073/pnas.1000099107
 [X]  - REGISTRY, (20130910), Database accession no. 1268657-11-9, URL: STN, XP055185531
 [A]  - KIM J. G. ET AL., "Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats", INTERNATIONAL DAIRY JOURNAL, (2009), vol. 19, pages 690 - 695, XP026562825

DOI:   http://dx.doi.org/10.1016/j.idairyj.2009.06.009
 [XP]  - MCCABE L. R. ET AL., "Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice", JOURNAL OF CELLULAR PHYSIOLOGY, (20130418), vol. 228, pages 1793 - 1798, XP055179166

DOI:   http://dx.doi.org/10.1002/jcp.24340
 [L]  - MCCABE L. R., "Probiotics and bone health - Role of gender and intestinal health", NIH OFFICE OF DIETARY SUPPLEMENTS GRANT ABSTRACT, GRANT NUMBER: 1 R21 AT005472-01 A1, XP055179188
by applicant   - NARVA et al., Effects of bioactive peptide, valyl-prolyl-proline (VPP), and lactobacillus helveticus fermented milk containing VPP on bone loss in ovariectomized rats
    - NARVA et al., The effect of Lactobacillus helveticus fermented milk on acute changes in calcium metabolism in postmenopausal women
    - YEO et al., Angiotensin I-converting enzyme inhibitory activity and bioconversion of isoflavones by probiotics in soymilk supplemented with prebiotics
    - KIM et al., Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats
    - WALTER et al., "Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm", PNAS, vol. 108, doi:doi:10.1073/pnas.1000099107, pages 4645 - 4652, XP055179162

DOI:   http://dx.doi.org/10.1073/pnas.1000099107
    - "GenBank", Database accession no. AP007281
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.