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Extract from the Register of European Patents

EP About this file: EP2865390

EP2865390 - MUCOSAL IMMUNITY-STIMULATING AGENT, AND ORAL PHARMACEUTICAL COMPOSITION FOR TREATING HPV INFECTION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.07.2020
Database last updated on 20.12.2024
FormerThe patent has been granted
Status updated on  19.07.2019
FormerGrant of patent is intended
Status updated on  17.03.2019
FormerExamination is in progress
Status updated on  28.09.2018
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK
published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
The University of Tokyo
3-1, Hongo 7-chome
Bunkyo-ku
Tokyo 113-8654 / JP
[2015/18]
Inventor(s)01 / KAWANA, Kei
c/o The University of Tokyo
3-1
Hongo 7-chome
Bunkyo-ku
Tokyo 113-8654 / JP
02 / TAGUCHI, Ayumi
c/o The University of Tokyo
3-1 Hongo 7-chome
Bunkyo-ku
Tokyo 113-8654 / JP
 [2016/03]
Former [2015/18]01 / KAWANA, Kei
c/o The University of Tokyo
3-1
Hongo 7-chome
Bunkyo-ku
Tokyo 113-8654 / JP
02 / TAGUCHI, Ayumi
c/o The University of Tokyo
3-1
Hongo 7-chome
Bunkyo-ku
Tokyo 113-8654 / JP
Representative(s)Graf von Stosch, Andreas, et al
Graf von Stosch
Patentanwaltsgesellschaft mbH
Prinzregentenstraße 22
80538 München / DE
[2019/34]
Former [2015/18]Graf von Stosch, Andreas, et al
Graf von Stosch Patentanwaltsgesellschaft mbH Prinzregentenstrasse 22
80538 München / DE
Application number, filing date13806404.319.06.2013
[2019/34]
WO2013JP66893
Priority number, dateJP2012013894320.06.2012         Original published format: JP 2012138943
[2015/18]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013191225
Date:27.12.2013
Language:JA
[2013/52]
Type: A1 Application with search report 
No.:EP2865390
Date:29.04.2015
Language:EN
[2015/18]
Type: B1 Patent specification 
No.:EP2865390
Date:21.08.2019
Language:EN
[2019/34]
Search report(s)International search report - published on:JP27.12.2013
(Supplementary) European search report - dispatched on:EP04.03.2016
ClassificationIPC:A61K45/00, A61K35/74, A61K36/25, A61K38/00, A61K39/12, A61K39/39, A61P35/00, A61P37/04, C07K14/01, C12N1/20, C12N1/21, C12N15/09
[2015/18]
CPC:
A61K39/12 (EP,KR,US); A61K39/39 (EP,KR,US); A61K35/747 (KR);
A61K36/25 (KR); A61K38/16 (KR); A61K45/06 (EP,US);
A61K9/006 (EP,US); A61P15/00 (EP); A61P31/20 (EP);
A61P31/22 (KR); A61P35/00 (EP); A61P37/04 (EP);
C07K14/025 (EP,US); C07K14/235 (EP,US); C07K14/245 (EP,US);
C07K14/28 (EP,US); C07K14/335 (KR); C07K14/34 (EP,US);
C12N7/00 (US); A61K2039/541 (EP,US); A61K2039/542 (EP,KR,US);
A61K2039/55511 (EP,US); A61K2039/55594 (EP,US); A61K38/00 (EP,US);
C12N2710/20022 (EP,US); C12N2710/20034 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/18]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:MUKOSALES IMMUNITÄTSSTIMULIERENDES MITTEL UND ORALE PHARMAZEUTISCHE ZUSAMMENSETZUNG ZUR BEHANDLUNG VON HPV-INFEKTIONEN[2015/18]
English:MUCOSAL IMMUNITY-STIMULATING AGENT, AND ORAL PHARMACEUTICAL COMPOSITION FOR TREATING HPV INFECTION[2015/18]
French:AGENT DE STIMULATION DE L'IMMUNITÉ MUQUEUSE ET COMPOSITION PHARMACEUTIQUE ORALE PERMETTANT DE TRAITER UNE INFECTION PAR LE VPH[2015/18]
Entry into regional phase15.01.2015Translation filed 
15.01.2015National basic fee paid 
15.01.2015Search fee paid 
15.01.2015Designation fee(s) paid 
15.01.2015Examination fee paid 
Examination procedure15.01.2015Examination requested  [2015/18]
11.08.2016Amendment by applicant (claims and/or description)
26.09.2018Despatch of a communication from the examining division (Time limit: M04)
21.01.2019Reply to a communication from the examining division
18.03.2019Communication of intention to grant the patent
12.07.2019Fee for grant paid
12.07.2019Fee for publishing/printing paid
12.07.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  26.09.2018
Opposition(s)03.06.2020No opposition filed within time limit [2020/32]
Fees paidRenewal fee
22.06.2015Renewal fee patent year 03
06.06.2016Renewal fee patent year 04
22.05.2017Renewal fee patent year 05
22.06.2018Renewal fee patent year 06
26.04.2019Renewal fee patent year 07
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU19.06.2013
AL21.08.2019
AT21.08.2019
CY21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
IT21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
MK21.08.2019
MT21.08.2019
NL21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SI21.08.2019
SK21.08.2019
SM21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
[2022/32]
Former [2022/27]HU19.06.2013
AL21.08.2019
AT21.08.2019
CY21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
IT21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
MT21.08.2019
NL21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SI21.08.2019
SK21.08.2019
SM21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2021/12]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
IT21.08.2019
LT21.08.2019
LV21.08.2019
MC21.08.2019
NL21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SI21.08.2019
SK21.08.2019
SM21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/37]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
IT21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SI21.08.2019
SK21.08.2019
SM21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/36]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
IT21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SK21.08.2019
SM21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/27]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
IT21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SK21.08.2019
SM21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
PT23.12.2019
IS24.02.2020
Former [2020/25]AL21.08.2019
AT21.08.2019
CZ21.08.2019
DK21.08.2019
EE21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
IT21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
SK21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
PT23.12.2019
IS24.02.2020
Former [2020/24]AL21.08.2019
AT21.08.2019
DK21.08.2019
EE21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
IT21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
PT23.12.2019
IS24.02.2020
Former [2020/23]AL21.08.2019
AT21.08.2019
DK21.08.2019
EE21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
IT21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
PL21.08.2019
RO21.08.2019
RS21.08.2019
SE21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/22]AL21.08.2019
DK21.08.2019
EE21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
RS21.08.2019
SE21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/17]AL21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
RS21.08.2019
SE21.08.2019
TR21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/15]AL21.08.2019
ES21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
RS21.08.2019
SE21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/12]ES21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
RS21.08.2019
SE21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
IS21.12.2019
PT23.12.2019
Former [2020/11]ES21.08.2019
FI21.08.2019
HR21.08.2019
LT21.08.2019
LV21.08.2019
NL21.08.2019
RS21.08.2019
SE21.08.2019
BG21.11.2019
NO21.11.2019
GR22.11.2019
PT23.12.2019
Former [2020/10]FI21.08.2019
LT21.08.2019
NL21.08.2019
SE21.08.2019
BG21.11.2019
NO21.11.2019
PT23.12.2019
Former [2020/09]FI21.08.2019
LT21.08.2019
NL21.08.2019
NO21.11.2019
Former [2020/08]LT21.08.2019
NO21.11.2019
Documents cited:Search[Y]WO2005000348  (ISIS INNOVATION [GB], et al) [Y] 1-15 * page 6, line 21 - page 7, line 17; example -; claim - * * page 33, line 35 - page 34, line 35 *;
 [IY]  - MATSUMOTO T1 ET AL, "Hochuekkito, a Kampo (traditional Japanese herbal) Medicine, Enhances Mucosal IgA Antibody Response in Mice Immunized with Antigen-entrapped Biodegradable Microparticles", EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE : ECAM, HINDAWI PUBLISHING CORPORATION, UNITED STATES, (20071029), vol. 7, no. 1, doi:10.1093/ECAM/NEM166, ISSN 1741-427X, pages 69 - 77, XP008175992 [I] 1 * abstract * * page 71, column r, paragraph 2 * * page 73, column r * [Y] 2-15

DOI:   http://dx.doi.org/10.1093/ecam/nem166
 [Y]  - KATSUYUKI ADACHI ET AL, "Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7", VACCINE, (20100401), vol. 28, no. 16, doi:10.1016/j.vaccine.2010.02.005, ISSN 0264-410X, pages 2810 - 2817, XP055182241 [Y] 1-15 * abstract * * page 2815, column r, paragraph l *

DOI:   http://dx.doi.org/10.1016/j.vaccine.2010.02.005
 [Y]  - VANUSA P DA HORA ET AL, "Non-toxic derivatives of LT as potent adjuvants", VACCINE, ELSEVIER LTD, GB, vol. 29, no. 8, doi:10.1016/J.VACCINE.2010.11.091, ISSN 0264-410X, (20101130), pages 1538 - 1544, (20101206), XP028139969 [Y] 1-15 * abstract * * page 1540, column l, paragraph l - page 1541, column r, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/j.vaccine.2010.11.091
 [A]  - FREYTAG L C ET AL, "Mucosal adjuvants", VACCINE, ELSEVIER LTD, GB, vol. 23, no. 15, ISSN 0264-410X, (20050307), pages 1804 - 1813, (20050307), XP027652249 [A] 1-15 * page 1809, column l, paragraph 2 - paragraph l *
 [A]  - HARANDI ALI M ET AL, "Mucosal Adjuvants", CURRENT HIV RESEARCH, BENTHAM SCIENCE PUBLISHERS, HILVERSUM, NL, (20100601), vol. 8, no. 4, ISSN 1570-162X, pages 330 - 335, XP009185085 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.2174/157016210791208695
 [A]  - CHINO A ET AL, "Juzentaihoto, a Kampo medicine, enhances IL-12 production by modulating Toll-like receptor 4 signaling pathways in murine peritoneal exudate macrophages", INTERNATIONAL IMMUNOPHARMACOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 5, no. 5, ISSN 1567-5769, (20050501), pages 871 - 882, (20050501), XP027686239 [A] 1-15 * abstract *
 [A]  - MITA Y ET AL, "Surface expression of toll-like receptor 4 on THP-1 cells is modulated by Bu-Zhong-Yi-Qi-Tang and Shi-Quan-Da-Bu-Tang.", METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY MAR 2002, (200203), vol. 24, no. 2, ISSN 0379-0355, pages 67 - 70, XP009188623 [A] 1-15 * abstract *
 [A]  - JERRY WELLS, "Mucosal Vaccination and Therapy with Genetically Modified Lactic Acid Bacteria", ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, US, (20110410), vol. 2, no. 1, doi:10.1146/annurev-food-022510-133640, ISSN 1941-1413, pages 423 - 445, XP055250437 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1146/annurev-food-022510-133640
International search[Y]JP2001523729  (DUPHAR INTERNATIONAL RESEARCH B.V.);
 [Y]JP2005500336  (NEW YORK UNIVERSITY);
 [Y]  - MATSUMOTO T ET AL., "Hochuekkito, a Kampo (traditional Japanese herbal) Medicine, Enhances Mucosal IgA Antibody Response in Mice Immunized with Antigen-entrapped Biodegradable Microparticles.", EVID BASED COMPLEMENT ALTERNAT MED., (20071029), vol. 7, no. 1, pages 69 - 77, XP008175992

DOI:   http://dx.doi.org/10.1093/ecam/nem166
 [Y]  - KOICHIRO SAITO, "Koto Nyutoshusho", JOHNS, (20110901), vol. 27, no. 9, pages 1460 - 1462, XP008175909
 [Y]  - CYONG J ET AL., "Immunomodulatory action of Kampo tonics and its potential mode of action in aged mice, Journal of traditional medicines", (19990227), vol. 15, no. 5, pages 280 - 281, XP008175991
 [Y]  - NORITO TAKEMOTO ET AL., "Effect of TJ-48 on murine cellular immunity", JAPANESE JOURNAL OF INFLAMMATION, (1989), vol. 9, no. 1, pages 49 - 52, XP003034247

DOI:   http://dx.doi.org/10.2492/jsir1981.9.49
 [Y]  - MATSUMOTO T ET AL., "Orally administered Kampo (Japanese herbal) medicine, ''Juzen-Taiho- To'' modulates cytokine secretion in gut associated lymphoreticular tissues in mice.", PHYTOMEDICINE., (200001), vol. 6, no. 6, pages 425 - 430, XP055182238
 [Y]  - ADACHI K ET AL., "Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7.", VACCINE., (20100217), vol. 28, no. 16, pages 2810 - 2817, XP055182241

DOI:   http://dx.doi.org/10.1016/j.vaccine.2010.02.005
 [XP]  - TAGUCHI A ET AL., "Adjuvant effect of Japanese herbal medicines on the mucosal type 1 immune responses to human papillomavirus (HPV) E7 in mice immunized orally with Lactobacillus-based therapeutic HPV vaccine in a synergistic manner.", VACCINE., (20120621), vol. 30, no. 36, pages 5368 - 5372, XP028428427

DOI:   http://dx.doi.org/10.1016/j.vaccine.2012.06.027
by applicantWO9606627
 WO9842375
 WO9926654
 WO0037609
 WO0045841
 WO03078455
 WO2004028561
 JP2005097267
 JP2006070217
 WO2006100108
 WO2007018152
    - R. HOPFL ET AL., LANCET, (2000), vol. 356, pages 1985 - 1986
    - C. L. TRIMBLE; I. H. FRAZER, LANCET ONCOL., (2009), vol. 10, pages 975 - 980
    - H. POO ET AL., INT J. CANCER, (2006), vol. 119, pages 1702 - 1709
    - N. G. CORTESS-PEREZ ET AL., VACCINE, (2007), vol. 25, pages 6581 - 6588
    - K. ADACHI ET AL., VACCINE, (2010), vol. 28, pages 2810 - 2817
    - H. KIYOHARA ET AL., EVID. BASED COMPLEMENT. ALTERNAT. MED., (2006), vol. 3, pages 459 - 467
    - A. DALPKE ET AL., IMMUNOLOGY, (2001), vol. 204, pages 667 - 676
    - D. MIZUNO ET AL., VACCINE, (2011), vol. 29, pages 5368 - 5378
    - H. KAYAMURO ET AL., BIOMATERIALS, (2009), vol. 30, pages 5869 - 5876
    - H. FUJITA ET AL., J. IMMUNOL., (2009), vol. 183, pages 254 - 260
    - Y. MORISHIMA ET AL., EUR. J. IMMUNOL., (2005), vol. 35, pages 2803 - 2814
    - POO H. ET AL., INT. J. IMMUNOL., (2006), vol. 119, pages 1702 - 1709
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.