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Extract from the Register of European Patents

EP About this file: EP2931898

EP2931898 - ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  14.02.2020
Database last updated on 29.10.2024
FormerThe patent has been granted
Status updated on  06.10.2019
Most recent event   Tooltip14.02.2020Revocation of patentpublished on 18.03.2020  [2020/12]
Applicant(s)For all designated states
The Broad Institute, Inc.
415 Main Street
Cambridge, MA 02142 / US
For all designated states
Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge MA 02142 / US
For all designated states
President and Fellows of Harvard College
17 Quincy Street
Cambridge, MA 02138 / US
[2015/43]
Inventor(s)01 / ZHANG, Feng
100 Pacific Street
Apt. 11
Cambridge, MA 02139 / US
02 / CONG, Le
100 Memorial Drive
Apt. 8-21B, Cambridge
MA 02142 / US
03 / PLATT, Randall, Jeffrey
72 Sixth Street Apt. 1
Cambridge, MA 02141 / US
04 / RAN, Fei
30 Clarendon Street
Boston, MA 02116 / US
05 / SANJANA, Neville, Espi
2a Union Terrace
Cambridge, MA 02142 / US
 [2015/43]
Representative(s)De Clercq, Ann G. Y., et al
De Clercq & Partners Edgard Gevaertdreef 10a
9830 Sint-Martens-Latem / BE
[N/P]
Former [2015/43]Wright, Simon Mark, et al
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date13814368.012.12.2013
[2015/43]
WO2013US74736
Priority number, dateUS201261736527P12.12.2012         Original published format: US 201261736527 P
US201361748427P02.01.2013         Original published format: US 201361748427 P
US201361758468P30.01.2013         Original published format: US 201361758468 P
US201361769046P25.02.2013         Original published format: US 201361769046 P
US201361802174P15.03.2013         Original published format: US 201361802174 P
US201361791409P15.03.2013         Original published format: US 201361791409 P
US201361806375P28.03.2013         Original published format: US 201361806375 P
US201361814263P20.04.2013         Original published format: US 201361814263 P
US201361819803P06.05.2013         Original published format: US 201361819803 P
US201361828130P28.05.2013         Original published format: US 201361828130 P
US201361835931P17.06.2013         Original published format: US 201361835931 P
US201361835936P17.06.2013         Original published format: US 201361835936 P
[2015/43]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2014093655
Date:19.06.2014
Language:EN
[2014/25]
Type: A2 Application without search report 
No.:EP2931898
Date:21.10.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 19.06.2014 takes the place of the publication of the European patent application.
[2015/43]
Type: B1 Patent specification 
No.:EP2931898
Date:09.03.2016
Language:EN
[2016/10]
Search report(s)International search report - published on:EP31.07.2014
ClassificationIPC:C12N15/63
[2015/43]
CPC:
C12N15/63 (EP,US); C12N15/01 (US); C12N15/102 (EP,US);
C12N15/85 (US); C12N15/86 (US); C12N7/00 (US);
C12N9/22 (EP,US); C12N15/1082 (EP,US); C12N2320/30 (EP,US);
C12N2740/15043 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/43]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:TECHNISCHE KONZEPTION UND OPTIMIERUNG VON SYSTEMEN, VERFAHREN UND ZUSAMMENSETZUNGEN ZUR SEQUENZMANIPULATION FUNKTIONELLEN DOMÄNEN[2015/43]
English:ENGINEERING AND OPTIMIZATION OF SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH FUNCTIONAL DOMAINS[2015/43]
French:FABRICATION ET OPTIMISATION DE SYSTÈMES, DE PROCÉDÉS ET DE COMPOSITIONS POUR LA MANIPULATION DE SÉQUENCE AVEC DES DOMAINES FONCTIONNELS[2015/43]
Entry into regional phase22.04.2015National basic fee paid 
22.04.2015Designation fee(s) paid 
22.04.2015Examination fee paid 
Examination procedure22.04.2015Examination requested  [2015/43]
23.04.2015Amendment by applicant (claims and/or description)
26.06.2015Observations by third parties
17.09.2015Despatch of a communication from the examining division (Time limit: M04)
01.10.2015Reply to a communication from the examining division
23.10.2015Despatch of a communication from the examining division (Time limit: M04)
30.10.2015Reply to a communication from the examining division
09.12.2015Communication of intention to grant the patent
17.12.2015Fee for grant paid
17.12.2015Fee for publishing/printing paid
17.12.2015Receipt of the translation of the claim(s)
Divisional application(s)EP15200860.3  / EP3045537
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  17.09.2015
Opposition(s)Opponent(s)01  14.07.2016  09.12.2016  ADMISSIBLE
Boxall Intellectual Property Management Limited
Homefield
133 Woodnesborough Road
Sandwich
Kent CT13 0BA / GB
Opponent's representative
Patent Boutique LLP
10A Printing House Yard
Hackney Road
London E2 7PR / GB
 02  05.12.2016  15.12.2016  ADMISSIBLE
Strawman Limited
Orchard Lea
Horns Lane
Combe, Witney
Oxfordshire OX29 8NH / GB
Opponent's representative
Sharp, Christopher William
Pinsent Masons LLP
30 Crown Place
Earl Street
London EC2A 4ES / GB
 03  09.12.2016  21.12.2016  ADMISSIBLE
CRISPR Therapeutics AG
Baarerstrasse 14
6300 Zug / CH
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB, et al, et al
Siebertstrasse 3
81675 München / DE
 04  09.12.2016  15.12.2016  ADMISSIBLE
Schlich, George William
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
Opponent's representative
Schlich, George William
Schlich
9 St. Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
 05  09.12.2016  05.09.2018  WITHDRAWN
COHAUSZ & FLORACK
Bleichstraße 14
40211 Düsseldorf / DE
Opponent's representative
Cohausz & Florack, et al, et al
Patent- & Rechtsanwälte
Partnerschaftsgesellschaft mbB
Bleichstraße 14
40211 Düsseldorf / DE
 06  09.12.2016  21.12.2016  ADMISSIBLE
Grund, Martin, Dr.
GRUND Intellectual Property Group Postfach 44 05 16
80754 München / DE
Opponent's representative
Grund, Martin
Grund Intellectual Property Group
Patentanwälte und Solicitor PartG mbB
Steinsdorfstraße 2
80538 München / DE
 [N/P]
Former [2018/44]
Opponent(s)01  14.07.2016  09.12.2016  ADMISSIBLE
Boxall Intellectual Property Management Limited
Homefield
133 Woodnesborough Road
Sandwich
Kent CT13 0BA / GB
Opponent's representative
Patent Boutique LLP
10A Printing House Yard
Hackney Road
London E2 7PR / GB
 02  05.12.2016  15.12.2016  ADMISSIBLE
Strawman Limited
Orchard Lea
Horns Lane
Combe, Witney
Oxfordshire OX29 8NH / GB
Opponent's representative
Sharp, Christopher William
Pinsent Masons LLP
30 Crown Place
Earl Street
London EC2A 4ES / GB
 03  09.12.2016  21.12.2016  ADMISSIBLE
CRISPR Therapeutics AG
Baarerstrasse 14
6300 Zug / CH
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB, et al, et al
Siebertstrasse 3
81675 München / DE
 04  09.12.2016  15.12.2016  ADMISSIBLE
Schlich, George
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
Opponent's representative
Schlich, George
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
 05  09.12.2016  05.09.2018  WITHDRAWN
COHAUSZ & FLORACK
Bleichstraße 14
40211 Düsseldorf / DE
Opponent's representative
Cohausz & Florack, et al, et al
Patent- & Rechtsanwälte
Partnerschaftsgesellschaft mbB
Bleichstraße 14
40211 Düsseldorf / DE
 06  09.12.2016  21.12.2016  ADMISSIBLE
Grund, Martin, Dr.
GRUND Intellectual Property Group Postfach 44 05 16
80754 München / DE
Opponent's representative
Grund, Martin
Grund Intellectual Property Group
Patentanwalt und Solicitor PartG mbB
Nikolaistrasse 15
80802 München / DE
Former [2018/41]
Opponent(s)01  14.07.2016  09.12.2016  ADMISSIBLE
Boxall Intellectual Property Management Limited
Homefield
133 Woodnesborough Road
Sandwich
Kent CT13 0BA / GB
Opponent's representative
Patent Boutique LLP
10A Printing House Yard
Hackney Road
London E2 7PR / GB
 02  05.12.2016  15.12.2016  ADMISSIBLE
Strawman Limited
Orchard Lea
Horns Lane
Combe, Witney
Oxfordshire OX29 8NH / GB
Opponent's representative
Sharp, Christopher William
Pinsent Masons LLP
30 Crown Place
Earl Street
London EC2A 4ES / GB
 03  09.12.2016  21.12.2016  ADMISSIBLE
CRISPR Therapeutics AG
Baarerstrasse 14
6300 Zug / CH
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB, et al, et al
Siebertstrasse 3
81675 München / DE
 04  09.12.2016  15.12.2016  ADMISSIBLE
Schlich, George
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
Opponent's representative
Schlich, George
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
 05  09.12.2016  05.09.2018  WITHDRAWN
COHAUSZ & FLORACK
Bleichstraße 14
40211 Düsseldorf / DE
Opponent's representative
Cohausz & Florack, et al, et al
Patent- & Rechtsanwälte
Partnerschaftsgesellschaft mbB
Bleichstraße 14
40211 Düsseldorf / DE
 06  09.12.2016  21.12.2016  ADMISSIBLE
Grund, Martin, Dr.
GRUND Intellectual Property Group Postfach 44 05 16
80754 München / DE
Former [2018/11]
Opponent(s)01  14.07.2016  09.12.2016  ADMISSIBLE
Boxall Intellectual Property Management Limited
Homefield
133 Woodnesborough Road
Sandwich
Kent CT13 0BA / GB
Opponent's representative
Patent Boutique LLP
Aldgate Tower
2 Leman Street
London E1 8FA / GB
 02  05.12.2016  15.12.2016  ADMISSIBLE
Strawman Limited
Orchard Lea
Horns Lane
Combe, Witney
Oxfordshire OX29 8NH / GB
Opponent's representative
Sharp, Christopher William
Pinsent Masons LLP
30 Crown Place
Earl Street
London EC2A 4ES / GB
 03  09.12.2016  21.12.2016  ADMISSIBLE
CRISPR Therapeutics AG
Baarerstrasse 14
6300 Zug / CH
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB, et al, et al
Siebertstrasse 3
81675 München / DE
 04  09.12.2016  15.12.2016  ADMISSIBLE
Schlich, George
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
Opponent's representative
Schlich, George
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
 05  09.12.2016  15.12.2016  ADMISSIBLE
COHAUSZ & FLORACK
Bleichstraße 14
40211 Düsseldorf / DE
Opponent's representative
Cohausz & Florack, et al, et al
Patent- & Rechtsanwälte
Partnerschaftsgesellschaft mbB
Bleichstraße 14
40211 Düsseldorf / DE
 06  09.12.2016  21.12.2016  ADMISSIBLE
Grund, Martin, Dr.
GRUND Intellectual Property Group Postfach 44 05 16
80754 München / DE
Former [2017/12]
Opponent(s)01  14.07.2016  09.12.2016  ADMISSIBLE
Boxall Intellectual Property Management Limited
Homefield
133 Woodnesborough Road
Sandwich
Kent CT13 0BA / GB
Opponent's representative
Patent Boutique LLP
Aldgate Tower
2 Leman Street
London E1 8FA / GB
 02  05.12.2016  15.12.2016  ADMISSIBLE
Strawman Limited
Orchard Lea
Horns Lane
Combe, Witney
Oxfordshire OX29 8NH / GB
Opponent's representative
Murray, Adrian D'Coligny
Pinsent Masons LLP
30 Crown Place
Earl Street
London EC2A 4ES / GB
 03  09.12.2016  21.12.2016  ADMISSIBLE
CRISPR Therapeutics AG
Aeschenvorstadt 36
4051 Basel / CH
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB, et al, et al
Siebertstrasse 3
81675 München / DE
 04  09.12.2016  15.12.2016  ADMISSIBLE
Schlich, George
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
Opponent's representative
Schlich, George
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
 05  09.12.2016  15.12.2016  ADMISSIBLE
COHAUSZ & FLORACK
Bleichstraße 14
40211 Düsseldorf / DE
Opponent's representative
Cohausz & Florack, et al, et al
Patent- & Rechtsanwälte
Partnerschaftsgesellschaft mbB
Bleichstraße 14
40211 Düsseldorf / DE
 06  09.12.2016  21.12.2016  ADMISSIBLE
Grund, Martin, Dr.
GRUND Intellectual Property Group Postfach 44 05 16
80754 München / DE
Former [2017/03]
Opponent(s)01  14.07.2016  09.12.2016  ADMISSIBLE
Boxall Intellectual Property Management Limited
Homefield
133 Woodnesborough Road
Sandwich
Kent CT13 0BA / GB
Opponent's representative
Boxall, Sarah Jane
Boxall IPM Ltd 9 King Street
Sandwich Kent CT13 9BT / GB
 02  05.12.2016  15.12.2016  ADMISSIBLE
Strawman Limited
Orchard Lea
Horns Lane
Combe, Witney
Oxfordshire OX29 8NH / GB
Opponent's representative
Murray, Adrian D'Coligny
Pinsent Masons
30 Crown Place
Earl Street
London
EC2A 4ES / GB
 03  09.12.2016   
CRISPR Therapeutics AG
Aeschenvorstadt 36
4051 Basel / CH
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB, et al, et al
Siebertstrasse 3
81675 München / DE
 04  09.12.2016  15.12.2016  ADMISSIBLE
Schlich, George
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
Opponent's representative
Schlich, George
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
 05  09.12.2016  15.12.2016  ADMISSIBLE
COHAUSZ & FLORACK
Bleichstraße 14
40211 Düsseldorf / DE
Opponent's representative
Cohausz & Florack, et al, et al
Patent- & Rechtsanwälte
Partnerschaftsgesellschaft mbB
Bleichstraße 14
40211 Düsseldorf / DE
 06  09.12.2016   
Grund, Martin, Dr.
GRUND Intellectual Property Group Postfach 44 05 16
80754 München / DE
Former [2016/34]
Opponent(s)01  14.07.2016   
Boxall Intellectual Property Management Limited
Homefield
133 Woodnesborough Road
Sandwich
Kent CT13 0BA / GB
Opponent's representative
Boxall, Sarah Jane
Boxall IPM Ltd 9 King Street
Sandwich Kent CT13 9BT / GB
17.01.2017Invitation to proprietor to file observations on the notice of opposition
27.03.2018Reply of patent proprietor to notice(s) of opposition
07.10.2019Despatch of communication that the patent will be revoked
30.01.2020Legal effect of revocation of patent [2020/12]
Appeal following opposition31.07.2019Appeal received No.  T2692/19
30.01.2020Result of appeal procedure: appeal of the proprietor withdrawn
15.05.2019Date of oral proceedings
07.10.2019Minutes of the oral proceedings despatched
Fees paidRenewal fee
28.12.2015Renewal fee patent year 03
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Lapses during opposition  TooltipHU12.12.2013
AL09.03.2016
CY09.03.2016
CZ09.03.2016
EE09.03.2016
HR09.03.2016
LT09.03.2016
LV09.03.2016
MC09.03.2016
MK09.03.2016
RO09.03.2016
RS09.03.2016
SI09.03.2016
SK09.03.2016
SM09.03.2016
TR09.03.2016
BG09.06.2016
GR10.06.2016
MT12.12.2016
[2018/46]
Former [2018/43]HU12.12.2013
CY09.03.2016
CZ09.03.2016
EE09.03.2016
HR09.03.2016
LT09.03.2016
LV09.03.2016
MC09.03.2016
MK09.03.2016
RO09.03.2016
RS09.03.2016
SI09.03.2016
SK09.03.2016
SM09.03.2016
BG09.06.2016
GR10.06.2016
MT12.12.2016
Former [2018/30]HU12.12.2013
CY09.03.2016
CZ09.03.2016
EE09.03.2016
HR09.03.2016
LT09.03.2016
LV09.03.2016
MC09.03.2016
MK09.03.2016
RO09.03.2016
RS09.03.2016
SI09.03.2016
SK09.03.2016
SM09.03.2016
BG09.06.2016
GR10.06.2016
Former [2017/47]CZ09.03.2016
EE09.03.2016
HR09.03.2016
LT09.03.2016
LV09.03.2016
MC09.03.2016
RO09.03.2016
RS09.03.2016
SI09.03.2016
SK09.03.2016
SM09.03.2016
BG09.06.2016
GR10.06.2016
Former [2017/37]CZ09.03.2016
EE09.03.2016
HR09.03.2016
LT09.03.2016
LV09.03.2016
RO09.03.2016
RS09.03.2016
SI09.03.2016
SK09.03.2016
SM09.03.2016
BG09.06.2016
GR10.06.2016
Former [2017/19]CZ09.03.2016
EE09.03.2016
HR09.03.2016
LT09.03.2016
LV09.03.2016
RO09.03.2016
RS09.03.2016
SK09.03.2016
SM09.03.2016
BG09.06.2016
GR10.06.2016
Former [2016/50]CZ09.03.2016
EE09.03.2016
HR09.03.2016
LT09.03.2016
LV09.03.2016
RO09.03.2016
RS09.03.2016
SK09.03.2016
SM09.03.2016
GR10.06.2016
Former [2016/49]EE09.03.2016
HR09.03.2016
LT09.03.2016
LV09.03.2016
RS09.03.2016
GR10.06.2016
Former [2016/39]HR09.03.2016
LT09.03.2016
LV09.03.2016
RS09.03.2016
GR10.06.2016
Former [2016/36]HR09.03.2016
LT09.03.2016
GR10.06.2016
Former [2016/35]HR09.03.2016
GR10.06.2016
Cited inInternational search[Y]  - CONG L ET AL, "Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains", NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, LONDON, UK, (20120724), vol. 3, doi:10.1038/NCOMMS1962, ISSN 2041-1723, pages 968 - 1, XP002700145 [Y] 1-33 * page 3, column r, paragraphs 2-3 *

DOI:   http://dx.doi.org/10.1038/ncomms1962
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DOI:   http://dx.doi.org/10.1126/science.1231143
 [Y]  - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055067740 [Y] 1-33 * Whole Document;; figures S1, S7, S8, S11 *

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    [ ] - M. JINEK ET AL, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity (Supplementary Material)", SCIENCE, (20120628), vol. 337, no. 6096, doi:10.1126/science.1225829, ISSN 0036-8075, pages 816 - 821, XP055067747 [ ] * figures S7, S8, S11; table S1 *

DOI:   http://dx.doi.org/10.1126/science.1225829
 [Y]  - G. GASIUNAS ET AL, "PNAS Plus: Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20120925), vol. 109, no. 39, doi:10.1073/pnas.1208507109, ISSN 0027-8424, pages E2579 - E2586, XP055068588 [Y] 1-33 * page E2579; figures 4, S9 * * page E2579 * * page E2583 *

DOI:   http://dx.doi.org/10.1073/pnas.1208507109
 [AP]  - JIANG WENYAN ET AL, "RNA-guided editing of bacterial genomes using CRISPR-Cas systems", NATURE BIOTECHNOLOGY,, (20130129), vol. 31, no. 3, pages 233 - 239, XP002699849 [AP] 1-33 * abstract *

DOI:   http://dx.doi.org/10.1038/nbt.2508
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DOI:   http://dx.doi.org/10.1038/nature09886
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    - "Is Lander's revisionist CRISPR history sexist?", PLOS Blogs, (20160201), URL: https://blogs. plos.org/blog/20 16/02/01/is-landers-revision ist-crispr-history-sexist/
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