-
EP2900274
European procedure
Extract from the Register of European Patents
EP About this file: EP2900274
| EP2900274 - CONJUGATE OF A FRAGMENT OF A CELLULAR WALL OF A BACTERIUM AND A MUCOPOLYSACCHARIDIC CARRIER, AND USES IN MEDICINE THEREOF [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 25.09.2020 Database last updated on 02.11.2024 | |
| Former | The patent has been granted Status updated on 18.10.2019 | ||
| Former | Grant of patent is intended Status updated on 16.07.2019 | ||
| Former | Examination is in progress Status updated on 13.10.2017 | Most recent event Tooltip | 03.10.2024 | Change - lapse in a contracting state State(s) deleted from list of lapses: AL | published on 06.11.2024 [2024/45] | Applicant(s) | For all designated states Aileens Pharma S.r.l. Via Donatori del Sangue, 1 20834 Nova Milanese (MB) / IT | [2018/34] |
| Former [2015/32] | For all designated states Claride Pharma S.A. Via della Posta, 4 6900 Lugano / CH | Inventor(s) | 01 /
LONGO, Sonia Via A. Della Pergola 4 20099 Sesto S. Giovanni / IT | 02 /
BIZZINI, Bernard 29 bis Blvd Marcou 11000 Carcassonne / FR | 03 /
VOLPATO, Ivo - deceased / IT | [2020/12] |
| Former [2015/32] | 01 /
LONGO, Sonia Via A. Della Pergola 4 20099 Sesto S. Giovanni / IT | ||
| 02 /
BIZZINI, Bernard 29 bis Blvd Marcou 11000 Carcassonne / FR | Representative(s) | Coppo, Alessandro, et al Notarbartolo & Gervasi S.p.A. Viale Achille Papa, 30 20149 Milano / IT | [N/P] |
| Former [2019/47] | Coppo, Alessandro, et al Notarbartolo & Gervasi S.p.A. Corso di Porta Vittoria, 9 20122 Milano / IT | ||
| Former [2015/32] | Coppo, Alessandro, et al Notarbartolo & Gervasi S.P.A. Corso di Porta Vittoria, 9 20122 Milano / IT | Application number, filing date | 13824348.0 | 25.09.2013 | [2019/47] | WO2013IB58842 | Priority number, date | IT2012MI01597 | 25.09.2012 Original published format: IT MI20121597 | [2015/32] | Filing language | IT | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2014049532 | Date: | 03.04.2014 | Language: | EN | [2014/14] | Type: | A2 Application without search report | No.: | EP2900274 | Date: | 05.08.2015 | Language: | EN | The application published by WIPO in one of the EPO official languages on 03.04.2014 takes the place of the publication of the European patent application. | [2015/32] | Type: | B1 Patent specification | No.: | EP2900274 | Date: | 20.11.2019 | Language: | EN | [2019/47] | Type: | B8 Corrected title page of specification | No.: | EP2900274 | Date: | 08.04.2020 | [2020/15] | Search report(s) | International search report - published on: | EP | 22.05.2014 | Classification | IPC: | A61K47/61, C08B37/00, C08B37/08, A61P31/00, A61P37/00, A61P15/00, A61P17/00 | [2019/30] | CPC: |
A61K39/05 (EP,US);
A61K45/06 (US);
A61K35/74 (EP,US);
A61K39/39 (EP,US);
A61K47/61 (EP,US);
A61K9/0014 (EP,US);
A61K9/0034 (US);
A61K9/06 (EP,US);
A61K9/08 (EP,US);
A61K9/10 (EP,US);
A61P17/00 (EP,US);
A61P17/06 (EP,US);
A61P17/10 (EP,US);
A61P17/16 (EP,US);
A61P31/00 (EP,US);
A61P31/04 (EP,US);
A61P31/10 (EP,US);
A61P31/22 (EP,US);
C08B37/0069 (EP,US);
C08B37/0072 (EP,US);
C08B37/0075 (EP,US);
|
| Former IPC [2015/32] | A61K47/48, A61P31/00, A61P37/00, A61P15/00, A61P17/00 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/32] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | KONJUGAT VON EINEM FRAGMENT DER ZELLWAND EINES BAKTERIUMS UND EINEM MUCOPOLYSACCHARIDTRÄGER, UND DESSEN VERWENDUNG IN DER MEDIZIN | [2019/32] | English: | CONJUGATE OF A FRAGMENT OF A CELLULAR WALL OF A BACTERIUM AND A MUCOPOLYSACCHARIDIC CARRIER, AND USES IN MEDICINE THEREOF | [2015/32] | French: | CONJUGUÉ D'UN FRAGMENT DE LA PAROI CELLULAIRE D'UNE BACTÉRIE ET D'UN VECTEUR MUCOPOLYSACCHARIDIQUE, ET SES UTILISATIONS MÉDICALES | [2019/30] |
| Former [2015/32] | KONJUGAT EINES FRAGMENTS EINER ZELLWAND EINES BAKTERIUMS UND EINES MUCOPOLYSACCHARIDHALTIGEN TRÄGERS UND VERWENDUNGEN IN ARZNEIMITTELN | ||
| Former [2015/32] | CONJUGUÉ D'UN FRAGMENT D'UNE PAROI CELLULAIRE D'UNE BACTÉRIE ET D'UN VECTEUR MUCOPOLYSACCHARIDIQUE, ET UTILISATIONS MÉDICALES ASSOCIÉES | Entry into regional phase | 23.04.2015 | National basic fee paid | 23.04.2015 | Designation fee(s) paid | 23.04.2015 | Examination fee paid | Examination procedure | 23.04.2015 | Examination requested [2015/32] | 10.12.2015 | Amendment by applicant (claims and/or description) | 17.10.2017 | Despatch of a communication from the examining division (Time limit: M06) | 28.05.2018 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 11.07.2018 | Reply to a communication from the examining division | 17.07.2019 | Communication of intention to grant the patent | 15.10.2019 | Fee for grant paid | 15.10.2019 | Fee for publishing/printing paid | 15.10.2019 | Receipt of the translation of the claim(s) | 07.02.2020 | Request for correction of the decision to grant filed | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 17.10.2017 | Opposition(s) | 21.08.2020 | No opposition filed within time limit [2020/44] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 11.07.2018 | Request for further processing filed | 11.07.2018 | Full payment received (date of receipt of payment) Request granted | 23.07.2018 | Decision despatched | Fees paid | Renewal fee | 25.11.2015 | Renewal fee patent year 03 | 29.09.2016 | Renewal fee patent year 04 | 12.09.2017 | Renewal fee patent year 05 | 11.09.2018 | Renewal fee patent year 06 | 13.09.2019 | Renewal fee patent year 07 | Penalty fee | Additional fee for renewal fee | 30.09.2015 | 03 M06 Fee paid on 25.11.2015 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | deleted | [2024/45] |
| Former [2020/32] | AL | 20.11.2019 | Cited in | International search | [I]EP0497525 (MERCK & CO INC [US]) [I] 1-12 * example - * * claim - *; | [I]WO0168128 (AVENTIS PASTEUR [FR], et al) [I] 1-12 * page 6, paragraph 1 * * page 10, line 4 - line 12 * * example - *; | [I]EP1234584 (GRISOTECH S A [CH]) [I] 1-12 * example - *; | [I]EP1243256 (GRISOTECH S A [CH]) [I] 1-12 * example - * * claims 24-32 *; | [I]WO2009143413 (CHILDREN SMEDICAL CT CORP [US], et al) [I] 1-12 * example - * * claims 1-4 *; | [I]WO2009149155 (AMANO ENZYME USA LTD [US], et al) [I] 1-12 * example 6 *; | [I]EP2201961 (GLAXOSMITHKLINE BIOLOG SA [BE]) [I] 1-12 * page 12; example 3 *; | [I] - MORALES A ET AL, "838 Phase 1 study with mycobacterial cell wall extract and hyaluronic acid for the intraprostatic treatment of localised prostate cancer", EUROPEAN UROLOGY SUPPLEMENTS, vol. 3, no. 2, ISSN 1569-9056, (200402), Database accession no. 838, page 212, (20040201), XP027535491 [I] 1-12 * the whole document * | [ID] - BIZZINI B ET AL, "Potentiation by nonspecific immunostimulation of the efficacy of antibiotics in the treatment of experimental bacterial infections", BIOMEDICINE AND PHARMACOTHERAPY, vol. 43, no. 10, doi:10.1016/0753-3322(89)90164-9, ISSN 0753-3322, (1989), pages 753 - 761, (19890101), XP023756522 [ID] 1-12 * the whole document * DOI: http://dx.doi.org/10.1016/0753-3322(89)90164-9 | [ID] - BIZZINI B ET AL, "Induction of various cytokines in mice and activation of the complement system in rats as a part of the mechanism of action of the Corynebacterium granulosum-derived P40 immunomodulator", FEMS MICROBIOLOGY LETTERS, vol. 105, no. 4, doi:10.1111/J.1574-6968.1992.TB05899.X, ISSN 0378-1097, (199210), pages 171 - 180, (19921001), XP023716203 [ID] 1-12 * the whole document * DOI: http://dx.doi.org/10.1111/j.1574-6968.1992.tb05899.x | by applicant | EP0097625 | - B. BIZZINI; B. MARO; P. LALLOUETTE, "Isolement et caracterisation d'une fraction, dite fraction P40 a partir de Corynebacterium granulosum", MED. ET MAL. INFECT., (1978), doi:doi:10.1016/S0399-077X(78)80066-3, pages 408 - 414, XP055414519 DOI: http://dx.doi.org/10.1016/S0399-077X(78)80066-3 | - E.H. RELYVELD; B. BIZZINI; R. OPHIR; S. BEN-EFRAIM, "Synergy between low-dose chemotherapy and immunotherapy in mouse 1210 leukemia", CANCER TREATMENT REPORT, (1987), vol. 71, pages 241 - 246 | - E. HENOCQ; J.C. BAZIN; B. BIZZINI; J. REYNIER, "Adjuvant P40 et reactions cutanees a I'antigene", MED. MAL. INFECT., (1978), vol. 8, pages 415 - 421 | - B. BIZZINI; E. HENOCQ; J. REYNIER; E.H. RELYVELD, "Experimental and clinical results with the Corynebacterium granulosum-derived immunomodulator P40", ASIAN PACIFIC J. ALLERGY ANG IMMUNOL., vol. 984, no. 2, pages 144 - 155 | - L. JACQUES; B. BIZZINI; D. MATHIEU, "Variation des activites complémentaires et phagocytaires chez les rats brutes. Effet d'une immunostimulation par Corynebacterium granulosum", MED. MAL. INFECT., (1978), vol. 8, pages 515 - 518 | - P. MASTROENI; B. BIZZINI; L. BONINA; D. LANNELLO ET AL., "The restoration of impaired macrophage functions using an immunomodulator the Corynebacterium granulosum-derid P40 fraction", IMMUNOPHARMACOLOGY, (1985), vol. 10, doi:doi:10.1016/0162-3109(85)90056-6, pages 27 - 34, XP023825910 DOI: http://dx.doi.org/10.1016/0162-3109(85)90056-6 | - B. BIZZINI; M. FATTAL-GERMAN, "Potentiation by nonspecific immunostimulation of the efficacy of antibiotics in the treatment of experimental bacterial infections", BIOMED. PHARMACOTHER., (1989), vol. 43, pages 753 - 762 | - M. FATTAL-GERMAN; B. BIZZINI, "The Corynebacterium granulosum-derived P40 immunomodulator exerts a synergistic effect on the activity of antiviral drugs in the treatment of experimental viral infections", BIOMED. PHARMACOTHER., (1988), vol. 42, pages 217 - 220 | - B. BIZZINI; M. CARLOTTI; M. FATTAL-GERMAN, "Induction of various cytokines in mice and activation of the complement system in rats as a part of the mechanism of action of the Corynebacterium granulosum-derived P40 immunomodulator", FEMS MICROBIOL. IMMUNOL., (1992), vol. 105, doi:doi:10.1111/j.1574-6968.1992.tb05899.x, pages 171 - 180, XP023716203 DOI: http://dx.doi.org/10.1111/j.1574-6968.1992.tb05899.x | - MATHIEU, D.; JACQUES, L.; AUER, J.; B. BIZZINI, "E. Coli infections of the lower urinary tract and their treatment by immunomodulation or combined immunomodulation and antigenic therapy", BIOMED. PHARMACOTHER., (1988), vol. 42, pages 271 - 278 | - M.R. ICKOVIC; E. HENOCQ; E.H. RELYVELD; B. BIZZINI, "Effect of immunomodulation with the Corynebacterium granulosum-derived Immunomodulator P40 on patients with recurring respiratory infections", J. ASTHMA, (1984), vol. 21, pages 29 - 33 | - E. HENOCQ; R. VERONESI; E.H. RELYVELD; B. BIZZINI, "Treatment of relapsing chronic infection of the respiratory tract. A comparative study of the effectiveness of non specific immunotherapy with the immunoadjuvant P40 and vaccinotherapy", REV.LNST. MED. TROP. SAO PAULO, (1984), vol. 26, pages 105 - 109 | - E. HENOCQ; G. ARVIS; M.C. DELSAUX; B. BIZZINI, "Traitement des infections urogénitaes recidivantes par immunomodulation", ANN. UROL., (1985), vol. 19, pages 371 - 375 | - E. HENOCQ; A. PROUVOST-DANON; B. BIZZINI, "Preliminary experimental and clinical results with inactivated allergens conjugated to the Corynebacterium granulosum-derived immunomodulator P40", BOLL. IST. SIEROTER. MILAN., (1987), vol. 66, pages 70 - 77 | - "Immunocompetence, immunostimulation: Experimental facts and clinical perspectives", J. REYNIER; B. BIZZINI; J.C BAZIN; R. VILLET, Advances in Immunomodulation, PYTHAGORA PRESS, (1988), pages 345 - 362 | - REYNIER, J; VILLET, R; BAZIN, J.C; BIZZINI, B.; GANDRIELLE, C ET AL., "Immunological investigation and immunotherapy in patients operated on for breast carcinoma", INT. SURGERY, (1982), vol. 67, pages 17 - 24 | - R. FLEISCHMAJER ET AL., "Dermal specificity", J. INVEST. DERMATOL., (1970), vol. 54, page 472 | - K. MEYER ET AL., "The acid mucopolysaccharides of connective tissue", BIOCHIM. BIOPHYS. ACTA, (1956), vol. 21, doi:doi:10.1016/0006-3002(56)90188-3, page 506, XP025935368 DOI: http://dx.doi.org/10.1016/0006-3002(56)90188-3 | - LAURENT ET AL., "Fractionation of hyaluronic acid. The polydispersity of hyaluronic acid from the bovine vitreous body", BIOCHIM. BIOPHYS ACTA, (1960), vol. 42, doi:doi:10.1016/0006-3002(60)90826-X, page 476, XP023382851 DOI: http://dx.doi.org/10.1016/0006-3002(60)90826-X | - SCHER, I. ET AL., BIOCHEM. J., (1972), vol. 126, page 1073 | - H. SCHUBERT ET AL., A primer on connective tissue biochemistry, LEA AND FEBIGER, page 968 | - J.H. FESSLER, "A structural function of mucopolysaccharides in connective tissue", BIOCHEM. J., (1960), vol. 76, page 124 | - T.C. LAURENT ET AL., "Interaction between polysaccharides and the macromolecules. The transport of glomerulal particles through hyaluronic acid solutions", BIOCHIM. BIOPHYS. ACTA, & C., vol. 78, doi:doi:10.1016/0006-3002(63)91645-7, page 351, XP023383851 DOI: http://dx.doi.org/10.1016/0006-3002(63)91645-7 | - B.P. TOOLE ET AL., Morphogenic recognition, PLENUM PRESS, (1976), page 275 | - W.D. COMPER ET AL., "Physiological function of connective tissue polysaccharides", PHYSIOL. REV., (1978), vol. 58, page 255 | - R. AMADO ET AL., FEBS LETT., (1974), vol. 39, page 49 | - K. MEYER ET AL., BIOCHIM. BIOPHYS. ACTA, (1956), vol. 21, page 506 | - J.R. BAKER ET AL., CONNECT. TISSUE, (1975), vol. 3, page 149 | - K. MEYER ET AL., J. BIOL. CHEM., (1941), vol. 138, page 491 | - R. MARBET ET AL., HELV. CHIM. ACTA, (1951), vol. 34, page 2311 | - H. SMITH ET AL., BIOCHEM. J., (1953), vol. 53, page 666 | - I. DANISHEFSKY ET AL., J. BIOL. CHEM., (1966), vol. 241, page 143 | - S.I. LAMBERG ET AL., "Glycosaminoglycans. A biochemical and clinical review", J. INVEST. DERMATOL., (1974), vol. 63, page 433 | - P.M. KRAEMER, BIOCHEMISTRY, (1971), page 1437 | - G. SLUKE ET AL., "Humandiploid fibroblast", MECH. AGEING DEV., (1981), vol. 16, page 19 | - KLEINMAN ET AL., CELL BIOL., (1981), vol. 88, page 473 | - B.P. TOOLE, Cell Biology of Extracellular Matrix, PLENUM PRESS, (1981), page 275 | - GROBSTEIN ET AL., In extracellular matrix influences gene expression, ACADEMIC PRESS, (1975), pages 9 - 16,804-8 | - A.VAHERI ET AL., Cellular Control in Differentiation, ACADEMIC PRESS, (1981), page 29 | - P M; KRAEMER, BIOCHEMISTRY, (1971), vol. 10, page 1437 | - Y.S. KANWAR ET AL., PROC; NATL. ACAD. SCI. USA, (1979), vol. 76, page 1303 | - B. BIZZINI ET AL., MED. MAL. INF., (1978), vol. 8, page 408 | - "Standardized infection models as a way of evaluating the potency of anti-infectious agents", B. BIZZINI; M. FATTAL-GERMAN, Develop. Biol. Standard, KARGER, (1992), vol. 77, pages 137 - 142 | - B. BIZZINI ET AL., FEMS MICROBIOL. IMMUNOL., (1990), vol. 64, page 155 | - M. FATTAL-GERMAN; B. BIZZINI, DEVELOP. BIOL. STANDARD., (1992), vol. 77, page 115 |