EP2888229 - alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF [Right-click to bookmark this link] | |||
Former [2015/27] | alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I | ||
[2018/37] | Status | No opposition filed within time limit Status updated on 13.12.2019 Database last updated on 03.04.2025 | |
Former | The patent has been granted Status updated on 04.01.2019 | ||
Former | Grant of patent is intended Status updated on 28.08.2018 | ||
Former | Examination is in progress Status updated on 24.11.2017 | Most recent event Tooltip | 01.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 03.08.2022 [2022/31] | Applicant(s) | For all designated states Merck Sharp & Dohme Corp. 126 East Lincoln Avenue Rahway, NJ 07065 / US | [2015/27] | Inventor(s) | 01 /
HARVEY, Andrew c/o Bionomics Limited 31 Dalgleish Street Thebarton South Australia 5031 / AU | 02 /
AVERY, Thomas c/o Bionomics Limited 31 Dalgleish Street Thebarton South Australia 5031 / AU | 03 /
PAUL, Dharam c/o Bionomics Limited 31 Dalgleish Street Thebarton South Australia 5031 / AU | 04 /
RIPPER, Justin c/o Bionomics Limited 31 Dalgleish Street Thebarton South Australia 5031 / AU | 05 /
HUFF, Belinda c/o Bionomics Limited 31 Dalgleish Street Thebarton South Australia 5031 / AU | 06 /
SINGH, Rajinder c/o Bionomics Limited 31 Dalgleish Street Thebarton South Australia 5031 / AU | 07 /
SCHAEFFER, Laurent c/o Prestwick Chemical Bd Gonthier d'Andernach Parc d'Innovation F-67400 Illkirch / FR | 08 /
JOSEPH, Christophe c/o Prestwick Chemical Bd Gonthier d'Andernach Parc d'Innovation F-67400 Illkirch / FR | 09 /
MORICE, Christophe c/o Prestwick Chemical Bd Gonthier d'Andernach Parc d'Innovation F-67400 Illkirch / FR | 10 /
GIETHLEN, Bruno c/o Prestwick Chemical Bd Gonthier d'Andernach Parc d'Innovation F-67400 Illkirch / FR | [2015/27] | Representative(s) | Jaap, David Robert, et al Merck Sharp & Dohme Corp. 120 Moorgate London, EC2M 6UR / GB | [N/P] |
Former [2019/06] | Jaap, David Robert, et al Merck Sharp & Dohme Corp. European Patent Department Hertford Road Hoddesdon, Hertfordshire EN11 9BU / GB | ||
Former [2015/27] | Buchan, Gavin MacNicol, et al Merck & Co., Inc. European Patent Department Hertford Road Hoddesdon, Hertfordshire EN11 9BU / GB | Application number, filing date | 13825992.4 | 01.08.2013 | [2019/06] | WO2013AU00849 | Priority number, date | AU20120903296 | 01.08.2012 Original published format: AU 2012903296 | AU20130900167 | 18.01.2013 Original published format: AU 2013900167 | [2015/27] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2014019023 | Date: | 06.02.2014 | Language: | EN | [2014/06] | Type: | A1 Application with search report | No.: | EP2888229 | Date: | 01.07.2015 | Language: | EN | The application published by WIPO in one of the EPO official languages on 06.02.2014 takes the place of the publication of the European patent application. | [2015/27] | Type: | B1 Patent specification | No.: | EP2888229 | Date: | 06.02.2019 | Language: | EN | [2019/06] | Search report(s) | International search report - published on: | AU | 06.02.2014 | (Supplementary) European search report - dispatched on: | EP | 02.03.2016 | Classification | IPC: | C07C311/37, C07D239/42, C07D239/47, C07D231/38, C07D277/42, C07D213/74, C07D241/20, C07D261/14, C07C311/08, C07D237/20, C07C311/48, C07C311/49, A61K31/18, A61K31/415 | [2015/27] | CPC: |
A61P25/00 (EP);
C07C311/37 (KR,US);
A61K31/18 (KR);
A61P25/18 (EP);
A61P25/22 (EP);
A61P25/24 (EP);
A61P25/28 (EP);
A61P29/00 (EP);
A61P43/00 (EP);
C07C211/53 (EP,KR,US);
C07C217/82 (KR,US);
C07C303/36 (KR,US);
C07C307/10 (EP,KR,US);
C07C311/08 (EP,KR,US);
C07C311/15 (KR);
C07C311/30 (US);
C07C311/39 (EP,KR,US);
C07C311/48 (EP,KR,US);
C07C311/49 (EP,KR,US);
C07D213/74 (EP,KR,US);
C07D231/38 (EP,KR,US);
C07D233/72 (EP,KR,US);
C07D237/20 (EP,KR,US);
C07D239/42 (EP,KR,US);
C07D239/47 (EP,KR,US);
C07D241/20 (EP,US);
C07D261/14 (EP,KR,US);
C07D277/42 (EP,KR,US);
C07D295/135 (EP,KR,US);
C07D305/08 (EP,KR,US);
C07F9/58 (EP,KR,US);
C07C2601/02 (EP,US);
C07C2601/14 (EP,US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/27] | Extension states | BA | 02.03.2015 | ME | 02.03.2015 | Title | German: | alpha7-NIKOTIN-ACETYLCHOLINREZEPTOR-MODULATOREN UND VERWENDUNGEN DAVON | [2018/37] | English: | alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF | [2018/37] | French: | MODULATEURS DU RÉCEPTEUR alpha7 NICOTINIQUE D'ACÉTYLCHOLINE ET LEURS UTILISATIONS | [2018/37] |
Former [2015/27] | alpha7-NIKOTIN-ACETYLCHOLINREZEPTOR-MODULATOREN UND VERWENDUNGEN DAVON I | ||
Former [2015/27] | alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS AND USES THEREOF-I | ||
Former [2015/27] | MODULATEURS DU RÉCEPTEUR A7 NICOTINIQUE D'ACÉTYLCHOLINE ET LEURS UTILISATIONS | Entry into regional phase | 02.03.2015 | National basic fee paid | 02.03.2015 | Search fee paid | 02.03.2015 | Designation fee(s) paid | 02.03.2015 | Examination fee paid | Examination procedure | 02.03.2015 | Examination requested [2015/27] | 21.09.2016 | Amendment by applicant (claims and/or description) | 28.11.2017 | Despatch of a communication from the examining division (Time limit: M04) | 05.04.2018 | Reply to a communication from the examining division | 29.08.2018 | Communication of intention to grant the patent | 18.12.2018 | Fee for grant paid | 18.12.2018 | Fee for publishing/printing paid | 18.12.2018 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 28.11.2017 | Opposition(s) | 07.11.2019 | No opposition filed within time limit [2020/03] | Fees paid | Renewal fee | 07.08.2015 | Renewal fee patent year 03 | 05.08.2016 | Renewal fee patent year 04 | 10.08.2017 | Renewal fee patent year 05 | 10.08.2018 | Renewal fee patent year 06 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 01.08.2013 | AL | 06.02.2019 | AT | 06.02.2019 | CY | 06.02.2019 | CZ | 06.02.2019 | DK | 06.02.2019 | EE | 06.02.2019 | ES | 06.02.2019 | FI | 06.02.2019 | HR | 06.02.2019 | IT | 06.02.2019 | LT | 06.02.2019 | LV | 06.02.2019 | MC | 06.02.2019 | MK | 06.02.2019 | MT | 06.02.2019 | NL | 06.02.2019 | PL | 06.02.2019 | RO | 06.02.2019 | RS | 06.02.2019 | SE | 06.02.2019 | SI | 06.02.2019 | SK | 06.02.2019 | SM | 06.02.2019 | TR | 06.02.2019 | BG | 06.05.2019 | NO | 06.05.2019 | GR | 07.05.2019 | IS | 06.06.2019 | PT | 06.06.2019 | IE | 01.08.2019 | LU | 01.08.2019 | BE | 31.08.2019 | CH | 31.08.2019 | LI | 31.08.2019 | [2022/31] |
Former [2021/34] | HU | 01.08.2013 | |
AL | 06.02.2019 | ||
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CY | 06.02.2019 | ||
CZ | 06.02.2019 | ||
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EE | 06.02.2019 | ||
ES | 06.02.2019 | ||
FI | 06.02.2019 | ||
HR | 06.02.2019 | ||
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PT | 06.06.2019 | ||
IE | 01.08.2019 | ||
LU | 01.08.2019 | ||
BE | 31.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
Former [2021/33] | HU | 01.08.2013 | |
AL | 06.02.2019 | ||
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PT | 06.06.2019 | ||
IE | 01.08.2019 | ||
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BE | 31.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
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TR | 06.02.2019 | ||
BG | 06.05.2019 | ||
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IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
IE | 01.08.2019 | ||
LU | 01.08.2019 | ||
BE | 31.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
Former [2020/38] | AL | 06.02.2019 | |
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CZ | 06.02.2019 | ||
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EE | 06.02.2019 | ||
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IT | 06.02.2019 | ||
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MC | 06.02.2019 | ||
NL | 06.02.2019 | ||
PL | 06.02.2019 | ||
RO | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
SI | 06.02.2019 | ||
SK | 06.02.2019 | ||
SM | 06.02.2019 | ||
TR | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
IE | 01.08.2019 | ||
LU | 01.08.2019 | ||
BE | 31.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
Former [2020/36] | AL | 06.02.2019 | |
AT | 06.02.2019 | ||
CZ | 06.02.2019 | ||
DK | 06.02.2019 | ||
EE | 06.02.2019 | ||
ES | 06.02.2019 | ||
FI | 06.02.2019 | ||
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IT | 06.02.2019 | ||
LT | 06.02.2019 | ||
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MC | 06.02.2019 | ||
NL | 06.02.2019 | ||
PL | 06.02.2019 | ||
RO | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
SI | 06.02.2019 | ||
SK | 06.02.2019 | ||
SM | 06.02.2019 | ||
TR | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
IE | 01.08.2019 | ||
LU | 01.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
Former [2020/25] | AL | 06.02.2019 | |
AT | 06.02.2019 | ||
CZ | 06.02.2019 | ||
DK | 06.02.2019 | ||
EE | 06.02.2019 | ||
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FI | 06.02.2019 | ||
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IT | 06.02.2019 | ||
LT | 06.02.2019 | ||
LV | 06.02.2019 | ||
MC | 06.02.2019 | ||
NL | 06.02.2019 | ||
PL | 06.02.2019 | ||
RO | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
SI | 06.02.2019 | ||
SK | 06.02.2019 | ||
SM | 06.02.2019 | ||
TR | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
LU | 01.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
Former [2020/17] | AL | 06.02.2019 | |
AT | 06.02.2019 | ||
CZ | 06.02.2019 | ||
DK | 06.02.2019 | ||
EE | 06.02.2019 | ||
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NL | 06.02.2019 | ||
PL | 06.02.2019 | ||
RO | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
SI | 06.02.2019 | ||
SK | 06.02.2019 | ||
SM | 06.02.2019 | ||
TR | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
Former [2020/13] | AL | 06.02.2019 | |
AT | 06.02.2019 | ||
CZ | 06.02.2019 | ||
DK | 06.02.2019 | ||
EE | 06.02.2019 | ||
ES | 06.02.2019 | ||
FI | 06.02.2019 | ||
HR | 06.02.2019 | ||
IT | 06.02.2019 | ||
LT | 06.02.2019 | ||
LV | 06.02.2019 | ||
NL | 06.02.2019 | ||
PL | 06.02.2019 | ||
RO | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
SI | 06.02.2019 | ||
SK | 06.02.2019 | ||
SM | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
Former [2020/03] | AL | 06.02.2019 | |
AT | 06.02.2019 | ||
CZ | 06.02.2019 | ||
DK | 06.02.2019 | ||
EE | 06.02.2019 | ||
ES | 06.02.2019 | ||
FI | 06.02.2019 | ||
HR | 06.02.2019 | ||
IT | 06.02.2019 | ||
LT | 06.02.2019 | ||
LV | 06.02.2019 | ||
NL | 06.02.2019 | ||
PL | 06.02.2019 | ||
RO | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
SK | 06.02.2019 | ||
SM | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
Former [2019/52] | AL | 06.02.2019 | |
CZ | 06.02.2019 | ||
DK | 06.02.2019 | ||
EE | 06.02.2019 | ||
ES | 06.02.2019 | ||
FI | 06.02.2019 | ||
HR | 06.02.2019 | ||
IT | 06.02.2019 | ||
LT | 06.02.2019 | ||
LV | 06.02.2019 | ||
NL | 06.02.2019 | ||
PL | 06.02.2019 | ||
RO | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
SK | 06.02.2019 | ||
SM | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
Former [2019/49] | AL | 06.02.2019 | |
CZ | 06.02.2019 | ||
DK | 06.02.2019 | ||
EE | 06.02.2019 | ||
ES | 06.02.2019 | ||
FI | 06.02.2019 | ||
HR | 06.02.2019 | ||
IT | 06.02.2019 | ||
LT | 06.02.2019 | ||
LV | 06.02.2019 | ||
NL | 06.02.2019 | ||
RO | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
SK | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
Former [2019/48] | DK | 06.02.2019 | |
ES | 06.02.2019 | ||
FI | 06.02.2019 | ||
HR | 06.02.2019 | ||
IT | 06.02.2019 | ||
LT | 06.02.2019 | ||
LV | 06.02.2019 | ||
NL | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
Former [2019/47] | ES | 06.02.2019 | |
FI | 06.02.2019 | ||
HR | 06.02.2019 | ||
IT | 06.02.2019 | ||
LT | 06.02.2019 | ||
LV | 06.02.2019 | ||
NL | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
Former [2019/46] | FI | 06.02.2019 | |
HR | 06.02.2019 | ||
IT | 06.02.2019 | ||
LT | 06.02.2019 | ||
LV | 06.02.2019 | ||
NL | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
Former [2019/39] | FI | 06.02.2019 | |
HR | 06.02.2019 | ||
LT | 06.02.2019 | ||
LV | 06.02.2019 | ||
NL | 06.02.2019 | ||
RS | 06.02.2019 | ||
SE | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
IS | 06.06.2019 | ||
PT | 06.06.2019 | ||
Former [2019/38] | FI | 06.02.2019 | |
LT | 06.02.2019 | ||
NL | 06.02.2019 | ||
SE | 06.02.2019 | ||
BG | 06.05.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
PT | 06.06.2019 | ||
Former [2019/37] | FI | 06.02.2019 | |
LT | 06.02.2019 | ||
NL | 06.02.2019 | ||
SE | 06.02.2019 | ||
NO | 06.05.2019 | ||
GR | 07.05.2019 | ||
PT | 06.06.2019 | ||
Former [2019/34] | FI | 06.02.2019 | |
LT | 06.02.2019 | ||
NL | 06.02.2019 | ||
SE | 06.02.2019 | ||
NO | 06.05.2019 | ||
PT | 06.06.2019 | ||
Former [2019/33] | FI | 06.02.2019 | |
LT | 06.02.2019 | ||
NO | 06.05.2019 | ||
PT | 06.06.2019 | Documents cited: | Search | [XA]US6235791 (BRELIERE JEAN CLAUDE [FR], et al) [X] 1,2,9,18,19 * abstract * * example 56 * * claims 1-3 * [A] 3-8,10-17,20; | [XAY]US2002032199 (POSS MICHAEL A [US], et al) [X] 1,2,9,18-20 * abstract * * page 22, column r; compound 7 * * paragraphs [0450] - [0451] * * paragraphs [0007] , [0031] , [0032] , [0036] , [0 41] , [0 46] , [0 52] , [0 63] , [0 84] , [ 104] , [ 166] , [ 170] * * claims 1-37 * [A] 16,17 [Y] 3-8,10-15; | [XAY]US2003073849 (MATTSON RONALD J [US], et al) [X] 1,2,9,18-20 * abstract * * page 43; example 138 * * paragraphs [0111] - [0132] * * claims 1-48 * [A] 16,17 [Y] 3-8,10-15; | [XA]EP1930001 (R & R INC [JP]) [X] 1,2,9,18,19 * abstract * * page 5, lines 39-40 * * claims 1-9 * [A] 3-8,10-17,20; | [Y]WO2009043784 (HOFFMANN LA ROCHE [CH], et al) [Y] 1-20 * abstract * * pages 20-40 * * page 44, line 15 - page 48, line 20 * * examples 1-9 * * claims 1-16 *; | [XAY]WO2011019538 (MERCK SHARP & DOHME [US], et al) [X] 1,2,9,18-20 * abstract * * pages 16-33 * * page 33, line 5 - page 40, line 27 * * examples 1-62 * * claims 1-34 * [A] 16,17 [Y] 3-8,10-15; | [X] - DIMAURO E F ET AL, "Structural modifications of N-arylamide oxadiazoles: Identification of N-arylpiperidine oxadiazoles as potent and selective agonists of CB2", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 18, no. 15, doi:10.1016/J.BMCL.2008.06.096, ISSN 0960-894X, (200808), pages 4267 - 4274, (20080703), XP023521529 [X] 1,2,9,18,19 * abstract * * page 4269; table 2; compound 9 * * Scheme 3 *; page 4273; compound 9 * DOI: http://dx.doi.org/10.1016/j.bmcl.2008.06.096 | [Y] - DANIELA GÜNDISCH ET AL, "Nicotinic acetylcholine receptor ligands, a patent review (2006 - 2011)", EXPERT OPINION ON THERAPEUTIC PATENTS, (201112), vol. 21, no. 12, doi:10.1517/13543776.2011.637919, ISSN 1354-3776, pages 1867 - 1896, XP055067779 [Y] 1-20 * abstract * * pages 14-16 * * figures 15-17 * * page 40; compound 105 * DOI: http://dx.doi.org/10.1517/13543776.2011.637919 | International search | [X]WO0185701 (SQUIBB BRISTOL MYERS CO [US]); | [X]WO02079152 (SQUIBB BRISTOL MYERS CO [US], et al); | [X]WO2010070032 (BOEHRINGER INGELHEIM INT [DE], et al); | [X]WO2011019538 (MERCK SHARP & DOHME [US], et al); | [AP]WO2012103583 (BIONOMICS LTD [AU], et al) | by applicant | WO2009043784 | - D. GUNDISCH; C. EIBL, Expert Opin. Ther. Pat., (20110000), vol. 21, no. 12, pages 1867 - 1896 | - J. Med. Chem., (20010000), vol. 44, page 3302 | - Tetrahedron, (19690000), vol. 25, page 2647 | - Synthesis, (20080000), vol. 20, page 3279 | - Tetrahedron, (20080000), page 7041 | - J. Org. Chem., (19880000), vol. 53, page 4945 | - J. Fluorine Chem., (20040000), vol. 125, page 459 | - J. Chem. Res., (20060000), vol. 9, page 591 | - J. Am. Chem. Soc., (19910000), page 726 | - J. Am. Chem. Soc., (19940000), page 2651 | - Tetrahedron Letters, (19920000), page 2575 | - J. Org. Chem, (20080000), page 5163 | - Org. Biomol. Chem., (20060000), page 323 | - JMC, (20000000), page 3923 | - JMC, (20110000), page 957 |