EP2882848 - METHOD, COMBINATION AND/OR COMPOSITION FOR INDUCING CARDIOMYOCYTE DIFFERENTATION [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 07.09.2018 Database last updated on 03.09.2024 | |
Former | The patent has been granted Status updated on 29.09.2017 | ||
Former | Grant of patent is intended Status updated on 05.06.2017 | ||
Former | Examination is in progress Status updated on 16.12.2016 | Most recent event Tooltip | 17.07.2020 | Lapse of the patent in a contracting state New state(s): AL | published on 19.08.2020 [2020/34] | Applicant(s) | For all designated states Singapore Health Services Pte Ltd 31 Third Hospital Avenue 03-03 Bowyer Block C Singapore 168753 / SG | [2015/25] | Inventor(s) | 01 /
SHIM, Se Ngie, Winston c/o National Heart Centre of Singapore Pte Ltd 31 Third Hospital Avenue 03-03 Bowyer Block Singapore 168753 / SG | 02 /
MEHTA, Ashish c/o National Heart Centre of Singapore Pte Ltd 31 Third Hospital Avenue 03-03 Bowyer Block Singapore 168753 / SG | 03 /
SEQUIERA, Glen Lester c/o National Heart Centre of Singapore Pte Ltd 31 Third Hospital Avenue 03-03 Bowyer Block Singapore 168753 / SG | [2015/25] | Representative(s) | Bailey, Jennifer Ann, et al Marks & Clerk LLP Alpha Tower Suffolk Street Queensway Birmingham B1 1TT / GB | [2017/44] |
Former [2015/25] | Fleck, Barbara Marks & Clerk LLP 62-68 Hills Road Cambridge CB2 1LA / GB | Application number, filing date | 13827480.8 | 07.08.2013 | [2017/44] | WO2013SG00334 | Priority number, date | US201261680512P | 07.08.2012 Original published format: US 201261680512 P | [2015/25] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2014025315 | Date: | 13.02.2014 | Language: | EN | [2014/07] | Type: | A1 Application with search report | No.: | EP2882848 | Date: | 17.06.2015 | Language: | EN | The application published by WIPO in one of the EPO official languages on 13.02.2014 takes the place of the publication of the European patent application. | [2015/25] | Type: | B1 Patent specification | No.: | EP2882848 | Date: | 01.11.2017 | Language: | EN | [2017/44] | Search report(s) | International search report - published on: | AU | 13.02.2014 | (Supplementary) European search report - dispatched on: | EP | 08.12.2015 | Classification | IPC: | C12N5/071, C12N5/077 | [2016/01] | CPC: |
C12N5/0657 (EP,US);
C12N2500/38 (EP,US);
C12N2500/50 (EP,US);
C12N2501/04 (EP,US);
C12N2501/115 (EP,US);
C12N2501/15 (US);
C12N2501/155 (EP,US);
C12N2501/16 (EP,US);
C12N2501/165 (EP,US);
C12N2501/415 (EP,US);
C12N2501/727 (EP,US);
C12N2506/02 (EP,US);
|
Former IPC [2015/25] | C12N5/071 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/25] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | VERFAHREN, KOMBINATION UND/ODER ZUSAMMENSETZUNG ZUR INDUKTION EINER KARDIOMYOZYTEN-DIFFERENZIERUNG | [2015/25] | English: | METHOD, COMBINATION AND/OR COMPOSITION FOR INDUCING CARDIOMYOCYTE DIFFERENTATION | [2015/25] | French: | PROCÉDÉ, COMBINAISON ET/OU COMPOSITION POUR INDUIRE LA DIFFÉRENCIATION DES CARDIOMYOCYTES | [2015/25] | Entry into regional phase | 06.03.2015 | National basic fee paid | 06.03.2015 | Search fee paid | 06.03.2015 | Designation fee(s) paid | 06.03.2015 | Examination fee paid | Examination procedure | 06.03.2015 | Examination requested [2015/25] | 13.07.2016 | Amendment by applicant (claims and/or description) | 05.08.2016 | Despatch of a communication from the examining division (Time limit: M04) | 14.12.2016 | Reply to a communication from the examining division | 01.03.2017 | Despatch of a communication from the examining division (Time limit: M02) | 28.04.2017 | Reply to a communication from the examining division | 06.06.2017 | Communication of intention to grant the patent | 25.09.2017 | Fee for grant paid | 25.09.2017 | Fee for publishing/printing paid | 25.09.2017 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 05.08.2016 | Opposition(s) | 02.08.2018 | No opposition filed within time limit [2018/41] | Fees paid | Renewal fee | 25.08.2015 | Renewal fee patent year 03 | 11.08.2016 | Renewal fee patent year 04 | 14.08.2017 | Renewal fee patent year 05 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 07.08.2013 | AL | 01.11.2017 | AT | 01.11.2017 | CY | 01.11.2017 | CZ | 01.11.2017 | DK | 01.11.2017 | EE | 01.11.2017 | ES | 01.11.2017 | FI | 01.11.2017 | HR | 01.11.2017 | IT | 01.11.2017 | LT | 01.11.2017 | LV | 01.11.2017 | MC | 01.11.2017 | MK | 01.11.2017 | NL | 01.11.2017 | PL | 01.11.2017 | PT | 01.11.2017 | RO | 01.11.2017 | RS | 01.11.2017 | SE | 01.11.2017 | SI | 01.11.2017 | SK | 01.11.2017 | SM | 01.11.2017 | TR | 01.11.2017 | BG | 01.02.2018 | NO | 01.02.2018 | GR | 02.02.2018 | IS | 01.03.2018 | [2020/34] |
Former [2020/31] | HU | 07.08.2013 | |
AT | 01.11.2017 | ||
CY | 01.11.2017 | ||
CZ | 01.11.2017 | ||
DK | 01.11.2017 | ||
EE | 01.11.2017 | ||
ES | 01.11.2017 | ||
FI | 01.11.2017 | ||
HR | 01.11.2017 | ||
IT | 01.11.2017 | ||
LT | 01.11.2017 | ||
LV | 01.11.2017 | ||
MC | 01.11.2017 | ||
MK | 01.11.2017 | ||
NL | 01.11.2017 | ||
PL | 01.11.2017 | ||
PT | 01.11.2017 | ||
RO | 01.11.2017 | ||
RS | 01.11.2017 | ||
SE | 01.11.2017 | ||
SI | 01.11.2017 | ||
SK | 01.11.2017 | ||
SM | 01.11.2017 | ||
TR | 01.11.2017 | ||
BG | 01.02.2018 | ||
NO | 01.02.2018 | ||
GR | 02.02.2018 | ||
IS | 01.03.2018 | ||
Former [2020/28] | HU | 07.08.2013 | |
AT | 01.11.2017 | ||
CY | 01.11.2017 | ||
CZ | 01.11.2017 | ||
DK | 01.11.2017 | ||
EE | 01.11.2017 | ||
ES | 01.11.2017 | ||
FI | 01.11.2017 | ||
HR | 01.11.2017 | ||
IT | 01.11.2017 | ||
LT | 01.11.2017 | ||
LV | 01.11.2017 | ||
MC | 01.11.2017 | ||
NL | 01.11.2017 | ||
PL | 01.11.2017 | ||
PT | 01.11.2017 | ||
RO | 01.11.2017 | ||
RS | 01.11.2017 | ||
SE | 01.11.2017 | ||
SI | 01.11.2017 | ||
SK | 01.11.2017 | ||
SM | 01.11.2017 | ||
TR | 01.11.2017 | ||
BG | 01.02.2018 | ||
NO | 01.02.2018 | ||
GR | 02.02.2018 | ||
IS | 01.03.2018 | ||
Former [2020/16] | AT | 01.11.2017 | |
CY | 01.11.2017 | ||
CZ | 01.11.2017 | ||
DK | 01.11.2017 | ||
EE | 01.11.2017 | ||
ES | 01.11.2017 | ||
FI | 01.11.2017 | ||
HR | 01.11.2017 | ||
IT | 01.11.2017 | ||
LT | 01.11.2017 | ||
LV | 01.11.2017 | ||
MC | 01.11.2017 | ||
NL | 01.11.2017 | ||
PL | 01.11.2017 | ||
RO | 01.11.2017 | ||
RS | 01.11.2017 | ||
SE | 01.11.2017 | ||
SI | 01.11.2017 | ||
SK | 01.11.2017 | ||
SM | 01.11.2017 | ||
TR | 01.11.2017 | ||
BG | 01.02.2018 | ||
NO | 01.02.2018 | ||
GR | 02.02.2018 | ||
IS | 01.03.2018 | ||
Former [2019/15] | AT | 01.11.2017 | |
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CZ | 01.11.2017 | ||
DK | 01.11.2017 | ||
EE | 01.11.2017 | ||
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SK | 01.11.2017 | ||
SM | 01.11.2017 | ||
BG | 01.02.2018 | ||
NO | 01.02.2018 | ||
GR | 02.02.2018 | ||
IS | 01.03.2018 | ||
Former [2018/52] | AT | 01.11.2017 | |
CY | 01.11.2017 | ||
CZ | 01.11.2017 | ||
DK | 01.11.2017 | ||
EE | 01.11.2017 | ||
ES | 01.11.2017 | ||
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HR | 01.11.2017 | ||
IT | 01.11.2017 | ||
LT | 01.11.2017 | ||
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NL | 01.11.2017 | ||
PL | 01.11.2017 | ||
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SK | 01.11.2017 | ||
SM | 01.11.2017 | ||
BG | 01.02.2018 | ||
NO | 01.02.2018 | ||
GR | 02.02.2018 | ||
IS | 01.03.2018 | ||
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CY | 01.11.2017 | ||
CZ | 01.11.2017 | ||
DK | 01.11.2017 | ||
EE | 01.11.2017 | ||
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SM | 01.11.2017 | ||
BG | 01.02.2018 | ||
NO | 01.02.2018 | ||
GR | 02.02.2018 | ||
IS | 01.03.2018 | ||
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CY | 01.11.2017 | ||
CZ | 01.11.2017 | ||
DK | 01.11.2017 | ||
EE | 01.11.2017 | ||
ES | 01.11.2017 | ||
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LT | 01.11.2017 | ||
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PL | 01.11.2017 | ||
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SM | 01.11.2017 | ||
BG | 01.02.2018 | ||
NO | 01.02.2018 | ||
GR | 02.02.2018 | ||
IS | 01.03.2018 | ||
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CZ | 01.11.2017 | ||
DK | 01.11.2017 | ||
EE | 01.11.2017 | ||
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LT | 01.11.2017 | ||
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PL | 01.11.2017 | ||
RS | 01.11.2017 | ||
SE | 01.11.2017 | ||
SK | 01.11.2017 | ||
SM | 01.11.2017 | ||
BG | 01.02.2018 | ||
NO | 01.02.2018 | ||
GR | 02.02.2018 | ||
IS | 01.03.2018 | ||
Former [2018/35] | AT | 01.11.2017 | |
CY | 01.11.2017 | ||
CZ | 01.11.2017 | ||
DK | 01.11.2017 | ||
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LT | 01.11.2017 | ||
LV | 01.11.2017 | ||
NL | 01.11.2017 | ||
RS | 01.11.2017 | ||
SE | 01.11.2017 | ||
SK | 01.11.2017 | ||
BG | 01.02.2018 | ||
NO | 01.02.2018 | ||
GR | 02.02.2018 | ||
IS | 01.03.2018 | ||
Former [2018/24] | AT | 01.11.2017 | |
ES | 01.11.2017 | ||
FI | 01.11.2017 | ||
HR | 01.11.2017 | ||
LT | 01.11.2017 | ||
LV | 01.11.2017 | ||
NL | 01.11.2017 | ||
RS | 01.11.2017 | ||
SE | 01.11.2017 | ||
BG | 01.02.2018 | ||
NO | 01.02.2018 | ||
GR | 02.02.2018 | ||
IS | 01.03.2018 | ||
Former [2018/22] | ES | 01.11.2017 | |
FI | 01.11.2017 | ||
LT | 01.11.2017 | ||
NL | 01.11.2017 | ||
NO | 01.02.2018 | Documents cited: | Search | [XY]WO2007070964 (ES CELL INT PTE LTD [SG], et al) [X] 13 * abstract * * page 13, line 1 - line 6 * * page 57; claims 1,5,6 * [Y] 1-12,14-18; | [Y]WO2011157029 (INST BIOPHYSICS CN ACAD SCI [CN], et al) [Y] 1-18 * abstract * * page 36; claims 1,2 * * page 37; claim 19 *; | [Y] - AGAPIOS SACHINIDIS ET AL, "Identification of Small Signalling Molecules Promoting Cardiac-Specific Differentiation of Mouse Embryonic Stem Cells", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, (20061120), vol. 18, no. 6, doi:10.1159/000097608, pages 303 - 314, XP055230342 [Y] 1-18 * abstract * * page 305; table 1 * DOI: http://dx.doi.org/10.1159/000097608 | International search | [X]WO2012067266 (UNIV KYOTO [JP], et al); | [X] - GRAICHEN R ET AL., "Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor ofp38 MAPK.", DIFFERENTIATION., (200804), vol. 76, no. 4, pages 357 - 70, XP026772221 DOI: http://dx.doi.org/10.1111/j.1432-0436.2007.00236.x | [X] - GAUR M ET AL., "Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes.", CYTOTHERAPY., (201010), vol. 12, no. 6, pages 807 - 17, XP055196533 DOI: http://dx.doi.org/10.3109/14653249.2010.491821 | [X] - BURRIDGE PW ET AL., "Production of de novo cardiomyocytes:human pluripotent stem cell differentiation and direct reprogramming.", CELL STEM CELL., (20120106), vol. 10, no. 1, pages 16 - 28, XP028434719 DOI: http://dx.doi.org/10.1016/j.stem.2011.12.013 | [X] - MUMMERY CL ET AL., "Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview.", CIRC RES., (20120720), vol. 111, no. 3, pages 344 - 58, XP055187227 DOI: http://dx.doi.org/10.1161/CIRCRESAHA.110.227512 | [X] - VARADARAJAN, S, "p38 MAPKs coordinately regulate distinct phases of autophagy and lysosomal biogenesis.", PROQUEST, (2011), XP055196557 | [X] - GAITANAKI C ET AL., "et al. Oxidative stress stimulates multiple MAPK signalling pathways and phosphorylation of the small HSP27 in the perfused amphibian heart.", J EXP BIOL., (200308), vol. 206, pages 2759 - 69., XP055196560 DOI: http://dx.doi.org/10.1242/jeb.00483 | [Y] - YAN P ET AL., "Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells.", BIOCHEM BIOPHYS RES COMMUN., (20090130), vol. 379, no. 1, pages 115 - 20, XP025770136 DOI: http://dx.doi.org/10.1016/j.bbrc.2008.12.019 | [Y] - LI J ET AL., "The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation.", MOL BIOL CELL., (200609), vol. 17, no. 9, pages 3978 - 88, XP055196563 DOI: http://dx.doi.org/10.1091/mbc.E05-06-0532 | [A] - BIKKAVILLI RK ET AL., "p38 mitogen-activated protein kinase regulates canonical Wnt-beta- catenin signaling by inactivation of GSK3beta.", J CELL SCI., (20081101), vol. 121, pages 3598 - 607, XP055196567 DOI: http://dx.doi.org/10.1242/jcs.032854 | [A] - MA L ET AL., "Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway.", J BIOL CHEM., (20070928), vol. 282, no. 39, pages 28980 - 90, XP055196569 DOI: http://dx.doi.org/10.1074/jbc.M702840200 | [A] - SMITH JL ET AL., "Targeting combinatorial transcriptional complex assembly at specific modules within the interleukin-2 promoter by the immunosuppressant SB203580.", J BIOL CHEM., (20031017), vol. 278, no. 42, pages 41034 - 46, XP055196570 DOI: http://dx.doi.org/10.1074/jbc.M305615200 | Examination | - James Hudson ET AL, "Primitive Cardiac Cells from Human Embryonic Stem Cells", Stem Cells and Development, (20120610), vol. 21, no. 9, doi:10.1089/scd.2011.0254, ISSN 1547-3287, pages 1513 - 1523, XP055157300 DOI: http://dx.doi.org/10.1089/scd.2011.0254 |