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Extract from the Register of European Patents

EP About this file: EP2882848

EP2882848 - METHOD, COMBINATION AND/OR COMPOSITION FOR INDUCING CARDIOMYOCYTE DIFFERENTATION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.09.2018
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  29.09.2017
FormerGrant of patent is intended
Status updated on  05.06.2017
FormerExamination is in progress
Status updated on  16.12.2016
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Singapore Health Services Pte Ltd
31 Third Hospital Avenue
03-03 Bowyer Block C
Singapore 168753 / SG
[2015/25]
Inventor(s)01 / SHIM, Se Ngie, Winston
c/o National Heart Centre of Singapore Pte Ltd
31 Third Hospital Avenue
03-03 Bowyer Block
Singapore 168753 / SG
02 / MEHTA, Ashish
c/o National Heart Centre of Singapore Pte Ltd
31 Third Hospital Avenue
03-03 Bowyer Block
Singapore 168753 / SG
03 / SEQUIERA, Glen Lester
c/o National Heart Centre of Singapore Pte Ltd
31 Third Hospital Avenue
03-03 Bowyer Block
Singapore 168753 / SG
 [2015/25]
Representative(s)Bailey, Jennifer Ann, et al
Marks & Clerk LLP
Alpha Tower
Suffolk Street Queensway
Birmingham B1 1TT / GB
[2017/44]
Former [2015/25]Fleck, Barbara
Marks & Clerk LLP
62-68 Hills Road
Cambridge CB2 1LA / GB
Application number, filing date13827480.807.08.2013
[2017/44]
WO2013SG00334
Priority number, dateUS201261680512P07.08.2012         Original published format: US 201261680512 P
[2015/25]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014025315
Date:13.02.2014
Language:EN
[2014/07]
Type: A1 Application with search report 
No.:EP2882848
Date:17.06.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 13.02.2014 takes the place of the publication of the European patent application.
[2015/25]
Type: B1 Patent specification 
No.:EP2882848
Date:01.11.2017
Language:EN
[2017/44]
Search report(s)International search report - published on:AU13.02.2014
(Supplementary) European search report - dispatched on:EP08.12.2015
ClassificationIPC:C12N5/071, C12N5/077
[2016/01]
CPC:
C12N5/0657 (EP,US); C12N2500/38 (EP,US); C12N2500/50 (EP,US);
C12N2501/04 (EP,US); C12N2501/115 (EP,US); C12N2501/15 (US);
C12N2501/155 (EP,US); C12N2501/16 (EP,US); C12N2501/165 (EP,US);
C12N2501/415 (EP,US); C12N2501/727 (EP,US); C12N2506/02 (EP,US);
C12N2506/03 (US); C12N2506/45 (EP,US); C12N2533/54 (EP,US) (-)
Former IPC [2015/25]C12N5/071
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/25]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN, KOMBINATION UND/ODER ZUSAMMENSETZUNG ZUR INDUKTION EINER KARDIOMYOZYTEN-DIFFERENZIERUNG[2015/25]
English:METHOD, COMBINATION AND/OR COMPOSITION FOR INDUCING CARDIOMYOCYTE DIFFERENTATION[2015/25]
French:PROCÉDÉ, COMBINAISON ET/OU COMPOSITION POUR INDUIRE LA DIFFÉRENCIATION DES CARDIOMYOCYTES[2015/25]
Entry into regional phase06.03.2015National basic fee paid 
06.03.2015Search fee paid 
06.03.2015Designation fee(s) paid 
06.03.2015Examination fee paid 
Examination procedure06.03.2015Examination requested  [2015/25]
13.07.2016Amendment by applicant (claims and/or description)
05.08.2016Despatch of a communication from the examining division (Time limit: M04)
14.12.2016Reply to a communication from the examining division
01.03.2017Despatch of a communication from the examining division (Time limit: M02)
28.04.2017Reply to a communication from the examining division
06.06.2017Communication of intention to grant the patent
25.09.2017Fee for grant paid
25.09.2017Fee for publishing/printing paid
25.09.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  05.08.2016
Opposition(s)02.08.2018No opposition filed within time limit [2018/41]
Fees paidRenewal fee
25.08.2015Renewal fee patent year 03
11.08.2016Renewal fee patent year 04
14.08.2017Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.08.2013
AL01.11.2017
AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
MK01.11.2017
NL01.11.2017
PL01.11.2017
PT01.11.2017
RO01.11.2017
RS01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
SM01.11.2017
TR01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
[2020/34]
Former [2020/31]HU07.08.2013
AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
MK01.11.2017
NL01.11.2017
PL01.11.2017
PT01.11.2017
RO01.11.2017
RS01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
SM01.11.2017
TR01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2020/28]HU07.08.2013
AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
NL01.11.2017
PL01.11.2017
PT01.11.2017
RO01.11.2017
RS01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
SM01.11.2017
TR01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2020/16]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
RS01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
SM01.11.2017
TR01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2019/15]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
MC01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
RS01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
SM01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/52]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
RS01.11.2017
SE01.11.2017
SI01.11.2017
SK01.11.2017
SM01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/40]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
PL01.11.2017
RO01.11.2017
RS01.11.2017
SE01.11.2017
SK01.11.2017
SM01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/39]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
IT01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
PL01.11.2017
RS01.11.2017
SE01.11.2017
SK01.11.2017
SM01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/37]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
PL01.11.2017
RS01.11.2017
SE01.11.2017
SK01.11.2017
SM01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/35]AT01.11.2017
CY01.11.2017
CZ01.11.2017
DK01.11.2017
EE01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
RS01.11.2017
SE01.11.2017
SK01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/24]AT01.11.2017
ES01.11.2017
FI01.11.2017
HR01.11.2017
LT01.11.2017
LV01.11.2017
NL01.11.2017
RS01.11.2017
SE01.11.2017
BG01.02.2018
NO01.02.2018
GR02.02.2018
IS01.03.2018
Former [2018/22]ES01.11.2017
FI01.11.2017
LT01.11.2017
NL01.11.2017
NO01.02.2018
Documents cited:Search[XY]WO2007070964  (ES CELL INT PTE LTD [SG], et al) [X] 13 * abstract * * page 13, line 1 - line 6 * * page 57; claims 1,5,6 * [Y] 1-12,14-18;
 [Y]WO2011157029  (INST BIOPHYSICS CN ACAD SCI [CN], et al) [Y] 1-18 * abstract * * page 36; claims 1,2 * * page 37; claim 19 *;
 [Y]  - AGAPIOS SACHINIDIS ET AL, "Identification of Small Signalling Molecules Promoting Cardiac-Specific Differentiation of Mouse Embryonic Stem Cells", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, (20061120), vol. 18, no. 6, doi:10.1159/000097608, pages 303 - 314, XP055230342 [Y] 1-18 * abstract * * page 305; table 1 *

DOI:   http://dx.doi.org/10.1159/000097608
International search[X]WO2012067266  (UNIV KYOTO [JP], et al);
 [X]  - GRAICHEN R ET AL., "Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor ofp38 MAPK.", DIFFERENTIATION., (200804), vol. 76, no. 4, pages 357 - 70, XP026772221

DOI:   http://dx.doi.org/10.1111/j.1432-0436.2007.00236.x
 [X]  - GAUR M ET AL., "Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes.", CYTOTHERAPY., (201010), vol. 12, no. 6, pages 807 - 17, XP055196533

DOI:   http://dx.doi.org/10.3109/14653249.2010.491821
 [X]  - BURRIDGE PW ET AL., "Production of de novo cardiomyocytes:human pluripotent stem cell differentiation and direct reprogramming.", CELL STEM CELL., (20120106), vol. 10, no. 1, pages 16 - 28, XP028434719

DOI:   http://dx.doi.org/10.1016/j.stem.2011.12.013
 [X]  - MUMMERY CL ET AL., "Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview.", CIRC RES., (20120720), vol. 111, no. 3, pages 344 - 58, XP055187227

DOI:   http://dx.doi.org/10.1161/CIRCRESAHA.110.227512
 [X]  - VARADARAJAN, S, "p38 MAPKs coordinately regulate distinct phases of autophagy and lysosomal biogenesis.", PROQUEST, (2011), XP055196557
 [X]  - GAITANAKI C ET AL., "et al. Oxidative stress stimulates multiple MAPK signalling pathways and phosphorylation of the small HSP27 in the perfused amphibian heart.", J EXP BIOL., (200308), vol. 206, pages 2759 - 69., XP055196560

DOI:   http://dx.doi.org/10.1242/jeb.00483
 [Y]  - YAN P ET AL., "Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells.", BIOCHEM BIOPHYS RES COMMUN., (20090130), vol. 379, no. 1, pages 115 - 20, XP025770136

DOI:   http://dx.doi.org/10.1016/j.bbrc.2008.12.019
 [Y]  - LI J ET AL., "The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation.", MOL BIOL CELL., (200609), vol. 17, no. 9, pages 3978 - 88, XP055196563

DOI:   http://dx.doi.org/10.1091/mbc.E05-06-0532
 [A]  - BIKKAVILLI RK ET AL., "p38 mitogen-activated protein kinase regulates canonical Wnt-beta- catenin signaling by inactivation of GSK3beta.", J CELL SCI., (20081101), vol. 121, pages 3598 - 607, XP055196567

DOI:   http://dx.doi.org/10.1242/jcs.032854
 [A]  - MA L ET AL., "Mitogen-activated protein kinase p38 regulates the Wnt/cyclic GMP/Ca2+ non-canonical pathway.", J BIOL CHEM., (20070928), vol. 282, no. 39, pages 28980 - 90, XP055196569

DOI:   http://dx.doi.org/10.1074/jbc.M702840200
 [A]  - SMITH JL ET AL., "Targeting combinatorial transcriptional complex assembly at specific modules within the interleukin-2 promoter by the immunosuppressant SB203580.", J BIOL CHEM., (20031017), vol. 278, no. 42, pages 41034 - 46, XP055196570

DOI:   http://dx.doi.org/10.1074/jbc.M305615200
Examination   - James Hudson ET AL, "Primitive Cardiac Cells from Human Embryonic Stem Cells", Stem Cells and Development, (20120610), vol. 21, no. 9, doi:10.1089/scd.2011.0254, ISSN 1547-3287, pages 1513 - 1523, XP055157300

DOI:   http://dx.doi.org/10.1089/scd.2011.0254
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