EP2890708 - PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 10.07.2020 Database last updated on 03.09.2024 | |
Former | The patent has been granted Status updated on 05.07.2019 | ||
Former | Grant of patent is intended Status updated on 14.02.2019 | ||
Former | Examination is in progress Status updated on 07.04.2017 | ||
Former | Request for examination was made Status updated on 12.01.2017 | Most recent event Tooltip | 01.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 03.08.2022 [2022/31] | Applicant(s) | For all designated states The Governors of the University of Alberta 4000 Enterprise Square 10230 Jasper Avenue Edmonton, Alberta T5J 4P6 / CA | For all designated states Doschak, Michael 2-108 Katz Group Centre For Pharmacy And Public Health Research Edmonton, AB T6G 2N8 / CA | For all designated states Yang, Yang 2-108 Katz Group Centre For Pharmacy And Public Health Research Edmonton, AB T6G 2N8 / CA | For all designated states Bhandari, Krishna, Hari 2-108 Katz Group Centre For Pharmacy And Public Health Research Edmonton, AB T6G 2N8 / CA | [2015/28] | Inventor(s) | 01 /
DOSCHAK, Michael 2-108 Katz Group Centre For Pharmacy And Public Health Research Edmonton, AB T6G 2N8 / CA | 02 /
YANG, Yang 2-108 Katz Group Centre For Pharmacy And Public Health Research Edmonton, AB T6G 2N8 / CA | 03 /
BHANDARI, Krishna, Hari 2-108 Katz Group Centre For Pharmacy And Public Health Research Edmonton, AB T6G 2N8 / CA | [2015/28] | Representative(s) | Dehns St. Bride's House 10 Salisbury Square London EC4Y 8JD / GB | [2019/32] |
Former [2015/28] | Wilkins, Christopher George Dehns St Bride's House 10 Salisbury Square London EC4Y 8JD / GB | Application number, filing date | 13832369.6 | 28.08.2013 | [2019/32] | WO2013IB02349 | Priority number, date | US201261693818P | 28.08.2012 Original published format: US 201261693818 P | [2015/28] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2014033540 | Date: | 06.03.2014 | Language: | EN | [2014/10] | Type: | A2 Application without search report | No.: | EP2890708 | Date: | 08.07.2015 | Language: | EN | The application published by WIPO in one of the EPO official languages on 06.03.2014 takes the place of the publication of the European patent application. | [2015/28] | Type: | B1 Patent specification | No.: | EP2890708 | Date: | 07.08.2019 | Language: | EN | [2019/32] | Search report(s) | International search report - published on: | CA | 17.04.2014 | (Supplementary) European search report - dispatched on: | EP | 06.05.2016 | Classification | IPC: | A61K31/663, A61K38/29, A61K47/54, A61K47/60, C07K14/62, C07K14/635, C07K14/65, C08F299/02 | [2019/08] | CPC: |
C07K14/62 (EP,US);
A61K31/663 (US);
A61K38/29 (EP,US);
A61K47/548 (EP,US);
A61K47/60 (EP,US);
A61P19/02 (EP);
A61P19/08 (EP);
C07K14/635 (EP,US);
C07K14/65 (EP,US);
C08F299/02 (US)
(-)
|
Former IPC [2016/10] | C07K14/65, A61K38/28, A61P19/08, C07K14/62, C07K14/635, C07K17/08, A61K47/48, C08F299/02 | ||
Former IPC [2015/28] | C07K14/65, A61K38/28, A61P19/08, C07K14/62, C07K14/635, C07K17/08 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2015/28] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | PARATHYROIDHORMON, INSULIN UND VERWANDTE MIT KNOCHENANZIELENDEN EINHEITEN VERBUNDENE PEPTIDE SOWIE VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON | [2015/28] | English: | PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF | [2015/28] | French: | PARATHORMONE, INSULINE, ET PEPTIDES ASSOCIÉS CONJUGUÉS À DES FRACTIONS DE CIBLAGE OSSEUX, ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE CEUX-CI | [2015/28] | Entry into regional phase | 26.03.2015 | National basic fee paid | 26.03.2015 | Search fee paid | 26.03.2015 | Designation fee(s) paid | 26.03.2015 | Examination fee paid | Examination procedure | 26.03.2015 | Examination requested [2015/28] | 14.03.2017 | Amendment by applicant (claims and/or description) | 06.04.2017 | Despatch of a communication from the examining division (Time limit: M06) | 31.08.2017 | Reply to a communication from the examining division | 11.12.2017 | Despatch of a communication from the examining division (Time limit: M06) | 20.07.2018 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 28.09.2018 | Reply to a communication from the examining division | 10.12.2018 | Invitation to indicate the basis for amendments (Time limit: M01) | 14.01.2019 | Reply to an invitation to indicate the basis for amendments | 15.02.2019 | Communication of intention to grant the patent | 24.06.2019 | Fee for grant paid | 24.06.2019 | Fee for publishing/printing paid | 24.06.2019 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 06.04.2017 | Opposition(s) | 03.06.2020 | No opposition filed within time limit [2020/33] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 28.09.2018 | Request for further processing filed | 28.09.2018 | Full payment received (date of receipt of payment) Request granted | 11.10.2018 | Decision despatched | The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report | 14.03.2017 | Request for further processing filed | 14.03.2017 | Full payment received (date of receipt of payment) Request granted | 27.03.2017 | Decision despatched | Fees paid | Renewal fee | 18.08.2015 | Renewal fee patent year 03 | 30.08.2016 | Renewal fee patent year 04 | 18.08.2017 | Renewal fee patent year 05 | 28.08.2018 | Renewal fee patent year 06 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 28.08.2013 | AL | 07.08.2019 | AT | 07.08.2019 | CY | 07.08.2019 | CZ | 07.08.2019 | DK | 07.08.2019 | EE | 07.08.2019 | ES | 07.08.2019 | FI | 07.08.2019 | HR | 07.08.2019 | IT | 07.08.2019 | LT | 07.08.2019 | LV | 07.08.2019 | MC | 07.08.2019 | MK | 07.08.2019 | MT | 07.08.2019 | NL | 07.08.2019 | PL | 07.08.2019 | RO | 07.08.2019 | RS | 07.08.2019 | SE | 07.08.2019 | SI | 07.08.2019 | SK | 07.08.2019 | SM | 07.08.2019 | TR | 07.08.2019 | IE | 28.08.2019 | LU | 28.08.2019 | BE | 31.08.2019 | CH | 31.08.2019 | LI | 31.08.2019 | BG | 07.11.2019 | NO | 07.11.2019 | GR | 08.11.2019 | IS | 07.12.2019 | PT | 09.12.2019 | [2022/31] |
Former [2021/34] | HU | 28.08.2013 | |
AL | 07.08.2019 | ||
AT | 07.08.2019 | ||
CY | 07.08.2019 | ||
CZ | 07.08.2019 | ||
DK | 07.08.2019 | ||
EE | 07.08.2019 | ||
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
IT | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
MC | 07.08.2019 | ||
MT | 07.08.2019 | ||
NL | 07.08.2019 | ||
PL | 07.08.2019 | ||
RO | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
SI | 07.08.2019 | ||
SK | 07.08.2019 | ||
SM | 07.08.2019 | ||
TR | 07.08.2019 | ||
IE | 28.08.2019 | ||
LU | 28.08.2019 | ||
BE | 31.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
IS | 07.12.2019 | ||
PT | 09.12.2019 | ||
Former [2021/32] | HU | 28.08.2013 | |
AL | 07.08.2019 | ||
AT | 07.08.2019 | ||
CY | 07.08.2019 | ||
CZ | 07.08.2019 | ||
DK | 07.08.2019 | ||
EE | 07.08.2019 | ||
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
IT | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
MC | 07.08.2019 | ||
NL | 07.08.2019 | ||
PL | 07.08.2019 | ||
RO | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
SI | 07.08.2019 | ||
SK | 07.08.2019 | ||
SM | 07.08.2019 | ||
TR | 07.08.2019 | ||
IE | 28.08.2019 | ||
LU | 28.08.2019 | ||
BE | 31.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
IS | 07.12.2019 | ||
PT | 09.12.2019 | ||
Former [2021/26] | AL | 07.08.2019 | |
AT | 07.08.2019 | ||
CY | 07.08.2019 | ||
CZ | 07.08.2019 | ||
DK | 07.08.2019 | ||
EE | 07.08.2019 | ||
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
IT | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
MC | 07.08.2019 | ||
NL | 07.08.2019 | ||
PL | 07.08.2019 | ||
RO | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
SI | 07.08.2019 | ||
SK | 07.08.2019 | ||
SM | 07.08.2019 | ||
TR | 07.08.2019 | ||
IE | 28.08.2019 | ||
LU | 28.08.2019 | ||
BE | 31.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
IS | 07.12.2019 | ||
PT | 09.12.2019 | ||
Former [2020/37] | AL | 07.08.2019 | |
AT | 07.08.2019 | ||
CZ | 07.08.2019 | ||
DK | 07.08.2019 | ||
EE | 07.08.2019 | ||
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
IT | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
MC | 07.08.2019 | ||
NL | 07.08.2019 | ||
PL | 07.08.2019 | ||
RO | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
SI | 07.08.2019 | ||
SK | 07.08.2019 | ||
SM | 07.08.2019 | ||
TR | 07.08.2019 | ||
IE | 28.08.2019 | ||
LU | 28.08.2019 | ||
BE | 31.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
IS | 07.12.2019 | ||
PT | 09.12.2019 | ||
Former [2020/36] | AL | 07.08.2019 | |
AT | 07.08.2019 | ||
CZ | 07.08.2019 | ||
DK | 07.08.2019 | ||
EE | 07.08.2019 | ||
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
IT | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
MC | 07.08.2019 | ||
NL | 07.08.2019 | ||
PL | 07.08.2019 | ||
RO | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
SK | 07.08.2019 | ||
SM | 07.08.2019 | ||
TR | 07.08.2019 | ||
IE | 28.08.2019 | ||
LU | 28.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
IS | 07.12.2019 | ||
PT | 09.12.2019 | ||
Former [2020/27] | AL | 07.08.2019 | |
AT | 07.08.2019 | ||
CZ | 07.08.2019 | ||
DK | 07.08.2019 | ||
EE | 07.08.2019 | ||
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
IT | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
MC | 07.08.2019 | ||
NL | 07.08.2019 | ||
PL | 07.08.2019 | ||
RO | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
SK | 07.08.2019 | ||
SM | 07.08.2019 | ||
TR | 07.08.2019 | ||
LU | 28.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
PT | 09.12.2019 | ||
IS | 24.02.2020 | ||
Former [2020/25] | AL | 07.08.2019 | |
AT | 07.08.2019 | ||
CZ | 07.08.2019 | ||
DK | 07.08.2019 | ||
EE | 07.08.2019 | ||
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
IT | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
NL | 07.08.2019 | ||
PL | 07.08.2019 | ||
RO | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
SK | 07.08.2019 | ||
TR | 07.08.2019 | ||
LU | 28.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
PT | 09.12.2019 | ||
IS | 24.02.2020 | ||
Former [2020/24] | AL | 07.08.2019 | |
AT | 07.08.2019 | ||
DK | 07.08.2019 | ||
EE | 07.08.2019 | ||
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
IT | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
NL | 07.08.2019 | ||
PL | 07.08.2019 | ||
RO | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
TR | 07.08.2019 | ||
CH | 31.08.2019 | ||
LI | 31.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
PT | 09.12.2019 | ||
IS | 24.02.2020 | ||
Former [2020/23] | AL | 07.08.2019 | |
AT | 07.08.2019 | ||
DK | 07.08.2019 | ||
EE | 07.08.2019 | ||
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
IT | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
NL | 07.08.2019 | ||
PL | 07.08.2019 | ||
RO | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
TR | 07.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
IS | 07.12.2019 | ||
PT | 09.12.2019 | ||
Former [2020/22] | AL | 07.08.2019 | |
DK | 07.08.2019 | ||
EE | 07.08.2019 | ||
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
NL | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
TR | 07.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
IS | 07.12.2019 | ||
PT | 09.12.2019 | ||
Former [2020/17] | AL | 07.08.2019 | |
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
NL | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
TR | 07.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
IS | 07.12.2019 | ||
PT | 09.12.2019 | ||
Former [2020/15] | AL | 07.08.2019 | |
ES | 07.08.2019 | ||
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
NL | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
IS | 07.12.2019 | ||
PT | 09.12.2019 | ||
Former [2020/12] | ES | 07.08.2019 | |
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
NL | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
IS | 07.12.2019 | ||
PT | 09.12.2019 | ||
Former [2020/11] | ES | 07.08.2019 | |
FI | 07.08.2019 | ||
HR | 07.08.2019 | ||
LT | 07.08.2019 | ||
LV | 07.08.2019 | ||
NL | 07.08.2019 | ||
RS | 07.08.2019 | ||
SE | 07.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
GR | 08.11.2019 | ||
PT | 09.12.2019 | ||
Former [2020/10] | FI | 07.08.2019 | |
LT | 07.08.2019 | ||
NL | 07.08.2019 | ||
SE | 07.08.2019 | ||
BG | 07.11.2019 | ||
NO | 07.11.2019 | ||
PT | 09.12.2019 | ||
Former [2020/09] | FI | 07.08.2019 | |
LT | 07.08.2019 | ||
NL | 07.08.2019 | ||
NO | 07.11.2019 | ||
Former [2020/08] | LT | 07.08.2019 | |
NO | 07.11.2019 | Documents cited: | Search | [Y]WO2011045668 (UNIV ALBERTA [CA], et al) [Y] 1,5,7-15 * page 35 - page 41 * * claims 1-39 *; | [Y] - STEWART A. LOW ET AL, "Targeting polymer therapeutics to bone", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, (20120128), vol. 64, no. 12, doi:10.1016/j.addr.2012.01.012, ISSN 0169-409X, pages 1189 - 1204, XP055245113 [Y] 1,5,7-15 * the whole document * DOI: http://dx.doi.org/10.1016/j.addr.2012.01.012 | [Y] - GITTENS S A ET AL, "Designing proteins for bone targeting", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 57, no. 7, ISSN 0169-409X, (20050525), pages 1011 - 1036, (20050525), XP027771432 [Y] 1,5,7-15 * the whole document * | [Y] - Jivan N Yewle, "BIFUNCTIONAL BISPHOSPHONATES FOR DELIVERING BIOMOLECULES TO BONE", UKnowledge Theses and Dissertations--Chemistry Chemistry 2012, (20120113), URL: http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1004&context=chemistry_etds, (20160127), XP055245123 [Y] 1-4,7-14 * experimetnal section * | [YP] - YEWLE JIVAN N ET AL, "Bifunctional bisphosphonates for delivering PTH (1-34) to bone mineral with enhanced bioactivity", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, (20130129), vol. 34, no. 12, doi:10.1016/J.BIOMATERIALS.2013.01.059, ISSN 0142-9612, pages 3141 - 3149, XP028971179 [YP] 1-4,7-14 * the whole document * DOI: http://dx.doi.org/10.1016/j.biomaterials.2013.01.059 | International search | [Y]WO2011045668 (UNIV ALBERTA [CA], et al); | [Y] - PONNAPAKKAM, T. ET AL., "A Single Injection of the Anabolic Bone Agent, Parathyroid Hormone-Collagen Binding Domain (PTH-CBD) Results in Sustained Increases in Bone Mineral Density for up to 12 Months in Normal Female Mice.", CALCIFIED TISSUE INTERNATIONAL, (20120718), vol. 91, pages 196 - 203, XP035097493 DOI: http://dx.doi.org/10.1007/s00223-012-9626-1 | [Y] - PONNAPAKKAM, T. ET AL., "Monthly Administration of a Novel PTH-Collagen Binding Domain Fusion Protein is Anabolic in Mice.", CALCIFIED TISSUE INTERNATIONAL, (20110422), vol. 88, pages 511 - 520, XP019902068 DOI: http://dx.doi.org/10.1007/s00223-011-9485-1 | [Y] - XIAN, L. ET AL., "Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells.", NATURE MEDICINE, (20120624), vol. 18, no. 7, pages 1095 - 1101, XP055241500 DOI: http://dx.doi.org/10.1038/nm.2793 | by applicant | WO2011045688 | - LOW et al., Advanced Drug Delivery Reviews, (20120000), vol. 64, pages 1189 - 1204 | - GITTENS et al., Advanced Drug Delivery Reviews, (20050000), vol. 57, pages 1011 - 1036 |