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Extract from the Register of European Patents

EP About this file: EP2890708

EP2890708 - PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.07.2020
Database last updated on 03.09.2024
FormerThe patent has been granted
Status updated on  05.07.2019
FormerGrant of patent is intended
Status updated on  14.02.2019
FormerExamination is in progress
Status updated on  07.04.2017
FormerRequest for examination was made
Status updated on  12.01.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
The Governors of the University of Alberta
4000 Enterprise Square
10230 Jasper Avenue
Edmonton, Alberta T5J 4P6 / CA
For all designated states
Doschak, Michael
2-108 Katz Group Centre For Pharmacy And
Public Health Research
Edmonton, AB T6G 2N8 / CA
For all designated states
Yang, Yang
2-108 Katz Group Centre For Pharmacy And
Public Health Research
Edmonton, AB T6G 2N8 / CA
For all designated states
Bhandari, Krishna, Hari
2-108 Katz Group Centre For Pharmacy And
Public Health Research
Edmonton, AB T6G 2N8 / CA
[2015/28]
Inventor(s)01 / DOSCHAK, Michael
2-108 Katz Group Centre For Pharmacy And
Public Health Research
Edmonton, AB T6G 2N8 / CA
02 / YANG, Yang
2-108 Katz Group Centre For Pharmacy And
Public Health Research
Edmonton, AB T6G 2N8 / CA
03 / BHANDARI, Krishna, Hari
2-108 Katz Group Centre For Pharmacy And
Public Health Research
Edmonton, AB T6G 2N8 / CA
 [2015/28]
Representative(s)Dehns
St. Bride's House
10 Salisbury Square
London EC4Y 8JD / GB
[2019/32]
Former [2015/28]Wilkins, Christopher George
Dehns
St Bride's House
10 Salisbury Square
London EC4Y 8JD / GB
Application number, filing date13832369.628.08.2013
[2019/32]
WO2013IB02349
Priority number, dateUS201261693818P28.08.2012         Original published format: US 201261693818 P
[2015/28]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2014033540
Date:06.03.2014
Language:EN
[2014/10]
Type: A2 Application without search report 
No.:EP2890708
Date:08.07.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 06.03.2014 takes the place of the publication of the European patent application.
[2015/28]
Type: B1 Patent specification 
No.:EP2890708
Date:07.08.2019
Language:EN
[2019/32]
Search report(s)International search report - published on:CA17.04.2014
(Supplementary) European search report - dispatched on:EP06.05.2016
ClassificationIPC:A61K31/663, A61K38/29, A61K47/54, A61K47/60, C07K14/62, C07K14/635, C07K14/65, C08F299/02
[2019/08]
CPC:
C07K14/62 (EP,US); A61K31/663 (US); A61K38/29 (EP,US);
A61K47/548 (EP,US); A61K47/60 (EP,US); A61P19/02 (EP);
A61P19/08 (EP); C07K14/635 (EP,US); C07K14/65 (EP,US);
C08F299/02 (US) (-)
Former IPC [2016/10]C07K14/65, A61K38/28, A61P19/08, C07K14/62, C07K14/635, C07K17/08, A61K47/48, C08F299/02
Former IPC [2015/28]C07K14/65, A61K38/28, A61P19/08, C07K14/62, C07K14/635, C07K17/08
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/28]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:PARATHYROIDHORMON, INSULIN UND VERWANDTE MIT KNOCHENANZIELENDEN EINHEITEN VERBUNDENE PEPTIDE SOWIE VERFAHREN ZUR HERSTELLUNG UND VERWENDUNG DAVON[2015/28]
English:PARATHYROID HORMONE, INSULIN, AND RELATED PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF[2015/28]
French:PARATHORMONE, INSULINE, ET PEPTIDES ASSOCIÉS CONJUGUÉS À DES FRACTIONS DE CIBLAGE OSSEUX, ET PROCÉDÉS DE FABRICATION ET D'UTILISATION DE CEUX-CI[2015/28]
Entry into regional phase26.03.2015National basic fee paid 
26.03.2015Search fee paid 
26.03.2015Designation fee(s) paid 
26.03.2015Examination fee paid 
Examination procedure26.03.2015Examination requested  [2015/28]
14.03.2017Amendment by applicant (claims and/or description)
06.04.2017Despatch of a communication from the examining division (Time limit: M06)
31.08.2017Reply to a communication from the examining division
11.12.2017Despatch of a communication from the examining division (Time limit: M06)
20.07.2018Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
28.09.2018Reply to a communication from the examining division
10.12.2018Invitation to indicate the basis for amendments (Time limit: M01)
14.01.2019Reply to an invitation to indicate the basis for amendments
15.02.2019Communication of intention to grant the patent
24.06.2019Fee for grant paid
24.06.2019Fee for publishing/printing paid
24.06.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  06.04.2017
Opposition(s)03.06.2020No opposition filed within time limit [2020/33]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
28.09.2018Request for further processing filed
28.09.2018Full payment received (date of receipt of payment)
Request granted
11.10.2018Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
14.03.2017Request for further processing filed
14.03.2017Full payment received (date of receipt of payment)
Request granted
27.03.2017Decision despatched
Fees paidRenewal fee
18.08.2015Renewal fee patent year 03
30.08.2016Renewal fee patent year 04
18.08.2017Renewal fee patent year 05
28.08.2018Renewal fee patent year 06
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.08.2013
AL07.08.2019
AT07.08.2019
CY07.08.2019
CZ07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
IT07.08.2019
LT07.08.2019
LV07.08.2019
MC07.08.2019
MK07.08.2019
MT07.08.2019
NL07.08.2019
PL07.08.2019
RO07.08.2019
RS07.08.2019
SE07.08.2019
SI07.08.2019
SK07.08.2019
SM07.08.2019
TR07.08.2019
IE28.08.2019
LU28.08.2019
BE31.08.2019
CH31.08.2019
LI31.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
[2022/31]
Former [2021/34]HU28.08.2013
AL07.08.2019
AT07.08.2019
CY07.08.2019
CZ07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
IT07.08.2019
LT07.08.2019
LV07.08.2019
MC07.08.2019
MT07.08.2019
NL07.08.2019
PL07.08.2019
RO07.08.2019
RS07.08.2019
SE07.08.2019
SI07.08.2019
SK07.08.2019
SM07.08.2019
TR07.08.2019
IE28.08.2019
LU28.08.2019
BE31.08.2019
CH31.08.2019
LI31.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
Former [2021/32]HU28.08.2013
AL07.08.2019
AT07.08.2019
CY07.08.2019
CZ07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
IT07.08.2019
LT07.08.2019
LV07.08.2019
MC07.08.2019
NL07.08.2019
PL07.08.2019
RO07.08.2019
RS07.08.2019
SE07.08.2019
SI07.08.2019
SK07.08.2019
SM07.08.2019
TR07.08.2019
IE28.08.2019
LU28.08.2019
BE31.08.2019
CH31.08.2019
LI31.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
Former [2021/26]AL07.08.2019
AT07.08.2019
CY07.08.2019
CZ07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
IT07.08.2019
LT07.08.2019
LV07.08.2019
MC07.08.2019
NL07.08.2019
PL07.08.2019
RO07.08.2019
RS07.08.2019
SE07.08.2019
SI07.08.2019
SK07.08.2019
SM07.08.2019
TR07.08.2019
IE28.08.2019
LU28.08.2019
BE31.08.2019
CH31.08.2019
LI31.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
Former [2020/37]AL07.08.2019
AT07.08.2019
CZ07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
IT07.08.2019
LT07.08.2019
LV07.08.2019
MC07.08.2019
NL07.08.2019
PL07.08.2019
RO07.08.2019
RS07.08.2019
SE07.08.2019
SI07.08.2019
SK07.08.2019
SM07.08.2019
TR07.08.2019
IE28.08.2019
LU28.08.2019
BE31.08.2019
CH31.08.2019
LI31.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
Former [2020/36]AL07.08.2019
AT07.08.2019
CZ07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
IT07.08.2019
LT07.08.2019
LV07.08.2019
MC07.08.2019
NL07.08.2019
PL07.08.2019
RO07.08.2019
RS07.08.2019
SE07.08.2019
SK07.08.2019
SM07.08.2019
TR07.08.2019
IE28.08.2019
LU28.08.2019
CH31.08.2019
LI31.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
Former [2020/27]AL07.08.2019
AT07.08.2019
CZ07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
IT07.08.2019
LT07.08.2019
LV07.08.2019
MC07.08.2019
NL07.08.2019
PL07.08.2019
RO07.08.2019
RS07.08.2019
SE07.08.2019
SK07.08.2019
SM07.08.2019
TR07.08.2019
LU28.08.2019
CH31.08.2019
LI31.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
PT09.12.2019
IS24.02.2020
Former [2020/25]AL07.08.2019
AT07.08.2019
CZ07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
IT07.08.2019
LT07.08.2019
LV07.08.2019
NL07.08.2019
PL07.08.2019
RO07.08.2019
RS07.08.2019
SE07.08.2019
SK07.08.2019
TR07.08.2019
LU28.08.2019
CH31.08.2019
LI31.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
PT09.12.2019
IS24.02.2020
Former [2020/24]AL07.08.2019
AT07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
IT07.08.2019
LT07.08.2019
LV07.08.2019
NL07.08.2019
PL07.08.2019
RO07.08.2019
RS07.08.2019
SE07.08.2019
TR07.08.2019
CH31.08.2019
LI31.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
PT09.12.2019
IS24.02.2020
Former [2020/23]AL07.08.2019
AT07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
IT07.08.2019
LT07.08.2019
LV07.08.2019
NL07.08.2019
PL07.08.2019
RO07.08.2019
RS07.08.2019
SE07.08.2019
TR07.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
Former [2020/22]AL07.08.2019
DK07.08.2019
EE07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
LT07.08.2019
LV07.08.2019
NL07.08.2019
RS07.08.2019
SE07.08.2019
TR07.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
Former [2020/17]AL07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
LT07.08.2019
LV07.08.2019
NL07.08.2019
RS07.08.2019
SE07.08.2019
TR07.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
Former [2020/15]AL07.08.2019
ES07.08.2019
FI07.08.2019
HR07.08.2019
LT07.08.2019
LV07.08.2019
NL07.08.2019
RS07.08.2019
SE07.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
Former [2020/12]ES07.08.2019
FI07.08.2019
HR07.08.2019
LT07.08.2019
LV07.08.2019
NL07.08.2019
RS07.08.2019
SE07.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
IS07.12.2019
PT09.12.2019
Former [2020/11]ES07.08.2019
FI07.08.2019
HR07.08.2019
LT07.08.2019
LV07.08.2019
NL07.08.2019
RS07.08.2019
SE07.08.2019
BG07.11.2019
NO07.11.2019
GR08.11.2019
PT09.12.2019
Former [2020/10]FI07.08.2019
LT07.08.2019
NL07.08.2019
SE07.08.2019
BG07.11.2019
NO07.11.2019
PT09.12.2019
Former [2020/09]FI07.08.2019
LT07.08.2019
NL07.08.2019
NO07.11.2019
Former [2020/08]LT07.08.2019
NO07.11.2019
Documents cited:Search[Y]WO2011045668  (UNIV ALBERTA [CA], et al) [Y] 1,5,7-15 * page 35 - page 41 * * claims 1-39 *;
 [Y]  - STEWART A. LOW ET AL, "Targeting polymer therapeutics to bone", ADVANCED DRUG DELIVERY REVIEWS, AMSTERDAM, NL, (20120128), vol. 64, no. 12, doi:10.1016/j.addr.2012.01.012, ISSN 0169-409X, pages 1189 - 1204, XP055245113 [Y] 1,5,7-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.addr.2012.01.012
 [Y]  - GITTENS S A ET AL, "Designing proteins for bone targeting", ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER, AMSTERDAM, NL, vol. 57, no. 7, ISSN 0169-409X, (20050525), pages 1011 - 1036, (20050525), XP027771432 [Y] 1,5,7-15 * the whole document *
 [Y]  - Jivan N Yewle, "BIFUNCTIONAL BISPHOSPHONATES FOR DELIVERING BIOMOLECULES TO BONE", UKnowledge Theses and Dissertations--Chemistry Chemistry 2012, (20120113), URL: http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1004&context=chemistry_etds, (20160127), XP055245123 [Y] 1-4,7-14 * experimetnal section *
 [YP]  - YEWLE JIVAN N ET AL, "Bifunctional bisphosphonates for delivering PTH (1-34) to bone mineral with enhanced bioactivity", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, (20130129), vol. 34, no. 12, doi:10.1016/J.BIOMATERIALS.2013.01.059, ISSN 0142-9612, pages 3141 - 3149, XP028971179 [YP] 1-4,7-14 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2013.01.059
International search[Y]WO2011045668  (UNIV ALBERTA [CA], et al);
 [Y]  - PONNAPAKKAM, T. ET AL., "A Single Injection of the Anabolic Bone Agent, Parathyroid Hormone-Collagen Binding Domain (PTH-CBD) Results in Sustained Increases in Bone Mineral Density for up to 12 Months in Normal Female Mice.", CALCIFIED TISSUE INTERNATIONAL, (20120718), vol. 91, pages 196 - 203, XP035097493

DOI:   http://dx.doi.org/10.1007/s00223-012-9626-1
 [Y]  - PONNAPAKKAM, T. ET AL., "Monthly Administration of a Novel PTH-Collagen Binding Domain Fusion Protein is Anabolic in Mice.", CALCIFIED TISSUE INTERNATIONAL, (20110422), vol. 88, pages 511 - 520, XP019902068

DOI:   http://dx.doi.org/10.1007/s00223-011-9485-1
 [Y]  - XIAN, L. ET AL., "Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells.", NATURE MEDICINE, (20120624), vol. 18, no. 7, pages 1095 - 1101, XP055241500

DOI:   http://dx.doi.org/10.1038/nm.2793
by applicantWO2011045688
    - LOW et al., Advanced Drug Delivery Reviews, (20120000), vol. 64, pages 1189 - 1204
    - GITTENS et al., Advanced Drug Delivery Reviews, (20050000), vol. 57, pages 1011 - 1036
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.