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Extract from the Register of European Patents

EP About this file: EP2934551

EP2934551 - POST-SYNTHETIC ORTHOGONAL AMIDATION PLUS METAL CATALYZED AZIDE-ALKYNE CYCLOADDITION CLICK CHEMISTRY ON SI-RNA [Right-click to bookmark this link]
Former [2015/44]POST-SYNTHETIC ORTHOGONAL AMIDATION PLUS METAL CATALYZED AZIDE-ALKYNE CYCLOADDITION CLICK CHEMISTRY ON siRNA
[2017/25]
StatusNo opposition filed within time limit
Status updated on  05.10.2018
Database last updated on 19.10.2024
FormerThe patent has been granted
Status updated on  27.10.2017
FormerGrant of patent is intended
Status updated on  07.06.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL, IS		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Sirna Therapeutics, Inc.
300 Third Street
Cambridge MA 02142 / US
[2015/44]
Inventor(s)01 / ZEWGE, Daniel
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
02 / COPELAND, Gregory, T.
730 Harvard Avenue
Claremont, CA 91711 / US
03 / LI, Zhen
6 Hawthorne Drive
Westfield, NJ 07090 / US
04 / ARMSTRONG, Joseph, D., III
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
 [2015/44]
Representative(s)Müller-Boré & Partner Patentanwälte PartG mbB
Friedenheimer Brücke 21
80639 München / DE
[2015/44]
Application number, filing date13865727.518.12.2013
[2015/44]
WO2013US75914
Priority number, dateUS201261740083P20.12.2012         Original published format: US 201261740083 P
[2015/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014100069
Date:26.06.2014
Language:EN
[2014/26]
Type: A1 Application with search report 
No.:EP2934551
Date:28.10.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 26.06.2014 takes the place of the publication of the European patent application.
[2015/44]
Type: B1 Patent specification 
No.:EP2934551
Date:29.11.2017
Language:EN
[2017/48]
Search report(s)International search report - published on:US26.06.2014
(Supplementary) European search report - dispatched on:EP03.05.2016
ClassificationIPC:A61K31/712, C07H21/02
[2016/22]
CPC:
C12N15/113 (EP,US); A61K31/712 (EP,US); C07H21/02 (EP,US);
C12N15/111 (EP,US); C12N2310/14 (EP,US); C12N2310/317 (EP,US);
C12N2310/321 (EP,US); C12N2310/322 (US); C12N2310/332 (EP,US);
C12N2330/30 (EP,US) (-)
Former IPC [2015/44]A61K31/712
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/44]
Extension statesBA09.07.2015
ME09.07.2015
TitleGerman:POSTSYNTHETISCHE ORTHOGONALE AMIDIERUNG PLUS METALLKATALYSIERTER AZID-ALKYN-CYCLOADDITIONS-CLICK-CHEMIE AUF SI-RNA[2017/25]
English:POST-SYNTHETIC ORTHOGONAL AMIDATION PLUS METAL CATALYZED AZIDE-ALKYNE CYCLOADDITION CLICK CHEMISTRY ON SI-RNA[2017/25]
French:AMIDATION ORTHOGONALE POST-SYNTHÈSE PLUS CHIMIE CLICK DE CYCLOADDITION AZOTURE-ALCYNE CATALYSÉE PAR UN MÉTAL SUR SI-ARN[2017/25]
Former [2015/44]POSTSYNTHETISCHE ORTHOGONALE AMIDIERUNG PLUS METALLKATALYSIERTER AZID-ALKYN-CYCLOADDITIONS-CLICK-CHEMIE AUF SIRNA
Former [2015/44]POST-SYNTHETIC ORTHOGONAL AMIDATION PLUS METAL CATALYZED AZIDE-ALKYNE CYCLOADDITION CLICK CHEMISTRY ON siRNA
Former [2015/44]AMIDATION ORTHOGONALE POST-SYNTHÈSE PLUS CHIMIE CLICK DE CYCLOADDITION AZOTURE-ALCYNE CATALYSÉE PAR UN MÉTAL SUR ARNSI
Entry into regional phase09.07.2015National basic fee paid 
09.07.2015Search fee paid 
09.07.2015Designation fee(s) paid 
09.07.2015Examination fee paid 
Examination procedure09.07.2015Examination requested  [2015/44]
22.11.2016Amendment by applicant (claims and/or description)
08.06.2017Communication of intention to grant the patent
11.10.2017Receipt of the translation of the claim(s)
12.10.2017Fee for grant paid
12.10.2017Fee for publishing/printing paid
Divisional application(s)EP17001941.8  / EP3357499
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  08.06.2017
Opposition(s)30.08.2018No opposition filed within time limit [2018/45]
Fees paidRenewal fee
28.12.2015Renewal fee patent year 03
27.12.2016Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.12.2013
AL29.11.2017
AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
MC29.11.2017
MK29.11.2017
NL29.11.2017
PL29.11.2017
PT29.11.2017
RO29.11.2017
RS29.11.2017
SE29.11.2017
SI29.11.2017
SK29.11.2017
SM29.11.2017
TR29.11.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
IS29.03.2018
[2020/33]
Former [2020/28]HU18.12.2013
AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
MC29.11.2017
MK29.11.2017
NL29.11.2017
PL29.11.2017
PT29.11.2017
RO29.11.2017
RS29.11.2017
SE29.11.2017
SI29.11.2017
SK29.11.2017
SM29.11.2017
TR29.11.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2020/16]HU18.12.2013
AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
MC29.11.2017
MK29.11.2017
NL29.11.2017
PL29.11.2017
RO29.11.2017
RS29.11.2017
SE29.11.2017
SI29.11.2017
SK29.11.2017
SM29.11.2017
TR29.11.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2019/52]HU18.12.2013
AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
MC29.11.2017
MK29.11.2017
NL29.11.2017
PL29.11.2017
RO29.11.2017
RS29.11.2017
SE29.11.2017
SI29.11.2017
SK29.11.2017
SM29.11.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2019/31]HU18.12.2013
AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
MC29.11.2017
NL29.11.2017
PL29.11.2017
RO29.11.2017
RS29.11.2017
SE29.11.2017
SI29.11.2017
SK29.11.2017
SM29.11.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2019/30]AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
MC29.11.2017
NL29.11.2017
PL29.11.2017
RO29.11.2017
RS29.11.2017
SE29.11.2017
SI29.11.2017
SK29.11.2017
SM29.11.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2018/52]AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
NL29.11.2017
PL29.11.2017
RO29.11.2017
RS29.11.2017
SE29.11.2017
SI29.11.2017
SK29.11.2017
SM29.11.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2018/50]AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
NL29.11.2017
PL29.11.2017
RO29.11.2017
RS29.11.2017
SE29.11.2017
SK29.11.2017
SM29.11.2017
LU18.12.2017
MT18.12.2017
BE31.12.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2018/43]AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
NL29.11.2017
PL29.11.2017
RO29.11.2017
RS29.11.2017
SE29.11.2017
SK29.11.2017
SM29.11.2017
LU18.12.2017
MT18.12.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2018/40]AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
NL29.11.2017
PL29.11.2017
RO29.11.2017
RS29.11.2017
SE29.11.2017
SK29.11.2017
SM29.11.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2018/39]AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
IT29.11.2017
LT29.11.2017
LV29.11.2017
NL29.11.2017
PL29.11.2017
RS29.11.2017
SE29.11.2017
SK29.11.2017
SM29.11.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2018/37]AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
LT29.11.2017
LV29.11.2017
NL29.11.2017
PL29.11.2017
RS29.11.2017
SE29.11.2017
SK29.11.2017
SM29.11.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2018/35]AT29.11.2017
CY29.11.2017
CZ29.11.2017
DK29.11.2017
EE29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
LT29.11.2017
LV29.11.2017
NL29.11.2017
RS29.11.2017
SE29.11.2017
SK29.11.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2018/34]AT29.11.2017
DK29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
LT29.11.2017
LV29.11.2017
NL29.11.2017
RS29.11.2017
SE29.11.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2018/24]AT29.11.2017
ES29.11.2017
FI29.11.2017
HR29.11.2017
LT29.11.2017
LV29.11.2017
RS29.11.2017
SE29.11.2017
BG28.02.2018
NO28.02.2018
GR01.03.2018
Former [2018/22]ES29.11.2017
FI29.11.2017
LT29.11.2017
NO28.02.2018
Documents cited:Search[X]WO2010101951  (ALNYLAM PHARMACEUTICALS INC [US], et al) [X] 1-15 * scheme 32, pages 29, 33, 59-74;; example -; claim - *;
 [I]WO2011090968  (MERCK SHARP & DOHME [US], et al) [I] 1-15 * example -; claim - *;
 [I]  - PRAKASH T P ET AL, "2'-O-[2-(Amino)-2-oxoethyl] Oligonucleotides", ORGANIC LETTERS, AMERICAN CHEMICAL SOCIETY, US, vol. 5, no. 4, doi:10.1021/OL027131K, ISSN 1523-7060, (20030220), pages 403 - 406, (20030123), XP002579219 [I] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1021/ol027131k
 [A]  - WATTS J K ET AL, "Chemically modified siRNA: tools and applications", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 13, no. 19/20, doi:10.1016/J.DRUDIS.2008.05.007, ISSN 1359-6446, (20081001), pages 842 - 855, (20080707), XP002558509 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.drudis.2008.05.007
International search[Y]US2012035115  (MANOHARAN MUTHIAH [US], et al);
 [Y]US5532147  (NILSSON KURT [SE]);
 [A]US2011137010  (SRIVASTAVA SURESH C [US], et al);
 [Y]  - IYER ET AL., "Synthesis, in Vitro Anti-Breast Cancer Activity, and Intracellular Decomposition of Amino Acid Methyl Ester and Alkyl Amide Phosphoramidate Monoesters of 3' -Azido-3' -deoxythymidine (AZT", J. MED. CHEM., (20000101), vol. 43, no. 11, doi:10.1021/JM000110G, pages 2266 - 2274, XP055261212

DOI:   http://dx.doi.org/10.1021/jm000110g
 [A]  - AMBLARD ET AL., "CU(I)-CATALYZED HUISGEN AZIDE-ALKYNE 1,3-DIPOLAR CYCLOADDITION REACTION IN NUCLEOSIDE, NUCLEOTIDE, AND OLIGONUCLEOTIDE CHEMISTRY.", CHEM REV., (20090101), vol. 109, no. 9, doi:10.1021/CR9001462, pages 4207 - 4220, XP055261215

DOI:   http://dx.doi.org/10.1021/cr9001462
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.