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Extract from the Register of European Patents

EP About this file: EP2772251

EP2772251 - Protamine/RNA nanoparticles for immunostimulation [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.01.2022
Database last updated on 22.01.2025
FormerThe patent has been granted
Status updated on  29.01.2021
FormerGrant of patent is intended
Status updated on  23.09.2020
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024  [2024/41]
Applicant(s)For all designated states
Universität Zürich
Rämistrasse 71
8006 Zürich / CH
[2014/36]
Inventor(s)01 / Pascolo, Steve
Kanzleistrasse 231
8004 Zürich / CH
02 / Knuth, Alexander
Parkring 61
8002 Zürich / CH
 [2014/36]
Representative(s)Habermann, Hruschka & Schnabel
Patentanwälte
Montgelasstraße 2
81679 München / DE
[2014/36]
Application number, filing date14157188.526.05.2009
[2014/36]
Priority number, dateEP2008000958126.05.2008         Original published format: EP 08009581
[2014/36]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2772251
Date:03.09.2014
Language:EN
[2014/36]
Type: B1 Patent specification 
No.:EP2772251
Date:03.03.2021
Language:EN
[2021/09]
Search report(s)(Supplementary) European search report - dispatched on:EP06.08.2014
ClassificationIPC:A61K9/51, A61K47/62, A61P37/04, A61K39/00
[2020/38]
CPC:
A61K9/5169 (EP,US); A61K47/62 (EP,US); A61P37/04 (EP);
A61K2039/55555 (EP,US)
Former IPC [2014/36]A61K9/51, A61K39/00, A61K47/48, A61K48/00
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2021/09]
Former [2014/36]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Protamin-/RNA-Nanopartikel für die Immunstimulierung[2014/36]
English:Protamine/RNA nanoparticles for immunostimulation[2014/36]
French:Nanoparticules d'ARN/protamine pour l'immunostimulation[2014/36]
Examination procedure02.03.2015Amendment by applicant (claims and/or description)
02.03.2015Examination requested  [2015/15]
24.09.2020Communication of intention to grant the patent
21.01.2021Fee for grant paid
21.01.2021Fee for publishing/printing paid
21.01.2021Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP09753885.4  / EP2306993
Opposition(s)06.12.2021No opposition filed within time limit [2022/06]
Fees paidRenewal fee
28.02.2014Renewal fee patent year 03
28.02.2014Renewal fee patent year 04
28.02.2014Renewal fee patent year 05
28.02.2014Renewal fee patent year 06
25.03.2015Renewal fee patent year 07
21.03.2016Renewal fee patent year 08
08.05.2017Renewal fee patent year 09
12.04.2018Renewal fee patent year 10
17.05.2019Renewal fee patent year 11
20.03.2020Renewal fee patent year 12
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU26.05.2009
CY03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
MK03.03.2021
MT03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
IE26.05.2021
LU26.05.2021
BE31.05.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
[2024/41]
Former [2024/22]HU26.05.2009
CY03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
MK03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
IE26.05.2021
LU26.05.2021
BE31.05.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2023/29]HU26.05.2009
CY03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
IE26.05.2021
LU26.05.2021
BE31.05.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2023/24]CY03.03.2021
CZ03.03.2021
DK03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
IE26.05.2021
LU26.05.2021
BE31.05.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2022/34]CZ03.03.2021
DK03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
IE26.05.2021
LU26.05.2021
BE31.05.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2022/23]CZ03.03.2021
DK03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
IE26.05.2021
LU26.05.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2022/21]CZ03.03.2021
DK03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
IE26.05.2021
LU26.05.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
PT05.07.2021
Former [2022/13]CZ03.03.2021
DK03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SI03.03.2021
SK03.03.2021
LU26.05.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
PT05.07.2021
Former [2022/10]CZ03.03.2021
DK03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SK03.03.2021
LU26.05.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
PT05.07.2021
Former [2022/08]CZ03.03.2021
DK03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SK03.03.2021
LU26.05.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2022/07]CZ03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
MC03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SK03.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2021/51]CZ03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SK03.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
IS03.07.2021
PT05.07.2021
Former [2021/50]CZ03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
PL03.03.2021
RO03.03.2021
SE03.03.2021
SK03.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
PT05.07.2021
Former [2021/48]CZ03.03.2021
EE03.03.2021
FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
PL03.03.2021
SE03.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
Former [2021/39]FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
PL03.03.2021
SE03.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
Former [2021/38]FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
SE03.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
Former [2021/37]FI03.03.2021
HR03.03.2021
LT03.03.2021
LV03.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
Former [2021/36]FI03.03.2021
HR03.03.2021
LT03.03.2021
BG03.06.2021
NO03.06.2021
GR04.06.2021
Former [2021/35]FI03.03.2021
HR03.03.2021
LT03.03.2021
NO03.06.2021
Former [2021/33]FI03.03.2021
LT03.03.2021
NO03.06.2021
Documents cited:Search[X]WO03051401  (CUREVAC GMBH [DE], et al) [X] 1-17 * examples 1,3 *;
 [X]WO2005016376  (CUREVAC GMBH [DE], et al) [X] 1-17 * page 12, line 19 - page 13, line 26 *;
 [X]WO2007121347  (ALCON MFG LTD [US], et al) [X] 1-17 * paragraph [0101] * * claims 1-4 *;
 [X]  - WEYERMANN J ET AL, "Albumin-protamine-oligonucleotide-nanoparticles as a new antisense delivery system. Part 2: cellular uptake and effect", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 59, no. 3, ISSN 0939-6411, (20050401), pages 431 - 438, (20050401), XP025317611 [X] 1-17 * abstract * * page 431, column L, line 1 - page 437, column L, line 13 *

DOI:   http://dx.doi.org/10.1016/j.ejpb.2004.07.014
 [X]  - HOERR I ET AL, "In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies", EUROPEAN JOURNAL OF IMMUNOLOGY, WILEY - V C H VERLAG GMBH & CO. KGAA, DE, (20000101), vol. 30, no. 1, ISSN 0014-2980, pages 1 - 7, XP002243972 [X] 1-17 * page 2, column L, line 17 - page 6, column L, line 32 *

DOI:   http://dx.doi.org/10.1002/1521-4141(200001)30:1<1::AID-IMMU1>3.3.CO;2-R
 [X]  - LI SHYH-DAR ET AL, "Targeted delivery of antisense oligodeoxynucleotide and small interference RNA into lung cancer cells", MOLECULAR PHARMACEUTICS, AMERICAN CHEMICAL SOCIETY, US, (20061001), vol. 3, no. 5, ISSN 1543-8384, pages 579 - 588, XP009121365 [X] 1-17 * abstract * * page 580, column L, line 1 - page 588, column R, line 2 *

DOI:   http://dx.doi.org/10.1021/mp060039w
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