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Extract from the Register of European Patents

EP About this file: EP2777398

EP2777398 - Method for isolating a chemotherapeutic agent resistant cancer cell with stem cell properties [Right-click to bookmark this link]
Former [2014/38]Method for using cancer cells encapsulated in agarose, and coated with agarose, to screen potential therapeutic agents, to isolate cancer cells possessing stem cell like properties, and the cells resulting therefrom
[2017/02]
StatusNo opposition filed within time limit
Status updated on  16.02.2018
Database last updated on 05.07.2024
FormerThe patent has been granted
Status updated on  10.03.2017
FormerGrant of patent is intended
Status updated on  17.01.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
The Rogosin Institute, Inc.
505 East 70th Street
New York, NY 10021 / US
[2015/17]
Former [2014/38]For all designated states
THE ROGOSIN INSTITUTE
505 East 70th Street
New York, NY 10021 / US
Inventor(s)01 / Gazda, Lawrence
c/o The Rogosin Institute
Xenia Division
740 Birch Road
Xenia, OH 45385-9606 / US
02 / Smith, Barry
c/o The Rogosin Institute
505 East 70th Street
New York, NY 10021 / US
 [2014/41]
Representative(s)Zaccaro, Elisabetta, et al
Notarbartolo & Gervasi S.p.A.
Viale Achille Papa, 30
20149 Milano / IT
[N/P]
Former [2014/38]Zaccaro, Elisabetta, et al
Notarbartolo & Gervasi S.p.A.
Corso di Porta Vittoria, 9
20122 Milano / IT
Application number, filing date14171733.022.11.2011
[2014/38]
Priority number, dateUS20100458391P23.11.2010         Original published format: US 458391 P
US20100458390P23.11.2010         Original published format: US 458390 P
[2014/38]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2777398
Date:17.09.2014
Language:EN
[2014/38]
Type: B1 Patent specification 
No.:EP2777398
Date:12.04.2017
Language:EN
[2017/15]
Search report(s)(Supplementary) European search report - dispatched on:EP06.08.2014
ClassificationIPC:C12N5/095, G01N33/543, A61K31/282, A61K31/337, A61K31/519, A61K31/704, A61K33/24, A61K31/437
[2017/02]
CPC:
A61K33/243 (EP,US); G01N33/54313 (EP,RU,US); C12N5/0693 (KR);
A61K31/282 (EP,RU,US); A61K31/337 (EP,RU,US); A61K31/437 (EP,RU,US);
A61K31/519 (EP,RU,US); A61K31/704 (EP,RU,US); C12N5/0695 (EP,RU,US);
C12Q1/04 (KR); C12N2503/02 (EP,RU,US); C12N2533/76 (EP,RU,US);
G01N2333/4703 (EP,RU,US) (-)
Former IPC [2014/38]A01N43/02, G01N33/543, C12N5/095
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/15]
Former [2014/38]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:Verfahren zur Isolierung einer Chemotherapeutika resistenten Krebszelle mit Stammzelleneigenschaften[2017/02]
English:Method for isolating a chemotherapeutic agent resistant cancer cell with stem cell properties[2017/02]
French:Méthode pour isoler une cellule cancéreuse résistante aux agents chimiothérapeutiques avec des propriétés de cellules souches[2017/02]
Former [2014/41]Verfahren zur Verwendung von in Agarose eingekapselten und mit Agarose beschichteten Krebszellen, um potentielle therapeutische Mittel zu screenen, um Krebszellen, die stammzellähnliche Eigenschaften besitzen, zu isolieren und daraus resultierende Zellen
Former [2014/38]Method for using cancer cells encapsulated in agarose, and coated with agarose, to screen potential therapeutic agents, to isolate cancer cells possessing stem cell like properties, and the cells resulting therefrom
Former [2014/41]Procédé pour utiliser des cellules de cancer encapsulées dans de l'agarose et revêtues avec de l'agarose, pour cribler des agents thérapeutiques potentiels, afin d'isoler des cellules cancéreuses possédant des propriétés analogues aux cellules souches, et les cellules qui en résultent
Examination procedure13.11.2014Amendment by applicant (claims and/or description)
13.11.2014Examination requested  [2014/52]
09.02.2016Despatch of a communication from the examining division (Time limit: M04)
10.03.2016Reply to a communication from the examining division
24.05.2016Despatch of a communication from the examining division (Time limit: M04)
19.08.2016Reply to a communication from the examining division
05.09.2016Despatch of a communication from the examining division (Time limit: M04)
03.10.2016Reply to a communication from the examining division
18.01.2017Communication of intention to grant the patent
02.03.2017Fee for grant paid
02.03.2017Fee for publishing/printing paid
02.03.2017Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP11842977.8  / EP2597952
Opposition(s)15.01.2018No opposition filed within time limit [2018/12]
Fees paidRenewal fee
08.07.2014Renewal fee patent year 03
26.11.2014Renewal fee patent year 04
30.11.2015Renewal fee patent year 05
28.11.2016Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL12.04.2017
CY12.04.2017
EE12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
MK12.04.2017
RO12.04.2017
RS12.04.2017
SI12.04.2017
SK12.04.2017
SM12.04.2017
BG12.07.2017
IS12.08.2017
LU22.11.2017
MT22.11.2017
[2020/34]
Former [2019/52]CY12.04.2017
EE12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
MK12.04.2017
RO12.04.2017
RS12.04.2017
SI12.04.2017
SK12.04.2017
SM12.04.2017
BG12.07.2017
IS12.08.2017
LU22.11.2017
MT22.11.2017
Former [2019/46]CY12.04.2017
EE12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
RO12.04.2017
RS12.04.2017
SI12.04.2017
SK12.04.2017
SM12.04.2017
BG12.07.2017
IS12.08.2017
LU22.11.2017
MT22.11.2017
Former [2018/43]EE12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
RO12.04.2017
RS12.04.2017
SI12.04.2017
SK12.04.2017
SM12.04.2017
BG12.07.2017
IS12.08.2017
LU22.11.2017
MT22.11.2017
Former [2018/41]EE12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
RO12.04.2017
RS12.04.2017
SI12.04.2017
SK12.04.2017
SM12.04.2017
BG12.07.2017
IS12.08.2017
LU22.11.2017
Former [2018/33]EE12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
MC12.04.2017
RO12.04.2017
RS12.04.2017
SI12.04.2017
SK12.04.2017
SM12.04.2017
BG12.07.2017
IS12.08.2017
Former [2018/25]EE12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
RO12.04.2017
RS12.04.2017
SI12.04.2017
SK12.04.2017
SM12.04.2017
BG12.07.2017
IS12.08.2017
Former [2018/11]EE12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
RO12.04.2017
RS12.04.2017
SK12.04.2017
SM12.04.2017
BG12.07.2017
IS12.08.2017
Former [2018/10]EE12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
RO12.04.2017
RS12.04.2017
SK12.04.2017
BG12.07.2017
IS12.08.2017
Former [2018/09]EE12.04.2017
HR12.04.2017
LT12.04.2017
LV12.04.2017
RS12.04.2017
BG12.07.2017
IS12.08.2017
Former [2017/51]HR12.04.2017
LT12.04.2017
LV12.04.2017
RS12.04.2017
BG12.07.2017
IS12.08.2017
Former [2017/49]HR12.04.2017
LT12.04.2017
IS12.08.2017
Documents cited:Search[A]US5888487  (BAUMOELLER GUIDO [DE], et al) [A] 1,2 * claims 1-5 * * examples 1-10 *;
 [A]WO2009098698  (COHEN SHAHAR [IL]) [A] 1,2 * claims 1-66 *;
 [A]US7704967  (GNATT AVERALL [US]) [A] 1,2* column 5, line 46 - line 54 *;
 [A]US2010273160  (DONAHOE PATRICIA K [US], et al) [A] 1,2 * paragraph [0291] * * claims 110-129 *;
 [IDP]  - B. H. SMITH ET AL, "Hydrophilic Agarose Macrobead Cultures Select for Outgrowth of Carcinoma Cell Populations That Can Restrict Tumor Growth", CANCER RESEARCH, (20110124), vol. 71, no. 3, doi:10.1158/0008-5472.CAN-10-2258, ISSN 0008-5472, pages 725 - 735, XP055093632 [IDP] 1,2 * the whole document *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-10-2258
 [IDP]  - B. H. SMITH ET AL, "Three-Dimensional Culture of Mouse Renal Carcinoma Cells in Agarose Macrobeads Selects for a Subpopulation of Cells with Cancer Stem Cell or Cancer Progenitor Properties", CANCER RESEARCH, (20110201), vol. 71, no. 3, doi:10.1158/0008-5472.CAN-10-2254, ISSN 0008-5472, pages 716 - 724, XP055050161 [IDP] 1,2 * the whole document *

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-10-2254
 [A]  - L. MA ET AL, "Cancer stem-like cells can be isolated with drug selection in human ovarian cancer cell line SKOV3", ACTA BIOCHIMICA ET BIOPHYSICA SINICA, (20100812), vol. 42, no. 9, doi:10.1093/abbs/gmq067, ISSN 1672-9145, pages 593 - 602, XP055093702 [A] 1,2 * abstract *

DOI:   http://dx.doi.org/10.1093/abbs/gmq067
 [A]  - ELAINE LAI-HAN LEUNG ET AL, "Non-Small Cell Lung Cancer Cells Expressing CD44 Are Enriched for Stem Cell-Like Properties", PLOS ONE, (20101119), vol. 5, no. 11, doi:10.1371/journal.pone.0014062, page e14062, XP055093684 [A] 1,2 * abstract *

DOI:   http://dx.doi.org/10.1371/journal.pone.0014062
 [A]  - CHAUCHEREAU A ET AL, "Stemness markers characterize IGR-CaP1, a new cell line derived from primary epithelial prostate cancer", EXPERIMENTAL CELL RESEARCH, ACADEMIC PRESS, US, vol. 317, no. 3, ISSN 0014-4827, (20100123), pages 262 - 275, (20101214), XP027558834 [A] 1,2 * abstract *
 [A]  - GURSKI L A ET AL, "Hyaluronic acid-based hydrogels as 3D matrices for in vitro evaluation of chemotherapeutic drugs using poorly adherent prostate cancer cells", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 30, no. 30, doi:10.1016/J.BIOMATERIALS.2009.07.054, ISSN 0142-9612, (20091001), pages 6076 - 6085, (20090819), XP026524674 [A] 1,2 * abstract *

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2009.07.054
 [A]  - HARMA VILLE ET AL, "A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses", PLOS ONE, PUBLIC LIBRARY OF SCIENCE, US, (20100501), vol. 5, no. 5, doi:10.1371/JOURNAL.PONE.0010431, ISSN 1932-6203, XP009158800 [A] 1,2 * abstract * * page 12, column left *

DOI:   http://dx.doi.org/10.1371/journal.pone.0010431
by applicantUS5888497
 US6303151
 US6808705
 US6818230
 US7041504
 US2007071732
 US7297331
    - SMITH ET AL., CANE RES., (2011), vol. 71, no. 3, pages 716 - 724
    - SMITH ET AL., CANE. RES., (2011), vol. 71, no. 3, pages 724 - 735
    - PARK ET AL., NATURE, (2008), vol. 451, no. 7475, pages 141 - 146
    - INTERNATIONAL STEM CELL INITIATIVE ET AL., NAT. BIOTECHNOL, (2007), vol. 25, no. 7, pages 803 - 16
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.