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Extract from the Register of European Patents

EP About this file: EP2865765

EP2865765 - Complex miRNA sets as novel biomarkers for an acute coronary syndrome [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  23.06.2017
Database last updated on 05.10.2024
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): IS		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
Hummingbird Diagnostics GmbH
Im Neuenheimer Feld 583
69120 Heidelberg / DE
[2016/28]
Former [2015/18]For all designated states
Comprehensive Biomarker Center GmbH
Im Neuenheimer Feld 583
69120 Heidelberg / DE
Inventor(s)01 / Keller, Andreas
Albert-Schweitzer-Str. 6
66346 Püttlingen / DE
02 / Stähler, Peer
Obere Clignetstr. 14
68167 Mannheim / DE
03 / Beier, Markus
Marc-Aurel-Weg 20
69469 Weinheim / DE
04 / Meder, Benjamin
Fliederweg 1
69221 Dossenheim / DE
05 / Katus, Hugo
Philosophenweg 17
69120 Heidelberg / DE
06 / Rottbauer, Wolfgang
Lange Lemppen 10
89075 Ulm / DE
 [2015/18]
Representative(s)Geling, Andrea
ZSP Patentanwälte PartG mbB
Hansastraße 32
80686 München / DE
[N/P]
Former [2016/33]Geling, Andrea
ZSP Patentanwälte PartG mbB
Radlkoferstrasse 2
81373 München / DE
Former [2015/18]Geling, Andrea
ZSP Patentanwälte
Partnerschaftsgesellschaft
Radlkoferstrasse 2
81373 München / DE
Application number, filing date14174637.019.04.2011
[2015/18]
Priority number, dateUS20100326043P20.04.2010         Original published format: US 326043 P
EP2010000419020.04.2010         Original published format: EP 10004190
EP2010018513601.10.2010         Original published format: EP 10185136
[2015/18]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2865765
Date:29.04.2015
Language:EN
[2015/18]
Type: B1 Patent specification 
No.:EP2865765
Date:17.08.2016
Language:EN
[2016/33]
Search report(s)(Supplementary) European search report - dispatched on:EP23.02.2015
ClassificationIPC:C12Q1/68
[2015/18]
CPC:
C12Q1/6883 (EP,US); C12Q1/6876 (US); C12Q2600/158 (EP,US);
C12Q2600/178 (EP,US); Y02A90/10 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/46]
Former [2015/18]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:Komplexe miRNA-Sätze als neuartige Biomarker für ein akutes Koronarsyndrom[2015/18]
English:Complex miRNA sets as novel biomarkers for an acute coronary syndrome[2015/18]
French:Ensembles miARN complexes en tant que nouveaux biomarqueurs d'un syndrome coronaire aigu[2015/18]
Examination procedure30.09.2015Amendment by applicant (claims and/or description)
30.09.2015Examination requested  [2015/46]
23.02.2016Communication of intention to grant the patent
30.06.2016Fee for grant paid
30.06.2016Fee for publishing/printing paid
30.06.2016Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP11715666.1  / EP2561091
Divisional application(s)EP16182837.1  / EP3124623
Opposition(s)18.05.2017No opposition filed within time limit [2017/30]
Fees paidRenewal fee
16.10.2014Renewal fee patent year 03
16.10.2014Renewal fee patent year 04
29.04.2015Renewal fee patent year 05
29.04.2016Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU19.04.2011
AL17.08.2016
AT17.08.2016
BE17.08.2016
CY17.08.2016
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DK17.08.2016
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[2020/33]
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Documents cited:Search[A]WO2009149182  (UNIV TEXAS [US], et al) [A] 1-15 * sequence 20020 *;
 [A]WO2009043353  (SANTARIS PHARMA AS [DK], et al) [A] 1-15 * page 93, line 35; sequence 233 *;
 [A]WO2009070653  (UNIV OHIO STATE RES FOUND [US], et al) [A] 1-15 * table 2 *
 [A]  - AI J ET AL, "Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC. ORLANDO, FL, US, vol. 391, no. 1, doi:10.1016/J.BBRC.2009.11.005, ISSN 0006-291X, (20100101), pages 73 - 77, (20091105), XP026907859 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1016/j.bbrc.2009.11.005
 [A]  - WANG GUO-KUN ET AL, "Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans.", EUROPEAN HEART JOURNAL, (201003), vol. 31, no. 6, ISSN 1522-9645, pages 659 - 666, XP002586116 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1093/EURHEART/EHQ013
 [A]  - HOEKSTRA MENNO ET AL, "The peripheral blood mononuclear cell microRNA signature of coronary artery disease", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (20100315), vol. 394, no. 3, pages 792 - 797, XP002586117 [A] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1016/J.BBRC.2010.03.075
 [A]  - TIJSEN ANKE J ET AL, "MiR423-5p as a circulating biomarker for heart failure.", CIRCULATION RESEARCH, (20100402), vol. 106, no. 6, ISSN 1524-4571, pages 1035 - 1039, XP002586118 [A] 1-15 * abstract * * Supplementary data Table 1; page 1036, column 1, paragraph 2 *

DOI:   http://dx.doi.org/10.1161/CIRCRESAHA.110.218297
    [ ] - Tijsen et al., "Supplement material", Circulation Research, (20100402), URL: http://circres.ahajournals.org/cgi/data/CIRCRESAHA.110.218297/DC1/1, (20100608) [ ] * page 9; table 1 *
    [ ] - "Sequence 20020 from Patent WO2009149182.", EMBL, (20100114), Database accession no. HC275573, URL: EBI, XP002637609 [ ] * compound . *
    [ ] - "Sequence 233 from Patent WO2009043353.", EMBL, (20090507), Database accession no. GN345469, URL: EBI, XP002637608 [ ] * compound . *
by applicant   - AI, BIOCHEM. AND BIOPHYSICAL RESEARCH COMMUNICATION, (2010), vol. 391, pages 73 - 77
    - WANG ET AL., EUROPEAN HEART JOURNAL, (2010), vol. 31, pages 659 - 666
    - PT NELSON ET AL., NATURE METHODS, (2004), vol. 1, no. 2, page 1
    - VORWERK S. ET AL., "Microfluidic based enzymatic on-chip labeling ofmiRNAs", N. BIOTECHNOL., (20080820), vol. 25, no. 2-3, doi:doi:10.1016/j.nbt.2008.08.005, pages 142 - 9, XP025711668

DOI:   http://dx.doi.org/10.1016/j.nbt.2008.08.005
    - ZHAO Y; SAMAL E; SRIVASTAVA D., "Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis", NATURE, (2005), vol. 436, doi:doi:10.1038/nature03817, pages 214 - 20, XP002396711

DOI:   http://dx.doi.org/10.1038/nature03817
    - DRESIOS J; ASCHRAFI A; OWENS GC; VANDERKLISH PW; EDELMAN GM; MAURO VP, "Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis", PROC NATL ACAD SCI U S A., (2005), vol. 102, doi:doi:10.1073/pnas.0409764102, pages 1865 - 70, XP002486928

DOI:   http://dx.doi.org/10.1073/pnas.0409764102
    - XU P; VERNOOY SY; GUO M; HAY BA, "The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism", CURR BIOL., (2003), vol. 13, doi:doi:10.1016/S0960-9822(03)00250-1, pages 790 - 5, XP002994326

DOI:   http://dx.doi.org/10.1016/S0960-9822(03)00250-1
    - CIMMINO A; CALIN GA; FABBRI M; IORIO MV; FERRACIN M; SHIMIZU M; WOJCIK SE; AQEILAN RI; ZUPO S; DONO M, "miR-15 and miR-16 induce apoptosis by targeting BCL2", PROC NATL ACAD SCI U S A., (2005), vol. 102, doi:doi:10.1073/pnas.0506654102, pages 13944 - 9, XP002484308

DOI:   http://dx.doi.org/10.1073/pnas.0506654102
    - CALIN GA; GARZON R; CIMMINO A; FABBRI M; CROCE CM, "MicroRNAs and leukemias: how strong is the connection?", LEUK RES., (2006), vol. 30, doi:doi:10.1016/j.leukres.2005.10.017, pages 653 - 5, XP025088126

DOI:   http://dx.doi.org/10.1016/j.leukres.2005.10.017
    - CALIN GA; FERRACIN M; CIMMINO A; DI LEVA G; SHIMIZU M; WOJCIK SE; IORIO MV; VISONE R; SEVER NI; FABBRI M, "A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia", N ENGL J MED., (2005), vol. 353, doi:doi:10.1056/NEJMoa050995, pages 1793 - 801, XP009058593

DOI:   http://dx.doi.org/10.1056/NEJMoa050995
    - LEE RC; FEINBAUM RL; AMBROS V., "The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14", CELL, (1993), vol. 75, doi:doi:10.1016/0092-8674(93)90529-Y, pages 843 - 54, XP024246130

DOI:   http://dx.doi.org/10.1016/0092-8674(93)90529-Y
    - DONG S; CHENG Y; YANG J; LI J; LIU X; WANG X; WANG D; KRALL TJ; DELPHIN ES; ZHANG C, "MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction", J BIOL CHEM., (2009), vol. 284, doi:doi:10.1074/jbc.M109.027896, pages 29514 - 25, XP055017446

DOI:   http://dx.doi.org/10.1074/jbc.M109.027896
    - NEWTON PJ; BETIHAVAS V; MACDONALD P, "The role of b-type natriuretic peptide in heart failure management", AUST CRIT CARE., (2009), vol. 22, pages 117 - 23, XP026447216
    - LAINSCAK M; ANKER MS; VON HAEHLING S; ANKER SD, "Biomarkers for chronic heart failure : diagnostic, prognostic, and therapeutic challenges", HERZ, (2009), vol. 34, pages 589 - 93, XP019782767
    - MANZANO-FERNANDEZ S; BORONAT-GARCIA M; ALBALADEJO-OTON MD; PASTOR P; GARRIDO IP; PASTOR-PEREZ FJ; MARTINEZ-HERNANDEZ P; VALDES M;, "Complementary prognostic value of cystatin C, N-terminal pro-B-type natriuretic Peptide and cardiac troponin T in patients with acute heart failure", AM J CARDIOL., (2009), vol. 103, doi:doi:10.1016/j.amjcard.2009.02.029, pages 1753 - 9, XP026192635

DOI:   http://dx.doi.org/10.1016/j.amjcard.2009.02.029
    - KATUS HA; REMPPIS A; LOOSER S; HALLERMEIER K; SCHEFFOLD T; KUBLER W, "Enzyme linked immuno assay of cardiac troponin T for the detection of acute myocardial infarction in patients", J MOL CELL CARDIOL., (1989), vol. 21, doi:doi:10.1016/0022-2828(89)90680-9, pages 1349 - 53, XP022998019

DOI:   http://dx.doi.org/10.1016/0022-2828(89)90680-9
    - MUKOYAMA M; NAKAO K; SAITO Y; OGAWA Y; HOSODA K; SUGA S; SHIRAKAMI G; JOUGASAKI M; IMURA H, "Increased human brain natriuretic peptide in congestive heart failure", N ENGL J MED., (1990), vol. 323, pages 757 - 8
    - GERSZTEN RE; WANG TJ, "The search for new cardiovascular biomarkers", NATURE, (2008), vol. 451, doi:doi:10.1038/nature06802, pages 949 - 52, XP055033236

DOI:   http://dx.doi.org/10.1038/nature06802
    - GALLEGO-DELGADO J; LAZARO A; OSENDE JI; BARDERAS MG; BLANCO-COLIO LM; DURAN MC; MARTIN-VENTURA JL; VIVANCO F; EGIDO J., "Proteomic approach in the search of new cardiovascular biomarkers", KIDNEY INT SUPPL., (2005), pages 5103 - 7
    - GIANNITSIS E; ROTH HJ; LEITHAUSER RM; SCHERHAG J; BENEKE R; KATUS HA, "New highly sensitivity assay used to measure cardiac troponin T concentration changes during a continuous 216-km marathon", CLIN CHEM., (2009), vol. 55, pages 590 - 2
    - GRIFFITHS-JONES S, "miRBase: the microRNA sequence database", METHODS MOL BIOL., (2006), vol. 342, pages 129 - 38
    - VORWERK S; GANTER K; CHENG Y; HOHEISEL J; STAHLER PF; BEIER M., "Microfluidic-based enzymatic on-chip labeling of miRNAs", N BIOTECHNOL., (2008), vol. 25, doi:doi:10.1016/j.nbt.2008.08.005, pages 142 - 9, XP025711668

DOI:   http://dx.doi.org/10.1016/j.nbt.2008.08.005
    - BENJAMINI Y; HOCHBERG Y, "Controlling the false discovery rate: A practical and powerful approach to multiple testing", J R STATIST SOC B., (1995), vol. 57, pages 289 - 300
    - MEDER B; KATUS HA; ROTTBAUER W., "Right into the heart of microRNA-133a", GENES DEV., (2008), vol. 22, pages 3227 - 31
    - THUM T; GROSS C; FIEDLER J; FISCHER T; KISSLER S; BUSSEN M; GALUPPO P; JUST S; ROTTBAUER W; FRANTZ S, "MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts", NATURE, (2008), vol. 456, pages 980 - 4
    - CHEN X; BA Y; MA L; CAI X; YIN Y; WANG K; GUO J; ZHANG Y; CHEN J; GUO X, "Characterization ofmicroRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases", CELL RES, (2008), vol. 18, pages 997 - 1006
    - "Risk stratification and survival after myocardial infarction", N ENGL J MED., (1983), vol. 309, pages 331 - 6
    - ROTTBAUER W; GRETEN T; MULLER-BARDORFF M; REMPPIS A; ZEHELEIN J; GRUNIG E; KATUS HA, "Troponin T: a diagnostic marker for myocardial infarction and minor cardiac cell damage", EUR HEART J., (1996), vol. 17, pages 3 - 8, XP000856391
    - KURZ K; SCHILD C; ISFORT P; KATUS HA; GIANNITSIS E, "Serial and single time-point measurements of cardiac troponin T for prediction of clinical outcomes in patients with acute ST-segment elevation myocardial infarction", CLIN RES CARDIOL., (2009), vol. 98, pages 94 - 100, XP019712489
    - TZIVONI D; KOUKOUI D; GUETTA V; NOVACK L; COWING G, "Comparison of Troponin T to creatine kinase and to radionuclide cardiac imaging infarct size in patients with ST-elevation myocardial infarction undergoing primary angioplasty", AM J CARDIOL., (2008), vol. 101, doi:doi:10.1016/j.amjcard.2007.09.119, pages 753 - 7, XP022512468

DOI:   http://dx.doi.org/10.1016/j.amjcard.2007.09.119
    - DUISTERS RF; TIJSEN AJ; SCHROEN B; LEENDERS JJ; LENTINK V; VAN DER MADE I; HERIAS V; VAN LEEUWEN RE; SCHELLINGS MW; BARENBRUG P, "miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling", CIRC RES., (2009), vol. 104, doi:doi:10.1161/CIRCRESAHA.108.182535, pages 170 - 8, XP008102625

DOI:   http://dx.doi.org/10.1161/CIRCRESAHA.108.182535
    - "Risk stratification and survival after myocardial infarction", N ENGL J MED, (1983), vol. 309, pages 331 - 336
    - ADACHI T; NAKANISHI M; OTSUKA Y; NISHIMURA K; HIROKAWA G; GOTO Y; NONOGI H; IWAI N, "Plasma microRNA 499 as a biomarker of acute myocardial infarction", CLIN CHEM, (2010), vol. 56, doi:doi:10.1373/clinchem.2010.144121, pages 1183 - 1185, XP055062403

DOI:   http://dx.doi.org/10.1373/clinchem.2010.144121
    - AI J; ZHANG R; LI Y; PU J; LU Y; JIAO J; LI K; YU B; LI Z; WANG R, "Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction", BIOCHEM BIOPHYS RES COMMUN, (2010), vol. 391, doi:doi:10.1016/j.bbrc.2009.11.005, pages 73 - 77, XP026907859

DOI:   http://dx.doi.org/10.1016/j.bbrc.2009.11.005
    - ALIFERIS CF; STATNIKOV A; TSAMARDINOS I; SCHILDCROUT JS; SHEPHERD BE; HARRELL FE, JR., "Factors influencing the statistical power of complex data analysis protocols for molecular signature development from microarray data", PLOS ONE, (2009), vol. 4, page E4922
    - BENJAMINI Y; HOCHBERG Y, "Controlling the false discovery rate: A practical and powerful approach to multiple testing", J R STATIST SOC B, (1995), vol. 57, pages 289 - 300
    - BOSE D; VON BIRGELEN C; ZHOU XY; SCHMERMUND A; PHILIPP S; SACK S; KONORZA T; MOHLENKAMP S; LEINEWEBER K; KLEINBONGARD P, "Impact of atherosclerotic plaque composition on coronary microembolization during percutaneous coronary interventions", BASIC RES CARDIOL, (2008), vol. 103, doi:doi:10.1007/s00395-008-0745-9, pages 587 - 597, XP019656915

DOI:   http://dx.doi.org/10.1007/s00395-008-0745-9
    - CAI B; PAN Z; LU Y, "The roles of microRNAs in heart diseases: a novel important regulator", CURR MED CHEM, (2010), vol. 17, pages 407 - 411
    - CIMMINO A; CALIN GA; FABBRI M; IORIO MV; FERRACIN M; SHIMIZU M; WOJCIK SE; AQEILAN RI; ZUPO S; DONO M, "miR-15 and miR-16 induce apoptosis by targeting BCL2", PROC NATL ACAD SCI U S A, (2005), vol. 102, doi:doi:10.1073/pnas.0506654102, pages 13944 - 13949, XP002484308

DOI:   http://dx.doi.org/10.1073/pnas.0506654102
    - DONG S; CHENG Y; YANG J; LI J; LIU X; WANG X; WANG D; KRALL TJ; DELPHIN ES; ZHANG C, "MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction", J BIOL CHEM, (2009), vol. 284, doi:doi:10.1074/jbc.M109.027896, pages 29514 - 29525, XP055017446

DOI:   http://dx.doi.org/10.1074/jbc.M109.027896
    - DRESIOS J; ASCHRAFI A; OWENS GC; VANDERKLISH PW; EDELMAN GM; MAURO VP, "Cold stress-induced protein Rbm3 binds 60S ribosomal subunits, alters microRNA levels, and enhances global protein synthesis", PROC NATL ACAD SCI USA, (2005), vol. 102, doi:doi:10.1073/pnas.0409764102, pages 1865 - 1870, XP002486928

DOI:   http://dx.doi.org/10.1073/pnas.0409764102
    - CIRC RES, (2009), vol. 104, pages 170 - 178
    - FLEISSNER F; JAZBUTYTE V; FIEDLER J; GUPTA SK; YIN X; XU Q; GALUPPO P; KNEITZ S; MAYR M; ERTL G, "Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism", CIRC RES, (2010), vol. 107, pages 138 - 143
    - GALLEGO-DELGADO J; LAZARO A; OSENDE JI; BARDERAS MG; BLANCO-COLIO LM; DURAN MC; MARTIN-VENTURA JL; VIVANCO F; EGIDO J, "Proteomic approach in the search of new cardiovascular biomarkers", KIDNEY INT, (2005), pages 103 - 107
    - GERSZTEN RE; WANG TJ, "The search for new cardiovascular biomarkers", NATURE, (2008), vol. 451, doi:doi:10.1038/nature06802, pages 949 - 952, XP055033236

DOI:   http://dx.doi.org/10.1038/nature06802
    - GIANNITSIS E; ROTH HJ; LEITHAUSER RM; SCHERHAG J; BENEKE R; KATUS HA, "New highly sensitivity assay used to measure cardiac troponin T concentration changes during a continuous 216-km marathon", CLIN CHEM, (2009), vol. 55, pages 590 - 592
    - GRIFFITHS-JONES S, "miRBase: the microRNA sequence database", METHODS MOL BIOL, (2006), vol. 342, pages 129 - 138
    - HOCHBERG Y, "A sharper bonferroni procedure for multiple tests of significance", BIOMETRICA, (1988), vol. 75, pages 185 - 193
    - HOEKSTRA M; VAN DER LANS CA; HALVORSEN B; GULLESTAD L; KUIPER J; AUKRUST P; VAN BERKEL TJ; BIESSEN EA, "The peripheral blood mononuclear cell microRNA signature of coronary artery disease", BIOCHEM BIOPHYS RES COMMUN, (2010), vol. 394, pages 792 - 797
    - JENNEWEIN C; VON KNETHEN A; SCHMID T; BRUNE B, "MicroRNA-27b contributes to lipopolysaccharide-mediated peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA destabilization", J BIOL CHEM, (2010), vol. 285, pages 11846 - 11853
    - KATUS HA; REMPPIS A; LOOSER S; HALLERMEIER K; SCHEFFOLD T; KUBLER W, "Enzyme linked immuno assay of cardiac troponin T for the detection of acute myocardial infarction in patients", J MOL CELL CARDIOL, (1989), vol. 21, doi:doi:10.1016/0022-2828(89)90680-9, pages 1349 - 1353, XP022998019

DOI:   http://dx.doi.org/10.1016/0022-2828(89)90680-9
    - KONSTANDIN MH; AKSOY H; WABNITZ GH; VOLZ C; ERBEL C; KIRCHGESSNER H; GIANNITSIS E; KATUS HA; SAMSTAG Y; DENGLER TJ, "Beta2-integrin activation on T cell subsets is an independent prognostic factor in unstable angina pectoris", BASIC RES CARDIOL, (2009), vol. 104, pages 341 - 351, XP019712690
    - KURZ K; SCHILD C; ISFORT P; KATUS HA; GIANNITSIS E, "Serial and single time-point measurements of cardiac troponin T for prediction of clinical outcomes in patients with acute ST-segment elevation myocardial infarction", CLIN RES CARDIOL, (2009), vol. 98, pages 94 - 100, XP019712489
    - LAINSCAK M; ANKER MS; VON HAEHLING S; ANKER SD, "Biomarkers for chronic heart failure : diagnostic, prognostic, and therapeutic challenges", HERZ, (2009), vol. 34, pages 589 - 593, XP019782767
    - LEE RC; FEINBAUM RL; AMBROS V, "The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14", CELL, (1993), vol. 75, doi:doi:10.1016/0092-8674(93)90529-Y, pages 843 - 854, XP024246130

DOI:   http://dx.doi.org/10.1016/0092-8674(93)90529-Y
    - LEIDINGER P; KELLER A; BORRIES A; REICHRATH J; RASS K; JAGER SU; LENHOF HP; MEESE E, "High-throughput miRNA profiling of human melanoma blood samples", BMC CANCER, (2010), vol. 10, doi:doi:10.1186/1471-2407-10-262, page 262, XP021075098

DOI:   http://dx.doi.org/10.1186/1471-2407-10-262
    - MANZANO-FERNANDEZ S; BORONAT-GARCIA M; ALBALADEJO-OTON MD; PASTOR P; GARRIDO IP; PASTOR-PEREZ FJ; MARTINEZ-HERNANDEZ P; VALDES M;, "Complementary prognostic value of cystatin C, N-terminal pro-B-type natriuretic Peptide and cardiac troponin T in patients with acute heart failure", AM J CARDIOL, (2009), vol. 103, doi:doi:10.1016/j.amjcard.2009.02.029, pages 1753 - 1759, XP026192635

DOI:   http://dx.doi.org/10.1016/j.amjcard.2009.02.029
    - MEDER B; KATUS HA; ROTTBAUER W, "Right into the heart of microRNA-133a", GENES DEV, (2008), vol. 22, pages 3227 - 3231
    - MEREDITH D; PANCHATCHARAM M; MIRIYALA S; TSAI YS; MORRIS AJ; MAEDA N, STOUFFER GA; SMYTH SS, "Dominant-negative loss of PPARgamma function enhances smooth muscle cell proliferation, migration, and vascular remodeling", ARTERIOSCLER THROMB VASE BIOL, (2009), vol. 29, pages 465 - 471
    - MUKOYAMA M; NAKAO K; SAITO Y; OGAWA Y; HOSODA K; SUGA S; SHIRAKAMI G; JOUGASAKI M; IMURA H, "Increased human brain natriuretic peptide in congestive heart failure", N ENGL J MED, (1990), vol. 323, pages 757 - 758
    - NEWTON PJ; BETIHAVAS V; MACDONALD P, "The role of b-type natriuretic peptide in heart failure management", AUST CRIT CARE, (2009), vol. 22, pages 117 - 123, XP026447216
    - PORELA P; PULKKI K; VOIPIO-PULKKI LM; PETTERSSON K; LEPPANEN V; NEVALAINEN TJ, "Level of circulating phospholipase A2 in prediction of the prognosis of patients with suspected myocardial infarction", BASIC RES CARDIOL, (2000), vol. 95, pages 413 - 417
    - ROTTBAUER W; GRETEN T; MULLER-BARDORFFM; REMPPIS A; ZEHELEIN J; GRUNIG E; KATUS HA, "Troponin T: a diagnostic marker for myocardial infarction and minor cardiac cell damage", EUR HEART J, (1996), vol. 17, pages 3 - 8, XP000856391
    - THUM T; GROSS C; FIEDLER J; FISCHER T; KISSLER S; BUSSEN M; GALUPPO P; JUST S; ROTTBAUER W; FRANTZ S, "MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts.", NATURE, (2008), vol. 456, pages 980 - 984
    - TZIVONI D; KOUKOUI D; GUETTA V; NOVACK L; COWING G, "Comparison of Troponin T to creatine kinase and to radionuclide cardiac imaging infarct size in patients with ST-elevation myocardial infarction undergoing primary angioplasty", AM J CARDIOL, (2008), vol. 101, doi:doi:10.1016/j.amjcard.2007.09.119, pages 753 - 757, XP022512468

DOI:   http://dx.doi.org/10.1016/j.amjcard.2007.09.119
    - VOELLENKLE C; VAN ROOIJ J; CAPPUZZELLO C; GRECO S; ARCELLI D; DI VITO L; MELILLO G; RIGOLINI R; COSTA E; CREA F, "MicroRNA signatures in peripheral blood mononuclear cells of chronic heart failure patients", PHYSIOL GENOMICS, (2010), vol. 42, doi:doi:10.1152/physiolgenomics.00211.2009, pages 420 - 426, XP008133127

DOI:   http://dx.doi.org/10.1152/physiolgenomics.00211.2009
    - VORWERK S; GANTER K; CHENG Y; HOHEISEL J; STAHLER PF; BEIER M, "Microfluidic-based enzymatic on-chip labeling of miRNAs", N BIOTECHNOL, (2008), vol. 25, doi:doi:10.1016/j.nbt.2008.08.005, pages 142 - 149, XP025711668

DOI:   http://dx.doi.org/10.1016/j.nbt.2008.08.005
    - WANG GK; ZHU JQ; ZHANG JT; LI Q; LI Y; HE J; QIN YW; JING Q, "Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans", EUR HEART J, (2010), vol. 31, doi:doi:10.1093/EURHEART/EHQ013, pages 659 - 666, XP002586116

DOI:   http://dx.doi.org/10.1093/EURHEART/EHQ013
    - XIN M; SMALL EM; SUTHERLAND LB; QI X; MCANALLY J; PLATO CF; RICHARDSON JA; BASSEL-DUBY R; OLSON EN, "MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury", GENES DEV, (2009), vol. 23, doi:doi:10.1101/gad.1842409, pages 2166 - 2178, XP008116941

DOI:   http://dx.doi.org/10.1101/gad.1842409
    - XU P; VERNOOY SY; GUO M; HAY BA, "The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism", CURR BIOL, (2003), vol. 13, doi:doi:10.1016/S0960-9822(03)00250-1, pages 790 - 795, XP002994326

DOI:   http://dx.doi.org/10.1016/S0960-9822(03)00250-1
    - ZHAO Y; SAMAL E; SRIVASTAVA D, "Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis", NATURE, (2005), vol. 436, doi:doi:10.1038/nature03817, pages 214 - 220, XP002396711

DOI:   http://dx.doi.org/10.1038/nature03817
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