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Extract from the Register of European Patents

EP About this file: EP2821480

EP2821480 - Culture substrate for human pluripotent stem cells and use thereof [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.06.2018
Database last updated on 14.09.2024
FormerThe patent has been granted
Status updated on  14.07.2017
FormerGrant of patent is intended
Status updated on  12.07.2017
FormerExamination is in progress
Status updated on  23.06.2017
FormerGrant of patent is intended
Status updated on  20.02.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Osaka University
1-1, Yamadaoka Suita-shi
Osaka 565-0871 / JP
For all designated states
Kyoto University
36-1, Yoshida-honmachi Sakyo-ku Kyoto-shi
Kyoto 606-8501 / JP
[2015/02]
Inventor(s)01 / Sekiguchi, Kiyotoshi
c/o Osaka University
1-1, Yamadaoka, Suita-shi
Osaka 565-0871 / JP
02 / Futaki, Sugiko
c/o Osaka University
1-1, Yamadaoka, Suita-shi
Osaka 565-0871 / JP
03 / Taniguchi, Yukimasa
c/o Osaka University
1-1, Yamadaoka, Suita-shi
Osaka 565-0871 / JP
04 / Hayashi, Maria
c/o Osaka University
1-1, Yamadaoka, Suita-shi
Osaka 565-0871 / JP
05 / Nakatsuji, Norio
c/o Institute for Integrated Cell-Material Sciences
Kyoto University
Yoshida Ushinomiya-cho
Sakyo-ku
Kyoto-shi Kyoto 606-8501 / JP
06 / Miyazaki, Takamichi
c/o Institute for Frontier Medical Sciences
Kyoto University
53 Kawahara-cho
Shogoin, Sakyo-ku
Kyoto-shi Kyoto 606-8507 / JP
07 / Kawase, Eihachiro
c/o Institute for Frontier Medical Sciences
Kyoto University
53 Kawahara-cho
Shogoin, Sakyo-ku
Kyoto-shi Kyoto 606-8507 / JP
08 / Suemori, Hirofumi
c/o Institute for Frontier Medical Sciences
Kyoto University
53 Kawahara-cho
Shogoin, Sakyo-ku
Kyoto-shi Kyoto 606-8507 / JP
 [2015/02]
Representative(s)Kalhammer, Georg, et al
Lederer & Keller
Patentanwälte Partnerschaft mbB
Unsöldstrasse 2
80538 München / DE
[2015/02]
Application number, filing date14187130.107.10.2010
[2015/02]
Priority number, dateJP2009023458308.10.2009         Original published format: JP 2009234583
[2015/02]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2821480
Date:07.01.2015
Language:EN
[2015/02]
Type: B1 Patent specification 
No.:EP2821480
Date:16.08.2017
Language:EN
[2017/33]
Search report(s)(Supplementary) European search report - dispatched on:EP01.12.2014
ClassificationIPC:C12N5/0735, C12N5/074
[2015/02]
CPC:
C12N5/0606 (EP,US); C12N5/0696 (EP,US); C12N2533/52 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/33]
Former [2015/02]AL,  AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MK,  MT,  NL,  NO,  PL,  PT,  RO,  RS,  SE,  SI,  SK,  SM,  TR 
TitleGerman:Kultursubstrat für menschliche pluripotente Stammzellen und Verwendung davon[2015/02]
English:Culture substrate for human pluripotent stem cells and use thereof[2015/02]
French:Substrat de culture pour cellules souches pluripotentes humaines, et son utilisation[2015/02]
Examination procedure07.07.2015Amendment by applicant (claims and/or description)
07.07.2015Examination requested  [2015/33]
21.09.2015Despatch of a communication from the examining division (Time limit: M04)
27.01.2016Reply to a communication from the examining division
21.02.2017Communication of intention to grant the patent
13.06.2017Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
13.06.2017Fee for grant paid
13.06.2017Fee for publishing/printing paid
11.07.2017Information about intention to grant a patent
11.07.2017Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP10822075.7  / EP2487236
Opposition(s)17.05.2018No opposition filed within time limit [2018/30]
Fees paidRenewal fee
30.09.2014Renewal fee patent year 03
30.09.2014Renewal fee patent year 04
30.09.2014Renewal fee patent year 05
29.09.2015Renewal fee patent year 06
27.09.2016Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.10.2010
AL16.08.2017
AT16.08.2017
CY16.08.2017
CZ16.08.2017
EE16.08.2017
HR16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
MK16.08.2017
PL16.08.2017
PT16.08.2017
RO16.08.2017
RS16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
TR16.08.2017
LU07.10.2017
MT07.10.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
[2020/34]
Former [2020/30]HU07.10.2010
AT16.08.2017
CY16.08.2017
CZ16.08.2017
EE16.08.2017
HR16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
MK16.08.2017
PL16.08.2017
PT16.08.2017
RO16.08.2017
RS16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
TR16.08.2017
LU07.10.2017
MT07.10.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2020/28]HU07.10.2010
AT16.08.2017
CY16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
MK16.08.2017
PL16.08.2017
PT16.08.2017
RO16.08.2017
RS16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
TR16.08.2017
LU07.10.2017
MT07.10.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2020/16]HU07.10.2010
AT16.08.2017
CY16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
MK16.08.2017
PL16.08.2017
RO16.08.2017
RS16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
TR16.08.2017
LU07.10.2017
MT07.10.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2019/52]HU07.10.2010
AT16.08.2017
CY16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
MK16.08.2017
PL16.08.2017
RO16.08.2017
RS16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
LU07.10.2017
MT07.10.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2019/47]HU07.10.2010
AT16.08.2017
CY16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
PL16.08.2017
RO16.08.2017
RS16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
LU07.10.2017
MT07.10.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2019/31]HU07.10.2010
AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
PL16.08.2017
RO16.08.2017
RS16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
LU07.10.2017
MT07.10.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/43]AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
PL16.08.2017
RO16.08.2017
RS16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
LU07.10.2017
MT07.10.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/39]AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
PL16.08.2017
RO16.08.2017
RS16.08.2017
SI16.08.2017
SK16.08.2017
SM16.08.2017
LU07.10.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/36]AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
PL16.08.2017
RO16.08.2017
RS16.08.2017
SK16.08.2017
SM16.08.2017
LU07.10.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/26]AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
MC16.08.2017
PL16.08.2017
RO16.08.2017
RS16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/25]AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
PL16.08.2017
RO16.08.2017
RS16.08.2017
SK16.08.2017
SM16.08.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/23]AT16.08.2017
CZ16.08.2017
EE16.08.2017
LT16.08.2017
LV16.08.2017
PL16.08.2017
RO16.08.2017
RS16.08.2017
SK16.08.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/21]AT16.08.2017
CZ16.08.2017
LT16.08.2017
LV16.08.2017
PL16.08.2017
RS16.08.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/12]AT16.08.2017
LT16.08.2017
LV16.08.2017
PL16.08.2017
RS16.08.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/11]AT16.08.2017
LT16.08.2017
PL16.08.2017
RS16.08.2017
BG16.11.2017
GR17.11.2017
IS16.12.2017
Former [2018/10]AT16.08.2017
LT16.08.2017
RS16.08.2017
Former [2018/07]LT16.08.2017
Documents cited:Search[XI]  - Y. TANIGUCHI ET AL, "The C-terminal Region of Laminin Chains Modulates the Integrin Binding Affinities of Laminins", JOURNAL OF BIOLOGICAL CHEMISTRY, (20090101), vol. 284, no. 12, doi:10.1074/jbc.M809332200, ISSN 0021-9258, pages 7820 - 7831, XP055022477 [X] 1-4 * the whole document * [I] 5,6

DOI:   http://dx.doi.org/10.1074/jbc.M809332200
 [T]  - TAKAMICHI MIYAZAKI ET AL, "Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells", NATURE COMMUNICATIONS, (20121204), vol. 3, doi:10.1038/ncomms2231, page 1236, XP055055638 [T] * the whole document *

DOI:   http://dx.doi.org/10.1038/ncomms2231
by applicant   - MIYAZAKI T; FUTAKI S; HASEGAWA K; KAWASAKI M; SANZEN N; HAYASHI M; KAWASE E; SEKIGUCHI K; NAKATSUJI N; SUEMORI H, "Recombinant human laminin isoforms can support the undifferentiated growth of human embryonic stem cells", BIOCHEM. BIOPHYS. RES. COMMUN., (2008), vol. 375, pages 27 - 35
    - TANIGUCHI Y; IDO H; SANZEN N; HAYASHI M; SATO-NISHIUCHI R; FUTAKI S; SEKIGUCHI K, "The C-terminal region of laminin beta chains modulates the integrin binding affinities of laminins", J. BIOL. CHEM., (2009), vol. 284, doi:doi:10.1074/jbc.M809332200, pages 7820 - 7831, XP055022477

DOI:   http://dx.doi.org/10.1074/jbc.M809332200
    - EDGAR D.; TIMPL R.; THOENEN H., "The heparin-binding domain of laminin is responsible for its effects on neurite outgrowth and neuronal survival", EMBO J., (1984), vol. 3, pages 1463 - 1468, XP055222218
    - GOODMAN SL.; DEUTZMANN R.; VON DER MARK K., "Two distinct cell-binding domains in laminin can independently promote nonneuronal cell adhesion and spreading", J. CELL BIOL., (1987), vol. 105, doi:doi:10.1083/jcb.105.1.589, pages 589 - 598, XP055304702

DOI:   http://dx.doi.org/10.1083/jcb.105.1.589
    - HIROYUKI IDO; AYA NAKAMURA; REIKO KOBAYASHI; SHUNSUKE ITO; SHAOLIANG LI; SUGIKO FUTAKI; KIYOTOSHI SEKIGUCHI, "The requirement of the glutamic acid residue at the third position from the carboxyl termini of the laminin y chains in integrin binding by laminins", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2007), vol. 282, doi:doi:10.1074/jbc.M609402200, pages 11144 - 11154, XP008153460

DOI:   http://dx.doi.org/10.1074/jbc.M609402200
    - LIU, Y. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., (2006), vol. 346, pages 131 - 139
    - VALLIER, L. ET AL., J. CELL SCI., (2005), vol. 118, pages 4495 - 4509
    - LI, Y. ET AL., BIOTECHNOL. BIOENG., (2005), vol. 91, pages 688 - 698
    - YAO, S. ET AL., PROC. NATL. ACAD. SCI. U.S.A., (2006), vol. 103, pages 6907 - 6912
    - LU, J. ET AL., PROC. NATL. ACAD. SCI. U.S.A., (2006), vol. 103, pages 5688 - 5693
    - SEKIGUCHI K.; HAKOMORI S., "Domain structure of human plasma fibronectin. Differences and similarities between human and hamster fibronectins", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2003), vol. 258, pages 3967 - 3973
    - YATOHGO T.; IZUMI, M.; KASHIWAGI, H.; HAYASHI, M., "Novel purification of vitronectin from human plasma by heparin affinity chromatography", CELL STRUCTURE AND FUNCTION, (1988), vol. 13, pages 281 - 292
    - IDO ET AL., J. BIOL. CHEM., (2004), vol. 279, pages 10946 - 10954
    - IDO ET AL., J. BIOL. CHEM., (2007), vol. 282, pages 11144 - 11154
    - HIROYUKI IDO; KENJI HARADA; SUGIKO FUTAKI; YOSHITAKA HAYASHI; RYOKO NISHIUCHI; YUKO NATSUKA; SHAOLIANG LI; YOSHINAO WADA; ARIANA C, "Molecular dissection of the a-dystroglycan- and integrin-binding sites within the globular domain of human laminin-10", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2004), vol. 279, pages 10946 - 10954
    - HIROYUKI IDO; KENJI HARADA; YOSHIKI YAGI; KIYOTOSHI SEKIGUCHI, "Probing the integrin-binding site within the globular domain of laminin-511 with the function-blocking monoclonal antibody 4C7", MATRIX BIOLOGY, (2006), vol. 25, pages 112 - 117
    - YUKIMASA TANIGUCHI; HIROYUKI IDO; NORIKO SANZEN; MARIA HAYASHI; RYOKO SATO-NISHIUCHI; SUGIKO FUTAKI; KIYOTOSHI SEKIGUCHI, "The C-terminal region of laminin (3 chains modulates the integrin binding affinities of laminins", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (2009), vol. 284, doi:doi:10.1074/jbc.M809332200, pages 7820 - 7831, XP055022477

DOI:   http://dx.doi.org/10.1074/jbc.M809332200
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