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Extract from the Register of European Patents

EP About this file: EP2970321

EP2970321 - BUPRENORPHINE ANALOGS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.05.2019
Database last updated on 13.07.2024
FormerThe patent has been granted
Status updated on  25.05.2018
FormerGrant of patent is intended
Status updated on  11.01.2018
FormerExamination is in progress
Status updated on  11.01.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK
published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Purdue Pharma LP
One Stamford Forum 201 Tresser Boulevard
Stamford, CT 06901 / US
[2016/03]
Inventor(s)01 / GOEHRING, Richard, R.
2348 County Road 229 D
Henderson, Texas 75652 / US
02 / TAFESSE, Laykea
8 Windward Way
Robbinsville, NJ 08690 / US
03 / YAO, Jiangchao
10 Bellflower Court
Princeton, NJ 08540 / US
 [2016/08]
Former [2016/03]01 / GOEHRING, Richard, R.
525 Aspen Woods Drive
Yardley, PA 19067 / US
02 / TAFESSE, Laykea
8 Windward Way
Robbinsville, NJ 08690 / US
03 / YAO, Jiangchao
10 Bellflower Court
Princeton, NJ 08540 / US
Representative(s)Braun, Nils
Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
[N/P]
Former [2018/26]Braun, Nils
Maiwald Patentanwalts- und
Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Former [2016/03]Braun, Nils
Maiwald Patentanwalts GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
Application number, filing date14713577.614.03.2014
[2016/03]
WO2014IB00394
Priority number, dateUS201361786997P15.03.2013         Original published format: US 201361786997 P
[2016/03]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2014140784
Date:18.09.2014
Language:EN
[2014/38]
Type: A2 Application without search report 
No.:EP2970321
Date:20.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 18.09.2014 takes the place of the publication of the European patent application.
[2016/03]
Type: B1 Patent specification 
No.:EP2970321
Date:27.06.2018
Language:EN
[2018/26]
Search report(s)International search report - published on:EP12.03.2015
ClassificationIPC:C07D489/12, A61K31/485, A61P25/04
[2016/03]
CPC:
C07D489/02 (EP,US); A61K31/439 (EP,US); A61K31/497 (EP,US);
A61P1/10 (EP); A61P25/04 (EP); A61P43/00 (EP);
C07D489/12 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/03]
Extension statesBA15.10.2015
ME15.10.2015
TitleGerman:BUPRENORPHIN-ANALOGA[2016/03]
English:BUPRENORPHINE ANALOGS[2016/03]
French:ANALOGUES DE LA BUPRÉNORPHINE[2016/03]
Entry into regional phase15.10.2015National basic fee paid 
15.10.2015Designation fee(s) paid 
15.10.2015Examination fee paid 
Examination procedure15.10.2015Amendment by applicant (claims and/or description)
15.10.2015Examination requested  [2016/03]
18.10.2016Despatch of a communication from the examining division (Time limit: M04)
09.01.2017Reply to a communication from the examining division
26.01.2017Despatch of a communication from the examining division (Time limit: M06)
21.07.2017Reply to a communication from the examining division
12.01.2018Communication of intention to grant the patent
09.05.2018Fee for grant paid
09.05.2018Fee for publishing/printing paid
09.05.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  18.10.2016
Opposition(s)28.03.2019No opposition filed within time limit [2019/23]
Fees paidRenewal fee
08.01.2016Renewal fee patent year 03
07.03.2017Renewal fee patent year 04
23.03.2018Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU14.03.2014
AL27.06.2018
AT27.06.2018
CY27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
MK27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
TR27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
PT29.10.2018
GB14.03.2019
IE14.03.2019
LU14.03.2019
MT14.03.2019
[2022/31]
Former [2021/32]HU14.03.2014
AL27.06.2018
AT27.06.2018
CY27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
TR27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
PT29.10.2018
GB14.03.2019
IE14.03.2019
LU14.03.2019
MT14.03.2019
Former [2021/26]AL27.06.2018
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CY27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
TR27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
PT29.10.2018
GB14.03.2019
IE14.03.2019
LU14.03.2019
MT14.03.2019
Former [2020/29]AL27.06.2018
AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
TR27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
PT29.10.2018
GB14.03.2019
IE14.03.2019
LU14.03.2019
MT14.03.2019
Former [2020/16]AL27.06.2018
AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
TR27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
GB14.03.2019
IE14.03.2019
LU14.03.2019
Former [2020/11]AL27.06.2018
AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
GB14.03.2019
IE14.03.2019
LU14.03.2019
Former [2020/09]AL27.06.2018
AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
IE14.03.2019
LU14.03.2019
Former [2020/01]AL27.06.2018
AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
LU14.03.2019
Former [2019/51]AL27.06.2018
AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/46]AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/37]AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/26]AT27.06.2018
CZ27.06.2018
DK27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/12]AT27.06.2018
CZ27.06.2018
EE27.06.2018
ES27.06.2018
FI27.06.2018
HR27.06.2018
IT27.06.2018
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PL27.06.2018
RO27.06.2018
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SK27.06.2018
SM27.06.2018
BG27.09.2018
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GR28.09.2018
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Former [2019/11]AT27.06.2018
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NO27.09.2018
GR28.09.2018
IS27.10.2018
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CZ27.06.2018
EE27.06.2018
FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
PL27.06.2018
RO27.06.2018
RS27.06.2018
SE27.06.2018
SK27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/09]EE27.06.2018
FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
RS27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
Former [2019/08]FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
RS27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
IS27.10.2018
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HR27.06.2018
LT27.06.2018
LV27.06.2018
NL27.06.2018
RS27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
Former [2018/52]FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
SE27.06.2018
BG27.09.2018
NO27.09.2018
GR28.09.2018
Former [2018/51]FI27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
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Cited inInternational search[X]WO2012038813  (PURDUE PHARMA LP [US], et al) [X] 1-9,11,14-43,46-76,83-103 * claim 1; compounds 29,30,81 *;
 [X]  - DERRICK I ET AL, "Cinnamoyl derivatives of 7alpha-amino- and 7alpha-(aminomethyl)-N-(cyclopropylmethyl)-6,14-endo-ethanotetrahydronororipavines are high-potency opioid antagonists", HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA, (20000101), vol. 83, ISSN 0018-019X, pages 3122 - 3130, XP002666946 [X] 1-9,11,14-43,46-76,83-103 * compounds 4d,5d *

DOI:   http://dx.doi.org/10.1002/1522-2675(20001220)83:12<3122::AID-HLCA3122>3.3.CO;2-U
 [X]  - HUMPHREY A. MOYNIHAN ET AL, "Fumaroylamino-4,5-epoxymorphinans and Related Opioids with Irreversible [mu] Opioid Receptor Antagonist Effects", JOURNAL OF MEDICINAL CHEMISTRY, (20121126), vol. 55, no. 22, doi:10.1021/jm301096s, ISSN 0022-2623, pages 9868 - 9874, XP055127464 [X] 1-9,11,14-43,46-76,83-103 * compounds 4a,5a,6a *

DOI:   http://dx.doi.org/10.1021/jm301096s
 [X]  - DAVID RENNISON ET AL, "Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 50, no. 21, doi:10.1021/JM070255O, ISSN 0022-2623, (20070101), pages 5176 - 5182, (20070922), XP002666945 [X] 1-9,11,14-43,46-76,83-103 * compounds 4a,5a,6a *

DOI:   http://dx.doi.org/10.1021/JM070255O
Examination   - PAOLA CIAPETTI AND BRUNO GIETHLEN ED - CAMILLE GEORGES WERMUTH, Chapter 15 - Molecular Variations Based on Isosteric Replacements, THE PRACTICE OF MEDICINAL CHEMISTRY (THIRD EDITION), ELSEVIER, NL, PAGE(S) 290 - 342, (20080101), ISBN 978-0-12-374194-3, XP009142466

DOI:   http://dx.doi.org/10.1016/B978-0-12-374194-3.00015-9
by applicantWO9948492
 WO9854168
 US2011136846
 US5698155
 US3845770
 US3916899
 US3536809
 US3598123
 US4008719
 US5674533
 US5059595
 US5591767
 US5120548
 US5073543
 US5639476
 US5354556
 US5733566
 US6136839
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