Extract from the Register of European Patents

EP About this file: EP2970874

EP2970874 - METHODS FOR INCREASING MANNOSE CONTENT OF RECOMBINANT PROTEINS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.07.2019
Database last updated on 09.04.2026
FormerThe patent has been granted
Status updated on  17.08.2018
FormerGrant of patent is intended
Status updated on  03.04.2018
FormerExamination is in progress
Status updated on  27.01.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK
published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Amgen Inc.
One Amgen Center Drive
Thousand Oaks, California 91320-1799 / US
[2016/03]
Inventor(s)01 / WU, Jian
3117 216th Place SE
Bothell, Washington 98021 / US
02 / DAVERN, Sean
2929 1st Avenue
Unit 401
Seattle, Washington 98121 / US
03 / PETROVAN, Simina, Crina
23819 23rd Avenue West
Bothell, Washington 98021 / US
04 / BRANDENSTEIN, Michael, Charles
14704 204th Place NE
Woodinville, Washington 98077 / US
05 / LINDAHL, Katherine, Rose
4250 34th Avenue West
Seattle, Washington 98199 / US
06 / LILLIE, Shawn, Erik
2418 43rd Avenue SE
Puyallup, Washington 98374 / US
 [2016/03]
Representative(s)Dörries, Hans Ulrich
df-mp Patentanwälte Rechtsanwälte PartG mbB
Theatinerstraße 16
80333 München / DE
[N/P]
Former [2016/03]Dörries, Hans Ulrich
df-mp Dörries Frank-Molnia & Pohlman
Patentanwälte Rechtsanwälte PartG mbB
Theatinerstrasse 16
80333 München / DE
Application number, filing date14714521.310.03.2014
[2016/03]
WO2014US22738
Priority number, dateUS201361784639P14.03.2013         Original published format: US 201361784639 P
[2016/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014159259
Date:02.10.2014
Language:EN
[2014/40]
Type: A1 Application with search report 
No.:EP2970874
Date:20.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 02.10.2014 takes the place of the publication of the European patent application.
[2016/03]
Type: B1 Patent specification 
No.:EP2970874
Date:19.09.2018
Language:EN
[2018/38]
Search report(s)International search report - published on:EP02.10.2014
ClassificationIPC:C12N1/38, C12P21/00, C12N5/00, C07K16/00
[2016/03]
CPC:
C12P21/005 (EP,US); C07K16/00 (EP,US); C12N1/38 (EP,US);
C12N5/0037 (EP,US); C07K2317/14 (EP,US); C07K2317/41 (EP,US);
C12N2500/32 (EP,US); C12N2500/34 (EP,US); C12N2510/02 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/03]
Extension statesBA14.10.2015
ME14.10.2015
TitleGerman:VERFAHREN ZUR ERHÖHUNG DES MANNOSEGEHALTS REKOMBINANTER PROTEINE[2016/03]
English:METHODS FOR INCREASING MANNOSE CONTENT OF RECOMBINANT PROTEINS[2016/03]
French:MÉTHODES POUR AUGMENTER LA TENEUR EN MANNOSE DE PROTÉINES RECOMBINANTES[2016/03]
Entry into regional phase14.10.2015National basic fee paid 
14.10.2015Designation fee(s) paid 
14.10.2015Examination fee paid 
Examination procedure14.10.2015Amendment by applicant (claims and/or description)
14.10.2015Examination requested  [2016/03]
26.01.2017Despatch of a communication from the examining division (Time limit: M04)
19.05.2017Reply to a communication from the examining division
27.07.2017Despatch of a communication from the examining division (Time limit: M04)
27.11.2017Reply to a communication from the examining division
04.04.2018Communication of intention to grant the patent
01.08.2018Fee for grant paid
01.08.2018Fee for publishing/printing paid
01.08.2018Receipt of the translation of the claim(s)
Divisional application(s)EP18194714.4  / EP3434760
EP22179111.4  / EP4141104
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  26.01.2017
Opposition(s)20.06.2019No opposition filed within time limit [2019/35]
Fees paidRenewal fee
10.03.2016Renewal fee patent year 03
10.03.2017Renewal fee patent year 04
13.03.2018Renewal fee patent year 05
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Lapses during opposition  TooltipAL19.09.2018
HR19.09.2018
MK19.09.2018
RS19.09.2018
SM19.09.2018
NO19.12.2018
[2022/31]
Former [2019/27]AL19.09.2018
HR19.09.2018
RS19.09.2018
SM19.09.2018
NO19.12.2018
Former [2019/12]AL19.09.2018
HR19.09.2018
RS19.09.2018
NO19.12.2018
Former [2019/11]HR19.09.2018
RS19.09.2018
NO19.12.2018
Former [2019/08]NO19.12.2018
Cited inInternational search[XI] JPH06292592  (SNOW BRAND MILK PRODUCTS CO LTD et al.)
 [XI] WO9928455  (ROCHE DIAGNOSTICS GMBH et al.)
 [XI] WO2004008100  (IMMUNEX CORP et al.)
 [XI]   GRAMER M J ET AL: "Modulation of Antibody Galactosylation Through Feeding of Uridine, Manganese Chloride, and Galactose", BIOTECHNOLOGY AND BIOENGINEERING, WILEY & SONS, HOBOKEN, NJ, US, vol. 108, no. 7, 1 July 2011 (2011-07-01), pages 1591 - 1602, XP002688515, ISSN: 0006-3592, [retrieved on 20110218], DOI: 10.1002/BIT.23075

DOI:   http://dx.doi.org/10.1002/bit.23075
 [A]   WONG DANNY CHEE FURNG ET AL: "Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures", BIOTECHNOLOGY AND BIOENGINEERING, WILEY & SONS, HOBOKEN, NJ, US, vol. 89, no. 2, 20 January 2005 (2005-01-20), pages 164 - 177, XP009142862, ISSN: 0006-3592
 [A]   EFREN PACIS ET AL: "Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform", BIOTECHNOLOGY AND BIOENGINEERING, vol. 108, no. 10, 1 October 2011 (2011-10-01), pages 2348 - 2358, XP055080567, ISSN: 0006-3592, DOI: 10.1002/bit.23200

DOI:   http://dx.doi.org/10.1002/bit.23200
 [A]   HILLS A E ET AL: "METABOLIC CONTROL OF RECOMBINANT MONOCLONAL ANTIBODY N-GLYCOSYLATION IN GS-NS0 CELLS", BIOTECHNOLOGY AND BIOENGINEERING, WILEY & SONS, HOBOKEN, NJ, US, vol. 75, no. 2, 20 October 2001 (2001-10-20), pages 239 - 251, XP001206784, ISSN: 0006-3592, DOI: 10.1002/BIT.10022

DOI:   http://dx.doi.org/10.1002/bit.10022
 [A]   JAMES 1 REARICKS ET AL: "Glucose Starvation Alters Lipid-linked Oligosaccharide Biosynthesis in Chinese Hamster Ovary Cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 256, no. 12, 25 June 1981 (1981-06-25), pages 6255 - 6261, XP055124811
by applicantUS6544424
 WO2013006479
 WO2012145682
 WO9428391
 WO0136637
 WO9701633
 AU588819
 US6204363
 US4695623
 US4897471
 US5395760
 US5610279
 EP0460846
 US4968607
 US5767064
 US6337072
 US5981713
 US6096728
 US5075222
 EP0367566
 US5856296
 US6271349
 US6015938
 US5272064
 US5149792
 US6235883
 WO9410308
 US8354105
   GOETZE ET AL., GLYCOBIOLOGY, vol. 21, 2011, pages 949 - 59
   YU ET AL., MABS, vol. 4, 2012, pages 475 - 87
   PACIS, BIOTECHNOL BIOENG, vol. 108, 2011, pages 2348 - 2358
   CHEE FURNG WONG ET AL., BIOTECHNOL BIOENG, vol. 89, 2005, pages 164 - 177
   AHN, BIOTECHNOL BIOENG, vol. 101, 2008, pages 1234 - 44
   HUBBARD; IVATT, ANN. REV. BIOCHEM., vol. 50, 1981, pages 555 - 583
   D. RICKWOOD,: "Animal cell culture: A Practical Approach", 1992, OXFORD UNIVERSITY PRESS
   VOISARD ET AL., BIOTECHNOLOGY AND BIOENGINEERING, vol. 82, 2003, pages 751 - 65
   STETTLER, BIOTECHNOL BIOENG., vol. 95, no. 6, 20 December 2006 (2006-12-20), pages 1228 - 33
   AUSUBEL ET AL.,: "Current Protocols in Molecular Biology", 1988, WILEY & SONS
   SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING LABORATORY PRESS
   KAUFMAN, R.J., LARGE SCALE MAMMALIAN CELL CULTURE, 1990, pages 15 - 69
   BRASEL ET AL., BLOOD, vol. 88, 1996, pages 2004 - 2012
   KAUFMAN ET AL., J. BIOL CHEM, vol. 263, 1988, pages 6352 - 6362
   MCKINNON ET AL., J. MOL ENDOCRINOL, vol. 6, 1991, pages 231 - 239
   WOOD ET AL., J. IMMUNOL., vol. 145, 1990, pages 3011 - 3016
   URLAUB ET AL., PROC NATL ACAD SCI USA, vol. 77, 1980, pages 4216 - 4220
   KAUFMAN R.J., METH ENZYMOL, vol. 185, 1990, pages 537 - 566
   "Remington's Pharmaceutical Sciences, 18th ed.", 1995, MACK PUBLISHING COMPANY
   MAISONPIERRE ET AL., SCIENCE, vol. 277, no. 5322, 1997, pages 55 - 60
   RUEGG; PYTELA, GENE, vol. 160, 1995, pages 257 - 62
   AGGARWAL AND GUTTERMAN,: "Human Cytokines: Handbook for Basic and Clinical Research", 1998, BLACKWELL SCIENCES
   MCKAY AND LEIGH,: "Growth Factors: A Practical Approach", 1993, OXFORD UNIVERSITY PRESS INC.
   THOMPSON AND LOTZE: "The Cytokine Handbook", vol. 1, 2, 2003, ACADEMIC PRESS
   "Leukocyte Typing VI", 1996, article "Proceedings of the VIth International Workshop and Conference"
   DO; CHEN-KIANG, CVTOKINE GROWTH FACTOR REV., vol. 13, no. 1, 2002, pages 19 - 25
   LOVEJOY ET AL., SCIENCE, vol. 259, 1993, pages 1288 - 1293
   HARBURY ET AL., SCIENCE, vol. 262, 1993, pages 1401 - 05
   HARBURY ET AL., NATURE, vol. 371, 1994, pages 80 - 83
   HKANSSON ET AL., STRUCTURE, vol. 7, 1999, pages 255 - 64
   SAMBROOK ET AL.: "Molecular Cloning: A Laboratory Manual 3rd ed.,", 2001, COLD SPRING HARBOR LABORATORY PRESS
   AUSUBEL ET AL.: "Current Protocols in Molecular Biology", 1992, GREENE PUBLISHING ASSOCIATES
   HARLOW; LANE: "Antibodies: A Laboratory Manual", 1990, COLD SPRING HARBOR LABORATORY PRESS
   SCHMELZER; MILLER, BIOTECHNOL. PROG., vol. 18, 2002, pages 346 - 353
   SCHMELZER; MILLER, BIOTECHNOL. BIOENG, vol. 77, no. 4, 15 February 2002 (2002-02-15)
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