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Extract from the Register of European Patents

EP About this file: EP2970193

EP2970193 - PYRROLE AMIDE INHIBITORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  31.05.2019
Database last updated on 25.09.2024
FormerThe patent has been granted
Status updated on  22.06.2018
FormerGrant of patent is intended
Status updated on  16.05.2018
FormerExamination is in progress
Status updated on  19.05.2017
FormerRequest for examination was made
Status updated on  16.12.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
AbbVie Inc.
1 North Waukegan Road
North Chicago, IL 60064 / US
[2018/30]
Former [2016/03]For all designated states
AbbVie Inc.
1 North Waukegan Road
North Chicago, IL 60064 / US
Inventor(s)01 / HASVOLD, Lisa, A.
552 Shakespeare Drive
Grayslake, Illinois 60030 / US
02 / LIU, Dachun
1276 Georgetown Way
Vernon Hills, Illinois 60061 / US
03 / PRATT, John, K.
8210 61st. Avenue
Kenosha, Wisconsin 53142 / US
04 / SHEPPARD, George, S.
807 Locust Road
Wilmette, Illinois 60091 / US
05 / MCDANIEL, Keith, F.
26029 W. Laurel Court
Wauconda, Illinois 60084 / US
06 / ELMORE, Steven, W.
2139 Ash Lane
Northbrook, Illinois 60062 / US
07 / HUBBARD, Robert, D.
7684 Marker Road
San Diego, California 92130 / US
 [2016/03]
Representative(s)Schlich, George William, et al
Schlich
9 St. Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
[N/P]
Former [2018/30]Schlich, George, et al
Schlich
9 St Catherine's Road
Littlehampton, West Sussex BN17 5HS / GB
Former [2016/03]Modiano, Micaela Nadia
Modiano & Partners
Thierschstrasse 11
80538 München / DE
Application number, filing date14718832.012.03.2014
[2016/03]
WO2014US24508
Priority number, dateUS201361777749P12.03.2013         Original published format: US 201361777749 P
[2016/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014165127
Date:09.10.2014
Language:EN
[2014/41]
Type: A1 Application with search report 
No.:EP2970193
Date:20.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 09.10.2014 takes the place of the publication of the European patent application.
[2016/03]
Type: B1 Patent specification 
No.:EP2970193
Date:25.07.2018
Language:EN
[2018/30]
Search report(s)International search report - published on:EP09.10.2014
ClassificationIPC:C07D401/12, C07D401/10, C07D403/04, C07D403/10, C07D405/12, C07D407/12, C07D409/10, C07D409/12, C07D413/10, C07D471/04, C07D207/36, C07D403/12, A61K31/4439, A61K31/4704, A61K31/4725
[2016/03]
CPC:
C07D207/34 (EP,US); A61P1/04 (EP); A61P1/16 (EP);
A61P1/18 (EP); A61P11/00 (EP); A61P11/06 (EP);
A61P13/12 (EP); A61P15/16 (EP); A61P17/02 (EP);
A61P17/06 (EP); A61P19/02 (EP); A61P19/06 (EP);
A61P21/00 (EP); A61P25/00 (EP); A61P25/28 (EP);
A61P27/02 (EP); A61P27/14 (EP); A61P29/00 (EP);
A61P3/00 (EP); A61P3/04 (EP); A61P3/06 (EP);
A61P3/10 (EP); A61P31/04 (EP); A61P31/18 (EP);
A61P35/00 (EP); A61P35/02 (EP); A61P37/00 (EP);
A61P37/06 (EP); A61P5/14 (EP); A61P5/50 (EP);
A61P7/02 (EP); A61P9/04 (EP); A61P9/10 (EP);
A61P9/14 (EP); C07D207/36 (EP,US); C07D401/10 (EP,US);
C07D401/12 (EP,US); C07D403/04 (EP,US); C07D403/10 (EP,US);
C07D403/12 (EP,US); C07D405/12 (EP,US); C07D407/12 (EP,US);
C07D409/10 (EP,US); C07D409/12 (EP,US); C07D413/10 (EP,US);
C07D413/12 (EP,US); C07D471/04 (EP,US); C07D207/335 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/03]
Extension statesBA23.09.2015
ME23.09.2015
TitleGerman:PYRROLAMIDINHIBITOREN[2016/03]
English:PYRROLE AMIDE INHIBITORS[2016/03]
French:INHIBITEURS DE PYRROLE-AMIDE[2016/03]
Entry into regional phase23.09.2015National basic fee paid 
23.09.2015Designation fee(s) paid 
23.09.2015Examination fee paid 
Examination procedure23.09.2015Examination requested  [2016/03]
24.05.2016Application deemed to be withdrawn, date of legal effect  [2016/47]
12.09.2016Amendment by applicant (claims and/or description)
deletedDeletion: Application deemed to be withdrawn, date of legal effect  [2017/03]
01.07.2016Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time  [2017/03]
18.05.2017Despatch of a communication from the examining division (Time limit: M08)
25.01.2018Reply to a communication from the examining division
17.05.2018Communication of intention to grant the patent
18.06.2018Fee for grant paid
18.06.2018Fee for publishing/printing paid
18.06.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  18.05.2017
Opposition(s)26.04.2019No opposition filed within time limit [2019/27]
Request for further processing for:12.09.2016Request for further processing filed
12.09.2016Full payment received (date of receipt of payment)
Request granted
06.10.2016Decision despatched
Loss of rights: Claims
12.09.2016Request for further processing filed
12.09.2016Full payment received (date of receipt of payment)
Request granted
06.10.2016Decision despatched
Fees paidRenewal fee
08.03.2016Renewal fee patent year 03
07.03.2017Renewal fee patent year 04
08.03.2018Renewal fee patent year 05
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Lapses during opposition  TooltipHU12.03.2014
AL25.07.2018
AT25.07.2018
CY25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
MK25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
TR25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
PT25.11.2018
IE12.03.2019
LU12.03.2019
MT12.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
[2022/31]
Former [2021/32]HU12.03.2014
AL25.07.2018
AT25.07.2018
CY25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
TR25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
PT25.11.2018
IE12.03.2019
LU12.03.2019
MT12.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
Former [2021/26]AL25.07.2018
AT25.07.2018
CY25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
TR25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
PT25.11.2018
IE12.03.2019
LU12.03.2019
MT12.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
Former [2020/29]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
TR25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
PT25.11.2018
IE12.03.2019
LU12.03.2019
MT12.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
Former [2020/16]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
TR25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
IE12.03.2019
LU12.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
Former [2020/11]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
IE12.03.2019
LU12.03.2019
BE31.03.2019
CH31.03.2019
LI31.03.2019
Former [2020/09]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
IE12.03.2019
LU12.03.2019
Former [2020/01]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
LU12.03.2019
Former [2019/46]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
MC25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/37]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SI25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/26]AL25.07.2018
AT25.07.2018
CZ25.07.2018
DK25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SK25.07.2018
SM25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/23]AL25.07.2018
AT25.07.2018
CZ25.07.2018
EE25.07.2018
ES25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
SK25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/22]AL25.07.2018
AT25.07.2018
CZ25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RO25.07.2018
RS25.07.2018
SE25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/21]AL25.07.2018
AT25.07.2018
FI25.07.2018
HR25.07.2018
IT25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RS25.07.2018
SE25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/12]AL25.07.2018
AT25.07.2018
FI25.07.2018
HR25.07.2018
LT25.07.2018
LV25.07.2018
NL25.07.2018
PL25.07.2018
RS25.07.2018
SE25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/11]AT25.07.2018
FI25.07.2018
HR25.07.2018
LT25.07.2018
NL25.07.2018
PL25.07.2018
RS25.07.2018
SE25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/10]AT25.07.2018
FI25.07.2018
LT25.07.2018
NL25.07.2018
PL25.07.2018
RS25.07.2018
SE25.07.2018
BG25.10.2018
NO25.10.2018
GR26.10.2018
IS25.11.2018
Former [2019/08]FI25.07.2018
LT25.07.2018
NL25.07.2018
NO25.10.2018
IS25.11.2018
Former [2019/07]LT25.07.2018
NL25.07.2018
Former [2019/04]NL25.07.2018
Cited inInternational search[X]WO2008034600  (NOVARTIS AG [CH], et al) [X] 1-6 * page 119 - page 129; examples 129, 142a, 142b, 142c *;
 [X]WO9802430  (PFIZER PHARMA [JP], et al) [X] 1-6 * page 74 - page 77; compounds 43, 85, 93 *;
 [XP]WO2013130660  (AMGEN INC [US]) [XP] 1-6,13,14,21 * pages 531-532; claims 1-50, 52; compound 417 *;
 [X]  - MARIA MENICHINCHERI ET AL, "Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding", vol. 53, no. 20, doi:10.1021/JM100504D, ISSN 0022-2623, (20100901), pages 7296 - 7315, JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, URL: http://pubs.acs.org/doi/abs/10.1021/jm100504d, (20100927), XP002619675 [X] 1-6 * page 7300; table 1; compounds 4-6 *

DOI:   http://dx.doi.org/10.1021/JM100504D
 [X]  - TESTA M L ET AL, "A new entry to the substituted pyrrolo[3,2-c]quinoline derivatives of biological interest by intramolecular heteroannulation of internal imines", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, (20040705), vol. 60, no. 28, doi:10.1016/J.TET.2004.05.047, ISSN 0040-4020, pages 5873 - 5880, XP004519798 [X] 1-7 * page 5874; compounds 2b, 3b *

DOI:   http://dx.doi.org/10.1016/j.tet.2004.05.047
 [X]  - ANANDA HERATH ET AL, "One-Step Continuous Flow Synthesis of Highly Substituted Pyrrole-3-carboxylic Acid Derivatives via in Situ Hydrolysis of tert- Butyl Esters", ORGANIC LETTERS, (20101119), vol. 12, no. 22, doi:10.1021/ol102216x, ISSN 1523-7060, pages 5182 - 5185, XP055117166 [X] 1-3 * Table 5 Entries 1-4; page 5185 *

DOI:   http://dx.doi.org/10.1021/ol102216x
 [X]  - E. AIELLO ET AL, "New synthesis of condensed heterocycles from isoxazole derivatives VI. 2,5-Dimethyl-3-aeetyl-7-amino-1 H -pyrrolo[3,2-b] pyridine", JOURNAL OF HETEROCYCLIC CHEMISTRY, (19780601), vol. 15, no. 4, doi:10.1002/jhet.5570150402, ISSN 0022-152X, pages 537 - 539, XP055117160 [X] 1-3 * page 538; compound 4a *

DOI:   http://dx.doi.org/10.1002/jhet.5570150402
 [X]  - JOTI SARUP AGGARWAL ET AL, "STUDIES IN CHEMOTHERAPY: ATTEMPTS TO FIND ANTIMALARIALS. II. PYRRYL INDOLES", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (19321001), vol. 54, no. 10, doi:10.1021/ja01349a025, ISSN 0002-7863, pages 3988 - 3992, XP055117161 [X] 1-3 * 5-phenyl-3-aceto-2-methyl-2-methylpyrrole; page 3989 *

DOI:   http://dx.doi.org/10.1021/ja01349a025
 [X]  - DATTOLO G ET AL, "Polycondensed nitrogen heterocycles. Part 15. Reactivity of 3-diazopyrroles. 3. 1H-Pyrrolo<3,2-c>cinnoline and pyrrolo<3,4-c>pyridazine", HETEROCYCLES,, (19840101), vol. 22(10), ISSN 0385-5417, pages 2269 - 2276, XP009177885 [X] 1-3 * page 2270; compound 2a *
 [X]  - KATO T ET AL, "Reaction of .beta.-aminocrotonamides with .alpha.-haloketones and .alpha.-hydroxyketones", HETEROCYCLES : AN INTERNATIONAL JOURNAL FOR REVIEWS AND COMMUNICATIONS IN HETEROCYCLIC CHEMISTRY, JAPAN INSTITUTE OF HETEROCYCLIC CHEMISTRY, JP, (19780101), vol. 10, no. Special Issue, ISSN 0385-5414, pages 261 - 264, XP009178881 [X] 1-5,7 * page 264; compound 6 *
 [X]  - "1H-Pyrrole-3-carboxamide, 2-methyl-5-(4-pyridinyl)-", REGISTRY, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US, (20100829), Database accession no. 1248540-92-2, XP002726751 [X] 1-6 * Compound with Registry Number 1248540-92-2 *
 [A]  - PAUL BAMBOROUGH ET AL, "Fragment-Based Discovery of Bromodomain Inhibitors Part 2: Optimization of Phenylisoxazole Sulfonamides", JOURNAL OF MEDICINAL CHEMISTRY, (20120126), vol. 55, no. 2, doi:10.1021/jm201283q, ISSN 0022-2623, pages 587 - 596, XP055061954 [A] 1-21 * page 591; table 2 *

DOI:   http://dx.doi.org/10.1021/jm201283q
 [A]  - HEWINGS D S ET AL, "3,5-Dimethylisoxazoles Act As Acetyl-lysine-mimetic Bromodomain Ligands", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 54, no. 19, doi:10.1021/JM200640V, ISSN 0022-2623, (20111013), pages 6761 - 6770, (20110906), XP002689396 [A] 1-21 * page 6764; table 1 *

DOI:   http://dx.doi.org/10.1021/jm200640v
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