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Extract from the Register of European Patents

EP About this file: EP3011031

EP3011031 - DELIVERY AND USE OF THE CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS FOR HEPATIC TARGETING AND THERAPY [Right-click to bookmark this link]
StatusThe patent has been granted
Status updated on  28.08.2020
Database last updated on 02.11.2024
FormerGrant of patent is intended
Status updated on  15.06.2020
FormerExamination is in progress
Status updated on  18.02.2020
FormerGrant of patent is intended
Status updated on  04.12.2019
FormerExamination is in progress
Status updated on  03.03.2017
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024  [2024/41]
Applicant(s)For all designated states
The Broad Institute Inc.
415 Main Street
Cambridge, MA 02142 / US
For all designated states
Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, MA 02142 / US
For all designated states
President and Fellows of Harvard College
17 Quincy Street
Cambridge, MA 02138 / US
[2020/01]
Former [2016/17]For all designated states
The Broad Institute, Inc.
415 Main Street
Cambridge, MA 02142 / US
For all designated states
Massachusetts Institute of Technology
77 Massachusetts Avenue
Cambridge, MA 02142 / US
For all designated states
President and Fellows of Harvard College
17 Quincy Street
Cambridge, MA 02138 / US
Inventor(s)01 / ZHANG, Feng
100 Pacific Street
Apt. 11
Cambridge, MA 02139 / US
02 / CONG, Le
100 Memorial Drive
Apt. 8-21B
Cambridge, MA 02142 / US
03 / RAN, Fei
30 Clarendon Street
Boston, MA 02116 / US
 [2016/17]
Representative(s)Paemen, Liesbet R.J., et al
De Clercq & Partners Edgard Gevaertdreef 10 a
9830 Sint-Martens-Latem / BE
[2016/17]
Application number, filing date14734710.810.06.2014
[2016/17]
WO2014US41804
Priority number, dateUS201361836123P17.06.2013         Original published format: US 201361836123 P
US201361847537P17.07.2013         Original published format: US 201361847537 P
US201361862355P05.08.2013         Original published format: US 201361862355 P
US201361871301P28.08.2013         Original published format: US 201361871301 P
WO2013US7466712.12.2013         Original published format: PCT/US2013/074667
US201361915325P12.12.2013         Original published format: US 201361915325 P
US201461979733P15.04.2014         Original published format: US 201461979733 P
[2020/44]
Former [2016/17]US201361836123P17.06.2013
US201361847537P17.07.2013
US201361862355P05.08.2013
US201361871301P28.08.2013
WOUS307466712.12.2013
US201361915325P12.12.2013
US201461979733P15.04.2014
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014204726
Date:24.12.2014
Language:EN
[2014/52]
Type: A1 Application with search report 
No.:EP3011031
Date:27.04.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 24.12.2014 takes the place of the publication of the European patent application.
[2016/17]
Type: B1 Patent specification 
No.:EP3011031
Date:30.09.2020
Language:EN
[2020/40]
Search report(s)International search report - published on:EP24.12.2014
ClassificationIPC:C12N15/63, C12N15/10, C40B40/08, C12N9/22
[2016/17]
CPC:
C12N15/907 (EP,IL,RU,US); A01K67/0275 (EP,IL,RU,US); A61K48/0058 (IL,RU,US);
A61K48/0091 (US); A61P1/16 (EP); A61P43/00 (EP);
C12N15/102 (EP); C12N15/1082 (EP,IL,US); C12N15/63 (EP,IL,RU,US);
C12N15/86 (EP,IL,US); C12N7/00 (IL,US); C12N9/22 (EP,IL,RU,US);
A01K2217/052 (EP,IL,US); A01K2227/105 (EP,US); A01K2267/0312 (EP,US);
A01K2267/0331 (EP,US); A01K2267/0362 (EP,US); A61K48/00 (EP,US);
C12N2310/20 (EP); C12N2710/24144 (EP,US); C12N2740/15043 (EP,US);
C12N2750/14132 (US); C12N2750/14143 (EP,US); C12N2750/14152 (US);
C12Y301/00 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/17]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:ABGABE UND VERWENDUNG VON CRISPR-CAS-SYSTEMEN, VEKTOREN UND ZUSAMMENSETZUNGEN FÜR LEBER-TARGETING UND -BEHANDLUNG[2016/17]
English:DELIVERY AND USE OF THE CRISPR-CAS SYSTEMS, VECTORS AND COMPOSITIONS FOR HEPATIC TARGETING AND THERAPY[2016/17]
French:ADMINISTRATION ET UTILISATION DE SYSTÈMES CRISPR-CAS, VECTEURS ET COMPOSITIONS POUR LE CIBLAGE ET LE TRAITEMENT DU FOIE[2016/17]
Entry into regional phase15.01.2016National basic fee paid 
15.01.2016Designation fee(s) paid 
15.01.2016Examination fee paid 
Examination procedure15.01.2016Examination requested  [2016/17]
24.08.2016Amendment by applicant (claims and/or description)
03.03.2017Despatch of a communication from the examining division (Time limit: M06)
13.09.2017Reply to a communication from the examining division
24.10.2017Despatch of a communication from the examining division (Time limit: M04)
02.03.2018Reply to a communication from the examining division
19.04.2018Despatch of a communication from the examining division (Time limit: M04)
14.08.2018Reply to a communication from the examining division
02.11.2018Despatch of a communication from the examining division (Time limit: M04)
07.03.2019Reply to a communication from the examining division
25.06.2019Despatch of a communication from the examining division (Time limit: M04)
01.10.2019Reply to a communication from the examining division
05.12.2019Communication of intention to grant the patent
07.02.2020Observations by third parties
18.02.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
21.02.2020Despatch of a communication from the examining division (Time limit: M04)
28.05.2020Reply to a communication from the examining division
16.06.2020Communication of intention to grant the patent
20.08.2020Fee for grant paid
20.08.2020Fee for publishing/printing paid
20.08.2020Receipt of the translation of the claim(s)
Divisional application(s)EP20195409.6  / EP3825406
Opposition(s)Opponent(s)01  13.11.2020   
CRISPR Therapeutics AG
Baarerstrasse 14
6300 Zug / CH
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
 02  23.02.2021   
Patent Boutique LLP
10A Printing House Yard
Hackney Road
London, E2 7PR / GB
 [2021/13]
Former [2020/52]
Opponent(s)01  13.11.2020   
CRISPR Therapeutics AG
Baarerstrasse 14
6300 Zug / CH
Opponent's representative
Vossius & Partner Patentanwälte Rechtsanwälte mbB
Siebertstrasse 3
81675 München / DE
02.06.2021No. 01: Notification indicating deficiencies in the notice of opposition
02.06.2021No. 02: Notification indicating deficiencies in the notice of opposition
29.06.2021No. 01: Reply to notification indicating deficiencies in the notice of opposition
29.06.2021No. 02: Reply to notification indicating deficiencies in the notice of opposition
16.07.2021Invitation to proprietor to file observations on the notice of opposition
26.01.2022Reply of patent proprietor to notice(s) of opposition
16.11.2023Date of oral proceedings
14.12.2023Despatch of minutes of oral proceedings
14.12.2023Despatch of communication that the patent will be revoked
Appeal following opposition13.02.2024Appeal received No.  T0240/24
13.02.2024Payment of appeal fee
15.04.2024Statement of grounds filed
Fees paidRenewal fee
27.06.2016Renewal fee patent year 03
27.06.2017Renewal fee patent year 04
27.06.2018Renewal fee patent year 05
27.06.2019Renewal fee patent year 06
29.06.2020Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU10.06.2014
AL30.09.2020
AT30.09.2020
CY30.09.2020
CZ30.09.2020
EE30.09.2020
ES30.09.2020
HR30.09.2020
IT30.09.2020
LT30.09.2020
LV30.09.2020
MC30.09.2020
MK30.09.2020
MT30.09.2020
PL30.09.2020
RO30.09.2020
RS30.09.2020
SI30.09.2020
SK30.09.2020
SM30.09.2020
TR30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
[2024/41]
Former [2024/29]HU10.06.2014
AL30.09.2020
AT30.09.2020
CY30.09.2020
CZ30.09.2020
EE30.09.2020
ES30.09.2020
HR30.09.2020
IT30.09.2020
LT30.09.2020
LV30.09.2020
MC30.09.2020
MK30.09.2020
PL30.09.2020
RO30.09.2020
RS30.09.2020
SI30.09.2020
SK30.09.2020
SM30.09.2020
TR30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2024/22]HU10.06.2014
AL30.09.2020
AT30.09.2020
CY30.09.2020
CZ30.09.2020
EE30.09.2020
ES30.09.2020
HR30.09.2020
IT30.09.2020
LT30.09.2020
LV30.09.2020
MC30.09.2020
MK30.09.2020
PL30.09.2020
RO30.09.2020
RS30.09.2020
SI30.09.2020
SK30.09.2020
SM30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2023/30]HU10.06.2014
AL30.09.2020
AT30.09.2020
CY30.09.2020
CZ30.09.2020
EE30.09.2020
ES30.09.2020
HR30.09.2020
IT30.09.2020
LT30.09.2020
LV30.09.2020
MC30.09.2020
PL30.09.2020
RO30.09.2020
RS30.09.2020
SI30.09.2020
SK30.09.2020
SM30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2023/29]HU10.06.2014
AL30.09.2020
AT30.09.2020
CZ30.09.2020
EE30.09.2020
ES30.09.2020
HR30.09.2020
IT30.09.2020
LT30.09.2020
LV30.09.2020
MC30.09.2020
PL30.09.2020
RO30.09.2020
RS30.09.2020
SI30.09.2020
SK30.09.2020
SM30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2022/08]AL30.09.2020
AT30.09.2020
CZ30.09.2020
EE30.09.2020
ES30.09.2020
HR30.09.2020
IT30.09.2020
LT30.09.2020
LV30.09.2020
MC30.09.2020
PL30.09.2020
RO30.09.2020
RS30.09.2020
SI30.09.2020
SK30.09.2020
SM30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2021/50]AL30.09.2020
AT30.09.2020
CZ30.09.2020
EE30.09.2020
ES30.09.2020
HR30.09.2020
IT30.09.2020
LT30.09.2020
LV30.09.2020
PL30.09.2020
RO30.09.2020
RS30.09.2020
SI30.09.2020
SK30.09.2020
SM30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2021/48]AL30.09.2020
AT30.09.2020
CZ30.09.2020
EE30.09.2020
ES30.09.2020
HR30.09.2020
IT30.09.2020
LT30.09.2020
LV30.09.2020
PL30.09.2020
RO30.09.2020
RS30.09.2020
SK30.09.2020
SM30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2021/28]AL30.09.2020
AT30.09.2020
CZ30.09.2020
EE30.09.2020
ES30.09.2020
HR30.09.2020
LT30.09.2020
LV30.09.2020
PL30.09.2020
RO30.09.2020
RS30.09.2020
SK30.09.2020
SM30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2021/25]AL30.09.2020
AT30.09.2020
CZ30.09.2020
EE30.09.2020
ES30.09.2020
HR30.09.2020
LT30.09.2020
LV30.09.2020
PL30.09.2020
RO30.09.2020
RS30.09.2020
SM30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2021/24]AT30.09.2020
CZ30.09.2020
EE30.09.2020
HR30.09.2020
LT30.09.2020
LV30.09.2020
RO30.09.2020
RS30.09.2020
SM30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2021/23]CZ30.09.2020
EE30.09.2020
HR30.09.2020
LT30.09.2020
LV30.09.2020
RO30.09.2020
RS30.09.2020
SM30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2021/22]CZ30.09.2020
EE30.09.2020
HR30.09.2020
LT30.09.2020
LV30.09.2020
RO30.09.2020
RS30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2021/21]HR30.09.2020
LT30.09.2020
LV30.09.2020
RS30.09.2020
BG30.12.2020
GR31.12.2020
PT01.02.2021
Former [2021/20]HR30.09.2020
LT30.09.2020
LV30.09.2020
RS30.09.2020
BG30.12.2020
GR31.12.2020
Former [2021/10]HR30.09.2020
LV30.09.2020
RS30.09.2020
BG30.12.2020
GR31.12.2020
Cited inInternational search[Y]US2006234247  (PUTTARAJU MADAIAH [US], et al);
ExaminationWO2015006747
otherWO2014093622
 EP2931897
OppositionWO2006036502
 WO2011101869
 WO2013074667
 WO2013176772
 US2006234247
 WO2009127060
 WO2011000107
 WO2011005799
 WO2011068810
 WO2012000104
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.