blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

Italy joins the Federated Register

Click here for more information on the Federated Register.

2025-06-12

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register User Manual
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP3019185

EP3019185 - COMBINATION TREATMENT FOR ATOPIC DERMATITIS [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  25.06.2025
Database last updated on 07.04.2026
FormerThe patent has been granted
Status updated on  16.10.2020
FormerGrant of patent is intended
Status updated on  29.06.2020
FormerExamination is in progress
Status updated on  02.03.2018
Most recent event   Tooltip27.06.2025Revocation of patentpublished on 30.07.2025  [2025/31]
Applicant(s)For all designated states
Micreos Human Health B.V.
Bankaplein 2
2585 EV Den Haag / NL
[2016/20]
Inventor(s)01 / OFFERHAUS, Mark Leonard
Kiplaan 3
NL-2566 SN Den Haag / NL
02 / EICHENSEHER, Fritz
Schwamendingenstrasse 30
CH-Zürich Ch-8050 / CH
 [2016/20]
Representative(s)Nederlandsch Octrooibureau
P.O. Box 29720
2502 LS The Hague / NL
[2016/20]
Application number, filing date14747994.310.07.2014
[2016/20]
WO2014NL50470
Priority number, dateEP2013017603411.07.2013         Original published format: EP 13176034
[2016/20]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015005787
Date:15.01.2015
Language:EN
[2015/02]
Type: A1 Application with search report 
No.:EP3019185
Date:18.05.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 15.01.2015 takes the place of the publication of the European patent application.
[2016/20]
Type: B1 Patent specification 
No.:EP3019185
Date:18.11.2020
Language:EN
[2020/47]
Search report(s)International search report - published on:EP15.01.2015
ClassificationIPC:A61K38/16, A61K38/21, A61K31/56, A61K31/573, A61K45/06, A61P17/00, A61K38/47
[2020/29]
CPC:
A61K38/47 (EP,US); A61K38/162 (EP,KR,US); A61K31/56 (EP,US);
A61K31/573 (EP,KR,US); A61K38/217 (EP,US); A61K45/06 (EP,US);
A61P17/00 (EP,KR); A61K2300/00 (KR); C12Y302/01017 (EP,US) (-)
C-Set:
A61K31/573, A61K2300/00 (US,EP);
A61K38/162, A61K2300/00 (US,EP);
A61K38/217, A61K2300/00 (EP,US)
Former IPC [2016/20]A61K38/16, A61P17/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/20]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:KOMBINATIONSBEHANDLUNG ATOPISCHER DERMATITIS[2020/29]
English:COMBINATION TREATMENT FOR ATOPIC DERMATITIS[2016/20]
French:TRAITEMENT COMBINÉ DE LA DERMATITE ATOPIQUE[2020/29]
Former [2016/20]KOMBINATIONSBEHANDLUNG VON ATOPISCHER DERMATITIS
Former [2016/20]TRAITEMENT D'ASSOCIATION POUR LA DERMATITE ATOPIQUE
Entry into regional phase02.02.2016National basic fee paid 
02.02.2016Designation fee(s) paid 
02.02.2016Examination fee paid 
Examination procedure02.02.2016Examination requested  [2016/20]
19.09.2016Amendment by applicant (claims and/or description)
05.03.2018Despatch of a communication from the examining division (Time limit: M04)
16.07.2018Reply to a communication from the examining division
20.09.2019Despatch of a communication from the examining division (Time limit: M04)
28.01.2020Reply to a communication from the examining division
30.06.2020Communication of intention to grant the patent
09.10.2020Fee for grant paid
09.10.2020Fee for publishing/printing paid
09.10.2020Receipt of the translation of the claim(s)
Divisional application(s)EP20200722.5  / EP3789033
Opposition(s)Opponent(s)01  18.08.2021   
SONN Patentanwälte OG
Riemergasse 14
1010 Wien / AT
Opponent's representative
SONN Patentanwälte GmbH & Co KG
Riemergasse 14
1010 Wien / AT
 [N/P]
Former [2021/38]
Opponent(s)01  18.08.2021   
SONN Patentanwälte OG
Riemergasse 14
1010 Wien / AT
Opponent's representative
SONN Patentanwälte OG
Riemergasse 14
1010 Wien / AT
30.08.2021Invitation to proprietor to file observations on the notice of opposition
30.12.2021Reply of patent proprietor to notice(s) of opposition
21.03.2023Date of oral proceedings
20.04.2023Despatch of interlocutory decision in opposition
20.04.2023Despatch of minutes of oral proceedings
27.05.2025Legal effect of revocation of patent [2025/31]
24.06.2025Despatch of communication that the patent will be revoked
Appeal following opposition30.06.2023Appeal received No.  T1207/23
30.06.2023Payment of appeal fee
29.08.2023Statement of grounds filed
27.05.2025Result of appeal procedure: revocation of the patent
24.06.2025Despatch of the decision of the Board of Appeal
27.05.2025Date of oral proceedings
Fees paidRenewal fee
10.06.2016Renewal fee patent year 03
29.06.2017Renewal fee patent year 04
04.07.2018Renewal fee patent year 05
27.06.2019Renewal fee patent year 06
29.07.2020Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU10.07.2014
AL18.11.2020
CY18.11.2020
CZ18.11.2020
EE18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
MK18.11.2020
MT18.11.2020
RO18.11.2020
RS18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
[2024/41]
Former [2024/22]HU10.07.2014
AL18.11.2020
CY18.11.2020
CZ18.11.2020
EE18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
MK18.11.2020
RO18.11.2020
RS18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2023/30]HU10.07.2014
AL18.11.2020
CY18.11.2020
CZ18.11.2020
EE18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
RO18.11.2020
RS18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2023/29]HU10.07.2014
AL18.11.2020
CZ18.11.2020
EE18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
RO18.11.2020
RS18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2022/23]AL18.11.2020
CZ18.11.2020
EE18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
RO18.11.2020
RS18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2022/10]AL18.11.2020
CZ18.11.2020
EE18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
RO18.11.2020
RS18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
PT18.03.2021
IS24.12.2021
Former [2021/50]AL18.11.2020
CZ18.11.2020
EE18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
RO18.11.2020
RS18.11.2020
SI18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/45]AL18.11.2020
CZ18.11.2020
EE18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
RO18.11.2020
RS18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/36]CZ18.11.2020
EE18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
RO18.11.2020
RS18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/35]CZ18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
RO18.11.2020
RS18.11.2020
SK18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/34]CZ18.11.2020
HR18.11.2020
LT18.11.2020
LV18.11.2020
RS18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/33]HR18.11.2020
LT18.11.2020
LV18.11.2020
RS18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/32]HR18.11.2020
LV18.11.2020
RS18.11.2020
SM18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/28]HR18.11.2020
LV18.11.2020
RS18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/25]LV18.11.2020
RS18.11.2020
BG18.02.2021
GR19.02.2021
IS18.03.2021
PT18.03.2021
Former [2021/24]LV18.11.2020
RS18.11.2020
BG18.02.2021
GR19.02.2021
PT18.03.2021
Former [2021/23]LV18.11.2020
RS18.11.2020
GR19.02.2021
PT18.03.2021
Former [2021/22]RS18.11.2020
PT18.03.2021
Former [2021/21]PT18.03.2021
Cited inInternational search[XY] WO2011073437  (OREAL et al.) [X] 1,2,6,10 * the whole document * * page 66, lines 20-30; claim 22 *[Y] 1-15
 [Y] WO2012150858  (MICREOS HUMAN HEALTH BV et al.) [Y] 1-15 * the whole document * * example -; claim -; sequence - *
 [Y] WO2009035303  (INTRON BIOTECHNOLOGY INC et al.) [Y] 1-15 * the whole document * * pages 4-5,7; claim - *
 [Y]   RANGINEE CHOUDHURY ET AL.: "Staphylococcal Infection, Antibiotic Resistance and Therapeutics", 4 April 2012 (2012-04-04), pages 247 - 272, XP002709983, ISBN: 978-953-51-0472-8, Retrieved from the Internet [retrieved on 20130806] [Y] 1-15 * the whole document * * paragraph [04.2] - paragraph [04.5] *

DOI:   http://dx.doi.org/10.5772/29395
 [Y]   FRIEDMAN BAT-CHEN ET AL: "Anti-staphylococcal treatment in dermatitis.", CANADIAN FAMILY PHYSICIAN MDECIN DE FAMILLE CANADIEN, vol. 57, no. 6, June 2011 (2011-06-01), pages 669 - 671, XP002709984, ISSN: 1715-5258 [Y] 1-15 * the whole document *
 [Y]   HUNG S H ET AL: "Staphylococcus colonization in atopic dermatitis treated with fluticasone or tacrolimus with or without antibiotics", ANNALS OF ALLERGY, ASTHMA & IMMUNOLOGY, vol. 98, no. 1, 1 January 2007 (2007-01-01), ARLINGTON HEIGHTS, IL, US, pages 51 - 56, XP026959696, ISSN: 1081-1206, [retrieved on 20070101] [Y] 1-15 * the whole document * * page 55 *
 [Y]   IGOR ABAEV ET AL: "Staphylococcal Phage 2638A endolysin is lytic for Staphylococcus aureus and harbors an inter-lytic-domain secondary translational start site", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 97, no. 8, 1 April 2013 (2013-04-01), pages 3449 - 3456, XP055074168, ISSN: 0175-7598, DOI: 10.1007/s00253-012-4252-4 [Y] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1007/s00253-012-4252-4
 [Y]   FENTON MARK ET AL: "Bacteriophage-Derived Peptidase CHAP(K) Eliminates and Prevents Staphylococcal Biofilms.", INTERNATIONAL JOURNAL OF MICROBIOLOGY, vol. 2013, 625341, 3 February 2013 (2013-02-03), pages 1 - 8, XP002709985, ISSN: 1687-918X [Y] 1-15 * the whole document * * page 2 *

DOI:   http://dx.doi.org/10.1155/2013/625341
 [Y]   ANONYMOUS: "DOORBRAAK in ontstekingsbestrijding", PARADERMICA TIJDSCHRIFT VOOR PARAMEDISCHE DERMATOLOGIE, vol. Jun_13, 30 June 2013 (2013-06-30), pages 16 - 19, XP055146552 [Y] 1-15 * the whole document *
 [Y]   ANONYMOUS: "Bacterial skin balance", 20 March 2013 (2013-03-20), XP002731103, Retrieved from the Internet [retrieved on 20141014] [Y] 1-15 * the whole document *
Examination  ANONYMOUS: "Gladskin Composition", 7 June 2019 (2019-06-07), XP055622435, Retrieved from the Internet [retrieved on 20190916] [T] 1-12
   KARIM HNIA ET AL: "l-Arginine Decreases Inflammation and Modulates the Nuclear Factor-[kappa]B/Matrix Metalloproteinase Cascade in Mdx Muscle Fibers", AMERICAN JOURNAL OF PATHOLOGY., vol. 172, no. 6, 1 June 2008 (2008-06-01), US, pages 1509 - 1519, XP055622427, ISSN: 0002-9440, DOI: 10.2353/ajpath.2008.071009 [Y] 1-12

DOI:   http://dx.doi.org/10.2353/ajpath.2008.071009
   A C FLUIT ET AL: "Killing and lysis of Staphylococcus aureus and other staphylococci by an endolysin", CELLULAR MICROBIOLOGY, vol. 18, 1 January 2012 (2012-01-01), GB, XP055454414, ISSN: 1462-5814, DOI: 10.1111/cmi.12485 [Y] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.1111/cmi.12485
OppositionWO2011076432
 WO2012150858
   MARINA PANA (EDITOR): "Antibiotic Resistant Bacteria - A Continous Challenge in the New Millennium", 4 April 2012, INTECH, ISBN: 978-953-510-472-8, article RANGINEE CHOUDHURY, SASMITA PANDA, SAVITRI SHARMA AND DURG V. SINGH: "Staphylococcal Infection, Antibiotic Resistance and Therapeutics", pages: 247 - 272, XP002709983, DOI: 10.5772/29395 [Y] 1-13 * the whole document *

DOI:   http://dx.doi.org/10.5772/29395
   HON KAM LUN: "Combined antibiotic/corticosteroid cream in the empirical treatment of moderate to severe eczema: friend or foe?", JOURNAL OF DRUGS IN DERMATOLOGY, vol. 11, no. 7, 1 July 2012 (2012-07-01), pages 861 - 864, XP055838075
   LEE HARRISON H. ET AL: "Placebo responses in randomized controlled trials for systemic therapy in atopic dermatitis: A systematic review and meta-analysis", JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, MOSBY, INC, US, vol. 82, no. 1, 1 January 2020 (2020-01-01), US, pages 62 - 71, XP055838085, ISSN: 0190-9622, DOI: 10.1016/j.jaad.2019.05.102

DOI:   http://dx.doi.org/10.1016/j.jaad.2019.05.102
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.