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Extract from the Register of European Patents

EP About this file: EP2958932

EP2958932 - THERAPEUTIC AGENTS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  04.01.2019
Database last updated on 16.09.2024
FormerRequest for examination was made
Status updated on  24.09.2018
Most recent event   Tooltip04.01.2019Application deemed to be withdrawnpublished on 06.02.2019  [2019/06]
Applicant(s)For all designated states
National University of Singapore
21 Lower Kent Ridge Road
Singapore 119077 / SG
[2016/01]
Inventor(s)01 / GE, Ruowen
c/o National University of Singapore
Faculty of Science
Department of Biological Sciences
21 Lower Kent Ridge Road
Singapore 119077 / SG
02 / CHEN, Mo
c/o National University of Singapore
Faculty of Science
Department of Biological Sciences
21 Lower Kent Ridge Road
Singapore 119077 / SG
 [2016/01]
Representative(s)Docherty, Robert Charles
Symbiosis IP Limited
York Biotech Campus
Office 14FA05
Sand Hutton
York, YO41 1LZ / GB
[N/P]
Former [2016/01]Docherty, Robert Charles
Symbiosis IP Limited
106 Heworth Green
York YO31 7TQ / GB
Application number, filing date14754533.918.02.2014
[2016/01]
WO2014SG00062
Priority number, dateGB2013000283719.02.2013         Original published format: GB 201302837
US201361851412P07.03.2013         Original published format: US 201361851412 P
[2016/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014129969
Date:28.08.2014
Language:EN
[2014/35]
Type: A1 Application with search report 
No.:EP2958932
Date:30.12.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 28.08.2014 takes the place of the publication of the European patent application.
[2015/53]
Search report(s)International search report - published on:AU28.08.2014
(Supplementary) European search report - dispatched on:EP08.07.2016
ClassificationIPC:A61K38/04, A61K38/06, A61K38/12, A61K38/16, A61K38/17, A61K45/06, A61K49/00, A61K51/00, A61K51/08, C07K5/12, C07K7/64, C12Q1/68, C07K14/46, G01N33/574, G01N33/74, A61P35/00, A61P27/02, A61P27/06, A61P3/10, A61P17/06, A61P29/00
[2016/32]
CPC:
C07K14/461 (EP,US); C07K7/64 (US); A61K38/06 (EP,US);
A61K38/12 (EP,US); A61K38/16 (EP,US); A61K45/06 (US);
A61K49/0056 (US); A61K51/08 (US); A61P17/06 (EP);
A61P27/02 (EP); A61P27/06 (EP); A61P29/00 (EP);
A61P3/10 (EP); A61P35/00 (EP); C07K5/123 (EP,US);
G01N33/57407 (EP,US); G01N33/74 (EP,US); G01N2800/7014 (EP,US) (-)
Former IPC [2016/01]C07K5/12, C07K7/64, A61K38/04, A61K38/17, A61P35/00, A61P27/02, A61P27/06, A61P3/10, A61P17/06, A61P29/00, C12Q1/68
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/01]
TitleGerman:THERAPEUTIKA[2016/01]
English:THERAPEUTIC AGENTS[2016/01]
French:AGENTS THÉRAPEUTIQUES[2016/01]
Entry into regional phase26.08.2015National basic fee paid 
26.08.2015Search fee paid 
26.08.2015Designation fee(s) paid 
26.08.2015Examination fee paid 
Examination procedure26.08.2015Examination requested  [2015/53]
24.01.2017Amendment by applicant (claims and/or description)
01.09.2018Application deemed to be withdrawn, date of legal effect  [2019/06]
25.09.2018Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time  [2019/06]
Fees paidRenewal fee
06.01.2016Renewal fee patent year 03
10.02.2017Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
28.02.201805   M06   Not yet paid
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Documents cited:Search[X]WO2005090388  (UNIV QUEENSLAND [AU], et al) [X] 1,5,8-10,12,15,16 * claims 1-3,84-100 * * paragraphs [0031] , [0071] , [0209] , [0212]; sequences 49,50,51 *;
 [X]US2006057584  (BABAN SOHEYL [CA], et al) [X] 13,14 * paragraphs [0122] , [0209] , [0263]; table 1 * * claims 5,7,14,27 *;
 [I]US2008003200  (ARAP WADIH [US], et al) [I] 13,14* paragraphs [0074] - [0046] *;
 [X]WO2008148247  (GENE TECH PHARM GROUP DONG GUA [CN], et al) [X] 1,5 * abstract *;
 [X]WO2012012693  (HARVARD COLLEGE [US], et al) [X] 13,14 * paragraphs [0127] , [0145] , [0156] , [0176] , [0233] , [0341]; claims 122-124,141-144 *;
 [X]US2012040894  (GANZ TOMAS [US], et al) [X] 1,4,5 * claims 1,8,16 *
International search[X]WO2008136869  (BURNHAM INST MEDICAL RESEARCH [US], et al);
 [X]WO2009113965  (UNIV SINGAPORE [SG], et al);
 [X]  - ZHANG, Y. ET AL., "Isthmin exerts pro-survival and death-promoting effect on endothelial cells through alphavbeta5 integrin depending on its physical state", CELL DEATH AND DISEASE, (20110505), vol. 2, no. E153, doi:10.1038/CDDIS.2011.37, pages 1 - 10, XP055272191

DOI:   http://dx.doi.org/10.1038/cddis.2011.37
 [X]  - XIANG, W. ET AL., "Isthmin is a novel secreted angiogenesis inhibitor that inhibits tumour growth in mice", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, (20110101), vol. 15, no. 2, doi:10.1111/J.1582-4934.2009.00961.X, pages 359 - 374, XP055272202

DOI:   http://dx.doi.org/10.1111/j.1582-4934.2009.00961.x
 [L]  - LEE, A. S ET AL., "GRP78 Induction in Cancer: Therapeutic and Prognostic Implications", CANCER RESEARCH, (20070415), vol. 67, no. 8, doi:10.1158/0008-5472.CAN-07-0325, pages 3496 - 3499, XP055045534

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-07-0325
 [L]  - NI, M. ET AL., BIOCHEMICAL JOURNAL, (2011), vol. 434, pages 181 - 188, XP055272658

DOI:   http://dx.doi.org/10.1042/BJ20101569
 [XP]  - CHEN, M. ET AL., "Isthmin targets cell -surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction", CELL DEATH AND DIFFERENTIATION, (2014), vol. 21, no. 5, pages 797 - 810, XP055272684

DOI:   http://dx.doi.org/10.1038/cdd.2014.3
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