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Extract from the Register of European Patents

EP About this file: EP2968274

EP2968274 - MEROPENEM DERIVATIVES AND USES THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  21.08.2020
Database last updated on 02.08.2024
FormerThe patent has been granted
Status updated on  13.09.2019
FormerGrant of patent is intended
Status updated on  08.05.2019
FormerExamination is in progress
Status updated on  11.03.2019
FormerGrant of patent is intended
Status updated on  30.10.2018
FormerExamination is in progress
Status updated on  16.06.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Kala Pharmaceuticals, Inc.
490 Arsenal Way, Suite 120
Watertown, MA 02472 / US
[2019/23]
Former [2016/03]For all designated states
Kala Pharmaceuticals, Inc.
100 Beaver Street, Suite 201
Waltham, MA 02453 / US
Inventor(s)01 / ONG, Winston Zapanta
35 Summer Street
Stoneham, Massachusetts 02180 / US
02 / NOWAK, Pawel Wojciech
33 Bearbrook Drive
Woodcliff Lake, New Jersey 07677 / US
03 / KIM, Jinsoo
1476 Commonwealth Avenue
Brighton, Massachusetts 02135 / US
04 / ENLOW, Elizabeth M.
85 Black Bear Drive
Unit 1624
Waltham, Massachusetts 02451 / US
05 / BOURASSA, James
425 Broadway Apt. 15
Somerville, Massachusetts 02145 / US
06 / CU, Yen
334 Harvard Street Apt. F3
Cambridge, Massachusetts 02139 / US
07 / POPOV, Alexey
60 Hope Avenue
Waltham, Massachusetts 02453 / US
08 / CHEN, Hongming
16 Birch Hill Road
Belmont, Massachusetts 02478 / US
 [2016/03]
Representative(s)Mitchell, Simon James, et al
Murgitroyd & Company London
Euston House
24 Eversholt Street
London NW1 1AD / GB
[N/P]
Former [2019/42]Mitchell, Simon James, et al
Urquhart-Dykes & Lord LLP
Euston House
24 Eversholt Street
London NW1 1AD / GB
Former [2016/03]Green, Mark Charles, et al
Urquhart-Dykes & Lord LLP The Podium
1 Eversholt Street
London NW1 2DN / GB
Application number, filing date14762750.914.03.2014
[2016/03]
WO2014US28627
Priority number, dateUS201361789335P15.03.2013         Original published format: US 201361789335 P
[2016/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014144285
Date:18.09.2014
Language:EN
[2014/38]
Type: A1 Application with search report 
No.:EP2968274
Date:20.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 18.09.2014 takes the place of the publication of the European patent application.
[2016/03]
Type: B1 Patent specification 
No.:EP2968274
Date:16.10.2019
Language:EN
[2019/42]
Search report(s)International search report - published on:US18.09.2014
(Supplementary) European search report - dispatched on:EP21.07.2016
ClassificationIPC:A61K31/407, C07D477/20, C07D487/04
[2016/03]
CPC:
C07D477/20 (EP,US); A61K31/407 (EP,US); A61K45/06 (EP,US);
A61K9/5015 (EP,US); A61K9/5031 (US); A61K9/5123 (EP,US);
A61K9/5146 (US); A61P31/04 (EP); C07D487/04 (EP,US);
Y02A50/30 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/03]
Extension statesBA08.10.2015
ME08.10.2015
TitleGerman:MEROPENEMDERIVATE UND VERWENDUNGEN DAVON[2016/03]
English:MEROPENEM DERIVATIVES AND USES THEREOF[2016/03]
French:DÉRIVÉS DE MÉROPÉNÈME ET LEURS UTILISATIONS[2016/03]
Entry into regional phase08.10.2015National basic fee paid 
08.10.2015Search fee paid 
08.10.2015Designation fee(s) paid 
08.10.2015Examination fee paid 
Examination procedure08.10.2015Examination requested  [2016/03]
13.02.2017Amendment by applicant (claims and/or description)
19.06.2017Despatch of a communication from the examining division (Time limit: M06)
19.12.2017Reply to a communication from the examining division
16.03.2018Despatch of a communication from the examining division (Time limit: M04)
16.07.2018Reply to a communication from the examining division
31.10.2018Communication of intention to grant the patent
11.03.2019Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
09.05.2019Communication of intention to grant the patent
03.09.2019Fee for grant paid
03.09.2019Fee for publishing/printing paid
03.09.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  19.06.2017
Opposition(s)17.07.2020No opposition filed within time limit [2020/39]
Fees paidRenewal fee
13.01.2016Renewal fee patent year 03
10.03.2017Renewal fee patent year 04
23.03.2018Renewal fee patent year 05
26.03.2019Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU14.03.2014
AL16.10.2019
AT16.10.2019
CY16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
IT16.10.2019
LT16.10.2019
LV16.10.2019
MC16.10.2019
MK16.10.2019
MT16.10.2019
NL16.10.2019
PL16.10.2019
RO16.10.2019
RS16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
TR16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
IE14.03.2020
LU14.03.2020
BE31.03.2020
CH31.03.2020
LI31.03.2020
[2022/32]
Former [2022/27]HU14.03.2014
AL16.10.2019
AT16.10.2019
CY16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
IT16.10.2019
LT16.10.2019
LV16.10.2019
MC16.10.2019
MT16.10.2019
NL16.10.2019
PL16.10.2019
RO16.10.2019
RS16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
TR16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
IE14.03.2020
LU14.03.2020
BE31.03.2020
CH31.03.2020
LI31.03.2020
Former [2021/12]AL16.10.2019
AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
IT16.10.2019
LT16.10.2019
LV16.10.2019
MC16.10.2019
NL16.10.2019
PL16.10.2019
RO16.10.2019
RS16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
IE14.03.2020
LU14.03.2020
BE31.03.2020
CH31.03.2020
LI31.03.2020
Former [2021/07]AL16.10.2019
AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
IT16.10.2019
LT16.10.2019
LV16.10.2019
MC16.10.2019
NL16.10.2019
PL16.10.2019
RO16.10.2019
RS16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
IE14.03.2020
LU14.03.2020
CH31.03.2020
LI31.03.2020
Former [2021/04]AL16.10.2019
AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
IT16.10.2019
LT16.10.2019
LV16.10.2019
MC16.10.2019
NL16.10.2019
PL16.10.2019
RO16.10.2019
RS16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
LU14.03.2020
Former [2020/50]AL16.10.2019
AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
IT16.10.2019
LT16.10.2019
LV16.10.2019
MC16.10.2019
NL16.10.2019
PL16.10.2019
RO16.10.2019
RS16.10.2019
SE16.10.2019
SI16.10.2019
SK16.10.2019
SM16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
Former [2020/38]AL16.10.2019
AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
IT16.10.2019
LT16.10.2019
LV16.10.2019
NL16.10.2019
PL16.10.2019
RO16.10.2019
RS16.10.2019
SE16.10.2019
SK16.10.2019
SM16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
Former [2020/37]AL16.10.2019
AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
NL16.10.2019
PL16.10.2019
RO16.10.2019
RS16.10.2019
SE16.10.2019
SK16.10.2019
SM16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
Former [2020/36]AL16.10.2019
AT16.10.2019
CZ16.10.2019
DK16.10.2019
EE16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
NL16.10.2019
PL16.10.2019
RO16.10.2019
RS16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
IS16.02.2020
PT17.02.2020
Former [2020/35]AL16.10.2019
AT16.10.2019
CZ16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
NL16.10.2019
PL16.10.2019
RO16.10.2019
RS16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
PT17.02.2020
IS24.02.2020
Former [2020/32]AL16.10.2019
AT16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
NL16.10.2019
PL16.10.2019
RS16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
PT17.02.2020
IS24.02.2020
Former [2020/25]AT16.10.2019
ES16.10.2019
FI16.10.2019
HR16.10.2019
LT16.10.2019
LV16.10.2019
NL16.10.2019
PL16.10.2019
RS16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
PT17.02.2020
IS24.02.2020
Former [2020/24]AT16.10.2019
ES16.10.2019
FI16.10.2019
LT16.10.2019
LV16.10.2019
NL16.10.2019
PL16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
PT17.02.2020
IS24.02.2020
Former [2020/23]AT16.10.2019
ES16.10.2019
FI16.10.2019
LT16.10.2019
LV16.10.2019
NL16.10.2019
PL16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
GR17.01.2020
PT17.02.2020
Former [2020/22]FI16.10.2019
LT16.10.2019
NL16.10.2019
SE16.10.2019
BG16.01.2020
NO16.01.2020
PT17.02.2020
Former [2020/21]NL16.10.2019
NO16.01.2020
Former [2020/20]NL16.10.2019
Documents cited:Search[Y]WO9315078  (ZENECA LTD [GB], et al) [Y] 11 * claim 1 *;
 [Y]US2005065141  (ODINK DEBRA A [US], et al) [Y] 21 * claims 1, 10 *;
 [XYI]  - SHUNKICHI TANAKA ET AL, "Novel prodrugs of meropenem with two lipophilic promoieties: synthesis and pharmacokinetics", THE JOURNAL OF ANTIBIOTICS, GB, (20110301), vol. 64, no. 3, doi:10.1038/ja.2010.164, ISSN 0021-8820, pages 233 - 242, XP055234328 [X] 1-5,8,13 * page 235; compounds 4-10 * [Y] 11,21 [I] 6,7,9,10,12

DOI:   http://dx.doi.org/10.1038/ja.2010.164
 [A]  - WEI X ET AL, "Biodegradable polycaprolactone-poly(ethylene glycol) copolymers as drug delivery system", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL, vol. 381, no. 1, doi:10.1016/J.IJPHARM.2009.07.033, ISSN 0378-5173, (20091020), pages 1 - 18, (20090805), XP026642137 [A] 1-21 * chapter 3.2.1 *

DOI:   http://dx.doi.org/10.1016/j.ijpharm.2009.07.033
International search[Y]US6491903  (FORSTER DENIS [US], et al);
 [X]US2004176350  (MATSUI HIROSHI [JP]);
 [Y]US2011172200  (PREZELJ ANDREJ [SI], et al);
 [Y]WO2012063085  (REDX PHARMA LTD [GB], et al)
by applicantUS6410525
 US2004176350
 US2013316006
    - ., Handbook of Chemistry and Physics, 75th Ed.,, .
    - WILEN et al., Tetrahedron, (19770000), vol. 33, page 2725
    - WILEN, Tables of Resolving Agents and Optical Resolutions, Univ. of Notre Dame Press, (19720000), page 268
    - BERGE et al., "pharmaceutically acceptable salts", J. Pharmaceutical Sciences, (19770000), vol. 66, pages 1 - 19
    - BUNDGARD, H., Design of Prodrugs, Elsevier, (19850000), pages 7 - 9,21-24
    - BUDIJONO et al., Colloids and Surfaces A: Physicochem. Eng. Aspects, (20100000), vol. 360, pages 105 - 110
    - JOSHI et al., Anal. Chim. Acta, (19790000), vol. 104, pages 153 - 160
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.