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Extract from the Register of European Patents

EP About this file: EP2968204

EP2968204 - PHOSPHODIESTERASE INHIBITORS FOR TREATING TASTE AND SMELL DISORDERS [Right-click to bookmark this link]
Former [2016/03]PHOSPHODIESTERASE INHIBITOR TREATMENT
[2018/45]
StatusNo opposition filed within time limit
Status updated on  20.03.2020
Database last updated on 08.04.2026
FormerThe patent has been granted
Status updated on  12.04.2019
FormerGrant of patent is intended
Status updated on  22.11.2018
FormerExamination is in progress
Status updated on  28.07.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Henkin, Robert I.
6601 Broxburn Drive
Bethesda, MD 20817 / US
[2016/03]
Inventor(s)01 / see applicant
...
 [2018/51]
Former [2016/03]01 / HENKIN, Robert, I.
6601 Broxburn Drive
Bethesda MD 20817 / US
Representative(s)Avidity IP
Future Business Centre Cambridge Campus
Kings Hedges Road
Cambridge CB4 2HY / GB
[N/P]
Former [2019/20]Avidity IP
Broers Building
Hauser Forum
21 JJ Thomson Avenue
Cambridge CB3 0FA / GB
Former [2016/03]Cummings, Ross Martin, et al
Avidity IP
Broers Building
Hauser Forum
21 J.J. Thomson Avenue
Cambridge CB3 0FA / GB
Application number, filing date14763097.405.02.2014
[2016/03]
WO2014US14940
Priority number, dateUS201361802074P15.03.2013         Original published format: US 201361802074 P
[2016/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014143453
Date:18.09.2014
Language:EN
[2014/38]
Type: A1 Application with search report 
No.:EP2968204
Date:20.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 18.09.2014 takes the place of the publication of the European patent application.
[2016/03]
Type: B1 Patent specification 
No.:EP2968204
Date:15.05.2019
Language:EN
[2019/20]
Search report(s)International search report - published on:AU18.09.2014
(Supplementary) European search report - dispatched on:EP14.09.2016
ClassificationIPC:A61K31/522, A61P27/00, A61K31/4375, A61K31/52, A61K31/519, A61K31/444, A61K31/4704, A61K31/472, A61K31/401, A61K31/416, A61K31/44, A61K31/352, A61K31/473, A61K31/4985, A61K31/506, A61K9/00, A61K31/4709, A61M15/08, A61K31/495
[2016/41]
CPC:
A61K31/522 (EP,US); A61K31/44 (EP,US); A61K31/4709 (EP,US);
A61K31/472 (EP,US); A61K31/495 (EP,US); A61K31/4985 (EP,US);
A61K9/0043 (EP,US); A61M11/001 (US); A61M15/08 (EP,US);
A61P27/00 (EP); A61P43/00 (EP); A61M2202/064 (EP,US);
A61M2207/10 (US); A61M2209/06 (EP,US) (-)
Former IPC [2016/03]A61K9/72, A61K9/12, A61K31/495, A61K31/522, A61K31/4985, A61M11/02, A61M15/08, A61P43/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/03]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:PHOSPHODIESTERASEHEMMER ZUR BEHANDLUNG VON GESCHMACKS- UND GERUCHSSTÖRUNGEN[2018/45]
English:PHOSPHODIESTERASE INHIBITORS FOR TREATING TASTE AND SMELL DISORDERS[2018/45]
French:INHIBITEURS DE LA PHOSPHODIESTÉRASE DESTINÉS À TRAITER DES TROUBLES DU GOÛT ET DE L'ODORAT[2018/45]
Former [2016/03]BEHANDLUNG MIT EINEM PHOSPHODIESTERASE-HEMMER
Former [2016/03]PHOSPHODIESTERASE INHIBITOR TREATMENT
Former [2016/03]TRAITEMENT FAISAINT INTERVENIR UN INHIBITEUR DE LA PHOSPHODIESTÉRASE
Entry into regional phase12.10.2015National basic fee paid 
12.10.2015Search fee paid 
12.10.2015Designation fee(s) paid 
12.10.2015Examination fee paid 
Examination procedure12.10.2015Examination requested  [2016/03]
07.04.2017Amendment by applicant (claims and/or description)
27.07.2017Despatch of a communication from the examining division (Time limit: M06)
06.02.2018Reply to a communication from the examining division
26.04.2018Despatch of a communication from the examining division (Time limit: M02)
06.07.2018Reply to a communication from the examining division
23.11.2018Communication of intention to grant the patent
02.04.2019Fee for grant paid
02.04.2019Fee for publishing/printing paid
02.04.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  27.07.2017
Opposition(s)18.02.2020No opposition filed within time limit [2020/17]
Fees paidRenewal fee
26.02.2016Renewal fee patent year 03
27.02.2017Renewal fee patent year 04
27.02.2018Renewal fee patent year 05
27.02.2019Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU05.02.2014
AL15.05.2019
AT15.05.2019
CY15.05.2019
CZ15.05.2019
DK15.05.2019
EE15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
MC15.05.2019
MK15.05.2019
MT15.05.2019
NL15.05.2019
PL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
SI15.05.2019
SK15.05.2019
SM15.05.2019
TR15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
IS15.09.2019
PT15.09.2019
IE05.02.2020
LU05.02.2020
[2022/31]
Former [2022/30]HU05.02.2014
AL15.05.2019
AT15.05.2019
CY15.05.2019
CZ15.05.2019
DK15.05.2019
EE15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
MC15.05.2019
MT15.05.2019
NL15.05.2019
PL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
SI15.05.2019
SK15.05.2019
SM15.05.2019
TR15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
IS15.09.2019
PT15.09.2019
IE05.02.2020
LU05.02.2020
Former [2022/28]HU05.02.2014
AL15.05.2019
AT15.05.2019
CY15.05.2019
CZ15.05.2019
DK15.05.2019
EE15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
MC15.05.2019
MT15.05.2019
NL15.05.2019
PL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
SI15.05.2019
SK15.05.2019
SM15.05.2019
TR15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
IE05.02.2020
LU05.02.2020
Former [2021/08]AL15.05.2019
AT15.05.2019
CZ15.05.2019
DK15.05.2019
EE15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
MC15.05.2019
NL15.05.2019
PL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
SI15.05.2019
SK15.05.2019
SM15.05.2019
TR15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
IE05.02.2020
LU05.02.2020
Former [2020/50]AL15.05.2019
AT15.05.2019
CZ15.05.2019
DK15.05.2019
EE15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
MC15.05.2019
NL15.05.2019
PL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
SI15.05.2019
SK15.05.2019
SM15.05.2019
TR15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
LU05.02.2020
Former [2020/48]AL15.05.2019
AT15.05.2019
CZ15.05.2019
DK15.05.2019
EE15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
NL15.05.2019
PL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
SI15.05.2019
SK15.05.2019
SM15.05.2019
TR15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
LU05.02.2020
Former [2020/25]AL15.05.2019
AT15.05.2019
CZ15.05.2019
DK15.05.2019
EE15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
NL15.05.2019
PL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
SI15.05.2019
SK15.05.2019
SM15.05.2019
TR15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
Former [2020/17]AL15.05.2019
AT15.05.2019
CZ15.05.2019
DK15.05.2019
EE15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
NL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
SK15.05.2019
SM15.05.2019
TR15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
Former [2020/14]AL15.05.2019
AT15.05.2019
CZ15.05.2019
DK15.05.2019
EE15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
NL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
SK15.05.2019
SM15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
Former [2020/11]AL15.05.2019
AT15.05.2019
CZ15.05.2019
DK15.05.2019
EE15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
NL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
SK15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
Former [2020/10]AL15.05.2019
AT15.05.2019
CZ15.05.2019
DK15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
NL15.05.2019
RO15.05.2019
RS15.05.2019
SE15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
Former [2020/09]AL15.05.2019
CZ15.05.2019
DK15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
NL15.05.2019
RS15.05.2019
SE15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
Former [2019/51]AL15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
NL15.05.2019
RS15.05.2019
SE15.05.2019
BG15.08.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
Former [2019/50]AL15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
LV15.05.2019
NL15.05.2019
RS15.05.2019
SE15.05.2019
NO15.08.2019
GR16.08.2019
PT15.09.2019
Former [2019/49]AL15.05.2019
FI15.05.2019
HR15.05.2019
LT15.05.2019
NL15.05.2019
SE15.05.2019
NO15.08.2019
PT15.09.2019
Former [2019/48]FI15.05.2019
LT15.05.2019
SE15.05.2019
NO15.08.2019
PT15.09.2019
Former [2019/47]FI15.05.2019
LT15.05.2019
NO15.08.2019
Documents cited:Search[XY] US2010022563  (HENKIN ROBERT I et al.) [X] 1-5,15 * page 1, paragraphs [0003], [0004] * * page 5, paragraphs [0046], [0055] * * pages 5-6, paragraphs [0058], [0065], [0067] * * examples 4, 6, 7 * * page 23, paragraphs [0231]-[0235] * * page 24, paragraphs [0259]-[0266] * * claims 1-6, 10, 12-17 *[Y] 1-15
 [X] WO9901135  (PFIZER LTD et al.) [X] 1-3,5 * page 2, lines 6-10, 19-21 * * page 6, lines 11-28 * * page 7, lines 6-15 *
 [Y] WO2007044375  (NASTECH PHARM CO et al.) [Y] 1-15 * page 34, line 14 - page 36, line 27 * * example 8 * * claims 101-103, 105, 107, 108 *
 [Y] WO2010147981  (ALLERGAN INC et al.) [Y] 1-15 * page 4, paragraph [0011] - page 5, paragraph [0013] * * page 8, paragraph [0021] * * page 9, paragraphs [0026], [0029] * * page 12, paragraph [0047] * * pages 16-17, paragraph [0060] * * page 18, paragraph [0066] - page 19, paragraph [0067] * * example 4 * * claims 1, 22 * * figures 2, 3 *
 [Y] US2011023870  (WERMELING DANIEL P et al.) [Y] 1-15 * page 5, paragraphs [0051], [0070]-[0072] * * page 6, paragraphs [0074], [0082] * * examples 4, 5 * * claims 10, 20-22 *
 [A] US5169849  (KIECHEL JEAN-RENE et al.) [A] 1-15 * column 1, lines 18-36 * * column 3, lines 59-69 * * column 5, line 62 - column 6, line 20 * * claims 1, 5, 14, 15, 17, 22, 23, 26 *
 [A] WO0182931  (SURE MEDICAL INC et al.) [A] 1-15 * page 8, paragraph 2 * * example 1 * * claims 1, 2, 5, 9 *
 [E] WO2014055801  (HENKIN ROBERT I et al.) [E] 1-15 * claims 250-268, 271-306, 319-320, 326, 330 * * claims 341, 346, 351, 355, 410 *
 [A]   H KUBLIK ET AL: "Nasal delivery systems and their effect on deposition and absorption", ADVANCED DRUG DELIVERY REVIEWS, vol. 29, no. 1-2, 1 January 1998 (1998-01-01), AMSTERDAM, NL, pages 157 - 177, XP055248105, ISSN: 0169-409X, DOI: 10.1016/S0169-409X(97)00067-7 [A] 1-15 * page 161, column 1, paragraphs 2-3 * * page 162, column 2, paragraph l - page 164, column 1, paragraph 3 * * page 168, column 2, paragraph 1 * * page 173, column 2, paragraphs 1-2 * * page 175, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/S0169-409X(97)00067-7
International search[A]   ELSHAFEEY AH ET AL., IN VITRO EVALUATION AND IN VIVO PHARMACOKINETIC STUDY IN RABBITS;, vol. Intranas, no. 2, 2009, pages 361 - 367, XP055298275 [A] 1-34 * . Whole document. Particularly: Abstract; page 365; page 363 column 2 *

DOI:   http://dx.doi.org/10.1208/s12249-009-9213-6
 [A]   CHO HJ. ET AL.: "Development of udenafil-loaded microcmulsioos for intranasal delivery: In vitro and in vivo evaluations", INTERNATIONAL JOURNAL OF PHARMACEUTIES, vol. 423, 2012, pages 153 - 160, XP055289713 [A] 1-34 * . Whole document. Particularly: Abstract; page 155 column 1. *

DOI:   http://dx.doi.org/10.1016/j.ijpharm.2011.12.028
 [A]   HENKIN RI ET AL.: "Intranasal Theophylline Tirestment of Hyposmia and Hypogeusia", ARCH OTOLARYNGOL HEAD NECK SURG, vol. 138, no. 11, 2012, pages 1064 - 1070, XP008181389 [A] 1-34 * Whole document Particularly: Abstract page 1067-1069. *
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