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Extract from the Register of European Patents

EP About this file: EP2971033

EP2971033 - MANUFACTURING METHODS FOR PRODUCTION OF RNA TRANSCRIPTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.04.2020
Database last updated on 08.04.2026
FormerThe patent has been granted
Status updated on  26.04.2019
FormerGrant of patent is intended
Status updated on  16.12.2018
FormerExamination is in progress
Status updated on  23.03.2018
FormerRequest for examination was made
Status updated on  22.06.2017
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
ModernaTX, Inc.
320 Bent Street
Cambridge, MA 02141 / US
[2019/24]
Former [2016/03]For all designated states
Moderna Therapeutics, Inc.
320 Bent Street
Cambridge, Massachusetts 02141 / US
Inventor(s)01 / BANCEL, Stephane
Moderna Therapeutics Inc.
320 Bent Street
Cambridge, MA 02141 / US
02 / ISSA, William, Joseph
Moderna Therapeutics Inc.
200 Technology Square
Cambridge, MA 02139 / US
03 / AUNINS, John, Grant
Moderna Therapeutics Inc.
200 Technology Square
Cambridge, MA 02139 / US
04 / CHAKRABORTY, Tirtha
Moderna Therapeutics Inc.
200 Technology Square
Cambridge, MA 02139 / US
 [2016/03]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
[2016/03]
Application number, filing date14769839.313.03.2014
[2016/03]
WO2014US26835
Priority number, dateUS201361800049P15.03.2013         Original published format: US 201361800049 P
[2016/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014152027
Date:25.09.2014
Language:EN
[2014/39]
Type: A1 Application with search report 
No.:EP2971033
Date:20.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 25.09.2014 takes the place of the publication of the European patent application.
[2016/03]
Type: B1 Patent specification 
No.:EP2971033
Date:29.05.2019
Language:EN
[2019/22]
Type: B8 Corrected title page of specification 
No.:EP2971033
Date:10.07.2019
[2019/28]
Search report(s)International search report - published on:US25.09.2014
(Supplementary) European search report - dispatched on:EP18.10.2016
ClassificationIPC:C12N15/10, C12P19/34
[2018/52]
CPC:
C12Q1/6865 (EP,US); C12P19/34 (US); C12N15/101 (EP,US)
C-Set:
C12Q1/6865, C12Q2525/173, C12Q2565/629 (EP,US)
Former IPC [2016/46]C12P19/34, C12P19/30, C12P19/26, C12N15/10
Former IPC [2016/03]C12P19/34, C12P19/30, C12P19/26
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/03]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:HERSTELLUNGSVERFAHREN ZUR HERSTELLUNG VON RNA-TRANSKRIPTEN[2016/03]
English:MANUFACTURING METHODS FOR PRODUCTION OF RNA TRANSCRIPTS[2016/03]
French:PROCÉDÉS DE FABRICATION POUR LA PRODUCTION DE TRANSCRITS D'ARN[2016/03]
Entry into regional phase14.10.2015National basic fee paid 
14.10.2015Search fee paid 
14.10.2015Designation fee(s) paid 
14.10.2015Examination fee paid 
Examination procedure14.10.2015Examination requested  [2016/03]
23.06.2017Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
01.09.2017Amendment by applicant (claims and/or description)
28.03.2018Despatch of a communication from the examining division (Time limit: M04)
07.08.2018Reply to a communication from the examining division
17.12.2018Communication of intention to grant the patent
17.04.2019Fee for grant paid
17.04.2019Fee for publishing/printing paid
17.04.2019Receipt of the translation of the claim(s)
Divisional application(s)EP19171552.3  / EP3578663
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.03.2018
Opposition(s)03.03.2020No opposition filed within time limit [2020/19]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
01.09.2017Request for further processing filed
01.09.2017Full payment received (date of receipt of payment)
Request granted
11.09.2017Decision despatched
Fees paidRenewal fee
31.03.2016Renewal fee patent year 03
27.03.2017Renewal fee patent year 04
27.03.2018Renewal fee patent year 05
27.03.2019Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU13.03.2014
AL29.05.2019
AT29.05.2019
CY29.05.2019
CZ29.05.2019
DK29.05.2019
EE29.05.2019
ES29.05.2019
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Former [2022/30]HU13.03.2014
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Documents cited:Search[XAY] WO2007120863  (EPICT TECHNOLOGIES et al.) [X] 1,5,6,8,10,11 * page 96,; claim 64 *[A] 12-14 [Y] 2-4
 [Y] WO2008083949  (CUREVAC GMBH et al.) [Y] 2 * page 60, paragraph l *
 [A] WO2009149253  (UNIV WARSZAWSKI et al.) [A] 12 * example 1; claim 6 *
 [E] WO2014113089  (MODERNA THERAPEUTICS INC et al.) [E] 1,12 * paragraph [0285]; examples 2-4 *
 [E] WO2014152030  (MODERNA THERAPEUTICS INC et al.) [E] 1,12-14 * paragraphs [0008] , [0012] , [0105] *
 [XAY]   PASCOLO S: "Vaccination with messenger RNA", METHODS IN MOLECULAR MEDICINE,, 1 January 2006 (2006-01-01), pages 23 - 40, XP009117840, ISSN: 1543-1894 [X] 1,2,5-9 * pages 26,28-29; figure 1 * * pages 31-32; figure 5 * [A] 12-14 [Y] 3,4

DOI:   http://dx.doi.org/10.1385/1-59745-168-1:23
 [X]   WEISS RICHARD ET AL: "Prophylactic mRNA vaccination against allergy", CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, LIPPINCOTT WILLIAMS AND WILKINS, US, vol. 10, no. 6, 1 December 2010 (2010-12-01), pages 567 - 574, XP009164452, ISSN: 1528-4050, DOI: 10.1097/ACI.0B013E32833FD5B6 [X] 1 * page 568, *

DOI:   http://dx.doi.org/10.1097/ACI.0b013e32833fd5b6
 [Y]   VOMELOVA I ET AL: "Methods of RNA Purification. All Ways (Should) Lead to Rome", FOLIA BIOLOGICA (PRAHA),, vol. 55, no. 6, 1 January 2009 (2009-01-01), pages 243 - 251, XP002724956, ISSN: 0015-5500 [Y] 3,4 * page 247, column r *
International search[X] US2004259097  (DE BACKER MARIANNE DENISE et al.) [X]
 [Y] WO9105058  (KAWASAKI GLENN et al.) [Y]
 [Y] US6511832  (GUARINO LINDA A et al.) [Y]
 [A] US8093367  (KORE ANILKUMAR et al.) [A]
 [A] WO0244399  (ROSETTA INPHARMATICS INC et al.) [A]
 [YP] WO2014028429  (MODERNA THERAPEUTICS INC et al.) [YP]
ExaminationWO2008039669
   SAUMYA BHADURI ET AL: "Procedure for the Preparation of Milligram Quantities of Adenovirus Messenger Ribonucleic Acid", JOURNAL OF VIROLOGY., vol. 10, no. 6, 1 December 1972 (1972-12-01), US, pages 1126 - 1129, XP055232582, ISSN: 0022-538X [X] 1,2,5-9 * pages 26,28-29; figure 1 * * pages 31-32; figure 5 * [A] 12-14 [Y] 3,4
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.