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Extract from the Register of European Patents

EP About this file: EP2968360

EP2968360 - QUINOLINONE DERIVATIVES FOR THE INHIBITION OF BROMODOMAIN-CONTAINING PROTEINS [Right-click to bookmark this link]
Former [2016/03]METHODS AND COMPOSITIONS FOR INHIBITION OF BROMODOMAIN-CONTAINING PROTEINS
[2020/32]
StatusNo opposition filed within time limit
Status updated on  26.11.2021
Database last updated on 03.10.2024
FormerThe patent has been granted
Status updated on  18.12.2020
FormerGrant of patent is intended
Status updated on  26.07.2020
FormerExamination is in progress
Status updated on  02.02.2018
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024 [2024/41]
Applicant(s)For all designated states
ConverGene LLC
22 Firstfield Road
Suite 280
Gaithersburg, Maryland 20878 / US
[2016/07]
Former [2016/03]For all designated states
ConverGene LLC
22 Firstfield Road
Suite 280
Gaithersburg, Maryland 20878 / US
For all designated states
Vankayalapati, Hariprasad
11558 South Sugar Berry Road
Draper, Utah 84020 / US
For all designated states
Yoshioka, Makoto
18510 Boysenberry Road
Apt. 192
Gaithersburg, Maryland 20879 / US
For all designated states
Strovel, Jeffrey William
8580 Light Moon Way
Laurel, Maryland 20723 / US
For all designated states
Padia, Janak Khimchand
13628 Monarch Vista Drive
Germantown, Maryland 20874 / US
Inventor(s)01 / VANKAYALAPATI, Hariprasad
11558 South Sugar Berry Road
Draper, Utah 84020 / US
02 / YOSHIOKA, Makoto
18510 Boysenberry Road Apt. 192
Gaithersburg, Maryland 20879 / US
03 / STROVEL, Jeffrey William
8580 Light Moon Way
Laurel, Maryland 20723 / US
04 / PADIA, Janak Khimchand
13628 Monarch Vista Drive
Germantown, Maryland 20874 / US
 [2016/03]
Representative(s)Schiweck Weinzierl Koch Patentanwälte Partnerschaft mbB
Ganghoferstraße 68 B
80339 München / DE
[2021/03]
Former [2016/03]Schiweck, Weinzierl & Koch
European Patent Attorneys
Landsberger Straße 98
80339 München / DE
Application number, filing date14776141.513.03.2014
[2016/03]
WO2014US25289
Priority number, dateUS201361781988P14.03.2013         Original published format: US 201361781988 P
[2016/03]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014159837
Date:02.10.2014
Language:EN
[2014/40]
Type: A1 Application with search report 
No.:EP2968360
Date:20.01.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 02.10.2014 takes the place of the publication of the European patent application.
[2016/03]
Type: B1 Patent specification 
No.:EP2968360
Date:20.01.2021
Language:EN
[2021/03]
Search report(s)International search report - published on:KR02.10.2014
(Supplementary) European search report - dispatched on:EP06.02.2017
ClassificationIPC:C07D413/04, C07D413/14, C07D471/04, C07D487/04, C07C233/15, C07D261/08, A61K31/5517, A61K31/4745, A61K31/4709, A61P35/00, A61P19/02, A61P25/28, A61P31/18
[2016/30]
CPC:
C07D487/04 (EP,US); A61P1/04 (EP); A61P1/16 (EP);
A61P1/18 (EP); A61P11/00 (EP); A61P13/08 (EP);
A61P15/00 (EP); A61P19/02 (EP); A61P25/00 (EP);
A61P25/28 (EP); A61P29/00 (EP); A61P31/18 (EP);
A61P35/00 (EP); A61P35/02 (EP); A61P43/00 (EP);
A61P7/00 (EP); C07C217/84 (EP,US); C07D215/22 (EP,US);
C07D215/227 (EP,US); C07D215/38 (EP,US); C07D261/08 (EP,US);
C07D265/22 (EP,US); C07D265/26 (EP,US); C07D401/04 (EP,US);
C07D401/12 (EP,US); C07D401/14 (EP,US); C07D405/04 (EP,US);
C07D405/06 (EP,US); C07D409/06 (EP,US); C07D409/14 (EP,US);
C07D413/04 (EP,US); C07D413/14 (EP,US); C07D471/04 (EP,US) (-)
Former IPC [2016/03]A61K31/5517, A61K31/4738, A61K31/47, A61P35/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/03]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:CHINOLINON-DERIVATE ZUR HEMMUNG VON BROMDOMÄNENHALTIGEN PROTEINEN[2020/32]
English:QUINOLINONE DERIVATIVES FOR THE INHIBITION OF BROMODOMAIN-CONTAINING PROTEINS[2020/32]
French:DÉRIVÉS DE QUINOLINONE POUR L'INHIBITION DE PROTÉINES CONTENANT UN BROMODOMAINE[2020/32]
Former [2016/03]VERFAHREN UND ZUSAMMENSETZUNGEN ZUR HEMMUNG VON BROMDOMÄNENHALTIGEN PROTEINEN
Former [2016/03]METHODS AND COMPOSITIONS FOR INHIBITION OF BROMODOMAIN-CONTAINING PROTEINS
Former [2016/03]PROCÉDÉS ET COMPOSITIONS POUR L'INHIBITION DE PROTÉINES CONTENANT UN BROMODOMAINE
Entry into regional phase14.10.2015National basic fee paid 
14.10.2015Search fee paid 
14.10.2015Designation fee(s) paid 
14.10.2015Examination fee paid 
Examination procedure14.10.2015Examination requested  [2016/03]
05.09.2017Amendment by applicant (claims and/or description)
02.02.2018Despatch of a communication from the examining division (Time limit: M06)
13.08.2018Reply to a communication from the examining division
24.10.2018Despatch of a communication from the examining division (Time limit: M06)
30.04.2019Reply to a communication from the examining division
04.06.2019Despatch of a communication from the examining division (Time limit: M06)
16.12.2019Reply to a communication from the examining division
03.01.2020Despatch of a communication from the examining division (Time limit: M04)
06.05.2020Reply to a communication from the examining division
27.07.2020Communication of intention to grant the patent
07.12.2020Fee for grant paid
07.12.2020Fee for publishing/printing paid
07.12.2020Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  02.02.2018
Opposition(s)21.10.2021No opposition filed within time limit [2021/52]
Fees paidRenewal fee
31.03.2016Renewal fee patent year 03
30.03.2017Renewal fee patent year 04
13.03.2018Renewal fee patent year 05
13.03.2019Renewal fee patent year 06
12.03.2020Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU13.03.2014
AL20.01.2021
AT20.01.2021
CY20.01.2021
CZ20.01.2021
DK20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
IT20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
MK20.01.2021
MT20.01.2021
NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
IE13.03.2021
LU13.03.2021
FR20.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
BG20.04.2021
GB20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
DE01.10.2021
[2024/41]
Former [2024/22]HU13.03.2014
AL20.01.2021
AT20.01.2021
CY20.01.2021
CZ20.01.2021
DK20.01.2021
EE20.01.2021
ES20.01.2021
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MK20.01.2021
NL20.01.2021
PL20.01.2021
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SI20.01.2021
SK20.01.2021
SM20.01.2021
IE13.03.2021
LU13.03.2021
FR20.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
BG20.04.2021
GB20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
DE01.10.2021
Former [2023/30]HU13.03.2014
AL20.01.2021
AT20.01.2021
CY20.01.2021
CZ20.01.2021
DK20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
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NL20.01.2021
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SI20.01.2021
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SM20.01.2021
IE13.03.2021
LU13.03.2021
FR20.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
BG20.04.2021
GB20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
DE01.10.2021
Former [2023/27]HU13.03.2014
AL20.01.2021
AT20.01.2021
CZ20.01.2021
DK20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
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PL20.01.2021
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SI20.01.2021
SK20.01.2021
SM20.01.2021
IE13.03.2021
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FR20.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
BG20.04.2021
GB20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
DE01.10.2021
Former [2022/34]AL20.01.2021
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CZ20.01.2021
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EE20.01.2021
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PL20.01.2021
RO20.01.2021
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SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
IE13.03.2021
LU13.03.2021
FR20.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
BG20.04.2021
GB20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
DE01.10.2021
Former [2022/23]AL20.01.2021
AT20.01.2021
CZ20.01.2021
DK20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
IT20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
IE13.03.2021
LU13.03.2021
FR20.03.2021
CH31.03.2021
LI31.03.2021
BG20.04.2021
GB20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
DE01.10.2021
Former [2022/11]AL20.01.2021
AT20.01.2021
CZ20.01.2021
DK20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SI20.01.2021
SK20.01.2021
SM20.01.2021
IE13.03.2021
LU13.03.2021
FR20.03.2021
CH31.03.2021
LI31.03.2021
BG20.04.2021
GB20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
DE01.10.2021
Former [2022/10]AL20.01.2021
AT20.01.2021
CZ20.01.2021
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EE20.01.2021
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NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SK20.01.2021
SM20.01.2021
IE13.03.2021
LU13.03.2021
FR20.03.2021
CH31.03.2021
LI31.03.2021
BG20.04.2021
GB20.04.2021
NO20.04.2021
GR21.04.2021
PT20.05.2021
DE01.10.2021
Former [2022/08]AL20.01.2021
AT20.01.2021
CZ20.01.2021
DK20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
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NL20.01.2021
PL20.01.2021
RO20.01.2021
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SE20.01.2021
SK20.01.2021
SM20.01.2021
IE13.03.2021
LU13.03.2021
FR20.03.2021
BG20.04.2021
GB20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
DE01.10.2021
Former [2022/07]AL20.01.2021
AT20.01.2021
CZ20.01.2021
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EE20.01.2021
ES20.01.2021
FI20.01.2021
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MC20.01.2021
NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SK20.01.2021
SM20.01.2021
IE13.03.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
DE01.10.2021
Former [2021/51]AT20.01.2021
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DK20.01.2021
EE20.01.2021
ES20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
Former [2021/50]AT20.01.2021
CZ20.01.2021
DK20.01.2021
EE20.01.2021
FI20.01.2021
HR20.01.2021
LT20.01.2021
LV20.01.2021
MC20.01.2021
NL20.01.2021
PL20.01.2021
RO20.01.2021
RS20.01.2021
SE20.01.2021
SK20.01.2021
SM20.01.2021
BG20.04.2021
NO20.04.2021
GR21.04.2021
IS20.05.2021
PT20.05.2021
Former [2021/49]AT20.01.2021
CZ20.01.2021
DK20.01.2021
EE20.01.2021
FI20.01.2021
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MC20.01.2021
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PL20.01.2021
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Documents cited:Search[X]FR1369627  (GEIGY AG J R) [X] 1,6,11-13,15 * the whole document; in particular, page 3, example 1, the first two compounds of the penultimate paragraph *;
 [X]WO03106452  (MILLENNIUM PHARM INC [US], et al) [X] 1,6,11 * the whole document; in particular, pages 46-47, compounds V-17, V-18, and V-28 *;
 [X]WO2007109251  (AVANIR PHARMACEUTICALS [US], et al) [X] 1,6 * page 100; compound 133 *;
 [I]WO2011054844  (GLAXOSMITHKLINE LLC [US], et al) [I] 1-3,11-15 * the whole document *;
 [A]WO2011054846  (GLAXOSMITHKLINE LLC [US], et al) [A] 1-3,11-15 * the whole document *;
 [A]WO2011054848  (GLAXOSMITHKLINE LLC [US], et al) [A] 1,6,7,11-15* the whole document *;
 [A]  - JONATHAN SEAL ET AL, "Identification of a novel series of BET family bromodomain inhibitors: Binding mode and profile of I-BET151 (GSK1210151A)", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, (20120401), vol. 22, no. 8, doi:10.1016/j.bmcl.2012.02.041, ISSN 0960-894X, pages 2968 - 2972, XP055062908 [A] 1-3,11-15 * the whole document; in particular, page 2969, table 1, compound 5 *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2012.02.041
 [X]  - UKRAINETS I V ET AL, "4-Hydroxy-2-quinolones. 92. Reaction of 1-R-4-chloro-3-ethoxycarbonyl-2-oxo-1,2-dihydroquinolines with anilines", CHEMISTRY OF HETEROCYCLIC COMPOUNDS, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, (20060301), vol. 42, no. 3, doi:10.1007/S10593-006-0091-5, ISSN 1573-8353, pages 343 - 351, XP019393559 [X] 1,6 * page 344; compounds 3e - 3k *

DOI:   http://dx.doi.org/10.1007/s10593-006-0091-5
 [X]  - S ANDREAE ET AL, "Electrophile Aminierung von C-H-aciden Verbindungen mit l-Oxa-2-azaspiro[ 2.51 octan", EUROPEAN JOOURNAL OF EUROPEAN CHEMISTRY, (19920312), vol. 1992, no. 3, doi:10.1002/jlac.199219920143, pages 239 - 256, XP055306284 [X] 10 * page 243; compound 35c *

DOI:   http://dx.doi.org/10.1002/jlac.199219920143
International search[A]US2010286127  (MIYOSHI SHINJI [JP], et al);
 [A]US2012157428  (ALBRECHT BRIAN K [US], et al);
 [A]US2012220573  (GOSMINI ROMAIN LUC MARIE [FR], et al);
 [A]US2012252781  (BAILEY JAMES [GB], et al);
 [A]WO2013027168  (PFIZER [US], et al)
by applicantWO2011054848
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