blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2981617

EP2981617 - THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/CAS SYSTEMS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  10.05.2024
Database last updated on 31.08.2024
FormerThe patent has been granted
Status updated on  02.06.2023
FormerGrant of patent is intended
Status updated on  08.11.2022
FormerExamination is in progress
Status updated on  29.01.2021
FormerRequest for examination was made
Status updated on  31.01.2020
Most recent event   Tooltip02.08.2024Lapse of the patent in a contracting state
New state(s): SI		published on 04.09.2024 [2024/36]
Applicant(s)For all designated states
President and Fellows of Harvard College
17 Quincy Street
Cambridge, MA 02138 / US
For all designated states
The Children's Medical Center Corporation
55 Shattuck Street
Boston, Massachusetts 02115 / US
[2016/52]
Former [2016/06]For all designated states
President and Fellows of Harvard College
17 Quincy Street
Cambridge, MA 02138 / US
For all designated states
Children's Medical Center Corporation
55 Shattuck Street
Boston, MA 02115 / US
Inventor(s)01 / MUSUNURU, Kiran
60 Brattle Street Apt 206
Cambridge, MA 02138 / US
02 / COWAN, Chad, A.
5 Strong Place
Boston, MA 02114 / US
03 / ROSSI, Derrick, J.
162 Metropolitan Avenue
Roslindale, MA 02131 / US
 [2016/06]
Representative(s)Lock, Graham James
Fry Heath & Spence LLP
Unit A, Faraday Court
Faraday Road
Crawley, West Sussex RH10 9PU / GB
[2023/27]
Former [2016/06]Lock, Graham James
Fry Heath & Spence LLP The Gables
Massetts Road
Horley
Surrey RH6 7DQ / GB
Application number, filing date14779492.904.04.2014
[2016/06]
WO2014US33082
Priority number, dateUS201361808594P04.04.2013         Original published format: US 201361808594 P
[2016/06]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2014165825
Date:09.10.2014
Language:EN
[2014/41]
Type: A2 Application without search report 
No.:EP2981617
Date:10.02.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 09.10.2014 takes the place of the publication of the European patent application.
[2016/06]
Type: B1 Patent specification 
No.:EP2981617
Date:05.07.2023
Language:EN
[2023/27]
Search report(s)International search report - published on:US04.12.2014
(Supplementary) European search report - dispatched on:EP08.12.2016
ClassificationIPC:C12N15/87, C12N15/00, C12N15/11
[2016/06]
CPC:
C12N15/63 (EP,US); A61P31/00 (EP); A61P31/18 (EP);
A61P35/00 (EP); A61P43/00 (EP); C12N15/907 (EP,US);
C12N5/0606 (US); A61K48/00 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/06]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:THERAPEUTISCHE VERWENDUNGEN EINER GENOMÄNDERUNG MIT CRISPR-/CAS-SYSTEMEN[2016/06]
English:THERAPEUTIC USES OF GENOME EDITING WITH CRISPR/CAS SYSTEMS[2016/06]
French:UTILISATIONS THÉRAPEUTIQUES DE L'ÉDITION DE GÉNOME AU MOYEN DE SYSTÈMES CRISPR/CAS[2016/06]
Entry into regional phase04.11.2015National basic fee paid 
04.11.2015Search fee paid 
04.11.2015Designation fee(s) paid 
04.11.2015Examination fee paid 
Examination procedure06.10.2015Observations by third parties
04.11.2015Examination requested  [2016/06]
13.07.2017Amendment by applicant (claims and/or description)
02.02.2021Despatch of a communication from the examining division (Time limit: M06)
12.08.2021Reply to a communication from the examining division
29.09.2022Cancellation of oral proceeding that was planned for 30.09.2022
30.09.2022Date of oral proceedings (cancelled)
09.11.2022Communication of intention to grant the patent
06.03.2023Fee for grant paid
06.03.2023Fee for publishing/printing paid
09.03.2023Receipt of the translation of the claim(s)
Divisional application(s)EP23172496.4  / EP4286517
Opposition(s)08.04.2024No opposition filed within time limit [2024/24]
Fees paidRenewal fee
27.04.2016Renewal fee patent year 03
27.04.2017Renewal fee patent year 04
27.04.2018Renewal fee patent year 05
29.04.2019Renewal fee patent year 06
27.04.2020Renewal fee patent year 07
27.04.2021Renewal fee patent year 08
27.04.2022Renewal fee patent year 09
27.04.2023Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT05.07.2023
CZ05.07.2023
DK05.07.2023
EE05.07.2023
ES05.07.2023
FI05.07.2023
HR05.07.2023
IT05.07.2023
LT05.07.2023
LV05.07.2023
NL05.07.2023
PL05.07.2023
RO05.07.2023
RS05.07.2023
SE05.07.2023
SI05.07.2023
SK05.07.2023
SM05.07.2023
NO05.10.2023
GR06.10.2023
IS05.11.2023
PT06.11.2023
[2024/36]
Former [2024/26]AT05.07.2023
CZ05.07.2023
DK05.07.2023
EE05.07.2023
ES05.07.2023
FI05.07.2023
HR05.07.2023
IT05.07.2023
LT05.07.2023
LV05.07.2023
NL05.07.2023
PL05.07.2023
RO05.07.2023
RS05.07.2023
SE05.07.2023
SK05.07.2023
SM05.07.2023
NO05.10.2023
GR06.10.2023
IS05.11.2023
PT06.11.2023
Former [2024/23]AT05.07.2023
CZ05.07.2023
DK05.07.2023
EE05.07.2023
ES05.07.2023
FI05.07.2023
HR05.07.2023
LT05.07.2023
LV05.07.2023
NL05.07.2023
PL05.07.2023
RO05.07.2023
RS05.07.2023
SE05.07.2023
SK05.07.2023
SM05.07.2023
NO05.10.2023
GR06.10.2023
IS05.11.2023
PT06.11.2023
Former [2024/22]AT05.07.2023
CZ05.07.2023
DK05.07.2023
ES05.07.2023
FI05.07.2023
HR05.07.2023
LT05.07.2023
LV05.07.2023
NL05.07.2023
PL05.07.2023
RO05.07.2023
RS05.07.2023
SE05.07.2023
SM05.07.2023
NO05.10.2023
GR06.10.2023
IS05.11.2023
PT06.11.2023
Former [2024/20]AT05.07.2023
ES05.07.2023
FI05.07.2023
HR05.07.2023
LT05.07.2023
LV05.07.2023
NL05.07.2023
PL05.07.2023
RS05.07.2023
SE05.07.2023
SM05.07.2023
NO05.10.2023
GR06.10.2023
IS05.11.2023
PT06.11.2023
Former [2024/10]AT05.07.2023
ES05.07.2023
FI05.07.2023
HR05.07.2023
LT05.07.2023
LV05.07.2023
NL05.07.2023
PL05.07.2023
RS05.07.2023
SE05.07.2023
NO05.10.2023
GR06.10.2023
IS05.11.2023
PT06.11.2023
Former [2024/09]AT05.07.2023
ES05.07.2023
FI05.07.2023
LT05.07.2023
NL05.07.2023
SE05.07.2023
NO05.10.2023
GR06.10.2023
IS05.11.2023
Former [2024/08]LT05.07.2023
NL05.07.2023
NO05.10.2023
GR06.10.2023
Former [2024/05]NL05.07.2023
Documents cited:Search[XYI]  - MALI P. ET AL, "RNA-guided human genome engineering via Cas9", SCIENCE, (20130215), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 823 - 826, XP055300091 [X] 1,3-10 * the whole document * [Y] 11-14 [I] 2

DOI:   http://dx.doi.org/10.1126/science.1232033
    [ ] - P. MALI ET AL, "Supplementary Materials for RNA-Guided Human Genome Engineering via Cas9", SCIENCE, (20130103), vol. 339, no. 6121, doi:10.1126/science.1232033, ISSN 0036-8075, pages 1 - 36, XP055161524

DOI:   http://dx.doi.org/10.1126/science.1232033
 [Y]  - SEUNG WOO CHO ET AL, "Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease", NATURE BIOTECHNOLOGY, GALE GROUP INC, US, vol. 31, no. 3, doi:10.1038/NBT.2507, ISSN 1087-0156, (20130301), pages 230 - 232, (20130129), XP002699850 [Y] 11 * the whole document *

DOI:   http://dx.doi.org/10.1038/nbt.2507
 [Y]  - CRAIG B. WILEN ET AL, "Engineering HIV-Resistant Human CD4+ T Cells with CXCR4-Specific Zinc-Finger Nucleases", PLOS PATHOGENS, (20110401), vol. 7, no. 4, doi:10.1371/journal.ppat.1002020, ISSN 1553-7366, pages e1002020 - e1002020, XP055032912 [Y] 12 * the whole document *

DOI:   http://dx.doi.org/10.1371/journal.ppat.1002020
 [Y]  - BIN SHEN ET AL, "Generation of gene-modified mice via Cas9/RNA-mediated gene targeting", CELL RESEARCH - XIBAO YANJIU, GB, CN, (20130402), vol. 23, no. 5, doi:10.1038/cr.2013.46, ISSN 1001-0602, pages 720 - 723, XP055141533 [Y] 13 * the whole document *

DOI:   http://dx.doi.org/10.1038/cr.2013.46
 [Y]  - MANDAL PANKAJ K ET AL, "Reprogramming human fibroblasts to pluripotency using modified mRNA", NATURE PROTOCOLS, NATURE PUBLISHING GROUP, GB, (20130301), vol. 8, no. 3, doi:10.1038/NPROT.2013.019, ISSN 1750-2799, pages 568 - 582, XP008169776 [Y] 14 * the whole document *

DOI:   http://dx.doi.org/10.1038/nprot.2013.019
 [A]  - SIVAPRAKASH RAMALINGAM ET AL, "A CRISPR way to engineer the human genome", GENOME BIOLOGY, GB, (20130226), vol. 14, no. 2, doi:10.1038/nbt.2508, ISSN 1465-6906, page 107, XP055323697 [A] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1186/gb-2013-14-2-107
 [A]  - MARTIN JINEK ET AL, "RNA-programmed genome editing in human cells", ELIFE, GB, (20130129), vol. 2, doi:10.7554/eLife.00471, ISSN 2050-084X, pages e00471 - 1, XP055245475 [A] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.7554/eLife.00471
 [A]  - WOONG Y HWANG ET AL, "Efficient genome editing in zebrafish using a CRISPR-Cas system", NATURE BIOTECHNOLOGY, (20130129), vol. 31, no. 3, doi:10.1038/nbt.2501, ISSN 1087-0156, pages 227 - 229, XP055086625 [A] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1038/nbt.2501
 [A]  - WENYAN JIANG ET AL, "RNA-guided editing of bacterial genomes using CRISPR-Cas systems", NATURE BIOTECHNOLOGY, US, (20130129), vol. 31, no. 3, doi:10.1038/nbt.2508, ISSN 1087-0156, pages 233 - 239, XP055323877 [A] 1-14 * the whole document *

DOI:   http://dx.doi.org/10.1038/nbt.2508
International search[Y]US2002106742  (SAMSON MICHEL [FR], et al);
 [Y]US2006024819  (FINNEY ROBERT E [US]);
 [Y]US2010076057  (SONTHEIMER ERIK J [US], et al);
 [Y]US2010093617  (BARRANGOU RODOLPHE [US], et al);
 [Y]US2010227805  (KARIN NATHAN [IL], et al);
 [Y]US2011262406  (DEL CAMPO JACOB [US], et al);
 [Y]US2012192298  (WEINSTEIN EDWARD [US], et al);
 [Y]  - JINEK ET AL., "A Programmable Dual-RNA?Guided DNA Endonuclease in Adaptive Bacterial Immunity", SCIENCE, (20120817), vol. 337, pages 816 - 821, XP055229606

DOI:   http://dx.doi.org/10.1126/science.1225829
 [Y]  - CONG ET AL., "Multiplex genome engineering using CRISPR/Cas systems.", SCIENCE, (2013), vol. 339. 612, pages 819 - 823, XP055181424

DOI:   http://dx.doi.org/10.1126/science.1229223
 [Y]  - HOLT ET AL., "Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo.", NATURE BIOTECHNOLOGY, (2010), vol. 28.8, pages 839 - 847, XP055101952

DOI:   http://dx.doi.org/10.1038/nbt.1663
 [Y]  - RANDAU, LENNART., "RNA processing in the minimal organism Nanoarchaeum equitans.", GENOME BIOL, (2012), vol. 1 3.7, page R63, XP021133987

DOI:   http://dx.doi.org/10.1186/gb-2012-13-7-r63
otherUS2009286852
    - CHO S.W. ET AL., "TARGETED GENOME ENGINEERING IN HUMAN CELLS WITH THE CAS9 RNA-GUIDED ENDONUCLEASE", NATURE BIOTECHNOLOGY,, (201303), vol. 31, no. 3, pages 230 - 232, XP002699850

DOI:   http://dx.doi.org/10.1038/nbt.2507
    - MALI P. ET AL., "RNA-GUIDED HUMAN GENOME ENGINEERING VIA CAS9", SCIENCE, (20130215), vol. 339, no. 6121, pages 823 - 826, XP055159412

DOI:   http://dx.doi.org/10.1126/science.1232033
    - MALI P. ET AL., "SUPPLEMENTARY MATERIALS FOR RNA-GUIDED HUMAN GENOME ENGINEERING VIA CAS9", SCIENCE, (20130103), pages 1 - 36, XP055161524

DOI:   http://dx.doi.org/10.1126/science.1232033
    - CONG L. ET AL., "MULTIPLEX GENOME ENGINEERING USING CRISPR/CAS SYSTEMS", SCIENCE, (20130215), vol. 339, no. 6121, pages 819 - 823, XP055067741

DOI:   http://dx.doi.org/10.1126/science.1231143
    - CONG L. ET AL., "SUPPLEMENTARY MATERIAL TO : MULTIPLEX GENOME ENGINEERING USING CRISPR/CAS SYSTEMS", SCIENCE, (20120705), XP055067744

DOI:   http://dx.doi.org/10.1126/science.1231143
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.