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Extract from the Register of European Patents

EP About this file: EP3030556

EP3030556 - SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 04.09.2020 Database last updated on 25.09.2024
Former	The patent has been granted Status updated on 27.09.2019
Former	Grant of patent is intended Status updated on 05.04.2019
Former	Examination is in progress Status updated on 23.02.2018
Most recent event Tooltip	08.07.2022	Lapse of the patent in a contracting state New state(s): MK	published on 10.08.2022 [2022/32]
Applicant(s)	For all designated states Technische Universität Darmstadt Karolinenplatz 5 64289 Darmstadt / DE
	[2019/35]
Former [2016/24]	For all designated states Max-Planck-Gesellschaft zur Förderung der Wissenschaften Hofgartenstrasse 8 80539 Munich / DE
Inventor(s)	01 / GAALI, Steffen Georgenstrasse 140 80797 Munich / DE
	02 / HAUSCH, Felix Wingertstr. 18 64354 Reinheim / DE
	03 / KIRSCHNER, Alexander Elsenheimerstrasse 24 80687 Munich / DE
	04 / FENG, Xixi Schäftlarnstrasse 72 81371 Munich / DE
	05 / BRACHER, Andreas Grimmstrasse 5 80336 Munich / DE
	06 / RUEHTER, Gerd Vierzigstuecken 53a 21129 Hamburg / DE
	[2019/44]
Former [2017/10]	01 / GAALI, Steffen Georgenstrasse 140 80797 Munich / DE
	02 / HAUSCH, Felix Wingertstr. 18 64354 Reinheim / DE
	03 / KIRSCHNER, Alexander Elsenheimerstrasse 24 80687 Munich / DE
	04 / FENG, Xiri Schäftlarnstrasse 72 81371 Munich / DE
	05 / BRACHER, Andreas Grimmstrasse 5 80336 Munich / DE
	06 / RUEHTER, Gerd Vierzigstuecken 53a 21129 Hamburg / DE
Former [2016/24]	01 / GAALI, Steffen Georgenstrasse 140 80797 Munich / DE
	02 / HAUSCH, Felix Hohenzollernstrasse 146 80790 Munich / DE
	03 / KIRSCHNER, Alexander Elsenheimerstrasse 24 80687 Munich / DE
	04 / FENG, Xiri Wolkerweg 12 81375 Munich / DE
	05 / BRACHER, Andreas Grimmstrasse 5 80336 Munich / DE
	06 / RUEHTER, Gerd Vierzigstuecken 53a 21129 Hamburg / DE
Representative(s)	Fuchs Patentanwälte Partnerschaft mbB Tower 185 Friedrich-Ebert-Anlage 35-37 60327 Frankfurt am Main / DE
	[N/P]
Former [2019/44]	Fuchs Patentanwälte Partnerschaft mbB Westhafenplatz 1 60327 Frankfurt am Main / DE
Former [2016/24]	Arth, Hans-Lothar ABK Patent Attorneys Jasminweg 9 14052 Berlin / DE
Application number, filing date	14781059.2	15.09.2014
	[2016/24]
	WO2014EP02542
Priority number, date	EP20130185247	19.09.2013 Original published format: EP 13185247
	EP20130196561	10.12.2013 Original published format: EP 13196561
	EP20140151510	16.01.2014 Original published format: EP 14151510
	[2016/24]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	WO2015039758
	Date:	26.03.2015
	Language:	EN
	[2015/12]
	Type:	A1 Application with search report
	No.:	EP3030556
	Date:	15.06.2016
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 26.03.2015 takes the place of the publication of the European patent application.
	[2016/24]
	Type:	B1 Patent specification
	No.:	EP3030556
	Date:	30.10.2019
	Language:	EN
	[2019/44]
Search report(s)	International search report - published on:	EP	26.03.2015
Classification	IPC:	C07D401/14, C07D401/12, C07D405/12, C07D207/16, C07D279/12, C07D211/60, C07D211/78, C07K5/06, A61K31/445, A61K31/44, A61K31/40, A61P3/00, A61P25/00, A61P35/00, A61P37/00	[2019/13]
	CPC:	C07D207/16 (EP,US); A61P25/00 (EP); A61P3/00 (EP); A61P35/00 (EP); A61P37/00 (EP); C07D211/60 (EP,US); (+) C07D211/78 (EP,US); C07D279/12 (EP,US); C07D401/12 (EP,US); C07D401/14 (EP,US); C07D405/12 (EP,US); C07K5/06139 (EP,US); C12N9/90 (EP,US); C12Y502/01008 (EP,US); G16B15/00 (EP,US); G16B15/30 (EP,US); C07B2200/13 (EP,US) (-)
	Former IPC [2016/24]	C07D401/14, C07D401/12, C07D405/12, C07D207/16, C07D279/12, C07D211/60, C07D211/78, A61K31/445, A61K31/44, A61K31/40, A61P3/00, A61P25/00, A61P35/00, A61P37/00
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2016/24]
Extension states	BA	Not yet paid
	ME	Not yet paid
Title	German:	SELEKTIVE FKBP51-LIGANDEN ZUR BEHANDLUNG VON PSYCHIATRISCHEN STÖRUNGEN	[2016/24]
	English:	SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS	[2016/24]
	French:	LIGANDS FKBP51 SÉLECTIFS POUR LE TRAITEMENT DE TROUBLES PSYCHIATRIQUES	[2019/13]
	Former [2016/24]	LIGANDS SÉLECTIFS DE LA FKBP51 DESTINÉS AU TRAITEMENT DE TROUBLES PSYCHIATRIQUES
Entry into regional phase	10.03.2016	National basic fee paid
	10.03.2016	Designation fee(s) paid
	10.03.2016	Examination fee paid
Examination procedure	10.03.2016	Examination requested [2016/24]
	06.10.2016	Amendment by applicant (claims and/or description)
	23.02.2018	Despatch of a communication from the examining division (Time limit: M04)
	25.06.2018	Reply to a communication from the examining division
	04.10.2018	Despatch of a communication from the examining division (Time limit: M04)
	04.12.2018	Reply to a communication from the examining division
	05.04.2019	Communication of intention to grant the patent
	14.08.2019	Fee for grant paid
	14.08.2019	Fee for publishing/printing paid
	14.08.2019	Receipt of the translation of the claim(s)
Opposition(s)	31.07.2020	No opposition filed within time limit [2020/41]
Fees paid	Renewal fee
	09.09.2016	Renewal fee patent year 03
	17.08.2017	Renewal fee patent year 04
	25.08.2018	Renewal fee patent year 05
	23.09.2019	Renewal fee patent year 06
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	HU	15.09.2014
	AL	30.10.2019
	AT	30.10.2019
	CY	30.10.2019
	CZ	30.10.2019
	DK	30.10.2019
	EE	30.10.2019
	ES	30.10.2019
	FI	30.10.2019
	HR	30.10.2019
	IT	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	MC	30.10.2019
	MK	30.10.2019
	MT	30.10.2019
	PL	30.10.2019
	RO	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	SI	30.10.2019
	SK	30.10.2019
	SM	30.10.2019
	TR	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
	[2022/32]
Former [2022/27]	HU	15.09.2014
	AL	30.10.2019
	AT	30.10.2019
	CY	30.10.2019
	CZ	30.10.2019
	DK	30.10.2019
	EE	30.10.2019
	ES	30.10.2019
	FI	30.10.2019
	HR	30.10.2019
	IT	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	MC	30.10.2019
	MT	30.10.2019
	PL	30.10.2019
	RO	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	SI	30.10.2019
	SK	30.10.2019
	SM	30.10.2019
	TR	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2021/23]	AL	30.10.2019
	AT	30.10.2019
	CZ	30.10.2019
	DK	30.10.2019
	EE	30.10.2019
	ES	30.10.2019
	FI	30.10.2019
	HR	30.10.2019
	IT	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	MC	30.10.2019
	PL	30.10.2019
	RO	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	SI	30.10.2019
	SK	30.10.2019
	SM	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2020/51]	AL	30.10.2019
	AT	30.10.2019
	CZ	30.10.2019
	DK	30.10.2019
	EE	30.10.2019
	ES	30.10.2019
	FI	30.10.2019
	HR	30.10.2019
	IT	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	PL	30.10.2019
	RO	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	SI	30.10.2019
	SK	30.10.2019
	SM	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2020/38]	AL	30.10.2019
	CZ	30.10.2019
	DK	30.10.2019
	EE	30.10.2019
	ES	30.10.2019
	FI	30.10.2019
	HR	30.10.2019
	IT	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	PL	30.10.2019
	RO	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	SK	30.10.2019
	SM	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2020/37]	AL	30.10.2019
	CZ	30.10.2019
	DK	30.10.2019
	EE	30.10.2019
	ES	30.10.2019
	FI	30.10.2019
	HR	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	PL	30.10.2019
	RO	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	SK	30.10.2019
	SM	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2020/36]	AL	30.10.2019
	CZ	30.10.2019
	DK	30.10.2019
	EE	30.10.2019
	ES	30.10.2019
	FI	30.10.2019
	HR	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	PL	30.10.2019
	RO	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2020/35]	AL	30.10.2019
	CZ	30.10.2019
	ES	30.10.2019
	FI	30.10.2019
	HR	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	PL	30.10.2019
	RO	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2020/34]	AL	30.10.2019
	ES	30.10.2019
	FI	30.10.2019
	HR	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	PL	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2020/32]	AL	30.10.2019
	FI	30.10.2019
	HR	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	PL	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2020/25]	FI	30.10.2019
	HR	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	PL	30.10.2019
	RS	30.10.2019
	SE	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2020/24]	FI	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	PL	30.10.2019
	SE	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	IS	29.02.2020
	PT	02.03.2020
Former [2020/23]	FI	30.10.2019
	LT	30.10.2019
	LV	30.10.2019
	PL	30.10.2019
	SE	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	GR	31.01.2020
	PT	02.03.2020
Former [2020/22]	FI	30.10.2019
	LT	30.10.2019
	SE	30.10.2019
	BG	30.01.2020
	NO	30.01.2020
	PT	02.03.2020
Former [2020/21]	NO	30.01.2020
Cited in	International search	[A]US6268384 (NOVAK PERRY M [US], et al) [A] 1-15 * the whole document *;
		[Y]US6291510 (HAMILTON GREGORY S [US], et al) [Y] 1,2,5,8 * the whole document *;
		[X]US2003036654 (HOLT DENNIS A [US], et al) [X] 1,2,5,8 * example -; claim - *;
		[Y]WO2008055488 (ZEDIRA GMBH [DE], et al) [Y] 1,2,5,8 * the whole document *;
		[A]WO2008137476 (BURNHAM INST MEDICAL RESEARCH [US], et al) [A] 1-15 * example -; claim - *;
		[A]EP2589383 (MAX PLANCK GESELLSCHAFT [DE]) [A] 1-15* the whole document *
	Examination	- M. OTHMAN, ET AL., "Intramolecular cyclization of amido acids into pyrrolidinothieno(or [1]benzothieno)[3]azepinediones", JOURNAL OF HETEROCYCLIC CHEMISTRY, HeteroCorporation, Provo, UT, US, (199701), vol. 34, no. 1, doi:10.1002/jhet.5570340134, ISSN 0022-152X, pages 225 - 231, XP055451428 DOI: http://dx.doi.org/10.1002/jhet.5570340134
		- W.F. MCCALMONT, ET AL., "Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Elsevier Science Publishers, Oxford, GB, (20040607), vol. 14, no. 14, doi:10.1016/J.BMCL.2004.05.011, ISSN 0960-894X, pages 3691 - 3695, XP029594801 DOI: http://dx.doi.org/10.1016/j.bmcl.2004.05.011
		- M. NILSSON, ET AL., "Compounds Binding to the S2-S3 Pockets of Thrombin", JOURNAL OF MEDICINAL CHEMISTRY, American Chemical Society, Washington, DC, US, (20090416), vol. 52, no. 9, doi:10.1021/jm8011849, ISSN 0022-2623, pages 2708 - 2715, XP055451508 DOI: http://dx.doi.org/10.1021/jm8011849
		- C.M. TAYLOR, ET AL., "Factors affecting conformation in proline-containing peptides", ORGANIC LETTERS, American Chemical Society, Washington, DC, US, (20031018), vol. 5, no. 23, doi:10.1021/ol035711r, ISSN 1523-7060, pages 4413 - 4416, XP055451539 DOI: http://dx.doi.org/10.1021/ol035711r
		- L. MULEY, ET AL., "Enhancement of hydrophobic interactions and hydrogen bond strength by cooperativity: Synthesis, modeling, and molecular dynamics simulations of a congeneric series of thrombin inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, American Chemical Society, Washington, DC, US, (20100211), vol. 53, no. 5, doi:10.1021/jm9016416, ISSN 0022-2623, pages 2126 - 2135, XP055089735 DOI: http://dx.doi.org/10.1021/jm9016416
		- A. LILJEBLAD, ET AL., "Enantioselective lipase-catalysed reactions of methyl pipecolinate: transesterification and N-acylation", TETRAHEDRON LETTERS, Elsevier Science Publishers, Amsterdam, NL, (20020223), vol. 43, no. 13, doi:10.1016/S0040-4039(02)00288-5, ISSN 0040-4039, pages 2471 - 2474, XP004343003 DOI: http://dx.doi.org/10.1016/S0040-4039(02)00288-5
		- XIXI FENG, ET AL., "Structure-affinity relationship analysis of selective FKBP51 ligands", JOURNAL OF MEDICINAL CHEMISTRY, American Chemical Society, Washington, DC, US, (20150930), vol. 58, no. 19, doi:10.1021/acs.jmedchem.5b00785, ISSN 0022-2623, pages 7796 - 7806, XP055510638 DOI: http://dx.doi.org/10.1021/acs.jmedchem.5b00785
		- R. GOPALAKRISHNAN, ET AL., "Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52", JOURNAL OF MEDICINAL CHEMISTRY, American Chemical Society, Washington, DC, US, (20120510), vol. 55, no. 9, doi:10.1021/jm201746x, ISSN 0022-2623, pages 4114 - 4122, XP055050762 DOI: http://dx.doi.org/10.1021/jm201746x

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