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Extract from the Register of European Patents

EP About this file: EP3002588

EP3002588 - USE OF A BIOMARKER FOR DIAGNOSING SCHIZOPHRENIA [Right-click to bookmark this link]
Former [2016/14]BIOMARKER FOR PSYCHIATRIC AND NEUROLOGICAL DISORDERS
[2021/31]
StatusNo opposition filed within time limit
Status updated on  18.11.2022
Database last updated on 02.09.2024
FormerThe patent has been granted
Status updated on  10.12.2021
FormerGrant of patent is intended
Status updated on  29.07.2021
FormerExamination is in progress
Status updated on  18.11.2019
Most recent event   Tooltip27.04.2024Lapse of the patent in a contracting state
New state(s): MK		published on 29.05.2024  [2024/22]
Applicant(s)For all designated states
Ishikawa, Toru
601 Ferizu Minamiosawa
3-6 Shimoyugi, Hachioji-shi
Tokyo 192-0372 / JP
[2016/28]
Former [2016/14]For all designated states
Resvo Inc.
15-5, Omorikita 3-chome
Ota-ku
Tokyo 143-0016 / JP
Inventor(s)01 / OHNISHI, Arata
c/o NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
4-9-1 Anagawa
Inage-ku
Chiba-shi Chiba 263-8555 / JP
02 / MINAMIMOTO, Takafumi
c/o NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
4-9-1 Anagawa
Inage-ku
Chiba-shi Chiba 263-8555 / JP
03 / SUHARA, Tetsuya
c/o NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
4-9-1 Anagawa
Inage-ku
Chiba-shi Chiba 263-8555 / JP
 [2016/14]
Representative(s)Maikowski & Ninnemann Patentanwälte Partnerschaft mbB
Postfach 15 09 20
10671 Berlin / DE
[2022/02]
Former [2016/14]Maikowski & Ninnemann
Postfach 15 09 20
10671 Berlin / DE
Application number, filing date14797879.518.03.2014
[2016/14]
WO2014JP57227
Priority number, dateJP2013010412416.05.2013         Original published format: JP 2013104124
[2016/14]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014185145
Date:20.11.2014
Language:JA
[2014/47]
Type: A1 Application with search report 
No.:EP3002588
Date:06.04.2016
Language:EN
[2016/14]
Type: B1 Patent specification 
No.:EP3002588
Date:12.01.2022
Language:EN
[2022/02]
Search report(s)International search report - published on:JP20.11.2014
(Supplementary) European search report - dispatched on:EP20.07.2017
ClassificationIPC:G01N33/53, G01N33/543, C07K16/00, C12Q1/02, C07K16/42, G01N33/68
[2017/14]
CPC:
G01N33/6896 (EP,US); G01N33/6857 (US); C07K16/42 (EP,US);
G01N33/6863 (US); G01N33/6869 (US); G01N33/6893 (US);
G01N2333/525 (US); G01N2333/5412 (US); G01N2333/545 (US);
G01N2800/2821 (EP,US); G01N2800/301 (EP,US); G01N2800/302 (EP,US);
G01N2800/304 (EP,US) (-)
Former IPC [2016/14]G01N33/53, G01N33/543, C07K16/00, C12Q1/02
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/14]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERWENDUNG EINES BIOMARKERS ZUR DIAGNOSE VON SCHIZOPHRENIE[2021/31]
English:USE OF A BIOMARKER FOR DIAGNOSING SCHIZOPHRENIA[2021/31]
French:UTILISATION D'UN BIOMARQUEUR POUR LE DIAGNOSTIC DE SCHIZOPHRÉNIE.[2021/31]
Former [2016/14]BIOMARKER FÜR PSYCHIATRISCHE UND NEUROLOGISCHE ERKRANKUNGEN
Former [2016/14]BIOMARKER FOR PSYCHIATRIC AND NEUROLOGICAL DISORDERS
Former [2016/14]MARQUEUR BIOLOGIQUE POUR TROUBLES PSYCHIATRIQUES ET NEUROLOGIQUES
Entry into regional phase10.12.2015Translation filed 
10.12.2015National basic fee paid 
10.12.2015Search fee paid 
10.12.2015Designation fee(s) paid 
10.12.2015Examination fee paid 
Examination procedure10.12.2015Examination requested  [2016/14]
16.02.2018Amendment by applicant (claims and/or description)
21.11.2019Despatch of a communication from the examining division (Time limit: M04)
23.03.2020Reply to a communication from the examining division
25.06.2021Cancellation of oral proceeding that was planned for 02.07.2021
02.07.2021Date of oral proceedings (cancelled)
30.07.2021Communication of intention to grant the patent
29.11.2021Fee for grant paid
29.11.2021Fee for publishing/printing paid
29.11.2021Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  21.11.2019
Opposition(s)13.10.2022No opposition filed within time limit [2022/51]
Fees paidRenewal fee
11.03.2016Renewal fee patent year 03
16.03.2017Renewal fee patent year 04
26.03.2018Renewal fee patent year 05
14.03.2019Renewal fee patent year 06
16.03.2020Renewal fee patent year 07
29.03.2021Renewal fee patent year 08
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU18.03.2014
AL12.01.2022
AT12.01.2022
CY12.01.2022
CZ12.01.2022
DK12.01.2022
EE12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
IT12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
MK12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SI12.01.2022
SK12.01.2022
SM12.01.2022
IE18.03.2022
LU18.03.2022
BE31.03.2022
CH31.03.2022
LI31.03.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
[2024/22]
Former [2024/20]HU18.03.2014
AL12.01.2022
AT12.01.2022
CY12.01.2022
CZ12.01.2022
DK12.01.2022
EE12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
IT12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SI12.01.2022
SK12.01.2022
SM12.01.2022
IE18.03.2022
LU18.03.2022
BE31.03.2022
CH31.03.2022
LI31.03.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2024/18]HU18.03.2014
AL12.01.2022
AT12.01.2022
CZ12.01.2022
DK12.01.2022
EE12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
IT12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SI12.01.2022
SK12.01.2022
SM12.01.2022
IE18.03.2022
LU18.03.2022
BE31.03.2022
CH31.03.2022
LI31.03.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2023/35]AL12.01.2022
AT12.01.2022
CZ12.01.2022
DK12.01.2022
EE12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
IT12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SI12.01.2022
SK12.01.2022
SM12.01.2022
IE18.03.2022
LU18.03.2022
BE31.03.2022
CH31.03.2022
LI31.03.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2023/10]AL12.01.2022
AT12.01.2022
CZ12.01.2022
DK12.01.2022
EE12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SI12.01.2022
SK12.01.2022
SM12.01.2022
IE18.03.2022
LU18.03.2022
BE31.03.2022
CH31.03.2022
LI31.03.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2023/09]AL12.01.2022
AT12.01.2022
CZ12.01.2022
DK12.01.2022
EE12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SK12.01.2022
SM12.01.2022
IE18.03.2022
LU18.03.2022
CH31.03.2022
LI31.03.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2023/08]AL12.01.2022
AT12.01.2022
CZ12.01.2022
DK12.01.2022
EE12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SK12.01.2022
SM12.01.2022
IE18.03.2022
LU18.03.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2023/01]AL12.01.2022
AT12.01.2022
CZ12.01.2022
DK12.01.2022
EE12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SK12.01.2022
SM12.01.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2022/49]AT12.01.2022
CZ12.01.2022
DK12.01.2022
EE12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SK12.01.2022
SM12.01.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2022/48]AT12.01.2022
CZ12.01.2022
DK12.01.2022
EE12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SM12.01.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2022/47]AT12.01.2022
DK12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
MC12.01.2022
PL12.01.2022
RO12.01.2022
RS12.01.2022
SE12.01.2022
SM12.01.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2022/46]AT12.01.2022
DK12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
PL12.01.2022
RS12.01.2022
SE12.01.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2022/42]AT12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
PL12.01.2022
RS12.01.2022
SE12.01.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
IS12.05.2022
PT12.05.2022
Former [2022/39]AT12.01.2022
ES12.01.2022
FI12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
PL12.01.2022
RS12.01.2022
SE12.01.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
PT12.05.2022
Former [2022/36]AT12.01.2022
ES12.01.2022
HR12.01.2022
LT12.01.2022
LV12.01.2022
PL12.01.2022
RS12.01.2022
SE12.01.2022
BG12.04.2022
NO12.04.2022
GR13.04.2022
PT12.05.2022
Former [2022/35]ES12.01.2022
HR12.01.2022
LT12.01.2022
RS12.01.2022
SE12.01.2022
BG12.04.2022
NO12.04.2022
PT12.05.2022
Former [2022/34]ES12.01.2022
LT12.01.2022
NO12.04.2022
PT12.05.2022
Former [2022/33]LT12.01.2022
NO12.04.2022
Documents cited:Search[A]WO9302190  (WELLCOME FOUND [GB]) [A] 8-11;
 [X]WO2004039956  (GENENTECH INC [US], et al) [X] 1-3,6,7 * claim 1; sequence 2197 *;
 [X]WO2006089294  (ORIGEN THERAPEUTICS INC [US], et al) [X] 1-3,6,7 * claim 41 *;
 [X]WO2010141716  (MAYO FOUNDATION [US], et al) [X] 1-3,6,7 * example 1; sequence 19 *;
 [A]WO2012078623  (RIDGE DIAGNOSTICS INC [US], et al) [A] 1-7,12-14 * the whole document *;
 [A]  - POPOVIC ET AL, "Light chain deposition disease restricted to the brain: the first case report", HUMAN PATHOLOGY, SAUNDERS, PHILADELPHIA, PA, US, (20061212), vol. 38, no. 1, doi:10.1016/J.HUMPATH.2006.07.010, ISSN 0046-8177, pages 179 - 184, XP005820477 [A] 1-7,12-14

DOI:   http://dx.doi.org/10.1016/j.humpath.2006.07.010
 [A]  - Judith A Brebner ET AL, "Polyclonal free light chains: a biomarker of inflammatory disease or treatment target?", F1000 medicine reports, England, doi:10.3410/M5-4, (20130101), page 4, URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564472/pdf/medrep-05-04.pdf, (20170201), XP055346393 [A] 1-7,12-14 * the whole document *

DOI:   http://dx.doi.org/10.3410/M5-4
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DOI:   http://dx.doi.org/10.1373/clinchem.2011.169433
 [A]  - FAGNART O C ET AL, "Free kappa and lambda light chain levels in the cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases", JOURNAL OF NEUROIMMUNOLOGY, ELSEVIER SCIENCE PUBLISHERS BV, NL, vol. 19, no. 1-2, doi:10.1016/0165-5728(88)90041-0, ISSN 0165-5728, (19880801), pages 119 - 132, (19880801), XP023694532 [A] 1-7,12-14 * the whole document *

DOI:   http://dx.doi.org/10.1016/0165-5728(88)90041-0
 [A]  - M. D. RICHARD ET AL, "Schizophrenia and the immune system: Pathophysiology, prevention, and treatment", AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY., US, (20120501), vol. 69, no. 9, doi:10.2146/ajhp110271, ISSN 1079-2082, pages 757 - 766, XP055346122 [A] 1-7,12-14 * the whole document *

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DOI:   http://dx.doi.org/10.2215/CJN.01730506
 [X]  - Anonymous, "Freelite(TM) Human Lambda Free Kit For use on the Olympus AU(TM) series For in-vitro diagnostic use Product Code: LK018.AU", The Binding Site Group Ltd., PO Box 11712, Birmingham B14 4ZB, UK, (20091101), pages 1 - 3, URL: http://www.peramed.com/peramed/docs/LK018.AU_5051700006408_EN.pdf, (20170710), XP055389388 [X] 8-11 * the whole document *
 [X]  - Anonymous, "Freelite(TM) Human Kappa Free kit For use on the Roche cobas c systems For in-vitro diagnostic use Product Code: LK016.CB", The Binding Site Group Ltd., PO Box 11712, Birmingham B14 4ZB, UK, (20091001), pages 1 - 2, URL: http://peramed.com/peramed/docs/LK016.CB_5051700012090_EN.pdf, (20170710), XP055389391 [X] 8-11 * the whole document *
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 [X]  - O.C. FAGNART ET AL., "Free kappa and lambda light chain levels in the cerebrospinal fluid of patients with multiple sclerosis and other neurological diseases", JOURNAL OF NEUROIMMUNOLOGY, (198808), vol. 19, no. ISSUES, pages 119 - 132, XP023694532

DOI:   http://dx.doi.org/10.1016/0165-5728(88)90041-0
 [A]  - I.V.L. NARASIMHA RAO ET AL., "SERUM IMMUNOGLOBULINS AND SCHIZOPHRENIA", INDIAN J PSYCHIATRY, (1985), vol. 27, no. 4, pages 325 - 328, XP055295411
 [A]  - POPOVIC M ET AL., "Light chain deposition disease restricted to the brain: The first case report", HUM PATHOL, (200701), vol. 38, no. 1, pages 179 - 184, XP005820477

DOI:   http://dx.doi.org/10.1016/j.humpath.2006.07.010
Examination   - AVGUSTIN ET AL, "#2 Increased Th1 and Th2 immune reactivity with relative Th2 dominance in patients with acute exacerbation of schizophrenia and chronic schizophrenia", BRAIN, BEHAVIOR AND IMMUNITY, ACADEMIC PRESS, SAN DIEGO, CA, US, (20050701), vol. 19, no. 4, ISSN 0889-1591, pages e1 - e2
    - BOJANA AVGUSTIN ET AL, "Increased Th1 and Th2 immune reactivity with relative Th2 dominance in patients with acute exacerbation of schizophrenia", BRAIN, BEHAVIOR AND IMMUNITY., US, (20050701), vol. 446, no. 2, ISSN 0889-1591, pages 268 - 274
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    - ARATA OH-NISHI ET AL., BRAIN RESEARCH, (20101206), vol. 1363, pages 170 - 179
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.