Extract from the Register of European Patents

EP About this file: EP3062780

EP3062780 - ACTIVATORS OR STIMULATORS OF SOLUBLE GUANYLATE CYCLASE FOR USE IN TREATING CHRONIC FATIGUE SYNDROME [Right-click to bookmark this link]
StatusThe application has been refused
Status updated on  19.09.2018
Database last updated on 28.02.2026
FormerExamination is in progress
Status updated on  04.08.2017
Most recent event   Tooltip05.01.2019New entry: Additional fee for renewal fee: despatch of communication + time limit 
Applicant(s)For all designated states
Bergen Teknologioverføring AS
Thormøhlensgate 51
5006 Bergen / NO
[2016/36]
Inventor(s)01 / FLUGE, Öystein
Torvbakken 5
N-5122 Morvik / NO
02 / MELLA, Olav
Olsvikveien 143
N-5184 Olsvik / NO
 [2016/36]
Representative(s)Kröncke, Rolf
Gramm, Lins & Partner
Patent- und Rechtsanwälte PartGmbB
Freundallee 13 a
30173 Hannover / DE
[2016/36]
Application number, filing date14799685.403.11.2014
[2016/36]
WO2014EP73538
Priority number, dateUS201361898638P01.11.2013         Original published format: US 201361898638 P
[2016/36]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015063287
Date:07.05.2015
Language:EN
[2015/18]
Type: A1 Application with search report 
No.:EP3062780
Date:07.09.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 07.05.2015 takes the place of the publication of the European patent application.
[2016/36]
Search report(s)International search report - published on:EP07.05.2015
ClassificationIPC:A61K31/00, A61K31/195, A61K31/506, A61K31/519, C07K16/28, A61P43/00
[2016/36]
CPC:
A61K31/506 (EP,US); A61K31/00 (EP,US); A61K31/195 (EP,US);
A61K31/197 (US); A61K31/519 (EP,US); A61K39/3955 (US);
A61P43/00 (EP); C07K16/2887 (EP,US); A61K2039/505 (US) (-)
C-Set:
A61K31/195, A61K2300/00 (EP,US);
A61K31/506, A61K2300/00 (US,EP);
A61K31/519, A61K2300/00 (US,EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/36]
TitleGerman:AKTIVATOREN ODER STIMULATOREN LÖSLICHER GUANYLATCYCLASE ZUR VERWENDUNG BEI DER BEHANDLUNG DES CHRONISCHEN ERMÜDUNGSSYNDROMS[2016/36]
English:ACTIVATORS OR STIMULATORS OF SOLUBLE GUANYLATE CYCLASE FOR USE IN TREATING CHRONIC FATIGUE SYNDROME[2016/36]
French:ACTIVATEURS OU STIMULATEURS DE GUANYLATE CYCLASE SOLUBLE DESTINÉS À ÊTRE UTILISÉS POUR TRAITER UN SYNDROME DE FATIGUE CHRONIQUE[2016/36]
Entry into regional phase11.05.2016National basic fee paid 
11.05.2016Designation fee(s) paid 
11.05.2016Examination fee paid 
Examination procedure11.05.2016Amendment by applicant (claims and/or description)
11.05.2016Examination requested  [2016/36]
04.08.2017Despatch of a communication from the examining division (Time limit: M06)
08.01.2018Reply to a communication from the examining division
11.09.2018Cancellation of oral proceeding that was planned for 12.11.2018
20.09.2018Despatch of communication that the application is refused, reason: substantive examination [2019/06]
30.09.2018Application refused, date of legal effect [2019/06]
12.11.2018Date of oral proceedings (cancelled)
Fees paidRenewal fee
04.11.2016Renewal fee patent year 03
06.11.2017Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
30.11.201805   M06   Not yet paid
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Cited inInternational search[X]   PALL M L: "Cobalamin used in chronic fatigue syndrome therapy is a nitric oxide scavenger", JOURNAL OF CHRONIC FATIGUE SYNDROME 2001 US, vol. 8, no. 2, 2001, pages 39 - 44, XP008173751, ISSN: 1057-3321 [X] 1,12-14,19,20 * abstract * * page 40, paragraph 1 *

DOI:   http://dx.doi.org/10.1300/J092v08n02_04
 [A]   I. SHARINA ET AL: "Cobinamides Are Novel Coactivators of Nitric Oxide Receptor That Target Soluble Guanylyl Cyclase Catalytic Domain", JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 340, no. 3, 1 March 2012 (2012-03-01), pages 723 - 732, XP055156951, ISSN: 0022-3565, DOI: 10.1124/jpet.111.186957 [A] 1,12-14,19,20 * page 726, column 2, paragraph 1 * * figure 2B *

DOI:   http://dx.doi.org/10.1124/jpet.111.186957
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   MIHAYLOVA I. ET AL., NEURO ENDOCRINOL LETT, vol. 28, 2007, pages 477 - 83
   BRENU ET AL., J TRANS MED, vol. 10, 2012, pages 88
   STAINES DR., MED HYPOTHESES, vol. 64, 2005, pages 539 - 42
   FLUGE O.; MELLA O., BMC NEUROL., vol. 9, 2009, pages 28
   FLUGE O. ET AL., PLOS, vol. 6, 2011, pages E26359
   CHANG C.M., CANCER, vol. 118, 2012, pages 5929 - 36
   NOSSAMAN B. ET AL., CRITICAL CARE RESEARCH AND PRACTICE, 2012
   GHOFRANI ET AL., NEJM, vol. 369, 2013, pages 4
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