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Extract from the Register of European Patents

EP About this file: EP3049378

EP3049378 - PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-BETA-CIT [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  11.10.2019
Database last updated on 05.10.2024
FormerThe patent has been granted
Status updated on  02.11.2018
FormerGrant of patent is intended
Status updated on  25.06.2018
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
SpecGx LLC
385 Marshall Avenue
Webster Groves, Missouri 63119 / US
[2018/28]
Former [2018/16]For all designated states
SpecGx, LLC
385 Marshall Avenue
Webster Groves, Missouri 63119 / US
Former [2016/31]For all designated states
Mallinckrodt LLC
675 McDonnell Boulevard
Hazelwood, MO 63042 / US
Inventor(s)01 / HUDSON, Edmund C.
675 McDonnell Blvd.
Hazelwood, Missouri 63042 / US
 [2016/31]
Representative(s)Jones, Nicholas Andrew
Withers & Rogers LLP
2 London Bridge
London SE1 9RA / GB
[N/P]
Former [2016/31]Jones, Nicholas Andrew
Withers & Rogers LLP
4 More London Riverside
London, SE1 2AU / GB
Application number, filing date14849233.325.09.2014
[2016/31]
WO2014US57404
Priority number, dateUS201361882039P25.09.2013         Original published format: US 201361882039 P
[2016/31]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015048250
Date:02.04.2015
Language:EN
[2015/13]
Type: A1 Application with search report 
No.:EP3049378
Date:03.08.2016
Language:EN
The application published by WIPO in one of the EPO official languages on 02.04.2015 takes the place of the publication of the European patent application.
[2016/31]
Type: B1 Patent specification 
No.:EP3049378
Date:05.12.2018
Language:EN
[2018/49]
Search report(s)International search report - published on:US02.04.2015
(Supplementary) European search report - dispatched on:EP17.03.2017
ClassificationIPC:C07B59/00, C07D451/02, C07F7/08
[2016/31]
CPC:
A61K51/0448 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/31]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:HERSTELLUNG VON RADIO-IODINIERTEM 3-FLUOROPROPYL-NOR-BETA-CIT[2016/31]
English:PREPARATION OF RADIOIODINATED 3-FLUOROPROPYL-NOR-BETA-CIT[2016/31]
French:PRÉPARATION DE 3-FLUOROPROPYL-NOR-BETA-CIT RADIO-IODÉ[2016/31]
Entry into regional phase20.04.2016National basic fee paid 
20.04.2016Search fee paid 
20.04.2016Designation fee(s) paid 
20.04.2016Examination fee paid 
Examination procedure20.04.2016Examination requested  [2016/31]
16.10.2017Amendment by applicant (claims and/or description)
26.06.2018Communication of intention to grant the patent
24.10.2018Fee for grant paid
24.10.2018Fee for publishing/printing paid
24.10.2018Receipt of the translation of the claim(s)
Opposition(s)06.09.2019No opposition filed within time limit [2019/46]
Fees paidRenewal fee
27.09.2016Renewal fee patent year 03
27.09.2017Renewal fee patent year 04
27.09.2018Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU25.09.2014
AL05.12.2018
AT05.12.2018
CY05.12.2018
CZ05.12.2018
DK05.12.2018
EE05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
MC05.12.2018
MK05.12.2018
MT05.12.2018
NL05.12.2018
RO05.12.2018
RS05.12.2018
SE05.12.2018
SI05.12.2018
SK05.12.2018
SM05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
IS05.04.2019
PT05.04.2019
[2022/31]
Former [2021/34]HU25.09.2014
AL05.12.2018
AT05.12.2018
CY05.12.2018
CZ05.12.2018
DK05.12.2018
EE05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
MC05.12.2018
MT05.12.2018
NL05.12.2018
RO05.12.2018
RS05.12.2018
SE05.12.2018
SI05.12.2018
SK05.12.2018
SM05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
IS05.04.2019
PT05.04.2019
Former [2021/32]HU25.09.2014
AL05.12.2018
AT05.12.2018
CY05.12.2018
CZ05.12.2018
DK05.12.2018
EE05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
MC05.12.2018
NL05.12.2018
RO05.12.2018
RS05.12.2018
SE05.12.2018
SI05.12.2018
SK05.12.2018
SM05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
IS05.04.2019
PT05.04.2019
Former [2021/26]AL05.12.2018
AT05.12.2018
CY05.12.2018
CZ05.12.2018
DK05.12.2018
EE05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
MC05.12.2018
NL05.12.2018
RO05.12.2018
RS05.12.2018
SE05.12.2018
SI05.12.2018
SK05.12.2018
SM05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
IS05.04.2019
PT05.04.2019
Former [2020/25]AL05.12.2018
AT05.12.2018
CZ05.12.2018
DK05.12.2018
EE05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
MC05.12.2018
NL05.12.2018
RO05.12.2018
RS05.12.2018
SE05.12.2018
SI05.12.2018
SK05.12.2018
SM05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
IS05.04.2019
PT05.04.2019
Former [2019/50]AL05.12.2018
AT05.12.2018
CZ05.12.2018
DK05.12.2018
EE05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
NL05.12.2018
RO05.12.2018
RS05.12.2018
SE05.12.2018
SI05.12.2018
SK05.12.2018
SM05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
IS05.04.2019
PT05.04.2019
Former [2019/48]AL05.12.2018
AT05.12.2018
CZ05.12.2018
DK05.12.2018
EE05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
NL05.12.2018
RO05.12.2018
RS05.12.2018
SE05.12.2018
SK05.12.2018
SM05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
IS05.04.2019
PT05.04.2019
Former [2019/39]AL05.12.2018
AT05.12.2018
CZ05.12.2018
EE05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
NL05.12.2018
RO05.12.2018
RS05.12.2018
SE05.12.2018
SK05.12.2018
SM05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
IS05.04.2019
PT05.04.2019
Former [2019/37]AL05.12.2018
AT05.12.2018
CZ05.12.2018
EE05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
NL05.12.2018
RO05.12.2018
RS05.12.2018
SE05.12.2018
SM05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
PT05.04.2019
Former [2019/35]AL05.12.2018
AT05.12.2018
CZ05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
NL05.12.2018
RS05.12.2018
SE05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
PT05.04.2019
Former [2019/33]AL05.12.2018
AT05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
NL05.12.2018
RS05.12.2018
SE05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
PT05.04.2019
Former [2019/30]AL05.12.2018
AT05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
NL05.12.2018
RS05.12.2018
SE05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
Former [2019/26]AL05.12.2018
AT05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
RS05.12.2018
SE05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
Former [2019/25]AT05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
RS05.12.2018
SE05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
Former [2019/24]AT05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
SE05.12.2018
BG05.03.2019
NO05.03.2019
GR06.03.2019
Former [2019/23]AT05.12.2018
FI05.12.2018
HR05.12.2018
LT05.12.2018
LV05.12.2018
BG05.03.2019
NO05.03.2019
Former [2019/22]FI05.12.2018
LT05.12.2018
BG05.03.2019
NO05.03.2019
Former [2019/21]FI05.12.2018
LT05.12.2018
NO05.03.2019
Former [2019/20]LT05.12.2018
NO05.03.2019
Documents cited:Search[Y]US4190601  (DECKER QUINTIN W [US], et al) [Y] 1-15 * column 2, line 8 - line 20 *;
 [A]WO9818499  (GUILFORD PHARM INC [US]) [A] 1-15* page 9 *;
 [A]WO9857909  (MAP MEDICAL TECHNOLOGIES OY [FI], et al) [A] 1-15 * page 8 *;
 [Y]EP1127887  (NIHON MEDIPHYSICS CO LTD [JP]) [Y] 1-15 * page 6 *
International search[A]US4190601  (DECKER QUINTIN W [US], et al);
 [A]US6123917  (CARROLL FRANK IVY [US]);
 [A]US6447747  (PIROTTE ROBERT JEAN MARIE DENI [BE], et al);
 [A]US6548041  (MELTZER PETER C [US], et al);
 [A]US2003109708  (OKANO KYOKO [JP], et al);
 [A]US2010210843  (HUDSON EDUMND C [US], et al);
 [A]  - BOIS, F ET AL., "Synthesis, radiolabeling, and baboon SPECT imaging of 2beta-carbomethoxy- 3beta-(3'-[1231]iodophenyl)tropane ([1231]YP256) as a serotonin transporter radiotracer.([1231] YP256) a potential serotonin transporter radiotracer", NUCL MED BIOL., vol. 35, no. 1, (2008), pages 1 - 15, URL: http://www.nr-bi.nlm.nih.gov/pmc/articles/PMC2276982, XP022460551
 [A]  - STEHOUWER, JS ET AL., "Synthesis, Radiosynthesis, and Biological Evaluation of Fluorine-18 Labeled 2beta-Carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl phenyl) nortropanes: Candidate Radioligands for In Vivo Imaging of the Serotonin Transporter with Positron Emission Tomography", J MED CHEM., vol. 51, no. 24, (2008), pages 7788 - 7799, URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668213/pdf/nihms-86624.pdf, (20141124), XP055335440

DOI:   http://dx.doi.org/10.1021/jm800781a
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.