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Extract from the Register of European Patents

EP About this file: EP3078379

EP3078379 - DRUG FOR THE TREATMENT OF CHOLESTEROL ACCUMULATION DISORDERS, AND SCREENING METHOD FOR SAME [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  04.10.2019
Database last updated on 11.09.2024
FormerThe patent has been granted
Status updated on  26.10.2018
FormerGrant of patent is intended
Status updated on  21.06.2018
Most recent event   Tooltip03.07.2020Lapse of the patent in a contracting state
New state(s): CY, HU, MK		published on 05.08.2020  [2020/32]
Applicant(s)For all designated states
National University Corporation Kumamoto University
2-39-1 Kurokami
Chuo-ku
Kumamoto-shi, Kumamoto 860-8555 / JP
For all designated states
Nihon Shokuhin Kako Co., Ltd.
20F, Marunouchi kitaguchi Building
1-6-5, Marunouchi
Chiyoda-ku
Tokyo 100-0005 / JP
[2016/41]
Inventor(s)01 / ERA Takumi
c/o NATIONAL UNIVERSITY CORPORATION KUMAMOTO
UNIVERSITY
2-39-1 Kurokami
Chuo-ku
Kumamoto-shi Kumamoto 860-8555 / JP
02 / IRIE Tetsumi
c/o NATIONAL UNIVERSITY CORPORATION KUMAMOTO
UNIVERSITY
2-39-1 Kurokami
Chuo-ku
Kumamoto-shi Kumamoto 860-8555 / JP
 [2016/41]
Representative(s)Maiwald GmbH
Elisenhof
Elisenstraße 3
80335 München / DE
[N/P]
Former [2018/48]Maiwald Patent- und Rechtsanwaltsgesellschaft mbH
Elisenhof
Elisenstraße 3
80335 München / DE
Former [2016/41]Maiwald Patentanwalts GmbH
Elisenhof
Elisenstrasse 3
80335 München / DE
Application number, filing date14866984.903.12.2014
[2016/41]
WO2014JP81969
Priority number, dateJP2013025217405.12.2013         Original published format: JP 2013252174
JP2014013586501.07.2014         Original published format: JP 2014135865
[2016/41]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015083736
Date:11.06.2015
Language:JA
[2015/23]
Type: A1 Application with search report 
No.:EP3078379
Date:12.10.2016
Language:EN
[2016/41]
Type: B1 Patent specification 
No.:EP3078379
Date:28.11.2018
Language:EN
[2018/48]
Search report(s)International search report - published on:JP11.06.2015
(Supplementary) European search report - dispatched on:EP16.10.2017
ClassificationIPC:A61K31/724, A61P1/16, A61P19/00, A61P25/00, A61P25/28, A61P27/02, C12N5/07, C12Q1/02
[2016/41]
CPC:
A61K31/724 (EP,US); A61K9/0019 (US); A61P1/16 (EP);
A61P19/00 (EP); A61P25/00 (EP); A61P25/28 (EP);
A61P27/02 (EP); A61P3/00 (EP); C12N5/0696 (EP,US);
G01N33/5073 (EP,US); G01N33/92 (EP,US); G01N2500/04 (US);
G01N2500/10 (US); G01N2800/04 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2016/41]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:ARZNEIMITTEL ZUR BEHANDLUNG VON CHOLESTEROLANSAMMLUNGSERKRANKUNGEN UND SCREENINGVERFAHREN DAFÜR[2016/41]
English:DRUG FOR THE TREATMENT OF CHOLESTEROL ACCUMULATION DISORDERS, AND SCREENING METHOD FOR SAME[2016/41]
French:MÉDICAMENT POUR LE TRAITEMENT DE TROUBLES D'ACCUMULATION DE CHOLESTÉROL ET MÉTHODE DE SÉLECTION DE CE DERNIER[2016/41]
Entry into regional phase30.06.2016Translation filed 
30.06.2016National basic fee paid 
30.06.2016Search fee paid 
30.06.2016Designation fee(s) paid 
30.06.2016Examination fee paid 
Examination procedure30.06.2016Examination requested  [2016/41]
20.04.2018Amendment by applicant (claims and/or description)
22.06.2018Communication of intention to grant the patent
18.10.2018Fee for grant paid
18.10.2018Fee for publishing/printing paid
18.10.2018Receipt of the translation of the claim(s)
Opposition(s)29.08.2019No opposition filed within time limit [2019/45]
Fees paidRenewal fee
29.12.2016Renewal fee patent year 03
29.12.2017Renewal fee patent year 04
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.12.2014
AL28.11.2018
AT28.11.2018
CY28.11.2018
CZ28.11.2018
DK28.11.2018
EE28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
MC28.11.2018
MK28.11.2018
NL28.11.2018
PL28.11.2018
RO28.11.2018
RS28.11.2018
SE28.11.2018
SI28.11.2018
SK28.11.2018
SM28.11.2018
TR28.11.2018
IE03.12.2018
LU03.12.2018
MT03.12.2018
BE31.12.2018
CH31.12.2018
LI31.12.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
[2020/31]
Former [2020/17]AL28.11.2018
AT28.11.2018
CZ28.11.2018
DK28.11.2018
EE28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
MC28.11.2018
NL28.11.2018
PL28.11.2018
RO28.11.2018
RS28.11.2018
SE28.11.2018
SI28.11.2018
SK28.11.2018
SM28.11.2018
TR28.11.2018
IE03.12.2018
LU03.12.2018
MT03.12.2018
BE31.12.2018
CH31.12.2018
LI31.12.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2020/08]AL28.11.2018
AT28.11.2018
CZ28.11.2018
DK28.11.2018
EE28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
MC28.11.2018
NL28.11.2018
PL28.11.2018
RO28.11.2018
RS28.11.2018
SE28.11.2018
SI28.11.2018
SK28.11.2018
SM28.11.2018
IE03.12.2018
LU03.12.2018
MT03.12.2018
BE31.12.2018
CH31.12.2018
LI31.12.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2020/04]AL28.11.2018
AT28.11.2018
CZ28.11.2018
DK28.11.2018
EE28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
MC28.11.2018
NL28.11.2018
PL28.11.2018
RO28.11.2018
RS28.11.2018
SE28.11.2018
SI28.11.2018
SK28.11.2018
SM28.11.2018
IE03.12.2018
LU03.12.2018
BE31.12.2018
CH31.12.2018
LI31.12.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2019/50]AL28.11.2018
AT28.11.2018
CZ28.11.2018
DK28.11.2018
EE28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
MC28.11.2018
NL28.11.2018
PL28.11.2018
RO28.11.2018
RS28.11.2018
SE28.11.2018
SI28.11.2018
SK28.11.2018
SM28.11.2018
IE03.12.2018
LU03.12.2018
BE31.12.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2019/48]AL28.11.2018
AT28.11.2018
CZ28.11.2018
DK28.11.2018
EE28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
MC28.11.2018
NL28.11.2018
PL28.11.2018
RO28.11.2018
RS28.11.2018
SE28.11.2018
SK28.11.2018
SM28.11.2018
IE03.12.2018
LU03.12.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2019/40]AL28.11.2018
AT28.11.2018
CZ28.11.2018
DK28.11.2018
EE28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
MC28.11.2018
NL28.11.2018
PL28.11.2018
RO28.11.2018
RS28.11.2018
SE28.11.2018
SK28.11.2018
SM28.11.2018
LU03.12.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2019/39]AL28.11.2018
AT28.11.2018
CZ28.11.2018
DK28.11.2018
EE28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
NL28.11.2018
PL28.11.2018
RO28.11.2018
RS28.11.2018
SE28.11.2018
SK28.11.2018
SM28.11.2018
LU03.12.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2019/37]AL28.11.2018
AT28.11.2018
CZ28.11.2018
DK28.11.2018
EE28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
NL28.11.2018
PL28.11.2018
RO28.11.2018
RS28.11.2018
SE28.11.2018
SM28.11.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2019/35]AL28.11.2018
AT28.11.2018
CZ28.11.2018
DK28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
NL28.11.2018
PL28.11.2018
RS28.11.2018
SE28.11.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2019/34]AL28.11.2018
AT28.11.2018
DK28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
IT28.11.2018
LT28.11.2018
LV28.11.2018
NL28.11.2018
RS28.11.2018
SE28.11.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2019/30]AL28.11.2018
AT28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
LT28.11.2018
LV28.11.2018
NL28.11.2018
RS28.11.2018
SE28.11.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2019/26]AL28.11.2018
AT28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
LT28.11.2018
LV28.11.2018
RS28.11.2018
SE28.11.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
PT28.03.2019
Former [2019/25]AT28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
LT28.11.2018
LV28.11.2018
RS28.11.2018
SE28.11.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
Former [2019/24]AT28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
LT28.11.2018
LV28.11.2018
SE28.11.2018
BG28.02.2019
NO28.02.2019
GR01.03.2019
IS28.03.2019
Former [2019/23]AT28.11.2018
ES28.11.2018
FI28.11.2018
HR28.11.2018
LT28.11.2018
LV28.11.2018
BG28.02.2019
NO28.02.2019
IS28.03.2019
Former [2019/22]FI28.11.2018
LT28.11.2018
BG28.02.2019
NO28.02.2019
IS28.03.2019
Former [2019/21]FI28.11.2018
LT28.11.2018
NO28.02.2019
IS28.03.2019
Former [2019/20]LT28.11.2018
NO28.02.2019
Documents cited:Search[A]US2013123214  (ZHENG WEI [US], et al) [A] 1-5 * p. 4, paragraph [0040] - p. 6, paragraph [0057], claims 22-40 *;
 [A]  - BENNY LIU, "Therapeutic potential of cyclodextrins in the treatment of Niemann-Pick type C disease", CLINICAL LIPIDOLOGY, GB, (20120601), vol. 7, no. 3, doi:10.2217/clp.12.31, ISSN 1758-4299, pages 289 - 301, XP055375347 [A] 1-5 * the whole document *

DOI:   http://dx.doi.org/10.2217/clp.12.31
 [A]  - CHARINA M. RAMIREZ ET AL, "Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations", JOURNAL OF LIPID RESEARCH, US, (20110401), vol. 52, no. 4, doi:10.1194/jlr.M013789, ISSN 0022-2275, pages 688 - 698, XP055387038 [A] 1-5 * the whole document *

DOI:   http://dx.doi.org/10.1194/jlr.M013789
 [AP]  - MINAMI SOGA ET AL, "HPGCD Outperforms HPBCD as a Potential Treatment for Niemann-Pick Disease Type C During Disease Modeling with iPS Cells : HPGCD for NPC Treatment", STEM CELLS., US, (20150424), vol. 33, no. 4, doi:10.1002/stem.1917, ISSN 1066-5099, pages 1075 - 1088, XP055387040 [AP] 1-5 * the whole document *

DOI:   http://dx.doi.org/10.1002/stem.1917
International search[A]  - LIU B. ET AL., "Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npcl-/- mouse", PROC.NATL.ACAD.SCI.USA, (2009), vol. 106, pages 2377 - 2382, XP055144509

DOI:   http://dx.doi.org/10.1073/pnas.0810895106
 [A]  - IRIE T. ET AL., "Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation", J.PHRAM.SCI., (1997), vol. 86, pages 147 - 162, XP000643007

DOI:   http://dx.doi.org/10.1021/js960213f
 [A]  - COLLINS, C.J. ET AL., "Synthesis, characterization, and evaluation of pluronic- based beta-cyclodextrin polyrotaxanes for mobi", BIOCHEMISTRY, vol. 52, no. 19, pages 3242 - 3253, XP055294446

DOI:   http://dx.doi.org/10.1021/bi3010889
by applicantWO2012063817
    - LIU ET AL., PROC NATL ACAD SCI USA, (2009), vol. 106, page 2377
    - FUSAKI ET AL., PROC. JPN. ACAD. SER. B, PHYS. BIOL. SCI, (2009), vol. 85, pages 348 - 362
    - SEKI ET AL., CELL STEM CELL, (2010), vol. 7, pages 11 - 14
    - BAN ET AL., PROC. NATL. ACAD. SCI. USA, (2011), vol. 108, pages 14234 - 14239
    - IRIE ET AL., J. PHAR. SCI., (1997), vol. 86, no. 2, pages 147 - 162
    - HAMASAKI ET AL., STEM CELLS, (2012), vol. 30, pages 2437 - 2449
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.