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Extract from the Register of European Patents

EP About this file: EP3118305

EP3118305 - RECOMBINANT STREPTOMYCES PRODUCING TENVERMECTIN A AND TENVERMECTIN B AND USE THEREOF [Right-click to bookmark this link]
Former [2017/03]RECOMBINANT MICROORGANISM EXPRESSING AVERMECTIN ANALOGUE AND USE THEREOF
[2019/05]
StatusNo opposition filed within time limit
Status updated on  10.07.2020
Database last updated on 14.11.2024
FormerThe patent has been granted
Status updated on  12.07.2019
FormerGrant of patent is intended
Status updated on  17.03.2019
FormerRequest for examination was made
Status updated on  16.12.2016
Most recent event   Tooltip08.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 10.08.2022  [2022/32]
Applicant(s)For all designated states
Zhejiang Hisun Pharmaceutical Co. Ltd.
No. 46 Waisha Road
Jiaojiang District
Taizhou City
Zhejiang 318000 / CN
[2017/03]
Inventor(s)01 / HUANG, Jun
No.46 Waisha Road
Jiaojiang District
Taizhou City Zhejiang 318000 / CN
02 / WANG, Jidong
No.46 Waisha Road
Jiaojiang District
Taizhou City Zhejiang 318000 / CN
03 / CHEN, Anliang
School of Forestry and Biotechnolgy
Zhejiang Agricultural and Forestry University
No.88 Huanchengbeilu Road
Lin'an Zhejiang 311300 / CN
04 / DENG, Aiwen
No.46 Waisha Road
Jiaojiang District
Taizhou City Zhejiang 318000 / CN
05 / LIN, Jiatan
No.46 Waisha Road
Jiaojiang District
Taizhou City Zhejiang 318000 / CN
06 / YU, Zhen
No.46 Waisha Road
Jiaojiang District
Taizhou City Zhejiang 318000 / CN
07 / LI, Meihong
No.46 Waisha Road
Jiaojiang District
Taizhou City Zhejiang 318000 / CN
08 / LI, Na
No.46 Waisha Road
Jiaojiang District
Taizhou City Zhejiang 318000 / CN
09 / WANG, Haibin
No.46 Waisha Road
Jiaojiang District
Taizhou City Zhejiang 318000 / CN
10 / ZHENG, Linghui
No.46 Waisha Road
Jiaojiang District
Taizhou City Zhejiang 318000 / CN
11 / BAI, Hua
No.46 Waisha Road
Jiaojiang District
Taizhou City Zhejiang 318000 / CN
 [2017/03]
Representative(s)ABG Intellectual Property Law, S.L.
Avenida de Burgos, 16D
Edificio Euromor
28036 Madrid / ES
[N/P]
Former [2019/33]ABG Intellectual Property, S.L.
Avenida de Burgos, 16D
Edificio Euromor
28036 Madrid / ES
Former [2017/03]ABG Patentes, S.L.
Avenida de Burgos, 16D
Edificio Euromor
28036 Madrid / ES
Application number, filing date14885605.728.04.2014
[2017/03]
WO2014CN76372
Priority number, dateCN2014108543110.03.2014         Original published format: CN201410085431
[2017/03]
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2015135242
Date:17.09.2015
Language:ZH
[2015/37]
Type: A1 Application with search report 
No.:EP3118305
Date:18.01.2017
Language:EN
[2017/03]
Type: B1 Patent specification 
No.:EP3118305
Date:14.08.2019
Language:EN
[2019/33]
Search report(s)International search report - published on:CN17.09.2015
(Supplementary) European search report - dispatched on:EP20.02.2018
ClassificationIPC:C12P19/62, C12R1/465, C12N15/76
[2019/09]
CPC:
C12P19/623 (EP,IL,US); A01N43/90 (US); C12N1/205 (EP,IL,US);
C12N15/76 (US); C12R2001/465 (EP,IL,US)
Former IPC [2017/48]C12P19/62, C12R1/465, C12N15/76, A01N43/90
Former IPC [2017/03]C12N1/21, C12R1/465, C12N15/76, C12P19/62
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2017/03]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:TENVERMECTIN A UND TENVERMECTIN B PRODUZIERENDES REKOMBINANTES STREPTOMYCES UND DESSEN VERWENDUNG[2019/09]
English:RECOMBINANT STREPTOMYCES PRODUCING TENVERMECTIN A AND TENVERMECTIN B AND USE THEREOF[2019/09]
French:STREPTOMYCES RECOMBINÉ PRODUISANT TENVERMECTIN A ET TENVERMECTIN B ET SON UTILISATION[2019/09]
Former [2017/03]AVERMECTIN-ANALOGON EXPRIMIERENDER REKOMBINANTER MIKROORGANISMUS UND DAVON VERWENDUNG
Former [2017/03]RECOMBINANT MICROORGANISM EXPRESSING AVERMECTIN ANALOGUE AND USE THEREOF
Former [2017/03]MICROORGANISME RECOMBINÉ EXPRIMANT UN ANALOGUE DE L'AVERMECTINE ET SON UTILISATION
Entry into regional phase16.09.2016Translation filed 
16.09.2016National basic fee paid 
16.09.2016Search fee paid 
16.09.2016Designation fee(s) paid 
16.09.2016Examination fee paid 
Examination procedure16.09.2016Examination requested  [2017/03]
16.09.2016Date on which the examining division has become responsible
21.03.2017Despatch of communication that the application is refused, reason: Examination on filing A.90(5) {1}
06.09.2018Amendment by applicant (claims and/or description)
18.03.2019Communication of intention to grant the patent
04.07.2019Fee for grant paid
04.07.2019Fee for publishing/printing paid
04.07.2019Receipt of the translation of the claim(s)
Opposition(s)03.06.2020No opposition filed within time limit [2020/33]
Request for further processing for:The application was refused due to non-payment of the late furnishing fee for the sequence listing
17.03.2017Request for further processing filed
17.03.2017Full payment received (date of receipt of payment)
Request granted
29.03.2017Decision despatched
Fees paidRenewal fee
16.09.2016Renewal fee patent year 03
07.04.2017Renewal fee patent year 04
27.04.2018Renewal fee patent year 05
29.04.2019Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.04.2014
AL14.08.2019
AT14.08.2019
CY14.08.2019
CZ14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
IT14.08.2019
LT14.08.2019
LV14.08.2019
MC14.08.2019
MK14.08.2019
MT14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
SI14.08.2019
SK14.08.2019
SM14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
IE28.04.2020
LU28.04.2020
BE30.04.2020
CH30.04.2020
LI30.04.2020
[2022/32]
Former [2022/28]HU28.04.2014
AL14.08.2019
AT14.08.2019
CY14.08.2019
CZ14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
IT14.08.2019
LT14.08.2019
LV14.08.2019
MC14.08.2019
MT14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
SI14.08.2019
SK14.08.2019
SM14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
IE28.04.2020
LU28.04.2020
BE30.04.2020
CH30.04.2020
LI30.04.2020
Former [2021/20]AL14.08.2019
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MC14.08.2019
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PL14.08.2019
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RS14.08.2019
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SK14.08.2019
SM14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
IE28.04.2020
LU28.04.2020
BE30.04.2020
CH30.04.2020
LI30.04.2020
Former [2021/12]AL14.08.2019
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CZ14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
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IT14.08.2019
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LV14.08.2019
MC14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
SI14.08.2019
SK14.08.2019
SM14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
LU28.04.2020
BE30.04.2020
CH30.04.2020
LI30.04.2020
Former [2021/08]AL14.08.2019
AT14.08.2019
CZ14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
IT14.08.2019
LT14.08.2019
LV14.08.2019
MC14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
SI14.08.2019
SK14.08.2019
SM14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
LU28.04.2020
CH30.04.2020
LI30.04.2020
Former [2021/07]AL14.08.2019
AT14.08.2019
CZ14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
IT14.08.2019
LT14.08.2019
LV14.08.2019
MC14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
SI14.08.2019
SK14.08.2019
SM14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
CH30.04.2020
LI30.04.2020
Former [2020/52]AL14.08.2019
AT14.08.2019
CZ14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
IT14.08.2019
LT14.08.2019
LV14.08.2019
MC14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
SI14.08.2019
SK14.08.2019
SM14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
Former [2020/37]AL14.08.2019
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EE14.08.2019
ES14.08.2019
FI14.08.2019
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IT14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
SI14.08.2019
SK14.08.2019
SM14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
Former [2020/36]AL14.08.2019
AT14.08.2019
CZ14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
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IT14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
SK14.08.2019
SM14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
Former [2020/27]AL14.08.2019
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CZ14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
IT14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
SK14.08.2019
SM14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
PT16.12.2019
IS24.02.2020
Former [2020/25]AL14.08.2019
AT14.08.2019
CZ14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
IT14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
SK14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
PT16.12.2019
IS24.02.2020
Former [2020/24]AL14.08.2019
AT14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
IT14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
PT16.12.2019
IS24.02.2020
Former [2020/23]AL14.08.2019
AT14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
IT14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
PL14.08.2019
RO14.08.2019
RS14.08.2019
SE14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
Former [2020/22]AL14.08.2019
DK14.08.2019
EE14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
RS14.08.2019
SE14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
Former [2020/17]AL14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
RS14.08.2019
SE14.08.2019
TR14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
Former [2020/15]AL14.08.2019
ES14.08.2019
FI14.08.2019
HR14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
RS14.08.2019
SE14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
Former [2020/12]ES14.08.2019
FI14.08.2019
HR14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
RS14.08.2019
SE14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
IS14.12.2019
PT16.12.2019
Former [2020/11]ES14.08.2019
FI14.08.2019
HR14.08.2019
LT14.08.2019
LV14.08.2019
NL14.08.2019
RS14.08.2019
SE14.08.2019
BG14.11.2019
NO14.11.2019
GR15.11.2019
PT16.12.2019
Former [2020/10]FI14.08.2019
LT14.08.2019
NL14.08.2019
SE14.08.2019
BG14.11.2019
NO14.11.2019
PT16.12.2019
Former [2020/09]FI14.08.2019
LT14.08.2019
NL14.08.2019
NO14.11.2019
Former [2020/08]LT14.08.2019
NO14.11.2019
Documents cited:Search[A]DE4031039  (CIBA GEIGY AG [CH]) [A] 1-4,6,7,9-11 * page 7; example 2 * * page 8; table 1; compound 1.1 * * page 10; examples B-1 * * pages 10-11; examples B-4 ** pages 11-12; claims 1, 2, 4, 5, 8 *;
 [XI]  - HONG, Y.-S. ET AL., "Targeted gene disruption of the avermectin B O-methyltransferase gene in Streptomyces avermitilis", BIOTECHNOLOGY LETTERS, (200111), vol. 23, no. 21, pages 1765 - 1770, XP009500208 [X] 1-4,6,7,9,10 * abstract * * page 1768, column 1, line 12 - column 2, line 7 * * page 1768, column 2, line 25 - page 1769, column 1, line 19; figure 4B * [I] 11

DOI:   http://dx.doi.org/10.1023/A:1012496317299
 [A]  - TANG, H. & ZHANG, L.P., "Site-directed mutagenesis of Streptomyces avermitilis aveD gene", Agricultural Science & Technology - Hunan, vol. 12, no. 10, pages 1424 - 1426, URL: https://www.cabdirect.org/cabdirect/abstract/20133079932, (20170918), XP002773877 [A] 1-4,6,7,9-11 * abstract *
 [A]  - CHEN, Z. ET AL., "Effect of gene deletion of aveD on avermectins production in Streptomyces avermitilis.", BIOSIS, BIOSCIENCES INFORMATION SERVICE, (200210), Database accession no. PREV200300112617, XP002773878 [A] 1-4,6,7,9-11 * the whole document *
    [ ] - CHEN, Z. ET AL., "Effect of gene deletion of aveD on avermectins production in Streptomyces avermitilis.", WEISHENGWU XUEBAO, (200210), vol. 42, no. 5, pages 534 - 538
International search[E]CN103834605  (SHANGHAI INST ORGANIC CHEM, et al) [E] 1-3, 6, 12 * , claims, and description, page 1, paragraphs 0002-0003 *;
 [XA]  - ZHU, HAOJUN et al., "Cloning, Sequence Analysis and Gene Replacement of an Avermectin C5 - O methyltransferase Gene", CHINESE JOURNAL OF ANTIBIOTICS, (20030131), vol. 28, no. 1, pages 1 - 5, XP 008184571 [X] 1-4, 6-7, 12 * , see abstract, and figure 10 * [A] 5, 8-11
 [X]  - ZHOU, HAIJIAO et al., "The Construction of Gene -engineered Strain Only Producing Avermectin B", JOURNAL OF SHENYANG PHARMACEUTICAL, (20101130), vol. 27, no. 11, pages 919 - 923, XP008185753 [X] 1-4, 6-7, 12 * , see abstract, and figure 6 *
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.