Extract from the Register of European Patents

EP About this file: EP2883449

EP2883449 - HISTIDINE ENGINEERED LIGHT CHAIN ANTIBODIES AND GENETICALLY MODIFIED RODENTS FOR GENERATING THE SAME [Right-click to bookmark this link]
Former [2015/25]Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same
[2017/37]
StatusNo opposition filed within time limit
Status updated on  14.12.2018
Database last updated on 09.04.2026
FormerThe patent has been granted
Status updated on  05.01.2018
FormerGrant of patent is intended
Status updated on  31.08.2017
FormerExamination is in progress
Status updated on  06.01.2017
Most recent event   Tooltip14.12.2018No opposition filed within time limitpublished on 16.01.2019  [2019/03]
Applicant(s)For all designated states
Regeneron Pharmaceuticals, Inc.
777 Old Saw Mill River Road
Tarrytown, NY 10591 / US
[2015/25]
Inventor(s)01 / Mcwhirter, John
2035 Crescent Drive
Tarrytown, NY 10591 / US
02 / Macdonald, Lynn
16 Gedney Way
White Plains, NY 10605 / US
03 / Murphy, Andrew J.
10 Newton Court
Croton-on-Hudson, NY 10520 / US
 [2015/25]
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2018/06]J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Former [2015/25]Bentham, Andrew
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date15151655.615.03.2013
[2015/25]
Priority number, dateUS201261611950P16.03.2012         Original published format: US 201261611950 P
US201261736930P13.12.2012         Original published format: US 201261736930 P
[2015/25]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report 
No.:EP2883449
Date:17.06.2015
Language:EN
[2015/25]
Type: B1 Patent specification 
No.:EP2883449
Date:07.02.2018
Language:EN
[2018/06]
Search report(s)(Supplementary) European search report - dispatched on:EP24.04.2015
ClassificationIPC:A01K67/027, C07K16/00, C12N15/85
[2015/25]
CPC:
A01K67/0278 (EP,CN,IL,US); A01K67/0275 (CN,IL,RU,US); C07K16/28 (IL,US);
C07K16/00 (EP,CN,IL,US); C07K16/468 (CN,IL,US); C12N15/8509 (EP,CN,IL,US);
A01K2207/15 (CN,IL,US); A01K2217/072 (EP,CN,IL,US); A01K2217/075 (EP,CN,IL,US);
A01K2217/15 (EP,CN,IL,US); A01K2227/105 (EP,CN,IL,US); A01K2267/01 (EP,CN,IL,US);
C07K2317/24 (CN,IL); C07K2317/515 (EP,CN,IL,US); C07K2317/56 (CN,IL,US);
C07K2317/565 (CN,IL,US); C07K2317/92 (EP,CN,IL,US); C12N2800/204 (EP,CN,IL,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/25]
TitleGerman:DURCH HISTIDIN MANIPULIERTE LEICHTKETTIGE ANTIKÖRPER UND GENETISCH MODIFIZIERTE NAGER ZUR ERZEUGUNG DAVON[2017/37]
English:HISTIDINE ENGINEERED LIGHT CHAIN ANTIBODIES AND GENETICALLY MODIFIED RODENTS FOR GENERATING THE SAME[2017/37]
French:ANTICORPS À CHAÎNES LÉGÈRES MODIFIÉS AVEC DE L'HISTIDINE ET RONGEURS GÉNÉTIQUEMENT MODIFIÉS POUR GÉNÉRER CES ANTICORPS[2017/37]
Former [2015/25]Durch Histidin manipulierte leichtkettige Antikörper und genetisch modifizierte, nichtmenschliche Tiere zur Erzeugung davon
Former [2015/25]Histidine engineered light chain antibodies and genetically modified non-human animals for generating the same
Former [2015/25]Anticorps à chaîne légère de synthèse de l'histidine et animaux non humains génétiquement modifiés pour le générer
Examination procedure19.01.2015Examination requested  [2015/25]
15.12.2015Amendment by applicant (claims and/or description)
10.05.2016Despatch of a communication from the examining division (Time limit: M04)
20.09.2016Reply to a communication from the examining division
04.01.2017Despatch of a communication from the examining division (Time limit: M04)
15.05.2017Reply to a communication from the examining division
28.08.2017Communication of intention to grant the patent
21.12.2017Fee for grant paid
21.12.2017Fee for publishing/printing paid
21.12.2017Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP13713652.9  / EP2825036
Opposition(s)08.11.2018No opposition filed within time limit [2019/03]
Fees paidRenewal fee
19.01.2015Renewal fee patent year 03
23.03.2016Renewal fee patent year 04
23.03.2017Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[X] WO2011097603  (REGENERON PHARMA et al.)
 [Y] EP2275443  (CHUGAI PHARMACEUTICAL CO LTD et al.)
 [Y] WO2011111007  (RINAT NEUROSCIENCE CORP et al.)
 [YA] WO9203918  (GENPHARM INT et al.)
 [YA] US5545806  (LONBERG NILS et al.)
 [A]   JAVIER CHAPARRO-RIGGERS ET AL: "Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 287, no. 14, 31 January 2012 (2012-01-31), pages 11090 - 11097, XP002684539, ISSN: 0021-9258, [retrieved on 20120131], DOI: 10.1074/JBC.M111.319764

DOI:   http://dx.doi.org/10.1074/JBC.M111.319764
 [A]   IGAWA T ET AL: "Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 28, no. 11, 1 November 2010 (2010-11-01), pages 1203 - 1207, XP009153598, ISSN: 1087-0156, DOI: 10.1038/NBT.1691

DOI:   http://dx.doi.org/10.1038/nbt.1691
 [A]   IGAWA TOMOYUKI ET AL: "Engineering the variable region of therapeutic IgG antibodies", MABS, LANDES BIOSCIENCE, US, vol. 3, no. 3, 1 May 2011 (2011-05-01), pages 243 - 252, XP009153597, ISSN: 1942-0870
by applicantUS2011111406
 US2011195454
 US2012021409
 US2012192300
 US2013045492
 US2012192309
 US2007280945
 US2010331527
 US6586251
 US7294754
 US6596541
 US6774279
   LEFRANC ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77, Retrieved from the Internet
   GONNET ET AL.: "Exhaustive Matching of the Entire Protein Sequence Database", SCIENCE, vol. 256, 1992, pages 1443 - 45, XP008148163, DOI: doi:10.1126/science.1604319

DOI:   http://dx.doi.org/10.1126/science.1604319
   "MACVECTORTM 10.0.2", 2008, MACVECTOR INC.
   SIMISTER; MOSTOV: "An Fc receptor structurally related to MHC class I antigens", NATURE, vol. 337, 1989, pages 184 - 87, XP002616981, DOI: doi:10.1038/337184a0

DOI:   http://dx.doi.org/10.1038/337184a0
   VALENZUELA ET AL.: "High-throughput engineering of the mouse genome coupled with high-resolution expression analysis", NATURE BIOTECH., vol. 21, no. 6, 2003, pages 652 - 659
   KOHLER; MILSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
   TUTT ET AL., J. IMMUNOL., vol. 147, 1991, pages 60 - 69
   KUFER ET AL., TRENDS BIOTECHNOL., vol. 22, 2004, pages 238 - 244
   POUEYMIROU ET AL.: "FO generation mice that are essentially fully derived from the donor gene-targeted ES cells allowing immediate phenotypic analyses", NATURE BIOTECH., vol. 25, no. 1, 2007, pages 91 - 99
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.