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Extract from the Register of European Patents

EP About this file: EP2927213

EP2927213 - Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer [Right-click to bookmark this link]
Status	No opposition filed within time limit Status updated on 20.09.2019 Database last updated on 03.09.2024
Former	The patent has been granted Status updated on 12.10.2018
Former	Grant of patent is intended Status updated on 17.05.2018
Former	Examination is in progress Status updated on 02.12.2016
Most recent event Tooltip	20.09.2019	No opposition filed within time limit	published on 23.10.2019 [2019/43]
Applicant(s)	For all designated states Amgen Inc. One Amgen Center Drive M/S 28-2-C Thousand Oaks, CA 91320 / US
	[2015/41]
Inventor(s)	01 / Bartberger, Michael David 4471 Ventura Canyon Avenue D-105 Sherman Oaks, CA 91423 / US
	02 / Gonzalez Buenrostro, Ana 419 Turner Terrace Apt. 9 San Mateo, CA 94401 / US
	03 / Beck, Hilary Plake 115 Springdale Way Emerald Hills, CA 94062 / US
	04 / Chen, Xiaoqi 970 Blair Court Palo Alto, CA 94303 / US
	05 / Connors, Richard Victor 935 Crespi Drive Pacifica, CA 94044 / US
	06 / Deignan, Jeffery 860 Head Street San Francisco, CA 94132 / US
	07 / Duquette, Jason 460 Bayview Avenue Millbrae, CA 90403 / US
	08 / Eksterowicz, John 1845 Church Street San Francisco, CA 94131 / US
	09 / Fisher, Benjamin 1020 Yates Way Apt. 313 San Mateo, CA 94403 / US
	10 / Fox, Brian Matthew 124 Swallowtail Court Brisbane, CA 94005 / US
	11 / Fu, Jiasheng 221 Pelican Court Foster City, CA 94404 / US
	12 / Fu, Zice 788 Santa Maria Lane Foster City, CA 94404 / US
	13 / Gonzalez Lopez de Turiso, Felix 241 Cardinal Medeiros Avenue Cambridge, MA 02141 / US
	14 / Gribble, jr. Michael William 949 Capp Street Apt. 22 San Francisco, CA 94110 / US
	15 / Gustin, Darin James 433 Kehoe Avenue Half Moon Bay, CA 94019 / US
	16 / Heath, Julie Anne 6 Ivy Drive Orinda, CA 94563 / US
	17 / Huang, Xin 16 Abbott Road Wellesly, MA 02481 / US
	18 / Jiao, Xianjun 2603 All View Way Belmont, CA 94002 / US
	19 / Johnson, Michael 409 Clipper Street San Francisco, CA 94114 / US
	20 / Kayser, Frank 4150 17th Street, Apt. 25 San Francisco, CA 94114 / US
	21 / Kopecky, David John 12067 Guerin Street, Unit 202 Studio City, CA 91604 / US
	22 / Lai, SuJen 3 Rosewood Lane Natick, MA 01760 / US
	23 / Li, Yihong 821 Taylor Boulevard Millbrae, CA 94030 / US
	24 / Li, Zhihong 467 Anita Drive Millbrae, CA 94030 / US
	25 / Liu, Jiwen 250 Trysail Court Foster City, CA 94404 / US
	26 / Low, Jonathan Dante 19355 Sherman Way No. 39 Reseda, CA 91335 / US
	27 / Lucas, Brian Stuart 4 Brantwood Road Arlington, MA 02476 / US
	28 / Ma, Zhihua 12212 Campus Drive Lexington, MA 02421 / US
	29 / McGee, Lawrence 39 Big Sur Way Pacifica, CA 94044 / US
	30 / McIntosh, Joel 540 Fremont Avenue Pacifica, CA 94044 / US
	31 / McMinn, Dustin 1065 Grand Teton Pacifica, CA 94044 / US
	32 / Medina, Julio Cesar 2879 Roland Avenue San Carlos, CA 94070 / US
	33 / Mihalic, Jeffrey Thomas 300 3rd Street 523 San Francisco, CA 94107 / US
	34 / Olson, Steven Howard 406 Green Hills Drive Millbrae, CA 94030 / US
	35 / Rew, Yosup 828 Juno Lane Foster City, CA 94404 / US
	36 / Roveto, Philip Marley 921 Adams Street NE Albuquerque, NM 87110 / US
	37 / Sun, Daqing 804 Cortez Lane Foster City, CA 94404 / US
	38 / Wang, Xiaodong 821 Taylor Boulevard Millbrae, CA 94030 / US
	39 / Wang, Yingcai 860 Helen Drive Millbrae, CA 94030 / US
	40 / Yan, Xuelei 1120 Nimitz Lane Foster City, CA 94404 / US
	41 / Yu, Ming 42 Williams Lane Foster City, CA 94404 / US
	42 / Zhu, Jiang 747 Coastland Drive Palo Alto, CA 94303 / US
	[2018/46]
Former [2015/51]	01 / Bartberger, Michael David 4471 Ventura Canyon Avenue D-105 Sherman Oaks, CA 91423 / US
	02 / Gonzalez Buenrostro, Ana 419 Turner Terrace Apt. 9 San Mateo, CA 94401 / US
	03 / Beck, Hilary Plake 115 Springdale Way Emerald Hills, California 94062 / US
	04 / Chen, Xiaoqi 970 Blair Court Palo Alto, CA 94303 / US
	05 / Connors, Richard Victor 935 Crespi Drive Pacifica, CA 94044 / US
	06 / Deignan, Jeffery 860 Head Street San Francisco, CA 94132 / US
	07 / Duquette, Jason 460 Bayview Avenue Millbrae, CA 90403 / US
	08 / Eksterowicz, John 1845 Church Street San Francisco, CA 94131 / US
	09 / Fisher, Benjamin 1020 Yates Way Apt. 313 San Mateo, CA 94403 / US
	10 / Fox, Brian Matthew 124 Swallowtail Court Brisbane, CA 94005 / US
	11 / Fu, Jiasheng 221 Pelican Court Foster City, CA 94404 / US
	12 / Fu, Zice 788 Santa Maria Lane Foster City, CA 94404 / US
	13 / Gonzalez Lopez de Turiso, Felix 241 Cardinal Medeiros Avenue Cambridge, MA 02141 / US
	14 / Gribble, jr. Michael William 949 Capp Street Apt. 22 San Francisco, CA 94110 / US
	15 / Gustin, Darin James 433 Kehoe Avenue Half Moon Bay, CA 94019 / US
	16 / Heath, Julie Anne 6 Ivy Drive Orinda, CA 94563 / US
	17 / Huang, Xin 16 Abbott Road Wellesly, MA 02481 / US
	18 / Jiao, Xianjun 2603 All View Way Belmont, CA 94002 / US
	19 / Johnson, Michael 409 Clipper Street San Francisco, CA 94114 / US
	20 / Kayser, Frank 4150 17th Street, Apt. 25 San Francisco, CA 94114 / US
	21 / Kopecky, David John 12067 Guerin Street, Unit 202 Studio City, CA 91604 / US
	22 / Lai, SuJen 3 Rosewood Lane Natick, MA 01760 / US
	23 / Li, Yihong 821 Taylor Boulevard Millbrae, CA 94030 / US
	24 / Li, Zhihong 467 Anita Drive Millbrae, CA 94030 / US
	25 / Liu, Jiwen 250 Trysail Court Foster City, CA 94404 / US
	26 / Low, Jonathan Dante 19355 Sherman Way No. 39 Reseda, CA 91335 / US
	27 / Lucas, Brian Stuart 4 Brantwood Road Arlington, MA 02476 / US
	28 / Ma, Zhihua 12212 Campus Drive Lexington, MA 02421 / US
	29 / McGee, Lawrence 39 Big Sur Way Pacifica, CA 94044 / US
	30 / McIntosh, Joel 540 Fremont Avenue Pacifica, CA 94044 / US
	31 / McMinn, Dustin 1065 Grand Teton Pacifica, CA 94044 / US
	32 / Medina, Julio Cesar 2879 Roland Avenue San Carlos, CA 94070 / US
	33 / Mihalic, Jeffrey Thomas 300 3rd Street 523 San Francisco, CA 94107 / US
	34 / Olson, Steven Howard 406 Green Hills Drive Millbrae, CA 94030 / US
	35 / Rew, Yosup 828 Juno Lane Foster City, CA 94404 / US
	36 / Roveto, Philip Marley 921 Adams Street NE Albuquerque, NM 87110 / US
	37 / Sun, Daqing 804 Cortez Lane Foster City, CA 94404 / US
	38 / Wang, Xiaodong 821 Taylor Boulevard Millbrae, CA 94030 / US
	39 / Wang, Yingcai 860 Helen Drive Millbrae, CA 94030 / US
	40 / Yan, Xuelei 1120 Nimitz Lane Foster City, CA 94404 / US
	41 / Yu, Ming 42 Williams Lane Foster City, CA 94404 / US
	42 / Zhu, Jiang 747 Coastland Drive Palo Alto, CA 94303 / US
Former [2015/44]	01 / Bartberger, Michael David 4471 Ventura Canyon Avenue D-105 Sherman Oaks, CA 91423 / US
	02 / Gonzalez Buenrostro, Ana 419 Turner Terrace Apt. 9 San Mateo, CA 94401 / US
	03 / Beck, Hilary Plake 115 Springdale Way Emerald Hills, California 94062 / US
	04 / Chen, Xiaoqi 970 Blair Court Palo Alto, CA 94303 / US
	05 / Connors, Richard Victor 935 Crespi Drive Pacifica, CA 94044 / US
	06 / Deignan, Jeffery 500 29th Street San Francisco, CA 94131 / US
	07 / Duquette, Jason 460 Bayview Avenue Millbrae, CA 90403 / US
	08 / Eksterowicz, John 1845 Church Street San Francisco, CA 94131 / US
	09 / Fisher, Benjamin 1020 Yates Way Apt. 313 San Mateo, CA 94403 / US
	10 / Fox, Brian Matthew 124 Swallowtail Court Brisbane, CA 94005 / US
	11 / Fu, Jiasheng 221 Pelican Court Foster City, CA 94404 / US
	12 / Fu, Zice 788 Santa Maria Lane Foster City, CA 94404 / US
	13 / Gonzalez Lopez de Turiso, Felix 241 Cardinal Medeiros Avenue Cambridge, MA 02141 / US
	14 / Gribble, jr. Michael William 949 Capp Street Apt. 22 San Francisco, CA 94110 / US
	15 / Gustin, Darin James 433 Kehoe Avenue Half Moon Bay, CA 94019 / US
	16 / Heath, Julie Anne 6 Ivy Drive Orinda, CA 94563 / US
	17 / Huang, Xin 16 Abbott Road Wellesly, MA 02481 / US
	18 / Jiao, Xianjun 2603 All View Way Belmont, CA 94002 / US
	19 / Johnson, Michael 409 Clipper Street San Francisco, CA 94114 / US
	20 / Kayser, Frank 4150 17th Street, Apt. 25 San Francisco, CA 94114 / US
	21 / Kopecky, David John 12067 Guerin Street, Unit 202 Studio City, CA 91604 / US
	22 / Lai, SuJen 3 Rosewood Lane Natick, MA 01760 / US
	23 / Li, Yihong 821 Taylor Boulevard Millbrae, CA 94030 / US
	24 / Li, Zhihong 467 Anita Drive Millbrae, CA 94030 / US
	25 / Liu, Jiwen 250 Trysail Court Foster City, CA 94404 / US
	26 / Low, Jonathan Dante 19355 Sherman Way No. 39 Reseda, CA 91335 / US
	27 / Lucas, Brian Stuart 4 Brantwood Road Arlington, MA 02476 / US
	28 / Ma, Zhihua 12212 Campus Drive Lexington, MA 02421 / US
	29 / McGee, Lawrence 39 Big Sur Way Pacifica, CA 94044 / US
	30 / McIntosh, Joel 540 Fremont Avenue Pacifica, CA 94044 / US
	31 / McMinn, Dustin 1065 Grand Teton Pacifica, CA 94044 / US
	32 / Medina, Julio Cesar 2879 Roland Avenue San Carlos, CA 94070 / US
	33 / Mihalic, Jeffrey Thomas 300 3rd Street 523 San Francisco, CA 94107 / US
	34 / Olson, Steven Howard 406 Green Hills Drive Millbrae, CA 94030 / US
	35 / Rew, Yosup 828 Juno Lane Foster City, CA 94404 / US
	36 / Roveto, Philip Marley 921 Adams Street NE Albuquerque, NM 87110 / US
	37 / Sun, Daqing 804 Cortez Lane Foster City, CA 94404 / US
	38 / Wang, Xiaodong 821 Taylor Boulevard Millbrae, CA 94030 / US
	39 / Wang, Yingcai 860 Helen Drive Millbrae, CA 94030 / US
	40 / Yan, Xuelei 1120 Nimitz Lane Foster City, CA 94404 / US
	41 / Yu, Ming 42 Williams Lane Foster City, CA 94404 / US
	42 / Zhu, Jiang 747 Coastland Drive Palo Alto, CA 94303 / US
Representative(s)	Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE
	[2015/41]
Application number, filing date	15159363.9	03.06.2011
	[2015/41]
Priority number, date	US20100351827P	04.06.2010 Original published format: US 351827 P
	US20100352322P	07.06.2010 Original published format: US 352322 P
	US201161452578P	14.03.2011 Original published format: US 201161452578 P
	[2015/41]
Filing language	EN
Procedural language	EN
Publication	Type:	A1 Application with search report
	No.:	EP2927213
	Date:	07.10.2015
	Language:	EN
	[2015/41]
	Type:	B1 Patent specification
	No.:	EP2927213
	Date:	14.11.2018
	Language:	EN
	[2018/46]
Search report(s)	(Supplementary) European search report - dispatched on:	EP	23.07.2015
Classification	IPC:	C07D211/40, C07D401/04, C07D401/06, C07D407/04, C07D407/06, C07D409/04, C07D413/06, C07D417/06, C07D471/20, C07D279/02, C07D401/12, C07D498/08, C07D498/20, A61K31/4412, A61P35/00	[2015/41]
	CPC:	C07D211/76 (EP,IL,KR,US); C07D211/40 (CN,IL); A61K31/45 (IL); A61K31/451 (KR); A61P1/04 (EP,IL); A61P29/00 (EP,IL); (+) A61P31/04 (EP,IL); A61P31/12 (EP,IL); A61P35/00 (EP,IL,KR); A61P35/02 (EP,IL); A61P43/00 (EP,IL); C07D221/20 (EP,IL,US); C07D279/02 (EP,CN,IL,US); C07D401/04 (EP,CN,IL,US); C07D401/06 (EP,CN,IL,KR,US); C07D401/12 (EP,CN,IL,US); C07D405/04 (EP,CN,IL,US); C07D405/06 (CN,IL); C07D405/12 (EP,CN,IL,US); C07D407/04 (EP,IL,US); C07D407/06 (EP,IL,US); C07D409/04 (EP,CN,IL,US); C07D409/12 (EP,CN,IL,US); C07D413/06 (EP,CN,IL,KR,US); C07D417/06 (EP,CN,IL,US); C07D417/12 (EP,IL,US); C07D417/14 (EP,IL,US); C07D471/10 (EP,CN,IL,US); C07D491/08 (EP,CN,IL,US); C07D491/153 (EP,IL,US); C07D498/08 (EP,IL,US); C07D498/14 (EP,IL,US); C07D498/20 (EP,IL,US) (-)
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2016/17]
Former [2015/41]	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR
Extension states	BA	18.03.2016
	ME	18.03.2016
Title	German:	Piperidinonderivate als MDM2-Hemmer zur Krebsbehandlung	[2015/41]
	English:	Piperidinone derivatives as MDM2 inhibitors for the treatment of cancer	[2015/41]
	French:	Dérivés de pipéridone MDM2 utilisés comme inhibiteurs pour le traitement du cancer	[2015/41]
Examination procedure	18.03.2016	Examination requested [2016/17]
	31.03.2016	Amendment by applicant (claims and/or description)
	02.08.2016	Despatch of a communication from the examining division (Time limit: M06)
	13.02.2017	Reply to a communication from the examining division
	16.05.2017	Despatch of a communication from the examining division (Time limit: M06)
	02.01.2018	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
	12.03.2018	Reply to a communication from the examining division
	18.05.2018	Communication of intention to grant the patent
	28.09.2018	Fee for grant paid
	28.09.2018	Fee for publishing/printing paid
	28.09.2018	Receipt of the translation of the claim(s)
Parent application(s) Tooltip	EP11726581.9 / EP2576510
Divisional application(s)	EP18197155.7 / EP3483143
	EP22160459.8 / EP4092012
Opposition(s)	15.08.2019	No opposition filed within time limit [2019/43]
Request for further processing for:	The application is deemed to be withdrawn due to failure to reply to the examination report
	12.03.2018	Request for further processing filed
	12.03.2018	Full payment received (date of receipt of payment) Request granted
	22.03.2018	Decision despatched
Fees paid	Renewal fee
	17.03.2015	Renewal fee patent year 03
	17.03.2015	Renewal fee patent year 04
	10.06.2015	Renewal fee patent year 05
	10.06.2016	Renewal fee patent year 06
	16.06.2017	Renewal fee patent year 07
	27.06.2018	Renewal fee patent year 08
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition Tooltip	AL	14.11.2018
	[2019/26]
Documents cited:	Search	[I]WO2010028862 (PRIAXON AG [DE], et al)
	by applicant	WO2007110649
		US7354944
		WO2008118455
		WO2008118454
		WO2008118468
		US2009023761
		US2009030002
		US2009054405
		US7514566
		US2009137581
		US2009163489
		WO2009085185
		US2009270445
		US7700636
		WO2010083246
		WO2010096314
		WO2010108074
		US2010273764
		WO2010132598
		WO2010151791
		WO2010151737
		WO2010151735
		WO2010151740
		US2010331293
		US2010331306
		US7897619
		US7919514
		US7919504
		US2011092504
		US2011097305

The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.

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