| EP2942392 - DIFFERENTIATION OF PLURIPOTENT STEM CELLS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 09.08.2019 Database last updated on 14.03.2026 | |
| Former | The patent has been granted Status updated on 31.08.2018 | ||
| Former | Grant of patent is intended Status updated on 05.04.2018 | ||
| Former | Examination is in progress Status updated on 02.11.2016 | Most recent event Tooltip | 01.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 03.08.2022 [2022/31] | Applicant(s) | For all designated states Janssen Biotech, Inc. 800/850 Ridgeview Drive Horsham, PA 19044 / US | [2015/46] | Inventor(s) | 01 /
LIU, Jiajian J&J Consumer Companies 199 Grandview Road Skillman, NJ 08558 / US | 02 /
DAVIS, Janet J&J Consumer Companies 199 Grandview Road Skillman, NJ 08558 / US | 03 /
PARMENTER, Christine 3210 Merryfield Row San Diego, CA 92121 / US | 04 /
BONNET, Pascal Ghislain André Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse / BE | [2018/40] |
| Former [2015/46] | 01 /
LIU, Jiajian J&J Consumer Companies 199 Grandview Road Skillman, NJ New Jersey 08558 / US | ||
| 02 /
DAVIS, Janet J&J Consumer Companies 199 Grandview Road Skillman, NJ New Jersey 08558 / US | |||
| 03 /
PARMENTER, Christine 3210 Merryfield Row San Diego, CA California 92121 / US | |||
| 04 /
BONNET, Pascal Ghislain André Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse / BE | Representative(s) | Carpmaels & Ransford LLP One Southampton Row London WC1B 5HA / GB | [2015/46] | Application number, filing date | 15171064.7 | 30.06.2009 | [2015/46] | Priority number, date | US20080076908P | 30.06.2008 Original published format: US 76908 P | US20080076900P | 30.06.2008 Original published format: US 76900 P | US20080076915P | 30.06.2008 Original published format: US 76915 P | [2015/46] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | EP2942392 | Date: | 11.11.2015 | Language: | EN | [2015/46] | Type: | B1 Patent specification | No.: | EP2942392 | Date: | 03.10.2018 | Language: | EN | [2018/40] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 29.09.2015 | Classification | IPC: | C12N5/0735, C12N5/071 | [2015/46] | CPC: |
C12N5/0606 (EP,KR,US);
C12N5/0018 (KR,RU);
C07K14/475 (KR);
C12N5/00 (KR,RU);
C12N5/0676 (EP,US);
C12N5/0678 (US);
C12N5/0696 (KR);
C12N2500/25 (EP,US);
C12N2501/11 (EP,US);
C12N2501/115 (EP,US);
C12N2501/119 (EP,US);
C12N2501/135 (EP,US);
C12N2501/15 (EP,US);
C12N2501/155 (EP,US);
C12N2501/16 (EP,US);
C12N2501/165 (EP,US);
C12N2501/19 (EP,US);
C12N2501/385 (EP,US);
C12N2501/41 (EP,US);
C12N2501/415 (EP,US);
C12N2501/42 (EP,US);
C12N2501/727 (EP,US);
C12N2501/845 (EP,US);
C12N2501/999 (EP,US);
C12N2506/02 (EP,US);
C12N2531/00 (EP,US);
C12N2533/50 (EP,US);
C12N2533/90 (EP,US)
(-)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR [2016/25] |
| Former [2015/46] | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, TR | Title | German: | DIFFERENZIERUNG PLURIPOTENTER STAMMZELLEN | [2015/46] | English: | DIFFERENTIATION OF PLURIPOTENT STEM CELLS | [2015/46] | French: | DIFFÉRENCIATION DE CELLULES SOUCHES PLURIPOTENTES | [2015/46] | Examination procedure | 11.05.2016 | Amendment by applicant (claims and/or description) | 11.05.2016 | Examination requested [2016/25] | 22.06.2016 | Despatch of a communication from the examining division (Time limit: M06) | 30.12.2016 | Reply to a communication from the examining division | 29.09.2017 | Despatch of a communication from the examining division (Time limit: M04) | 08.02.2018 | Reply to a communication from the examining division | 05.04.2018 | Communication of intention to grant the patent | 15.08.2018 | Fee for grant paid | 15.08.2018 | Fee for publishing/printing paid | 15.08.2018 | Receipt of the translation of the claim(s) | Parent application(s) Tooltip | EP09774297.7 / EP2310492 | Opposition(s) | 04.07.2019 | No opposition filed within time limit [2019/37] | Fees paid | Renewal fee | 08.06.2015 | Renewal fee patent year 03 | 08.06.2015 | Renewal fee patent year 04 | 08.06.2015 | Renewal fee patent year 05 | 08.06.2015 | Renewal fee patent year 06 | 08.06.2015 | Renewal fee patent year 07 | 10.06.2016 | Renewal fee patent year 08 | 16.06.2017 | Renewal fee patent year 09 | 12.06.2018 | Renewal fee patent year 10 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 30.06.2009 | AT | 03.10.2018 | CY | 03.10.2018 | CZ | 03.10.2018 | DK | 03.10.2018 | EE | 03.10.2018 | FI | 03.10.2018 | HR | 03.10.2018 | LT | 03.10.2018 | LV | 03.10.2018 | MC | 03.10.2018 | MK | 03.10.2018 | MT | 03.10.2018 | NL | 03.10.2018 | RO | 03.10.2018 | SE | 03.10.2018 | SI | 03.10.2018 | SK | 03.10.2018 | TR | 03.10.2018 | BG | 03.01.2019 | NO | 03.01.2019 | GR | 04.01.2019 | IS | 03.02.2019 | PT | 03.02.2019 | BE | 30.06.2019 | CH | 30.06.2019 | IE | 30.06.2019 | LI | 30.06.2019 | LU | 30.06.2019 | PL | 30.06.2019 | [2022/31] |
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| Former [2019/17] | NL | 03.10.2018 | Documents cited: | Search | [A] WO2008048647 (CYTHERA INC et al.) | [A] MCLEAN AMANDA B ET AL: "Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed", STEM CELLS, ALPHAMED PRESS, DAYTON, OH, US, vol. 25, no. 1, 1 January 2007 (2007-01-01), pages 29 - 38, XP002482637, ISSN: 1066-5099 DOI: http://dx.doi.org/10.1634/stemcells.2006-0219 | [A] ARMSTRONG LYLE ET AL: "The role of PI3K/AKT, MAPK/ERK and NF kappa beta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, vol. 15, no. 11, 1 June 2006 (2006-06-01), pages 1894 - 1913, XP002471543, ISSN: 0964-6906 DOI: http://dx.doi.org/10.1093/hmg/ddl112 | [A] PALING N R D ET AL: "REGULATION OF EMBRYONIC STEM CELL SELF-RENEWAL BY PHOSPHOINOSITIDE 3-KINASE-DEPENDENT SIGNALING", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOCHEMICAL BIOLOGISTS, BIRMINGHAM, US, vol. 279, no. 46, 24 August 2004 (2004-08-24), pages 48063 - 48070, XP002380573, ISSN: 0021-9258 DOI: http://dx.doi.org/10.1074/jbc.M406467200 | [AD] HORI YUICHI ET AL: "Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 99, no. 25, 10 December 2002 (2002-12-10), pages 16105 - 16110, XP002392968, ISSN: 0027-8424 DOI: http://dx.doi.org/10.1073/pnas.252618999 | [A] MCKIERNAN EADAOIN ET AL: "Directed differentiation of mouse embryonic stem cells into pancreatic-like or neuronal- and glial-like phenotypes.", TISSUE ENGINEERING OCT 2007, vol. 13, no. 10, October 2007 (2007-10-01), pages 2419 - 2430, XP002547893, ISSN: 1076-3279 DOI: http://dx.doi.org/10.1089/ten.2006.0373 | [A] SHIRAKI NOBUAKI ET AL: "Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm.", STEM CELLS (DAYTON, OHIO) APR 2008, vol. 26, no. 4, April 2008 (2008-04-01), pages 874 - 885, XP002547894, ISSN: 1549-4918 DOI: http://dx.doi.org/10.1634/stemcells.2007-0608 | [A] KUBO A ET AL: "Development of definitive endoderm from embryonic stem cells in culture", DEVELOPMENT, COMPANY OF BIOLOGISTS, CAMBRIDGE, GB, vol. 131, no. 7, 1 April 2004 (2004-04-01), pages 1651 - 1662, XP002985523, ISSN: 0950-1991 DOI: http://dx.doi.org/10.1242/dev.01044 | by applicant | US2006003446 | US6200806 | WO9920741 | WO0151616 | US2005266554 | US2006040387 | US5843780 | WO2007003525 | US73690807 | US77931107 | US99052907 | US95317807 | US2004209901 | US2004132729 | US5770417 | US6022743 | US5567612 | US5759830 | US6626950 | US6534084 | US6306424 | US6365149 | US6599323 | US6656488 | US2004062753 | US4557264 | US6333029 | US6509369 | US6793945 | US6331298 | US2004220393 | US2004171623 | US11644708 | LUMELSKY ET AL., SCIENCE, vol. 292, 2001, pages 1389 | SORIA ET AL., DIABETES, vol. 49, 2000, pages 157 | HORI ET AL., PNAS, vol. 99, 2002, pages 16105 | BLYSZCZUK ET AL., PNAS, vol. 100, 2003, pages 998 | DIABETES, vol. 54, 2005, pages 301 | DIABETES, vol. 53, 2004, pages 1030 | BIOCHEM.J., vol. 379, 2004, pages 749 | GENES CELLS, vol. 10, no. 6, June 2005 (2005-06-01), pages 503 - 16 | GORDON ET AL., PNAS, vol. 103, 2006, pages 16806 | SCIENCE, vol. 282, 1998, pages 114 | SHAMBLOTT ET AL., PROC. NATL. ACAD. SCI. USA, vol. 95, 1998, pages 13726 | D'AMOUR ET AL., NATURE BIOTECHNOLOGY, vol. 24, 2006, pages 1392 - 1401 | BENVENISTRY; BENVENISTRY ET AL.: "We conclude that over-expression of PDX1 enhanced expression of pancreatic enriched genes, induction of insulin expression may require additional signals that are only present in vivo", STEM CELLS, vol. 24, 2006, pages 1923 - 1930 | PANGAS, S.A.; WOODRUFF, T.K: "Isolation of inhibin and activin from natural sources can only produce limited quantities ofbioactive protein.", J. ENDOCRINOL., vol. 172, 2002, pages 199 - 210 | ARAI, K. Y. ET AL.: "Isolation of activins from natural sources requires many steps and only produces limited quantities. Even though recombinant preparations have been used in recent studies, purification of recombinant activins still requires multiple steps.", PROTEIN EXPRESSION AND PURIFICATION, vol. 49, 2006, pages 78 - 82 | SCIENCE, vol. 282, 1998, pages 1145 | CURR. TOP. DEV. BIOL., vol. 38, 1998, pages 133 FF | PROC. NATL. ACAD. SCI. U.S.A., vol. 92, 1995, pages 7844 | TAKAHASHI ET AL., CELL, vol. 131, 2007, pages 1 - 12 | KLEINMAN, H.K. ET AL., BIOCHEMISTRY, vol. 25, 1986, pages 312 | HADLEY, M.A. ET AL., J.CELL.BIOL., vol. 101, 1985, pages 1511 | "Current Protocols in Molecular Biology", 2001 | HARLOW; LANE: "Using Antibodies: A Laboratory Manual", 1998, COLD SPRING HARBOR LABORATORY PRESS | D'AMOUR ET AL., NATURE BIOTECHNOLOGY, vol. 24, 2006, pages 1392 - 1401 | NATURE BIOTECHNOLOGY, vol. 24, 2006, pages 1392 - 1401 | D' AMOUR ET AL., NATURE BIOTECHNOLOGY, 2006 | EDLUND, NATURE REVIEWS GENETICS, vol. 3, 2002, pages 524 - 632 | J. PEDIATR. SURG., vol. 23, 1988, pages 3 - 9 | BIOTECHNOL. PROG., vol. 14, no. 2, 1998, pages 193 - 202 | J. BIOMED. MATER. RES., vol. 55, no. 3, 2001, pages 379 - 86 |