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Extract from the Register of European Patents

EP About this file: EP2963116

EP2963116 - TREATMENT OF SIRTUIN 1 (SIRT1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO SIRT 1 [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  17.09.2021
Database last updated on 13.07.2024
FormerThe patent has been granted
Status updated on  09.10.2020
FormerGrant of patent is intended
Status updated on  04.06.2020
FormerExamination is in progress
Status updated on  26.01.2018
FormerRequest for examination was made
Status updated on  03.11.2016
Most recent event   Tooltip14.06.2024Lapse of the patent in a contracting state
New state(s): TR		published on 17.07.2024 [2024/29]
Applicant(s)For all designated states
CuRNA, Inc.
4400 Biscayne Boulevard
Miami, FL 33137 / US
[2016/01]
Inventor(s)01 / COLLARD, Joseph
1004 Brooks Lane
Delray Beach, Florida 33483 / US
02 / KHORKOVA SHERMAN, Olga
18288 SE Heritage Drive
Tequesta, Florida 33469 / US
03 / COITO, Carlos
4518 Corniche Circle 26
West Palm Beach, Florida 33417 / US
04 / DE LEON, Belinda
720 S. Sapodilla Avenue 305
West Palm Beach, Florida 33401 / US
 [2020/46]
Former [2016/01]01 / COLLARD, Joseph
1004 Brooks Lane
Delray Beach, FL Florida 33483 / US
02 / KHORKOVA SHERMAN, Olga
18288 SE Heritage Drive
Tequesta, FL Florida 33469 / US
03 / COITO, Carlos
4518 Corniche Circle 26
West Palm Beach, FL Florida 33417 / US
04 / DE LEON, Belinda
720 S. Sapodilla Avenue 305
West Palm Beach, FL Florida 33401 / US
Representative(s)Mathys & Squire
The Shard
32 London Bridge Street
London SE1 9SG / GB
[2020/46]
Former [2016/01]Evenson, Jane Harriet, et al
Mathys & Squire LLP The Shard
32 London Bridge Street
London SE1 9SG / GB
Application number, filing date15180416.803.03.2010
[2016/01]
Priority number, dateUS20090157255P04.03.2009         Original published format: US 157255 P
US20090259072P06.11.2009         Original published format: US 259072 P
WO2009US6644502.12.2009         Original published format: PCT/US2009/066445
[2016/01]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2963116
Date:06.01.2016
Language:EN
[2016/01]
Type: A3 Search report 
No.:EP2963116
Date:23.03.2016
Language:EN
[2016/12]
Type: B1 Patent specification 
No.:EP2963116
Date:11.11.2020
Language:EN
[2020/46]
Search report(s)(Supplementary) European search report - dispatched on:EP22.02.2016
ClassificationIPC:C12N15/63, C12N15/11, C07H19/00, C12Q1/68
[2016/01]
CPC:
C12N15/1137 (EP,US); A61P1/00 (EP); A61P1/04 (EP);
A61P1/16 (EP); A61P11/00 (EP); A61P13/00 (EP);
A61P13/08 (EP); A61P13/12 (EP); A61P15/00 (EP);
A61P17/00 (EP); A61P19/00 (EP); A61P19/02 (EP);
A61P19/04 (EP); A61P19/10 (EP); A61P21/00 (EP);
A61P25/00 (EP); A61P25/14 (EP); A61P25/16 (EP);
A61P25/28 (EP); A61P25/32 (EP); A61P27/02 (EP);
A61P29/00 (EP); A61P3/00 (EP); A61P3/04 (EP);
A61P3/06 (EP); A61P3/08 (EP); A61P3/10 (EP);
A61P31/14 (EP); A61P31/18 (EP); A61P35/00 (EP);
A61P35/02 (EP); A61P43/00 (EP); A61P5/50 (EP);
A61P7/00 (EP); A61P9/00 (EP); A61P9/04 (EP);
A61P9/10 (EP); C12Y305/01098 (EP,US); C12N2310/11 (EP,US);
C12N2310/113 (EP,US); C12N2310/14 (EP,US) (-)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2016/01]
TitleGerman:BEHANDLUNG VON SIRTUIN 1 (SIRT1)-BEDINGTEN ERKRANKUNGEN MITTELS HEMMUNG DES NATÜRLICHEN ANTISENSE-TRANSKRIPTS GEGEN SIRT 1[2016/01]
English:TREATMENT OF SIRTUIN 1 (SIRT1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO SIRT 1[2016/01]
French:TRAITEMENT DE SIRTUINE 1 (SIRT1) ASSOCIÉE À DES MALADIES PAR INHIBITION DU TRANSCRIT ANTISENS NATUREL DE SIRT 1[2016/01]
Examination procedure10.08.2015Examination requested  [2016/01]
11.01.2017Amendment by applicant (claims and/or description)
01.02.2018Despatch of a communication from the examining division (Time limit: M08)
08.11.2018Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
07.01.2019Reply to a communication from the examining division
24.04.2019Despatch of a communication from the examining division (Time limit: M06)
24.10.2019Reply to a communication from the examining division
05.06.2020Communication of intention to grant the patent
05.10.2020Fee for grant paid
05.10.2020Fee for publishing/printing paid
05.10.2020Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP10749298.5  / EP2403946
Opposition(s)12.08.2021No opposition filed within time limit [2021/42]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
07.01.2019Request for further processing filed
07.01.2019Full payment received (date of receipt of payment)
Request granted
22.01.2019Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
11.01.2017Request for further processing filed
11.01.2017Full payment received (date of receipt of payment)
Request granted
27.01.2017Decision despatched
Fees paidRenewal fee
10.08.2015Renewal fee patent year 03
10.08.2015Renewal fee patent year 04
10.08.2015Renewal fee patent year 05
10.08.2015Renewal fee patent year 06
31.03.2016Renewal fee patent year 07
27.03.2017Renewal fee patent year 08
27.03.2018Renewal fee patent year 09
27.03.2019Renewal fee patent year 10
27.03.2020Renewal fee patent year 11
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.03.2010
AT11.11.2020
CY11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
MK11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
TR11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
LU03.03.2021
IS11.03.2021
PT11.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
[2024/29]
Former [2024/22]HU03.03.2010
AT11.11.2020
CY11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
MK11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
LU03.03.2021
IS11.03.2021
PT11.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
Former [2023/27]HU03.03.2010
AT11.11.2020
CY11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
LU03.03.2021
IS11.03.2021
PT11.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
Former [2023/24]AT11.11.2020
CY11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
LU03.03.2021
IS11.03.2021
PT11.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
Former [2022/34]AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
LU03.03.2021
IS11.03.2021
PT11.03.2021
BE31.03.2021
CH31.03.2021
LI31.03.2021
Former [2022/23]AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
LU03.03.2021
IS11.03.2021
PT11.03.2021
CH31.03.2021
LI31.03.2021
Former [2022/10]AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
LU03.03.2021
PT11.03.2021
CH31.03.2021
LI31.03.2021
Former [2022/09]AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
LU03.03.2021
IS11.03.2021
PT11.03.2021
Former [2021/50]AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SI11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/46]AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
NL11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/45]AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
MC11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/37]AT11.11.2020
CZ11.11.2020
DK11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/36]AT11.11.2020
CZ11.11.2020
EE11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/35]AT11.11.2020
CZ11.11.2020
FI11.11.2020
HR11.11.2020
LT11.11.2020
LV11.11.2020
PL11.11.2020
RO11.11.2020
SE11.11.2020
SK11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/34]AT11.11.2020
CZ11.11.2020
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HR11.11.2020
LT11.11.2020
LV11.11.2020
PL11.11.2020
SE11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/33]AT11.11.2020
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LT11.11.2020
LV11.11.2020
PL11.11.2020
SE11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/32]AT11.11.2020
FI11.11.2020
HR11.11.2020
LV11.11.2020
PL11.11.2020
SE11.11.2020
SM11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/28]AT11.11.2020
FI11.11.2020
HR11.11.2020
LV11.11.2020
PL11.11.2020
SE11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/25]AT11.11.2020
FI11.11.2020
LV11.11.2020
PL11.11.2020
SE11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
IS11.03.2021
PT11.03.2021
Former [2021/24]AT11.11.2020
FI11.11.2020
LV11.11.2020
SE11.11.2020
BG11.02.2021
NO11.02.2021
GR12.02.2021
PT11.03.2021
Former [2021/23]FI11.11.2020
LV11.11.2020
SE11.11.2020
NO11.02.2021
GR12.02.2021
PT11.03.2021
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Documents cited:Search[E]WO2010065662  (CURNA INC [US], et al) [E] 1-14 * claims 3,16-18,24 *;
 [A]  - KUEHBACHER ANGELIKA ET AL, "MicroRNA 92a Controls Vessel Growth And Functional Recovery After Ischemia", BIOSIS, BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US, (200810), Database accession no. PREV200900197869, XP002684082 [A] 1-14 * abstract *
 [AP]  - BONAUER ANGELIKA ET AL, "MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, (20090626), vol. 324, no. 5935, ISSN 0036-8075, pages 1710 - 1713, XP002575234 [AP] 1-14 * page 1711 *
 [A]  - SUN ET AL, "Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells", LUNG CANCER, ELSEVIER, AMSTERDAM, NL, (20070914), vol. 58, no. 1, doi:10.1016/J.LUNGCAN.2007.05.013, ISSN 0169-5002, pages 21 - 29, XP022242948 [A] 1-14 * page 23 *

DOI:   http://dx.doi.org/10.1016/j.lungcan.2007.05.013
 [A]  - WAHLESTEDT ET AL, "Natural antisense and noncoding RNA transcripts as potential drug targets", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 11, no. 11-12, ISSN 1359-6446, (20060601), pages 503 - 508, (20060601), XP027889295 [A] 1-14 * page 505 *
 [A]  - MUNEKAZU YAMAKUCHI ET AL, "miR-34a repression of SIRT1 regulates apoptosis", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, US, vol. 105, no. 36, doi:10.1073/PNAS.0801613105, ISSN 0027-8424, (20080909), pages 13421 - 13426, (20080828), XP008149911 [A] 1-14 * page 13421 *

DOI:   http://dx.doi.org/10.1073/pnas.0801613105
 [A]  - SMALHEISER N R ET AL, "Natural antisense transcripts are co-expressed with sense mRNAs in synaptoneurosomes of adult mouse forebrain", NEUROSCIENCE RESEARCH, ELSEVIER, SHANNON, IR, vol. 62, no. 4, doi:10.1016/J.NEURES.2008.08.010, ISSN 0168-0102, (20081201), pages 236 - 239, (20080904), XP025669354 [A] 1-14 * page 238 *

DOI:   http://dx.doi.org/10.1016/j.neures.2008.08.010
 [A]  - THIMMAPPA S. ANEKONDA ET AL, "Neuronal protection by sirtuins in Alzheimer's disease", JOURNAL OF NEUROCHEMISTRY, (20060101), vol. 96, no. 2, doi:10.1111/j.1471-4159.2005.03492.x, ISSN 0022-3042, pages 305 - 313, XP055039113 [A] 1-14 * page 307 *

DOI:   http://dx.doi.org/10.1111/j.1471-4159.2005.03492.x
 [A]  - "Mus musculus 13 days embryo male testis cDNA, RIKEN full-length enriched library, clone:6030437B01 product:synembryn, full insert sequence.", ENA, (20080923), Database accession no. AK031466, URL: EBI, XP002745421 [A] 1-14 * sequence . *
 [I]  - "xj35b03.x1 Soares_NFL_T_GBC_S1 Homo sapiens cDNA clone IMAGE:2659181 3', mRNA sequence.", ENA, (20000304), Database accession no. AW169958, URL: EBI, XP002745422 [I] 1-14 * sequence . *
 [AP]  - APARNA PURUSHOTHAM ET AL, "Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation", CELL METABOLISM, (20090408), vol. 9, no. 4, doi:10.1016/j.cmet.2009.02.006, ISSN 1550-4131, pages 327 - 338, XP055039151 [AP] 1-14 * page 328 *

DOI:   http://dx.doi.org/10.1016/j.cmet.2009.02.006
Examination   - "Mus musculus adult retina cDNA, RIKEN full-length enriched library, clone:A930026H04 product:hypothetical protein, full insert sequence.", EMBL, (20080923), Database accession no. AK044604, URL: EBI
    - L R Saunders ET AL, "Sirtuins: critical regulators at the crossroads between cancer and aging", ONCOGENE, (20070801), vol. 26, no. 37, doi:10.1038/sj.onc.1210616, ISSN 0950-9232, pages 5489 - 5504, XP055439842

DOI:   http://dx.doi.org/10.1038/sj.onc.1210616
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